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The map label for this gene is bcr [H]

Identifier: 134302479

GI number: 134302479

Start: 1536284

End: 1537477

Strand: Direct

Name: bcr [H]

Synonym: FTW_1629

Alternate gene names: 134302479

Gene position: 1536284-1537477 (Clockwise)

Preceding gene: 134302475

Following gene: 134302480

Centisome position: 80.92

GC content: 31.83

Gene sequence:

>1194_bases
ATGATTAAACAAGATAGTAAGCTTTTTATTCTTACACTTGGGCTTTTGGCAATGCTACCACCATTTGCAGTCAATACTTA
TGCTCCAGCTATCCCAAATATTGCTGAGCATTTTGGAATTCATCCAAACGATGTAATTTTCACCTTTACAACATATTTTA
TTGGCTTCTCTATAGGGATGCTTTTTTGGGGATCTTTTTCAGATAAGTTCGGTAGAAAGCTTAGTCTAATTTTAGGTATG
TTTTTATATGCTGCGAGTACTTTATTATGTGCCCATAGCCAAAGTTTTTCACAACTTGCTGTTTTTAGATTGATACAAGG
TTTAACAGACTCCTCAGGTACAGTGATTGCTTTAGCAATTGCTAGAGACTGCTATAGTGGTAAAAAACTAACAAATATCA
TCTCAACTCTAGCAATAATAATGTTGATTTCACCGATTATTTCTCCTATGATTGGAACCAGACTAATTGTATCAACACAA
AGTTGGAAAAGCTCTTTTTACTTTTTATTTGGATTTGGCATAGTACTTGTAATTCTTTGTAGTAAACTCCCAGAAACACA
TGCAAAAGAACAAAGAGAAAAATCTATCAAGAAATTATTTATAGCCTACTTCTACCATTTGCGAAATTTACCTTTTACTA
TATACACAATTTGTTCGGGTTTATTATTTGCTGCCTTTTTTAGTTATATTGGCGCTTCTTCTATAATTTATCTAAACGTC
TACGATACTGGCTATACTCTTTATATGTTATATTTTGCTTTAACGACTATCGGAGTTATCTTGGCAAATCTTACATTAAA
GCAATTAAGTGAATCAGTTGAACTTGAAGTATTTACACGTCTTGGACTTGGTATATCACTTCTTAGTGTGTTTGTTATGA
TTATTTATAGTCATACGCAATTCAAGCATGGTTATATTTTCATGTTATTAATGCTTATTACTTGTTATGGCTTAAGTCTA
AGTTCGACTTCACTATTAAGTCAGTCATTGCAGCTAATATCTAATCATTTTGGTGCAGCTACAGCTGTAAATAACTTTTT
CAAATTTTCACTTGCTGGCTTTGCCAACTTTGTAATGAGCTTTTCAGTTGGCTCTATGCTTGTATCAAACTTACCTTTAC
AGCAATTGACTATTATCTTAATCACAATAATACTTTTGTGTATTACTAAATACTATAAAAAAGCTAAGTCTTAA

Upstream 100 bases:

>100_bases
TTATATATTACAAAAAATTATACTTCTAATGTATATTTACAAAAAAACTACATAGTACTCTTAACAAAAATTGAATCAAA
ACTTTTAAGGAATTTTCATC

Downstream 100 bases:

>100_bases
CCATAACAACTGTAAGCGAAAGGTTTAAAATGACAAAACAAGAACTAAGAAACTACTATCAGCTAGCTTTTATTAATGGA
GTCAATGATGCGATTTCAGT

Product: drug resistance transporter, Bcr/CflA subfamily protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWGSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQGLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLGISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS

Sequences:

>Translated_397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWGSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQGLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLGISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
>Mature_397_residues
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGMLFWGSFSDKFGRKLSLILGM
FLYAASTLLCAHSQSFSQLAVFRLIQGLTDSSGTVIALAIARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQ
SWKSSFYFLFGFGIVLVILCSKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLGISLLSVFVMIIYSHTQFKHGYIFMLLMLITCYGLSL
SSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMSFSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=260, Percent_Identity=30.7692307692308, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI48994889, Length=402, Percent_Identity=23.3830845771144, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790146, Length=198, Percent_Identity=26.7676767676768, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87082312, Length=225, Percent_Identity=25.3333333333333, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787065, Length=312, Percent_Identity=23.3974358974359, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=199, Percent_Identity=25.1256281407035, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6325414, Length=152, Percent_Identity=27.6315789473684, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321577, Length=165, Percent_Identity=26.0606060606061, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44180; Mature: 44180

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGM
CCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
LFWGSFSDKFGRKLSLILGMFLYAASTLLCAHSQSFSQLAVFRLIQGLTDSSGTVIALAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEE
ARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQSWKSSFYFLFGFGIVLVILC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
SKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLGISLLSVFVMIIYSHTQ
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
FKHGYIFMLLMLITCYGLSLSSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMS
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKQDSKLFILTLGLLAMLPPFAVNTYAPAIPNIAEHFGIHPNDVIFTFTTYFIGFSIGM
CCCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
LFWGSFSDKFGRKLSLILGMFLYAASTLLCAHSQSFSQLAVFRLIQGLTDSSGTVIALAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEEE
ARDCYSGKKLTNIISTLAIIMLISPIISPMIGTRLIVSTQSWKSSFYFLFGFGIVLVILC
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
SKLPETHAKEQREKSIKKLFIAYFYHLRNLPFTIYTICSGLLFAAFFSYIGASSIIYLNV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
YDTGYTLYMLYFALTTIGVILANLTLKQLSESVELEVFTRLGLGISLLSVFVMIIYSHTQ
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
FKHGYIFMLLMLITCYGLSLSSTSLLSQSLQLISNHFGAATAVNNFFKFSLAGFANFVMS
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSVGSMLVSNLPLQQLTIILITIILLCITKYYKKAKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]