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The map label for this gene is ilvD [H]

Identifier: 134302054

GI number: 134302054

Start: 1030469

End: 1032151

Strand: Reverse

Name: ilvD [H]

Synonym: FTW_1090

Alternate gene names: 134302054

Gene position: 1032151-1030469 (Counterclockwise)

Preceding gene: 134302055

Following gene: 134302053

Centisome position: 54.37

GC content: 37.37

Gene sequence:

>1683_bases
ATGAAAAAAGTATTGAATAAATATAGTAGAAGATTAACTGAGGATAAGTCACAAGGTGCTTCTCAAGCAATGCTATATGG
CACAGAGATGAATGATGCAGATATGCATAAACCACAAATAGGGATTGGTAGTGTGTGGTATGAAGGAAATACATGTAATA
TGCATTTAAATCAGTTAGCACAATTTGTAAAAGATAGTGTTGAGAAAGAAAACCTCAAGGGGATGAGATTTAATACTATC
GGAGTTAGTGATGGTATTTCTATGGGTACAGATGGTATGAGCTACTCATTACAATCTAGAGATCTTATTGCAGACTCTAT
TGAGACTGTAATGTCTGCACACTGGTATGATGGTTTAGTATCTATACCTGGTTGTGATAAGAATATGCCAGGATGTATGA
TGGCTTTAGGTAGACTTAATAGACCAGGGTTTGTGATCTACGGAGGTACTATCCAAGCAGGTGTAATGCGTGGTAAACCA
ATAGATATCGTTACAGCATTTCAGAGTTATGGAGCATGTCTATCTGGTCAGATCACAGAGCAAGAGCGTCAAGAAACTAT
CAAAAAAGCATGTCCAGGTGCTGGAGCATGTGGTGGTATGTATACTGCAAATACTATGGCATGTGCTATAGAAGCACTAG
GTATGAGTTTGCCATTTAGTTCATCTACATCAGCAACATCTGTTGAGAAAGTACAAGAGTGTGATAAAGCTGGAGAAACA
ATTAAAAACTTGCTAGAGCTTGATATTAAACCAAGAGATATCATGACTCGTAAAGCTTTTGAAAATGCAATGGTACTTAT
CACCGTGATGGGAGGCTCTACAAATGCTGTACTTCACCTATTAGCTATGGCAAGCTCGGTAGATGTTGATTTAAGTATTG
ATGATTTCCAAGAAATAGCTAACAAAACGCCAGTTCTAGCTGACTTTAAACCTAGTGGTAAATATGTAATGGCTAATTTA
CATGCTATAGGTGGTACTCCAGCTGTGATGAAAATGCTACTAAAAGCTGGTATGCTCCATGGAGATTGTTTAACAGTAAC
AGGTAAGACTTTAGCAGAAAATCTTGAGAATGTTGCAGATCTTCCAGAAGATAATACAATCATACATAAATTAGATAATC
CTATTAAAAAGACAGGACATTTACAAATCTTAAAAGGTAATGTTGCACCAGAAGGATCTGTAGCTAAAATCACTGGTAAG
GAGGGAGAGATATTTGAAGGAGTTGCAAATGTCTTTGACTCAGAAGAAGAGATGGTTGCTGCGGTAGAAACAGGCAAAGT
CAAAAAAGGTGATGTAATAGTTATTCGTTATGAAGGCCCTAAAGGTGGTCCAGGTATGCCAGAAATGTTAAAGCCAACAT
CACTTATAATGGGGGCTGGTTTAGGTCAAGATGTTGCTTTGATTACAGATGGTCGTTTCTCTGGTGGGTCACATGGCTTT
ATTGTTGGACACATTACTCCAGAGGCTTATGAGGGAGGGATGATAGCTTTGCTTGAGAATGGTGATAAGATTACTATTGA
TGCTATCAATAACGTTATAAATGTTGATTTATCAGATCAGGAAATAGCCCAAAGAAAATCCAAATGGAGAGCATCTAAGC
AAAAAGCAAGTAGAGGAACTCTAAAGAAATACATAAAAACAGTATCATCAGCATCAACAGGATGTGTTACAGACTTAGAT
TAA

Upstream 100 bases:

