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The map label for this gene is asd [H]

Identifier: 134302493

GI number: 134302493

Start: 1552884

End: 1553984

Strand: Direct

Name: asd [H]

Synonym: FTW_1649

Alternate gene names: 134302493

Gene position: 1552884-1553984 (Clockwise)

Preceding gene: 134302489

Following gene: 134302504

Centisome position: 81.8

GC content: 34.88

Gene sequence:

>1101_bases
ATGCTTAAAGTTGGTTTTATTGGTTGGCGCGGAATGGTCGGCTCAGTTTTAATGTCTCGTATGATCGAATCAAAAGATTT
TGATTGTATTTTGCCAACGTTTTTTTCGACATCTCAGGTAGGGCAGCTGCCAACAGGTTTTATGCAACAATATGGAGCGT
TACAAGATGCCTATAGTATCGACCAACTAAGTAGTATGGATATACTTCTAAGTTGCCAAGGTGGTGAATATACCAAAGAA
ATACACCACAAATTAAGAGAAGCCGGCTGGCAAGGTTTCTGGATAGACGCTGCATCGACACTACGCTTAGACAAAGATAG
TACTCTAGTTCTAGACCCTCTAAATCACGATCAAATAATTAATGCTATTGATAATGGTAAAAAAGATTTTATCGGTAGTA
ATTGTACTGTTAGTCTAATGTCACTAGCTATAGCTGGACTACTCAAAGAAGATCTTGTTGAATGGGTTAACTCTAGTACT
TATCAAGCAATTTCAGGAGCGGGTGCCGCAGCAATGCAAGAACTACTTCAACAAACAAGCCTTTTAAGCAAAATTGATAA
TAGAGATGAAGATATTCTAATTAGAGAAAAAATTCTCAGAGAATTATCAAAAGACTCATCAAAAATCCCTCAACAAAAAA
CTGTACAAACTTTGGCTTATAATCTATTACCTTGGATAGATGTTGGTATGCCTAGTGGACAAACAAAAGAAGAGTACAAA
GCAGCTACAGAACTTAATAAAATTCTAGATACTAAAAAAACAATCCCTGTCGATGGTATATGTGTCAGAGTACCAAGTCT
AAGATCACACTCTCAAGCATTAACAGTCAAACTTAGACAGAAATTAACAATTGAAGAAATTAAGCAAAAAATATCTCAAG
GTAATGAATGGGTTAAAGTAATAGATAATAACAAAGAAGATACTTTAAAATACCTAACACCTCAAGCTACTTCAGGAACT
CTTGATATTGCTATAGGTCGTATCAAATCATCGTTATTAGCTGATGATATATTTCATTGTTTCACAGTAGGTGATCAGCT
ATTATGGGGAGCTGCTGAGCCTCTTAGAAGAGTTTTAAATATTATTAAAAATAAAATCTGA

Upstream 100 bases:

>100_bases
ATCATACTTTTTATACTCTTATGTTGAACAAATATCAAATTAGTTACTTTTGTATTATACTTTAACAGTAAATTTTATCA
CTAATAATTATGAGGGTTTT

Downstream 100 bases:

>100_bases
GATAAAAAATCTTAGAAAGTTTAAAAGATAATTATCAATACTTTTAGGCTTTTCCCAAACATAGCCTTTTGGCAAATCAC
AAGATACGCCTTTTTGACTT

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MLKVGFIGWRGMVGSVLMSRMIESKDFDCILPTFFSTSQVGQLPTGFMQQYGALQDAYSIDQLSSMDILLSCQGGEYTKE
IHHKLREAGWQGFWIDAASTLRLDKDSTLVLDPLNHDQIINAIDNGKKDFIGSNCTVSLMSLAIAGLLKEDLVEWVNSST
YQAISGAGAAAMQELLQQTSLLSKIDNRDEDILIREKILRELSKDSSKIPQQKTVQTLAYNLLPWIDVGMPSGQTKEEYK
AATELNKILDTKKTIPVDGICVRVPSLRSHSQALTVKLRQKLTIEEIKQKISQGNEWVKVIDNNKEDTLKYLTPQATSGT
LDIAIGRIKSSLLADDIFHCFTVGDQLLWGAAEPLRRVLNIIKNKI

