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The map label for this gene is hpt [H]

Identifier: 134302690

GI number: 134302690

Start: 1766885

End: 1767418

Strand: Reverse

Name: hpt [H]

Synonym: FTW_1883

Alternate gene names: 134302690

Gene position: 1767418-1766885 (Counterclockwise)

Preceding gene: 134302691

Following gene: 134302683

Centisome position: 93.1

GC content: 32.4

Gene sequence:

>534_bases
ATGACTTATTCTGCAGAAAATACTGAAGTTTATATAACAAGCCAACAACTTGAACAAGCTGTTACTAGATTAGCTGAACA
AATTAATCAAGACTATTCAGGACAGCAAGTTACACTTGTGTGTGTTTTAAAAGGCTCTTTTATGTTCTTTGCTGATCTTG
TGAGGAAGTTACGAATTGATCTAAGGACACAGTTTATTACAGCATCATCGTATGGTTCTAGTACTAAGAGTTCTGGGACA
GTGACTCTAACAGAAACATCGTTAAAAGAAGAGTATGTTAAAGATAAGAATATCATAATAATTGAAGATATAGTTGATAC
TGGACATACTTACCATAAGCTTATCGAGGGGATTGGTAAATATAATCCAAAAACTCTAAAGTTTGCAACTTTGTTATTTA
AGCCAGCTAGACTTGAAAGAGATGTTAAGCTTGATTATGTCTGCTTTGAAATAGAAGATAAATTTATTGTTGGCTATGGC
TTAGATTTCGATGAGAAATACCGTGAACTTCCATATATTGGTCTTATAAAATAA

Upstream 100 bases:

>100_bases
TATAGAGAATCACGTTGGTATTCCAATATCTTCATTAGCTTATGGACCATCTAGAGAACAAATTTTATTCTTTGAGGATT
ATTTCAAAAAGGGTTAATGT

Downstream 100 bases:

>100_bases
TTTTTTATCAATTCTTCATTAATAACTACTTATAAAAGTTTCTCTAAGAAAATCTTCAGCTAGTTTCCAAGCTCTTTTGT
TTGAAAGTTTATTAAATACC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFADLVRKLRIDLRTQFITASSYGSSTKSSGT
VTLTETSLKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIGKYNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYG
LDFDEKYRELPYIGLIK

Sequences:

>Translated_177_residues
MTYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFADLVRKLRIDLRTQFITASSYGSSTKSSGT
VTLTETSLKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIGKYNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYG
LDFDEKYRELPYIGLIK
>Mature_176_residues
TYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFADLVRKLRIDLRTQFITASSYGSSTKSSGTV
TLTETSLKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIGKYNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYGL
DFDEKYRELPYIGLIK

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=185, Percent_Identity=34.5945945945946, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI9910262, Length=177, Percent_Identity=32.7683615819209, Blast_Score=97, Evalue=8e-21,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=40, Blast_Score=138, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=183, Percent_Identity=34.4262295081967, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20311; Mature: 20179

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFADLVRKLRID
CCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LRTQFITASSYGSSTKSSGTVTLTETSLKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIGK
HHHEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHHHCC
YNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYGLDFDEKYRELPYIGLIK
CCCCCEEHHHHHCCCCCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHCCEEECCC
>Mature Secondary Structure 
TYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFADLVRKLRID
CCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
LRTQFITASSYGSSTKSSGTVTLTETSLKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIGK
HHHEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHHHCC
YNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYGLDFDEKYRELPYIGLIK
CCCCCEEHHHHHCCCCCCCCCCEEEEEEEEECCCEEEEECCCHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]