| Definition | Francisella tularensis subsp. tularensis WY96-3418, complete genome. |
|---|---|
| Accession | NC_009257 |
| Length | 1,898,476 |
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The map label for this gene is thrA [H]
Identifier: 134302492
GI number: 134302492
Start: 1550368
End: 1552788
Strand: Reverse
Name: thrA [H]
Synonym: FTW_1648
Alternate gene names: 134302492
Gene position: 1552788-1550368 (Counterclockwise)
Preceding gene: 134302494
Following gene: 134302491
Centisome position: 81.79
GC content: 33.95
Gene sequence:
>2421_bases ATGATAGTGCATAAGTTTGGTGGGAGTAGCCTTGCTAATGCAGAAAAAATAAAAAATGTTTCTAATATTATAAACTGTAA AGATGAAGCTGTAGTAGTTTCAGCTTCTGCAAAAACTACAAGAAATCTACAAAAAACTATAGATCAAGCTACAATAGCCC AAGATTACAGCGAAACTCTAGAGCAAATCTATGAGCATCATAATGAAATTATTAAGCAATTAATTCCGAATGATGAAACT CTAAGAACTTTGATTGTTACAGATTTAGCTAATATCAAGCATATTTTAAGTACCATCACTATTACAGGTTTTTGTGCAGA TAGTTTAAGGTTTTTTATTTTAGGTTTTGGTGAAATTTGGTCAGCTAGGATTCTAACAACTTATTTGAAGTCCAAGGGGA AAAAGGCGGCTTTTATAGATGCATCAGAATGTTTGATTGTCAATGATCGTAGTTACCCTGTAACAGTTGATTGGCAACAA AGTTTAGAAAAGTTAGAAATTATCAAAAGTGATACTCCTGCAGATGTATATGTTATAACAGGATTTATCGCACAGAATAA ATATGGTAAAAGAACTATTCTTGGTTTGAATTGTAGTGACTATTCTGCAGCTATTTTTGCAAAATTATTACAAGCTAATA AGTTGTATATTTGGACTGATGTTGCTGGTGTATATAGTGCTAATCCACAAGTTGTACCAGAGGCAAAGCCTCTAACTCAA TTAACATATAAAGAGGCTCTAGAGTTAGCATACTTTGGAGCATCTGTGGTTCATCCGCTTACAATAGCACCTATGGCTTT AGATAGGACGCCAATATATATAAAAAGTAGTTATACGCCAGATGAAGTTGGTACAAAGATAAGTGCAGATAAAGATGAGA ATCAAGGAATTATCAAGGGTTTAACAAGTGTATCAGACGTTGCTATTGTTCGAGTTCAAGGTGCTGGAATGATAGGAGTA TCAGGTATATCGTTTAAGGTATTCGGTGCGCTAGAAAAAGCTAATGTTTCAGTGATGATGATATCCCAGGCAAGTTCTGA ATACTCGATATGTTTTGCTATAGATAACCTTGATGTTGATAAAGCAACAGAGGCACTCAGACAAGAGTTTGCAAATGACA TAAAAAATAACTTAATAGAAGAAATAATTGTCCATAAGCACTATTCGCTAATTATAGCAGTTGGTGAGGGTATGAAGTCT AAGACTGGCTCGCTAGCAAAATTAGTCAATTCTCTTAAGTTAGCAAATATAAATATACATGCAATTGCTCAAGGTTCATC GGAGAGAAGTGTGACATTTGCTGTAAAAGCAGAGGATGAAGTTCGAGGTGTACAAGCAATGCATCGTCATTATAATTCTG TAAGTGATGATATTGCAATTGCGGTAATCGGTGCTGGTAATATTGGTAAAGCTTTCATCAGACAGCTTAAGCAGACTTAT GAAAAATGGTATGCAAAAGGTATTAATTTGGTATTGATAAGTGCTACTAATTCAAAAAAGATGAGATTTTCTTATGAAAA TTTATTATTTGAAAATATAAATAGTTTACTTGAGAAAAATACAGAACAAATTAATCTAGAGAAACTTGCTGAATTTATGT CGCATGCCTCAGCTACTAAAAAAATTGTTATCGATGCCATTGCAAGTGAAAGTGTATCAAAAAACTATATTAGTTTCTTA CAAAAAGGAATAAGTGTAATTACGCCAAATAAATATGCAAACTCAGGTAATTATGAGTTCTACCAAGAACTTAGAAAAGT CGCTAAACAAAATGGCACTAGCTTTTTGTATGAAACAAATGTTTGTGCTGGCCTTCCTCTCATAGTCACATTACAAAACA TGGTTCAAAGTGGTGATCATGTTAGAACTATCAAAGGGATTTTCTCAGGGACTTTGAGCTATTTGTTTACACAATTAAAT AATGGTGTAGTTTTTTCTGATGCAGTTAAGATGGCGTATGATGCAGGATATACAGAGCCAGATCCAAGACAAGATTTATC