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The map label for this gene is galK [H]

Identifier: 134301681

GI number: 134301681

Start: 613066

End: 614214

Strand: Reverse

Name: galK [H]

Synonym: FTW_0622

Alternate gene names: 134301681

Gene position: 614214-613066 (Counterclockwise)

Preceding gene: 134301682

Following gene: 134301671

Centisome position: 32.35

GC content: 32.72

Gene sequence:

>1149_bases
ATGATGGACTGTATCAAACATAATTTAATCAATCGTTTTGTTGAGCTCTATGGTAGAAAACCTCAATTATTTTTCTCACC
TGGTAGAGTGAATTTAATTGGTGAACATACTGATTACAATAATGGTTTTGTAATGCCGTTTGCCATAAATAAAGGGACAT
TTATTGCAATTGCAAAAAGAGATGACAATATAGTTAATGTATATAGCGAAAATTTAGATGACTCATCATCTTTTGACATT
ACCAAAATCAAACAAGAAATATCAAACACATGGCAAAACTATATAAAAGGCGTTATAAATATAATTAATCAAGATTTCAG
CAGTGATATCAAAGGGGCCGATATTTATATTTTTAGTGATCTACCCTTTGGTGCCGGCCTTTCTTCATCTGCTTCGCTAA
ATACTGCCTTAGCTTATGCTTATAATGATATTTACCAGCTAAATATCTCTAAAATTGACGTTGCAAAGATTGCACAAAAA
GTTGAGCATGAATATATTGGCACAAAATGTGGGCTTATGGATCAGATGGCTTGTTTGTTTTCACAGCAAAATGCCGCAAC
AATGATTGATTGTAATGATAACCACTATGACAACATTCCTTTTGAGCTTGATAATCTATCTGTGCTAATTTGTGATACAA
ATATTAAGCATAATTTAGCTGACTCTGCATATAATAAGCGCCGTCAAGTTTGTGAAAATATCGCTAGATTCCACAGCATA
AAATCACTTCGTGAATTAGATTCACAAAAGCTCGAAGATACAAAATTAAACTTCTCTGAAGAAGATCATAAATTGGCATT
ACATGTATTTACCGAAAATCAAAGAGTAATAGAAGCTACTAAAGCAATGGTAGCTAAAGACTGGCAAAAGCTAGGTAAAC
TAATGTATCAATCGCACAACTCGCTAAAAAATGATTACAAAGTTAGTTGTGATGAACTTGACTACCTAGTTGAGTTATCG
CAAAATTTTGCTGGAATTTATGGAGCTAGAATGACTGGTGGTGGTTTTGGCGGCTCGACCATACATCTTTTACCGACTAA
GCTTTTAAAAGAGTATGCTAGCTACCTAGAGAAAAATTATTTTGAAAAATTTAATATAAAACCTTCTTTCTATATTTCAA
AAGCTTGCCAAGGAACTTGTAAACTTTAA

Upstream 100 bases:

>100_bases
CAACAGTCAAAAAGTTTATGGTTGGATTTGAAATGCTTGGAGAATCGCAAAGAGATATTACTCCAGAATTAGCGGCACAA
GTTTTAAGAGATTTATAATC

Downstream 100 bases:

>100_bases
AATATACTCCTAACTTTTTCTCGTAGCTTATTTTTTTCTTGATCTGTATATGCTTTAGGCTCAATATTACCCCATACAGG
AGCTGGCCATACTGGATCAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MMDCIKHNLINRFVELYGRKPQLFFSPGRVNLIGEHTDYNNGFVMPFAINKGTFIAIAKRDDNIVNVYSENLDDSSSFDI
TKIKQEISNTWQNYIKGVINIINQDFSSDIKGADIYIFSDLPFGAGLSSSASLNTALAYAYNDIYQLNISKIDVAKIAQK
VEHEYIGTKCGLMDQMACLFSQQNAATMIDCNDNHYDNIPFELDNLSVLICDTNIKHNLADSAYNKRRQVCENIARFHSI
KSLRELDSQKLEDTKLNFSEEDHKLALHVFTENQRVIEATKAMVAKDWQKLGKLMYQSHNSLKNDYKVSCDELDYLVELS
QNFAGIYGARMTGGGFGGSTIHLLPTKLLKEYASYLEKNYFEKFNIKPSFYISKACQGTCKL

Sequences:

>Translated_382_residues
MMDCIKHNLINRFVELYGRKPQLFFSPGRVNLIGEHTDYNNGFVMPFAINKGTFIAIAKRDDNIVNVYSENLDDSSSFDI
TKIKQEISNTWQNYIKGVINIINQDFSSDIKGADIYIFSDLPFGAGLSSSASLNTALAYAYNDIYQLNISKIDVAKIAQK
VEHEYIGTKCGLMDQMACLFSQQNAATMIDCNDNHYDNIPFELDNLSVLICDTNIKHNLADSAYNKRRQVCENIARFHSI
KSLRELDSQKLEDTKLNFSEEDHKLALHVFTENQRVIEATKAMVAKDWQKLGKLMYQSHNSLKNDYKVSCDELDYLVELS
QNFAGIYGARMTGGGFGGSTIHLLPTKLLKEYASYLEKNYFEKFNIKPSFYISKACQGTCKL
>Mature_382_residues
MMDCIKHNLINRFVELYGRKPQLFFSPGRVNLIGEHTDYNNGFVMPFAINKGTFIAIAKRDDNIVNVYSENLDDSSSFDI
TKIKQEISNTWQNYIKGVINIINQDFSSDIKGADIYIFSDLPFGAGLSSSASLNTALAYAYNDIYQLNISKIDVAKIAQK
VEHEYIGTKCGLMDQMACLFSQQNAATMIDCNDNHYDNIPFELDNLSVLICDTNIKHNLADSAYNKRRQVCENIARFHSI
KSLRELDSQKLEDTKLNFSEEDHKLALHVFTENQRVIEATKAMVAKDWQKLGKLMYQSHNSLKNDYKVSCDELDYLVELS
QNFAGIYGARMTGGGFGGSTIHLLPTKLLKEYASYLEKNYFEKFNIKPSFYISKACQGTCKL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=378, Percent_Identity=38.0952380952381, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4503897, Length=413, Percent_Identity=27.8450363196126, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI48527957, Length=413, Percent_Identity=27.8450363196126, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1786972, Length=358, Percent_Identity=36.5921787709497, Blast_Score=248, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI71989053, Length=426, Percent_Identity=31.6901408450704, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319494, Length=453, Percent_Identity=24.7240618101545, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320212, Length=247, Percent_Identity=29.5546558704453, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24661292, Length=426, Percent_Identity=25.3521126760563, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21355577, Length=426, Percent_Identity=25.3521126760563, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24661285, Length=426, Percent_Identity=25.3521126760563, Blast_Score=108, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43421; Mature: 43421

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDCIKHNLINRFVELYGRKPQLFFSPGRVNLIGEHTDYNNGFVMPFAINKGTFIAIAKR
CCHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEEEEC
DDNIVNVYSENLDDSSSFDITKIKQEISNTWQNYIKGVINIINQDFSSDIKGADIYIFSD
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
LPFGAGLSSSASLNTALAYAYNDIYQLNISKIDVAKIAQKVEHEYIGTKCGLMDQMACLF
CCCCCCCCCCCCHHHHHHEEECCEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SQQNAATMIDCNDNHYDNIPFELDNLSVLICDTNIKHNLADSAYNKRRQVCENIARFHSI
CCCCCCEEEECCCCCCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KSLRELDSQKLEDTKLNFSEEDHKLALHVFTENQRVIEATKAMVAKDWQKLGKLMYQSHN
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKNDYKVSCDELDYLVELSQNFAGIYGARMTGGGFGGSTIHLLPTKLLKEYASYLEKNY
CCCCCCCCCHHHHHHHHHHHHHHHHHEECEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
FEKFNIKPSFYISKACQGTCKL
HHHCCCCCCCEEHHHCCCCCCC
>Mature Secondary Structure
MMDCIKHNLINRFVELYGRKPQLFFSPGRVNLIGEHTDYNNGFVMPFAINKGTFIAIAKR
CCHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCEEEEEEECCCEEEEEEEC
DDNIVNVYSENLDDSSSFDITKIKQEISNTWQNYIKGVINIINQDFSSDIKGADIYIFSD
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
LPFGAGLSSSASLNTALAYAYNDIYQLNISKIDVAKIAQKVEHEYIGTKCGLMDQMACLF
CCCCCCCCCCCCHHHHHHEEECCEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SQQNAATMIDCNDNHYDNIPFELDNLSVLICDTNIKHNLADSAYNKRRQVCENIARFHSI
CCCCCCEEEECCCCCCCCCCEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KSLRELDSQKLEDTKLNFSEEDHKLALHVFTENQRVIEATKAMVAKDWQKLGKLMYQSHN
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKNDYKVSCDELDYLVELSQNFAGIYGARMTGGGFGGSTIHLLPTKLLKEYASYLEKNY
CCCCCCCCCHHHHHHHHHHHHHHHHHEECEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
FEKFNIKPSFYISKACQGTCKL
HHHCCCCCCCEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA