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The map label for this gene is ttcA1 [H]

Identifier: 134302168

GI number: 134302168

Start: 1163425

End: 1164180

Strand: Direct

Name: ttcA1 [H]

Synonym: FTW_1235

Alternate gene names: 134302168

Gene position: 1163425-1164180 (Clockwise)

Preceding gene: 134302167

Following gene: 134302169

Centisome position: 61.28

GC content: 32.8

Gene sequence:

>756_bases
ATGACAAAGACCGAGAAAAAACTACGCCACTATATCACCAAGGCTATTGCAGACTATAAGCTTCTTGATAAAGGTGATAA
AGTTATGCTATGCCTATCTGGTGGTAAAGATTCTTTTGGACTTCTAAAAGTCTTACATGGTTTAATTGAAGATAAAACCT
ATGATATTGACCTTCATGTATATACACTAGATCAGTCTCAACCAGGTTGGGATGATAGTCAACTTAGAAAATATCTTGAT
GATCTCGGTGTATCTTATGAAATTGAGACAAAAAACACTTATGGTGTAATCATAGACAAAGTTCCAGAGGGTAAAACCTA
TTGCTCACTATGTTCTAGGCTACGTCGTGGTAACATCTATAGATATGCAAAAGAGCATAAAATGGATAAAATAATTCTGG
GACATCATCATGATGATTTAATTCAATCATTATTAATGTCTATACTTTACCAAGGTCAGATTAAATCTATGCCACCTAAG
TTTGTTACTCAAGATGGTGAAAATACTGTAATCCGCCCAATGGTGTTAGTACAAGAACGCGACTTAATAGAATTTGCTAA
AGAAGAGAATTTCCCGATAATCCCATGCAATCTATGTGGTTCACAGGAAAACCTAAAAAGAAAGAAAGTTAAAAAACTTA
TCCAAGATTTAGCTCTTGAAAATCCAAAAGTACCTAGTAATATTTTGAATTCACTATCAAATGTATTGCCTAGTCATTTG
ATGGATAAAAATTTACTTAACTCTTTAGAAAATTAA

Upstream 100 bases:

>100_bases
ATTAGCTCAAGGTAAAAAAGTTCATGATAAGCGCCAAGCACAAAAAGACAAAGACTGGGCACGCGAAAAAGATAGATTAT
TTAAAAAGGCTTATAAATAA

Downstream 100 bases:

>100_bases
ATTAGTATAGGTATGAAATATTATTTATATCTTTTTAGAACTTAAAACTGCATATCAAAGTAAAAGGTAAATAGAAATAT
TTATACAAAAAATAACTACT

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTKTEKKLRHYITKAIADYKLLDKGDKVMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLD
DLGVSYEIETKNTYGVIIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHHDDLIQSLLMSILYQGQIKSMPPK
FVTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
MDKNLLNSLEN

Sequences:

>Translated_251_residues
MTKTEKKLRHYITKAIADYKLLDKGDKVMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLD
DLGVSYEIETKNTYGVIIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHHDDLIQSLLMSILYQGQIKSMPPK
FVTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
MDKNLLNSLEN
>Mature_250_residues
TKTEKKLRHYITKAIADYKLLDKGDKVMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHVYTLDQSQPGWDDSQLRKYLDD
LGVSYEIETKNTYGVIIDKVPEGKTYCSLCSRLRRGNIYRYAKEHKMDKIILGHHHDDLIQSLLMSILYQGQIKSMPPKF
VTQDGENTVIRPMVLVQERDLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHLM
DKNLLNSLEN

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=247, Percent_Identity=46.1538461538462, Blast_Score=256, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI193211090, Length=238, Percent_Identity=31.5126050420168, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17540090, Length=234, Percent_Identity=26.9230769230769, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651972, Length=231, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28789; Mature: 28658

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTEKKLRHYITKAIADYKLLDKGDKVMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHV
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEE
YTLDQSQPGWDDSQLRKYLDDLGVSYEIETKNTYGVIIDKVPEGKTYCSLCSRLRRGNIY
EEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCH
RYAKEHKMDKIILGHHHDDLIQSLLMSILYQGQIKSMPPKFVTQDGENTVIRPMVLVQER
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEHHHHHHHHH
DLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
HHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
MDKNLLNSLEN
HHHHHHHHHCC
>Mature Secondary Structure 
TKTEKKLRHYITKAIADYKLLDKGDKVMLCLSGGKDSFGLLKVLHGLIEDKTYDIDLHV
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEE
YTLDQSQPGWDDSQLRKYLDDLGVSYEIETKNTYGVIIDKVPEGKTYCSLCSRLRRGNIY
EEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCH
RYAKEHKMDKIILGHHHDDLIQSLLMSILYQGQIKSMPPKFVTQDGENTVIRPMVLVQER
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCEEHHHHHHHHH
DLIEFAKEENFPIIPCNLCGSQENLKRKKVKKLIQDLALENPKVPSNILNSLSNVLPSHL
HHHHHHHCCCCCEEEHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
MDKNLLNSLEN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA