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The map label for this gene is fmt

Identifier: 134301840

GI number: 134301840

Start: 797020

End: 797961

Strand: Direct

Name: fmt

Synonym: FTW_0818

Alternate gene names: 134301840

Gene position: 797020-797961 (Clockwise)

Preceding gene: 134301839

Following gene: 134301841

Centisome position: 41.98

GC content: 32.17

Gene sequence:

>942_bases
ATGAAAAAACTAAATATAATTTTCGCTGGAACTCCTGATATTTCAGCTCAAGTTCTAAAAGACTTATATAAATCACAACA
TAATATCCAAGCTGTACTTACGCAACCAGATAGAGCAAAAGGTCGTGGTAAAAAAGTACAGTTTTCACCTGTTAAAGAAG
TTGCATTAGCAAATCATACTCCAGTATTTCAGCCATTATCTTTTAAAAAGAATCCTGAAGTACTCGAGCAAATCAAACAA
CTAAAACCGGATGTAATAGTTGTAATAGCTTATGGAATTATTGTTCCACAAGAGTTTTTAGATATACCAAGGTATGGCTG
CTTGAATATACATGTATCACTATTGCCTAAATGGCGAGGAGCTGCGCCTATTCAAAGAGCTATCCAAGCTGGTGATACAA
AAACGGGGGTCTGTATAATGCAGATGGATGCTGGCCTTGATACTGGAGATATTCTAAATACTTTAGAAATTGAAATACAA
GAAACTGATACTTCACAAACACTTCACGATAAATTTGCTAAGTTATCAATTAAGCCATTACTAGAAACTTTAGAAAAGAT
TGAAATAATTAAGCCCGAGCCACAACAAGGAGAGCCAACTTATGCACATAAGATTACTAAGCAAGAGGGATTAATTGATT
TTACAAAATCAGCATGGCAAATTAGTTGTCATATTAGAGCATTTACACCGTGGCCAGGAGCATATTTTATATTAGATGAT
GAAGCAATAAAGGTTGGTGAGTTTGAGATACTTTATCAAAATACGGATAATAGAAAAGCAGGTACAATTATAGATATTTA
TAGAAGTGGCTTTGATATTGCGACAAGTGATAAAATTATTAGATTTAGACAATTACAATTTCCTAATAAAAAAATGCTTA
ATATTGTAGATATTTTAAATGGAAAAGATTTAGATAAATATATTGGATACAAACTAGGATAA

Upstream 100 bases:

>100_bases
GGTGCTCATGAGATCAAATATATTTGTCTTTATCCAGAAGGGCAAATCAATGAGTTAAGTAGTGTTCAATTACGTGGATA
CGCTTTTAGAGATTAGGTAA

Downstream 100 bases:

>100_bases
ATAATGAAAGTTGGATTTATAATAGATAACTTAAACTCTTTTAATATTTCAAAAGATAGCACTTATATGATGCTACATGC
AGCCCAAGATAAAGGCTGGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQ
LKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQ
ETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDD
EAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG

Sequences:

>Translated_313_residues
MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQ
LKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQ
ETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDD
EAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG
>Mature_313_residues
MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHTPVFQPLSFKKNPEVLEQIKQ
LKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRGAAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQ
ETDTSQTLHDKFAKLSIKPLLETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDD
EAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILNGKDLDKYIGYKLG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=310, Percent_Identity=26.4516129032258, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI21614513, Length=241, Percent_Identity=29.8755186721992, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI164663775, Length=223, Percent_Identity=27.8026905829596, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789683, Length=304, Percent_Identity=46.3815789473684, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788589, Length=265, Percent_Identity=28.6792452830189, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133930964, Length=256, Percent_Identity=29.296875, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319458, Length=270, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550868, Length=228, Percent_Identity=32.8947368421053, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28571984, Length=150, Percent_Identity=38, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=28.9795918367347, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_FRAT1 (Q14HS3)

Other databases:

- EMBL:   AM286280
- RefSeq:   YP_667053.1
- ProteinModelPortal:   Q14HS3
- SMR:   Q14HS3
- STRING:   Q14HS3
- GeneID:   4199412
- GenomeReviews:   AM286280_GR
- KEGG:   ftf:FTF0925
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   Q14HS3
- ProtClustDB:   CLSK934754
- BioCyc:   FTUL393115:FTF0925-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35325; Mature: 35325

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHT
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHCCCC
PVFQPLSFKKNPEVLEQIKQLKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRG
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCHHHHCCCCCCEEEEEEEEECCCCC
AAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQETDTSQTLHDKFAKLSIKPL
CCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCHHHH
LETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDD
HHHHHHCEEECCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEEEEEEECCCCCEEEEEEC
EAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILN
CEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCC
GKDLDKYIGYKLG
CCCHHHHCCCCCC
>Mature Secondary Structure
MKKLNIIFAGTPDISAQVLKDLYKSQHNIQAVLTQPDRAKGRGKKVQFSPVKEVALANHT
CCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHCCCC
PVFQPLSFKKNPEVLEQIKQLKPDVIVVIAYGIIVPQEFLDIPRYGCLNIHVSLLPKWRG
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCHHHHCCCCCCEEEEEEEEECCCCC
AAPIQRAIQAGDTKTGVCIMQMDAGLDTGDILNTLEIEIQETDTSQTLHDKFAKLSIKPL
CCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCHHHH
LETLEKIEIIKPEPQQGEPTYAHKITKQEGLIDFTKSAWQISCHIRAFTPWPGAYFILDD
HHHHHHCEEECCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEEEEEEECCCCCEEEEEEC
EAIKVGEFEILYQNTDNRKAGTIIDIYRSGFDIATSDKIIRFRQLQFPNKKMLNIVDILN
CEEEECCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCC
GKDLDKYIGYKLG
CCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA