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The map label for this gene is fadA [H]

Identifier: 134301485

GI number: 134301485

Start: 390922

End: 392109

Strand: Reverse

Name: fadA [H]

Synonym: FTW_0400

Alternate gene names: 134301485

Gene position: 392109-390922 (Counterclockwise)

Preceding gene: 134301486

Following gene: 134301484

Centisome position: 20.65

GC content: 38.72

Gene sequence:

>1188_bases
ATGAGTGAAAATGTATATATAGTCGCTGCAAAACGCTCTGCTGTTACAAAAGGTAAAAAAGGTGGCTTTGCAAAAAAACG
TCCTGATGAGTTACTAGCAGATGTACTTAGAAGAACTGTCGCTGAAGCTAATATTAATCCTAACGATATAGAAGATATAG
TCGTCGGCTGTGCTATGCCTGAAGCTGAACAAGGCTTAAATGTTGCAAGAATATCATCTCTTTTGGCTGGACTACCTAAT
AGTGTTCCTGCTTTTACGATCAATCGTTACTGTAGCTCTGGACTACAGTCAATTGCTATTGCAGCAAATGAAATTGCTCA
AGGTAATATCGATGTTGCTATCGGTGCTGGTGTTGAAAGTATGAGTATGATTCCTTTTGGTGGTAACAAGATGTCTTTTA
GTAAAGAAATCTTTGCTAAGGATGAAAATGTTGCCATAGCTTATGGTATGGGTATCACAGCTGAGATGGTTGCTAAAGAT
TGGAATGTGTCACGACAAGATCAAGATGCTTTTGCTCTTGAAAGTCATCAAAAGGCTATCCATGCTATCGAGAGTGGTTA
TTTCAAAGATGAAATACTGCCTATAGATGTTGATCACAACAAACCAGATGAAGCAACTGGAGAGATCATTATTCATAAAC
AAACCATAACTGAAGATGAAGGGGCTCGAAAAGATACCTCACTAGAGGCATTAGCTAAACTAAAACCTGCTTTTGCTAAT
GGTGGATCTGTGACTGCTGGTAATAGTTCACAAGTATCAGACGGTGCTGCAGCTGTGATTTTAGTTAGTGAAAAATACCT
AAAAGAGCACAACCTAAAACCTTTAGGTAAGTTTCTAGGATTTGCTGTAGCTGGTGTTGATCCACGCATTATGGGTATTG
GCCCAATCAAAGCTATACCCAAAGTGCTTAGGCAAACTGGTTTAAATATCGATGATATTGACTGGATAGAGTTAAATGAA
GCTTTTGCGGCTCAATCACTCGCTGTGATTAATGATTTGAAACTTGATAAAAATAAAGTTAATCCTTGTGGTGGTGCTAT
TGCCTTAGGGCATCCACTTGGTGCAACAGGAACTATACTAACAGTCAAAGCACTACATGGACTACAACGCACTAGTAAAA
AATATGCTATGATTACGATGTGTATTGGTACTGGTATGGGTGCAGCTGGTATTATTGAAGCTTGTTAG

Upstream 100 bases:

>100_bases
GATAAACTTCAAAGAACTTGCGATATCTGAGAAAACAGAAGCTAGAATGAAATATATGCTAGAAACTGGCAAACCACTAA
GAAATTAAGGAGTAATTGAT

Downstream 100 bases:

>100_bases
TAGCTAATAATTCTGAACATTAATATAAAAAGTAACTAAATACCCAATAGGCTAAACTAAAATGATAAATTTAGATGATT
ATAAACCAATTGATTTCCCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSENVYIVAAKRSAVTKGKKGGFAKKRPDELLADVLRRTVAEANINPNDIEDIVVGCAMPEAEQGLNVARISSLLAGLPN
SVPAFTINRYCSSGLQSIAIAANEIAQGNIDVAIGAGVESMSMIPFGGNKMSFSKEIFAKDENVAIAYGMGITAEMVAKD
WNVSRQDQDAFALESHQKAIHAIESGYFKDEILPIDVDHNKPDEATGEIIIHKQTITEDEGARKDTSLEALAKLKPAFAN
GGSVTAGNSSQVSDGAAAVILVSEKYLKEHNLKPLGKFLGFAVAGVDPRIMGIGPIKAIPKVLRQTGLNIDDIDWIELNE
AFAAQSLAVINDLKLDKNKVNPCGGAIALGHPLGATGTILTVKALHGLQRTSKKYAMITMCIGTGMGAAGIIEAC

Sequences:

>Translated_395_residues
MSENVYIVAAKRSAVTKGKKGGFAKKRPDELLADVLRRTVAEANINPNDIEDIVVGCAMPEAEQGLNVARISSLLAGLPN
SVPAFTINRYCSSGLQSIAIAANEIAQGNIDVAIGAGVESMSMIPFGGNKMSFSKEIFAKDENVAIAYGMGITAEMVAKD
WNVSRQDQDAFALESHQKAIHAIESGYFKDEILPIDVDHNKPDEATGEIIIHKQTITEDEGARKDTSLEALAKLKPAFAN
GGSVTAGNSSQVSDGAAAVILVSEKYLKEHNLKPLGKFLGFAVAGVDPRIMGIGPIKAIPKVLRQTGLNIDDIDWIELNE
AFAAQSLAVINDLKLDKNKVNPCGGAIALGHPLGATGTILTVKALHGLQRTSKKYAMITMCIGTGMGAAGIIEAC
>Mature_394_residues
SENVYIVAAKRSAVTKGKKGGFAKKRPDELLADVLRRTVAEANINPNDIEDIVVGCAMPEAEQGLNVARISSLLAGLPNS
VPAFTINRYCSSGLQSIAIAANEIAQGNIDVAIGAGVESMSMIPFGGNKMSFSKEIFAKDENVAIAYGMGITAEMVAKDW
NVSRQDQDAFALESHQKAIHAIESGYFKDEILPIDVDHNKPDEATGEIIIHKQTITEDEGARKDTSLEALAKLKPAFANG
GSVTAGNSSQVSDGAAAVILVSEKYLKEHNLKPLGKFLGFAVAGVDPRIMGIGPIKAIPKVLRQTGLNIDDIDWIELNEA
FAAQSLAVINDLKLDKNKVNPCGGAIALGHPLGATGTILTVKALHGLQRTSKKYAMITMCIGTGMGAAGIIEAC

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.6428571428571, Blast_Score=321, Evalue=6e-88,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=39.9503722084367, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI148539872, Length=403, Percent_Identity=36.7245657568238, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=33.0845771144279, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=31.2020460358056, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI4504327, Length=409, Percent_Identity=32.7628361858191, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787663, Length=394, Percent_Identity=43.9086294416244, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=41.3098236775819, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=38.4039900249377, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=38.8613861386139, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1788683, Length=402, Percent_Identity=33.5820895522388, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI133906874, Length=400, Percent_Identity=38.75, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=368, Percent_Identity=35.3260869565217, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=32.75, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=410, Percent_Identity=31.4634146341463, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.2442748091603, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17537653, Length=322, Percent_Identity=26.7080745341615, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=43.25, Blast_Score=282, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=36.7396593673966, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=38.4615384615385, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=38.7654320987654, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=31.8295739348371, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137578, Length=438, Percent_Identity=31.7351598173516, Blast_Score=175, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41723; Mature: 41592

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENVYIVAAKRSAVTKGKKGGFAKKRPDELLADVLRRTVAEANINPNDIEDIVVGCAMP
CCCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
EAEQGLNVARISSLLAGLPNSVPAFTINRYCSSGLQSIAIAANEIAQGNIDVAIGAGVES
CHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
MSMIPFGGNKMSFSKEIFAKDENVAIAYGMGITAEMVAKDWNVSRQDQDAFALESHQKAI
EEEECCCCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
HAIESGYFKDEILPIDVDHNKPDEATGEIIIHKQTITEDEGARKDTSLEALAKLKPAFAN
HHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCHHHCC
GGSVTAGNSSQVSDGAAAVILVSEKYLKEHNLKPLGKFLGFAVAGVDPRIMGIGPIKAIP
CCCEECCCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHH
KVLRQTGLNIDDIDWIELNEAFAAQSLAVINDLKLDKNKVNPCGGAIALGHPLGATGTIL
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEE
TVKALHGLQRTSKKYAMITMCIGTGMGAAGIIEAC
EHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCC
>Mature Secondary Structure 
SENVYIVAAKRSAVTKGKKGGFAKKRPDELLADVLRRTVAEANINPNDIEDIVVGCAMP
CCCEEEEEECCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
EAEQGLNVARISSLLAGLPNSVPAFTINRYCSSGLQSIAIAANEIAQGNIDVAIGAGVES
CHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
MSMIPFGGNKMSFSKEIFAKDENVAIAYGMGITAEMVAKDWNVSRQDQDAFALESHQKAI
EEEECCCCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
HAIESGYFKDEILPIDVDHNKPDEATGEIIIHKQTITEDEGARKDTSLEALAKLKPAFAN
HHHHCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCHHHCC
GGSVTAGNSSQVSDGAAAVILVSEKYLKEHNLKPLGKFLGFAVAGVDPRIMGIGPIKAIP
CCCEECCCCCCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHCCCCCEEEECCHHHHHH
KVLRQTGLNIDDIDWIELNEAFAAQSLAVINDLKLDKNKVNPCGGAIALGHPLGATGTIL
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEE
TVKALHGLQRTSKKYAMITMCIGTGMGAAGIIEAC
EHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]