GGGTATGGATGTGGCGAGAAAGACTGTAATTTTGGCTAGAGAGATAGGTCTAAATATAGGTCTAAATGATTTAGTTATTG AAAATTTAGTACCAGAAGAATTAAGAGAGTGTAGTGTAGAAGAGTTTTTTGCTAAACTTCCTGCATTTAACGAGCAAATT ATGCAACAAATTGCTGATAAAAAGAAAAATTTAGCAGGCGTACATTATGTTGGATCTATAGTAAACGGTACTGCAAATGT CGGTATCCAAGCTTATGATGAGTCTAGTCCTTTTGCAAATGTGAAAGGTACAGATAATATCGTGATGATAAATACAGATA GATATACTCAGCCTATGGTTATCCAAGGTGCTGGTGCGGGTGTTGAGGTTACAGCAGCAGGTGTATATGCTGATGTTATA ACTGTGATAAGAGAAAAATAG
Upstream 100 bases:
>100_bases AGCATAAAACCCTCATAATTATTAGTGATAAAATTTACTGTTAAAGTATAATACAAAAGTAACTAATTTGATATTTGTTC AACATAAGAGTATAAAAAGT
Downstream 100 bases:
>100_bases TCATGAAATTAGCTAATATTAAATCAGCTAAGGCATTTGCTCCAGCAACTAGTGCAAATTTTGCAGTTGGTTATGATTTG CTTGGTTTTGCTATTGATGG
Product: bifunctional aspartokinase/homoserine dehydrogenase
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 806; Mature: 806
Protein sequence:
>806_residues MIVHKFGGSSLANAEKIKNVSNIINCKDEAVVVSASAKTTRNLQKTIDQATIAQDYSETLEQIYEHHNEIIKQLIPNDET LRTLIVTDLANIKHILSTITITGFCADSLRFFILGFGEIWSARILTTYLKSKGKKAAFIDASECLIVNDRSYPVTVDWQQ SLEKLEIIKSDTPADVYVITGFIAQNKYGKRTILGLNCSDYSAAIFAKLLQANKLYIWTDVAGVYSANPQVVPEAKPLTQ LTYKEALELAYFGASVVHPLTIAPMALDRTPIYIKSSYTPDEVGTKISADKDENQGIIKGLTSVSDVAIVRVQGAGMIGV SGISFKVFGALEKANVSVMMISQASSEYSICFAIDNLDVDKATEALRQEFANDIKNNLIEEIIVHKHYSLIIAVGEGMKS KTGSLAKLVNSLKLANINIHAIAQGSSERSVTFAVKAEDEVRGVQAMHRHYNSVSDDIAIAVIGAGNIGKAFIRQLKQTY EKWYAKGINLVLISATNSKKMRFSYENLLFENINSLLEKNTEQINLEKLAEFMSHASATKKIVIDAIASESVSKNYISFL QKGISVITPNKYANSGNYEFYQELRKVAKQNGTSFLYETNVCAGLPLIVTLQNMVQSGDHVRTIKGIFSGTLSYLFTQLN NGVVFSDAVKMAYDAGYTEPDPRQDLSGMDVARKTVILAREIGLNIGLNDLVIENLVPEELRECSVEEFFAKLPAFNEQI MQQIADKKKNLAGVHYVGSIVNGTANVGIQAYDESSPFANVKGTDNIVMINTDRYTQPMVIQGAGAGVEVTAAGVYADVI TVIREK
Sequences:
>Translated_806_residues MIVHKFGGSSLANAEKIKNVSNIINCKDEAVVVSASAKTTRNLQKTIDQATIAQDYSETLEQIYEHHNEIIKQLIPNDET LRTLIVTDLANIKHILSTITITGFCADSLRFFILGFGEIWSARILTTYLKSKGKKAAFIDASECLIVNDRSYPVTVDWQQ SLEKLEIIKSDTPADVYVITGFIAQNKYGKRTILGLNCSDYSAAIFAKLLQANKLYIWTDVAGVYSANPQVVPEAKPLTQ LTYKEALELAYFGASVVHPLTIAPMALDRTPIYIKSSYTPDEVGTKISADKDENQGIIKGLTSVSDVAIVRVQGAGMIGV SGISFKVFGALEKANVSVMMISQASSEYSICFAIDNLDVDKATEALRQEFANDIKNNLIEEIIVHKHYSLIIAVGEGMKS KTGSLAKLVNSLKLANINIHAIAQGSSERSVTFAVKAEDEVRGVQAMHRHYNSVSDDIAIAVIGAGNIGKAFIRQLKQTY EKWYAKGINLVLISATNSKKMRFSYENLLFENINSLLEKNTEQINLEKLAEFMSHASATKKIVIDAIASESVSKNYISFL QKGISVITPNKYANSGNYEFYQELRKVAKQNGTSFLYETNVCAGLPLIVTLQNMVQSGDHVRTIKGIFSGTLSYLFTQLN NGVVFSDAVKMAYDAGYTEPDPRQDLSGMDVARKTVILAREIGLNIGLNDLVIENLVPEELRECSVEEFFAKLPAFNEQI MQQIADKKKNLAGVHYVGSIVNGTANVGIQAYDESSPFANVKGTDNIVMINTDRYTQPMVIQGAGAGVEVTAAGVYADVI TVIREK >Mature_806_residues MIVHKFGGSSLANAEKIKNVSNIINCKDEAVVVSASAKTTRNLQKTIDQATIAQDYSETLEQIYEHHNEIIKQLIPNDET LRTLIVTDLANIKHILSTITITGFCADSLRFFILGFGEIWSARILTTYLKSKGKKAAFIDASECLIVNDRSYPVTVDWQQ SLEKLEIIKSDTPADVYVITGFIAQNKYGKRTILGLNCSDYSAAIFAKLLQANKLYIWTDVAGVYSANPQVVPEAKPLTQ LTYKEALELAYFGASVVHPLTIAPMALDRTPIYIKSSYTPDEVGTKISADKDENQGIIKGLTSVSDVAIVRVQGAGMIGV SGISFKVFGALEKANVSVMMISQASSEYSICFAIDNLDVDKATEALRQEFANDIKNNLIEEIIVHKHYSLIIAVGEGMKS KTGSLAKLVNSLKLANINIHAIAQGSSERSVTFAVKAEDEVRGVQAMHRHYNSVSDDIAIAVIGAGNIGKAFIRQLKQTY EKWYAKGINLVLISATNSKKMRFSYENLLFENINSLLEKNTEQINLEKLAEFMSHASATKKIVIDAIASESVSKNYISFL QKGISVITPNKYANSGNYEFYQELRKVAKQNGTSFLYETNVCAGLPLIVTLQNMVQSGDHVRTIKGIFSGTLSYLFTQLN NGVVFSDAVKMAYDAGYTEPDPRQDLSGMDVARKTVILAREIGLNIGLNDLVIENLVPEELRECSVEEFFAKLPAFNEQI MQQIADKKKNLAGVHYVGSIVNGTANVGIQAYDESSPFANVKGTDNIVMINTDRYTQPMVIQGAGAGVEVTAAGVYADVI TVIREK
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=819, Percent_Identity=37.973137973138, Blast_Score=535, Evalue=1e-153, Organism=Escherichia coli, GI1790376, Length=806, Percent_Identity=30.1488833746898, Blast_Score=360, Evalue=1e-100, Organism=Escherichia coli, GI1790455, Length=462, Percent_Identity=28.1385281385281, Blast_Score=142, Evalue=1e-34, Organism=Saccharomyces cerevisiae, GI6322599, Length=361, Percent_Identity=39.0581717451524, Blast_Score=199, Evalue=1e-51, Organism=Saccharomyces cerevisiae, GI6320893, Length=492, Percent_Identity=25.8130081300813, Blast_Score=135, Evalue=2e-32,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 88441; Mature: 88441
Theoretical pI: Translated: 6.46; Mature: 6.46
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIVHKFGGSSLANAEKIKNVSNIINCKDEAVVVSASAKTTRNLQKTIDQATIAQDYSETL CEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH EQIYEHHNEIIKQLIPNDETLRTLIVTDLANIKHILSTITITGFCADSLRFFILGFGEIW HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHEEEEEHHHHH SARILTTYLKSKGKKAAFIDASECLIVNDRSYPVTVDWQQSLEKLEIIKSDTPADVYVIT HHHHHHHHHHCCCCEEEEEECCCEEEECCCCCEEEECHHHHHHHHHHHCCCCCCEEEEEE GFIAQNKYGKRTILGLNCSDYSAAIFAKLLQANKLYIWTDVAGVYSANPQVVPEAKPLTQ EEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHCCCCCCCCCCCCCHHH LTYKEALELAYFGASVVHPLTIAPMALDRTPIYIKSSYTPDEVGTKISADKDENQGIIKG HHHHHHHHHHHHCHHHHCCCEECCEEECCCCEEEECCCCHHHHCCCCCCCCCCCCHHHHH LTSVSDVAIVRVQGAGMIGVSGISFKVFGALEKANVSVMMISQASSEYSICFAIDNLDVD HCCCCCEEEEEEECCCEEEECCCCEEEEECHHHCCEEEEEEEECCCCEEEEEEECCCCHH KATEALRQEFANDIKNNLIEEIIVHKHYSLIIAVGEGMKSKTGSLAKLVNSLKLANINIH HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHEEEEEEEE AIAQGSSERSVTFAVKAEDEVRGVQAMHRHYNSVSDDIAIAVIGAGNIGKAFIRQLKQTY EEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHH EKWYAKGINLVLISATNSKKMRFSYENLLFENINSLLEKNTEQINLEKLAEFMSHASATK HHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCHH KIVIDAIASESVSKNYISFLQKGISVITPNKYANSGNYEFYQELRKVAKQNGTSFLYETN HHEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC VCAGLPLIVTLQNMVQSGDHVRTIKGIFSGTLSYLFTQLNNGVVFSDAVKMAYDAGYTEP CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCC DPRQDLSGMDVARKTVILAREIGLNIGLNDLVIENLVPEELRECSVEEFFAKLPAFNEQI CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCHHHHHHHCCCHHHHH MQQIADKKKNLAGVHYVGSIVNGTANVGIQAYDESSPFANVKGTDNIVMINTDRYTQPMV HHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCEE IQGAGAGVEVTAAGVYADVITVIREK EEECCCCEEEEEHHHHHHHHHHHCCC >Mature Secondary Structure MIVHKFGGSSLANAEKIKNVSNIINCKDEAVVVSASAKTTRNLQKTIDQATIAQDYSETL CEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH EQIYEHHNEIIKQLIPNDETLRTLIVTDLANIKHILSTITITGFCADSLRFFILGFGEIW HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHEEEEEHHHHH SARILTTYLKSKGKKAAFIDASECLIVNDRSYPVTVDWQQSLEKLEIIKSDTPADVYVIT HHHHHHHHHHCCCCEEEEEECCCEEEECCCCCEEEECHHHHHHHHHHHCCCCCCEEEEEE GFIAQNKYGKRTILGLNCSDYSAAIFAKLLQANKLYIWTDVAGVYSANPQVVPEAKPLTQ EEECCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHCCCCCCCCCCCCCHHH LTYKEALELAYFGASVVHPLTIAPMALDRTPIYIKSSYTPDEVGTKISADKDENQGIIKG HHHHHHHHHHHHCHHHHCCCEECCEEECCCCEEEECCCCHHHHCCCCCCCCCCCCHHHHH LTSVSDVAIVRVQGAGMIGVSGISFKVFGALEKANVSVMMISQASSEYSICFAIDNLDVD HCCCCCEEEEEEECCCEEEECCCCEEEEECHHHCCEEEEEEEECCCCEEEEEEECCCCHH KATEALRQEFANDIKNNLIEEIIVHKHYSLIIAVGEGMKSKTGSLAKLVNSLKLANINIH HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHEEEEEEEE AIAQGSSERSVTFAVKAEDEVRGVQAMHRHYNSVSDDIAIAVIGAGNIGKAFIRQLKQTY EEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHH EKWYAKGINLVLISATNSKKMRFSYENLLFENINSLLEKNTEQINLEKLAEFMSHASATK HHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCCHH KIVIDAIASESVSKNYISFLQKGISVITPNKYANSGNYEFYQELRKVAKQNGTSFLYETN HHEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECC VCAGLPLIVTLQNMVQSGDHVRTIKGIFSGTLSYLFTQLNNGVVFSDAVKMAYDAGYTEP CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCC DPRQDLSGMDVARKTVILAREIGLNIGLNDLVIENLVPEELRECSVEEFFAKLPAFNEQI CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHCCHHHHHHHCCCHHHHH MQQIADKKKNLAGVHYVGSIVNGTANVGIQAYDESSPFANVKGTDNIVMINTDRYTQPMV HHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCEE IQGAGAGVEVTAAGVYADVITVIREK EEECCCCEEEEEHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7003595; 1630901; 7610040; 9278503; 6277952; 2410621; 387092; 6298218; 390305 [H]