>100_bases
GTAAATCAGTATCTCCAGATATAATTCAGGCGTCGGTTGAAGCATTTATTGATGCCTATAATATTGCATATGCTTAAAAA
TTTTTAAAGGGTGAAAGATT

Downstream 100 bases:

>100_bases
ATTTTTGTAAAAAAACTACTAAATATACTTTTTGTATTTAAAAATTGCAAGTCCATGTCTATAATGACTTAACATTTAGC
AAATAATTGTTTTGCTAGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLAQFVKDSVEKENLKGMRFNTI
GVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLVSIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKP
IDIVTAFQSYGACLSGQITEQERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGET
IKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIANKTPVLADFKPSGKYVMANL
HAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVADLPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGK
EGEIFEGVANVFDSEEEMVAAVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGF
IVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGTLKKYIKTVSSASTGCVTDLD

Sequences:

>Translated_560_residues
MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLAQFVKDSVEKENLKGMRFNTI
GVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLVSIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKP
IDIVTAFQSYGACLSGQITEQERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGET
IKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIANKTPVLADFKPSGKYVMANL
HAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVADLPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGK
EGEIFEGVANVFDSEEEMVAAVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGF
IVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGTLKKYIKTVSSASTGCVTDLD
>Mature_560_residues
MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLAQFVKDSVEKENLKGMRFNTI
GVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLVSIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKP
IDIVTAFQSYGACLSGQITEQERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGET
IKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIANKTPVLADFKPSGKYVMANL
HAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVADLPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGK
EGEIFEGVANVFDSEEEMVAAVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGF
IVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGTLKKYIKTVSSASTGCVTDLD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=612, Percent_Identity=37.5816993464052, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788157, Length=501, Percent_Identity=29.1417165668663, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI2367371, Length=461, Percent_Identity=32.5379609544469, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786464, Length=529, Percent_Identity=30.812854442344, Blast_Score=181, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=564, Percent_Identity=59.7517730496454, Blast_Score=686, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59899; Mature: 59899

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLA
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHH
QFVKDSVEKENLKGMRFNTIGVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLV
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEE
SIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKPIDIVTAFQSYGACLSGQITE
ECCCCCCCCCHHHHHHHCCCCCCEEEECCEEEECEECCCCCCEEEHHHHHCCHHCCCCCH
QERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGET
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIA
HHHHHHCCCCCHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCCEEECHHHHHHHH
NKTPVLADFKPSGKYVMANLHAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVAD
CCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHC
LPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGKEGEIFEGVANVFDSEEEMVA
CCCCCCEEECCCCCHHHCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHEE
AVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGF
EHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCE
IVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGT
EEEEECCCCCCCCEEEEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LKKYIKTVSSASTGCVTDLD
HHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKVLNKYSRRLTEDKSQGASQAMLYGTEMNDADMHKPQIGIGSVWYEGNTCNMHLNQLA
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHH
QFVKDSVEKENLKGMRFNTIGVSDGISMGTDGMSYSLQSRDLIADSIETVMSAHWYDGLV
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCEE
SIPGCDKNMPGCMMALGRLNRPGFVIYGGTIQAGVMRGKPIDIVTAFQSYGACLSGQITE
ECCCCCCCCCHHHHHHHCCCCCCEEEECCEEEECEECCCCCCEEEHHHHHCCHHCCCCCH
QERQETIKKACPGAGACGGMYTANTMACAIEALGMSLPFSSSTSATSVEKVQECDKAGET
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKNLLELDIKPRDIMTRKAFENAMVLITVMGGSTNAVLHLLAMASSVDVDLSIDDFQEIA
HHHHHHCCCCCHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHCCCEEECHHHHHHHH
NKTPVLADFKPSGKYVMANLHAIGGTPAVMKMLLKAGMLHGDCLTVTGKTLAENLENVAD
CCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHC
LPEDNTIIHKLDNPIKKTGHLQILKGNVAPEGSVAKITGKEGEIFEGVANVFDSEEEMVA
CCCCCCEEECCCCCHHHCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHEE
AVETGKVKKGDVIVIRYEGPKGGPGMPEMLKPTSLIMGAGLGQDVALITDGRFSGGSHGF
EHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCE
IVGHITPEAYEGGMIALLENGDKITIDAINNVINVDLSDQEIAQRKSKWRASKQKASRGT
EEEEECCCCCCCCEEEEEECCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LKKYIKTVSSASTGCVTDLD
HHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA