LOCUS NC_015756 18992 bp DNA circular BCT 07-JUL-2011 DEFINITION Weissella koreensis KACC 15510 plasmid WKp2903, complete sequence. ACCESSION NC_015756 VERSION NC_015756.1 GI:339635250 DBLINK Project: 68837 KEYWORDS . SOURCE Weissella koreensis KACC 15510 ORGANISM Weissella koreensis KACC 15510 Bacteria; Firmicutes; Lactobacillales; Weissella. REFERENCE 1 (bases 1 to 18992) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (06-JUL-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 2 (bases 1 to 18992) AUTHORS Lee,S.H. and Jeon,C.O. TITLE Direct Submission JOURNAL Submitted (28-JUN-2011) Life Science and Research Center for Biomolecules and Bioscience, Chung-ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul 156-756, Republic of Korea COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP002900. Annotation was added by the NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group. Information about the Pipeline can be found here: http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html. Please be aware that the annotation is done automatically with little or no manual curation. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..18992 /organism="Weissella koreensis KACC 15510" /mol_type="genomic DNA" /strain="KACC 15510" /isolation_source="kimchi" /culture_collection="KACC:15510" /db_xref="taxon:1045854" /plasmid="WKp2903" gene 618..1172 /locus_tag="WKK_06852" /db_xref="GeneID:10963519" CDS 618..1172 /locus_tag="WKK_06852" /note="COG1961 Site-specific recombinases, DNA invertase Pin homologs" /codon_start=1 /transl_table=11 /product="DNA invertase-like protein" /protein_id="YP_004717950.1" /db_xref="GI:339635251" /db_xref="GeneID:10963519" /translation="MKYGYARVSTTDQKLENQIENLKKSGAEIIYKEKFTGTTTERPE FNKLLNELKTDDTLIVTKLDRFARNTREALDIIEDLFKRDIKINILNMGIIDNTPTGQ LIFTIFSAFAQFERDMIVTRTHEGKEYAKRNDPYFHEGRPQTYTDEQIRLAYELRQQG MTYKMIARKTGISERTQQRRFKDI" misc_feature 618..1160 /locus_tag="WKK_06852" /note="multiple promoter invertase; Provisional; Region: mpi; PRK13413" /db_xref="CDD:184041" misc_feature 621..995 /locus_tag="WKK_06852" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768" /db_xref="CDD:58117" misc_feature order(636..638,642..644,807..812,819..821) /locus_tag="WKK_06852" /note="catalytic residues [active]" /db_xref="CDD:58117" misc_feature 642..644 /locus_tag="WKK_06852" /note="catalytic nucleophile [active]" /db_xref="CDD:58117" misc_feature order(804..806,936..941,945..950,960..962) /locus_tag="WKK_06852" /note="Presynaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(822..824,837..842,924..926,933..938,945..950, 957..959,966..968) /locus_tag="WKK_06852" /note="Synaptic Antiparallel dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(891..899,924..929,936..941,948..950,960..962, 969..971,981..983) /locus_tag="WKK_06852" /note="Synaptic Flat tetramer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(891..893,939..941,948..950,960..962,969..971, 981..983) /locus_tag="WKK_06852" /note="Synaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(963..965,981..986) /locus_tag="WKK_06852" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:58117" misc_feature 1035..1145 /locus_tag="WKK_06852" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569" /db_xref="CDD:119388" misc_feature order(1038..1046,1140..1145) /locus_tag="WKK_06852" /note="DNA-binding interface [nucleotide binding]; DNA binding site" /db_xref="CDD:119388" gene 2098..3333 /locus_tag="WKK_06857" /db_xref="GeneID:10963530" CDS 2098..3333 /locus_tag="WKK_06857" /codon_start=1 /transl_table=11 /product="plasmid mobilization protein, truncated" /protein_id="YP_004717951.1" /db_xref="GI:339635252" /db_xref="GeneID:10963530" /translation="MAHLKKNTRGAVPGLAVHFERKTDHHTNKEIDVSKTYLNQELMA DGSDMLSRFNARLNDVYCMKRDDVKALATWIVTLPEELAESPYEQQSAFFEATTNFLN DRYGQENAVAAVVHYDETTPHLHYAFVPVVFDDKKARYKVSAKEVLTRHDLQTFHEDL DQHLKKVLPFYERGILNNKTLPFENVAEIKKYNDQFNALKTELADIEDNIRAKQAVLK ITDQALTEVDLAEKQIDAFKQDLSKNLFGKTVLKPDDLDRFKSVLATMKKATLQSQHE TEELKQTLGQVKAQLADIQADYQNLKETHQALQKRQREQQQMDYAMRDMLKNDYGVDK IAHTDVEARYVLYKLDHEKLTQNKKVAQSWLKTLTTARADPDTKIAPTRLDRGIEQVK