Sequences:

>Translated_366_residues
MLKVGFIGWRGMVGSVLMSRMIESKDFDCILPTFFSTSQVGQLPTGFMQQYGALQDAYSIDQLSSMDILLSCQGGEYTKE
IHHKLREAGWQGFWIDAASTLRLDKDSTLVLDPLNHDQIINAIDNGKKDFIGSNCTVSLMSLAIAGLLKEDLVEWVNSST
YQAISGAGAAAMQELLQQTSLLSKIDNRDEDILIREKILRELSKDSSKIPQQKTVQTLAYNLLPWIDVGMPSGQTKEEYK
AATELNKILDTKKTIPVDGICVRVPSLRSHSQALTVKLRQKLTIEEIKQKISQGNEWVKVIDNNKEDTLKYLTPQATSGT
LDIAIGRIKSSLLADDIFHCFTVGDQLLWGAAEPLRRVLNIIKNKI
>Mature_366_residues
MLKVGFIGWRGMVGSVLMSRMIESKDFDCILPTFFSTSQVGQLPTGFMQQYGALQDAYSIDQLSSMDILLSCQGGEYTKE
IHHKLREAGWQGFWIDAASTLRLDKDSTLVLDPLNHDQIINAIDNGKKDFIGSNCTVSLMSLAIAGLLKEDLVEWVNSST
YQAISGAGAAAMQELLQQTSLLSKIDNRDEDILIREKILRELSKDSSKIPQQKTVQTLAYNLLPWIDVGMPSGQTKEEYK
AATELNKILDTKKTIPVDGICVRVPSLRSHSQALTVKLRQKLTIEEIKQKISQGNEWVKVIDNNKEDTLKYLTPQATSGT
LDIAIGRIKSSLLADDIFHCFTVGDQLLWGAAEPLRRVLNIIKNKI

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=364, Percent_Identity=49.7252747252747, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40775; Mature: 40775

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVGFIGWRGMVGSVLMSRMIESKDFDCILPTFFSTSQVGQLPTGFMQQYGALQDAYSI
CEEEEEECHHHHHHHHHHHHHHHCCCCCEECCCHHCCCHHCCCCHHHHHHHHHHHHHHHH
DQLSSMDILLSCQGGEYTKEIHHKLREAGWQGFWIDAASTLRLDKDSTLVLDPLNHDQII
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCEEEECCCCHHHHH
NAIDNGKKDFIGSNCTVSLMSLAIAGLLKEDLVEWVNSSTYQAISGAGAAAMQELLQQTS
HHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
LLSKIDNRDEDILIREKILRELSKDSSKIPQQKTVQTLAYNLLPWIDVGMPSGQTKEEYK
HHHHHCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AATELNKILDTKKTIPVDGICVRVPSLRSHSQALTVKLRQKLTIEEIKQKISQGNEWVKV
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEE
IDNNKEDTLKYLTPQATSGTLDIAIGRIKSSLLADDIFHCFTVGDQLLWGAAEPLRRVLN
ECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IIKNKI
HHHCCC
>Mature Secondary Structure
MLKVGFIGWRGMVGSVLMSRMIESKDFDCILPTFFSTSQVGQLPTGFMQQYGALQDAYSI
CEEEEEECHHHHHHHHHHHHHHHCCCCCEECCCHHCCCHHCCCCHHHHHHHHHHHHHHHH
DQLSSMDILLSCQGGEYTKEIHHKLREAGWQGFWIDAASTLRLDKDSTLVLDPLNHDQII
HHHCCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCEEEECCCCEEEECCCCHHHHH
NAIDNGKKDFIGSNCTVSLMSLAIAGLLKEDLVEWVNSSTYQAISGAGAAAMQELLQQTS
HHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
LLSKIDNRDEDILIREKILRELSKDSSKIPQQKTVQTLAYNLLPWIDVGMPSGQTKEEYK
HHHHHCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
AATELNKILDTKKTIPVDGICVRVPSLRSHSQALTVKLRQKLTIEEIKQKISQGNEWVKV
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCEEEE
IDNNKEDTLKYLTPQATSGTLDIAIGRIKSSLLADDIFHCFTVGDQLLWGAAEPLRRVLN
ECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IIKNKI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]