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The map label for this gene is manB [H]

Identifier: 134301526

GI number: 134301526

Start: 445142

End: 446626

Strand: Reverse

Name: manB [H]

Synonym: FTW_0452

Alternate gene names: 134301526

Gene position: 446626-445142 (Counterclockwise)

Preceding gene: 134301527

Following gene: 134301523

Centisome position: 23.53

GC content: 35.56

Gene sequence:

>1485_bases
ATGAGACAAACTATAATAAAAGAAATAATCAAATCTAGCGGCGTAAAGTTTGGTACTAGTGGAGTTAGAGGTCTTGTTTC
AGCTATGACAGATAAGATCTGTTGGCTTTATACAAAAGCTTTTATTCAATTCCTAGAGCAAAAATACTCTATTGCTAAGG
GTACTAAAATTGCTATAGCTCATGATCTACGTGAGAGTAGCCCTAGAATAACAACAGTTGTTATTAAAGCTATCATAGAT
AGTGGTCATGAGCCAATATACTGTGGTGAGATACCATCACCAGCTGTAATGCTATATGGTATATCTAATCAGATACCGTC
AGTTATGGTTACTGGTAGTCATATTCCAGAGGATAGAAATGGTATTAAGTTTAATACTCCATATGGTGAAGTTCTCAAAG
AAGATGAAGAAATGATTGTTAGCCAAACTATCAGCATTGATGAAAGTATTTTTGATAAAAATGGCATGTTTTTACAAAAA
CTAGAATTACCAGAGCCTAGTAAGCAAGCATATACACAGTATATTGACAGGTATGTAGATTTTTTCCCTAACAACTGTCT
AGCAGGTAAGACTATAGGGCTTTATCAGCACTCATCTGTAGGGCGAGAGATAGTCAAAGAGATTCTAGAGAAACTAGGTG
CTAAGGTTATCTTGCTAGAATTTTCCGAAAAATTTGTATCTGTAGATACCGAGGCAATTCGCCAGGAAGATGTAAAGCTT
GCTAAGCAGTGGGCAAGCAAGTATAAAGTTGATAGTATAGTTTCAACTGATGGCGATGCTGATAGGCCACTAGTTAGTGA
TGAGTATGGCAATTGGCTAAAAGGTGATATTTTAGGTGTACTGATAGCTAAATATCTCCAAGCCAATGTTATCGTGACAC
CAGTAAGTAGCAATACCGTGGCAGAAAAGATAGGTTATTTTAGTAACGTGATTAGAACTAAAATAGGCTCGCCGTATGTA
ATTGCTGCAATGAATGAATTACTCTCAAATAATCAAAATGCTGTGGTTGGATATGAGGCAAATGGAGGATTTCTATTGGC
TAGTGATATTTGTAAAGATGATAAAACTCTAAAAGCGCTGCCTACAAGAGATGCTGTTATACCAATGTTGGCTGTAATGA
TGCTATCTATCAACTCTAATAAAACCGTGTCAGAGCTTTTATTTGATTTGCCATCTCGATATACAGCAAGTAGTAAAATT
GATGATTTTGCTTCCGAGAAAAGCCAAGAAATCTTGAAGTCAATATTAGCAGGTGAATCAGATCTTTTAGATAAAATTAT
ATCGGAGCATTTTGATGGTAAAAATAGCATTGAAAATATCGATACTACAGATGGTGTTAGAGTAACTTTGACAAATCAAG
ATATTATCCATCTTAGACCATCTGGTAATGCTCCAGAGCTTAGGTGCTATACAGAGGCAGCTAGTGATGAGCAGGCAAAA
AGTTTAAATCAATATTGTGTGGATTTGATTAACAAAAACATTTGA

Upstream 100 bases:

>100_bases
TCTTATAGAAGTACAAGTTGGAGAATATATAAGTGAAGACGATATTGTTAGACTAGATACAAGTAGTTAATATAAAAACA
ATTAGATAGAAAAAAATATA

Downstream 100 bases:

>100_bases
AGATCAGTCAAAAATATTCCCTAACTTTTCTCTTCACCATTGAACCATTACTAACCTTATCTATAGCTAGCCACAGATAA
AAATGTCATGCTGGATTTAT

Product: phosphoglucomutase/phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIAHDLRESSPRITTVVIKAIID
SGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRNGIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQK
LELPEPSKQAYTQYIDRYVDFFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKL
AKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLIAKYLQANVIVTPVSSNTVAEKIGYFSNVIRTKIGSPYV
IAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKALPTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKI
DDFASEKSQEILKSILAGESDLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAK
SLNQYCVDLINKNI

Sequences:

>Translated_494_residues
MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIAHDLRESSPRITTVVIKAIID
SGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRNGIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQK
LELPEPSKQAYTQYIDRYVDFFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKL
AKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLIAKYLQANVIVTPVSSNTVAEKIGYFSNVIRTKIGSPYV
IAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKALPTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKI
DDFASEKSQEILKSILAGESDLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAK
SLNQYCVDLINKNI
>Mature_494_residues
MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIAHDLRESSPRITTVVIKAIID
SGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRNGIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQK
LELPEPSKQAYTQYIDRYVDFFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKL
AKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLIAKYLQANVIVTPVSSNTVAEKIGYFSNVIRTKIGSPYV
IAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKALPTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKI
DDFASEKSQEILKSILAGESDLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAK
SLNQYCVDLINKNI

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1789566, Length=505, Percent_Identity=23.5643564356436, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 54654; Mature: 54654

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIA
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HDLRESSPRITTVVIKAIIDSGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRN
EHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCC
GIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQKLELPEPSKQAYTQYIDRYVD
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
FFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKL
HCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCHHHHHHHHHHH
AKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLIAKYLQANVIVTPVSSNTV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHH
AEKIGYFSNVIRTKIGSPYVIAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKAL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCEECC
PTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKIDDFASEKSQEILKSILAGES
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
DLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAK
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCHHHHH
SLNQYCVDLINKNI
HHHHHHHHHHHCCC
>Mature Secondary Structure
MRQTIIKEIIKSSGVKFGTSGVRGLVSAMTDKICWLYTKAFIQFLEQKYSIAKGTKIAIA
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
HDLRESSPRITTVVIKAIIDSGHEPIYCGEIPSPAVMLYGISNQIPSVMVTGSHIPEDRN
EHHHCCCCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCC
GIKFNTPYGEVLKEDEEMIVSQTISIDESIFDKNGMFLQKLELPEPSKQAYTQYIDRYVD
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
FFPNNCLAGKTIGLYQHSSVGREIVKEILEKLGAKVILLEFSEKFVSVDTEAIRQEDVKL
HCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCHHHHHHHHHHH
AKQWASKYKVDSIVSTDGDADRPLVSDEYGNWLKGDILGVLIAKYLQANVIVTPVSSNTV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHH
AEKIGYFSNVIRTKIGSPYVIAAMNELLSNNQNAVVGYEANGGFLLASDICKDDKTLKAL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCEECC
PTRDAVIPMLAVMMLSINSNKTVSELLFDLPSRYTASSKIDDFASEKSQEILKSILAGES
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH
DLLDKIISEHFDGKNSIENIDTTDGVRVTLTNQDIIHLRPSGNAPELRCYTEAASDEQAK
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCHHHHH
SLNQYCVDLINKNI
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379320 [H]