ALINRIIELTRDIFKGPSL" misc_feature 2098..2637 /locus_tag="WKK_06857" /note="Plasmid recombination enzyme; Region: Mob_Pre; pfam01076" /db_xref="CDD:110101" misc_feature <2551..3297 /locus_tag="WKK_06857" /note="chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169" /db_xref="CDD:162740" gene 3836..4990 /locus_tag="WKK_06862" /db_xref="GeneID:10963520" CDS 3836..4990 /locus_tag="WKK_06862" /note="COG5527 Protein involved in initiation of plasmid replication" /codon_start=1 /transl_table=11 /product="RepB protein" /protein_id="YP_004717952.1" /db_xref="GI:339635253" /db_xref="GeneID:10963520" /translation="MSIIPESKTRQVHTLNELSKRKVVEHNSLITSIAKMDKTPLKMF ELAVSLIDTENPPEDQTVYLSKRELFAFFQVDDSNKHSRFKEAVEKMQKQAFFQIKKE QDKGFKFISIVPIPYVEWTDYNDEVKIEFHREIMPYLINLKNNFTQHALSDIAELNSK YAIILYRWLSMNYNQYEHYSVKGGRREEQVESYRNPEISMRDLRQMTDTIDEYKRFDH FEKRVLNEPLSEITKHTTFNVTYEKLKKGRSIDSIVFHITKKQVADDISYKLDDPVYI EGKIRQEETEDMLTVKAIKSPYTKLLMEQFLLSYIDLTDTTILSGLQKNVYPLYDELK ESRGLKGVKEHLAYIRDKQDDYSKKNIAKYLKKSIEQYLPIVKRQDIDHE" misc_feature 3863..4975 /locus_tag="WKK_06862" /note="Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527" /db_xref="CDD:35086" misc_feature 3890..4606 /locus_tag="WKK_06862" /note="Initiator Replication protein; Region: Rep_3; cl03080" /db_xref="CDD:186548" misc_feature 4613..4978 /locus_tag="WKK_06862" /note="Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430" /db_xref="CDD:115107" gene 4983..5549 /locus_tag="WKK_06867" /db_xref="GeneID:10963521" CDS 4983..5549 /locus_tag="WKK_06867" /codon_start=1 /transl_table=11 /product="hypothetical cytosolic protein" /protein_id="YP_004717953.1" /db_xref="GI:339635254" /db_xref="GeneID:10963521" /translation="MSENLKTIRELAEELGVSKQAIQYHIKSLTNKTRQTNDKGIVVL SLEEQHFIRSKVDKQTNKNKTNKQTNDKQTDKETKWDIHNYLISELDEVKKNRDKQLA VKDKQLENKDSQIAQMQNLLDQQQRLALQDKQLLEEYKAEIKDLKALTMAPHDDGEKE VTSDKQLEPENSTPESQPKPKKWWRFGK" misc_feature <5001..5081 /locus_tag="WKK_06867" /note="Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055" /db_xref="CDD:197420" gene 5663..5881 /locus_tag="WKK_06872" /db_xref="GeneID:10963522" CDS 5663..5881 /locus_tag="WKK_06872" /note="COG2963 Transposase and inactivated derivatives" /codon_start=1 /transl_table=11 /product="ORFA of IS3-like IS" /protein_id="YP_004717954.1" /db_xref="GI:339635255" /db_xref="GeneID:10963522" /translation="MIRYKKEFKQSLVEMHNQGRSYTDLSAEYGPSVDSIRNWVKLYA VHEVDGEKWTQADVNALQKGKRQTSRRT" misc_feature 5669..5851 /locus_tag="WKK_06872" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116" /db_xref="CDD:186341" gene 6092..6547 /locus_tag="WKK_06877" /db_xref="GeneID:10963523" CDS 6092..6547 /locus_tag="WKK_06877" /note="COG3682 Predicted transcriptional regulator" /codon_start=1 /transl_table=11 /product="TcrY" /protein_id="YP_004717955.1" /db_xref="GI:339635256" /db_xref="GeneID:10963523" /translation="MSTIVVNPHITDAEWEVMRVVWANGRVTSKEIISILKEKMDWKQ ATIKTLLGRLVEKGVLNTEQEGRKFIYTTNIEEKEAVGNYTDDIFNRICRKNVGNVVG SIIEDHVLSFDDIQRLEEILEMKKAFAVEEVDCQCTEGQCDCHLHHHGE" misc_feature 6119..6505 /locus_tag="WKK_06877" /note="copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698" /db_xref="CDD:131745" misc_feature 6119..6460 /locus_tag="WKK_06877" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:193654" gene 6560..6712 /locus_tag="WKK_06882" /db_xref="GeneID:10963524" CDS 6560..6712 /locus_tag="WKK_06882" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004717956.1" /db_xref="GI:339635257" /db_xref="GeneID:10963524" /translation="MENKSFAIEGVESVEVDLATKKAVLESQTEIDTETLNAALAETN YSVLSA" misc_feature <6578..6700 /locus_tag="WKK_06882" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207" /db_xref="CDD:193707" gene 6851..8929 /locus_tag="WKK_06887" /db_xref="GeneID:10963525" CDS 6851..8929 /locus_tag="WKK_06887" /note="COG2217 Cation transport ATPase" /codon_start=1 /transl_table=11 /product="Cu2+-Cu+-Ag+-P-type ATPase" /protein_id="YP_004717957.1" /db_xref="GI:339635258" /db_xref="GeneID:10963525" /translation="MRNNKQHSSHSHHNHGDMDHSKHDHNEMEHSQMDHGKMNHSAMD HSEMDHGGHMMHMGDMSKKLKVAIILMIPLLLISPIAGFTILKFPGSEILQLILGTII FFYSGTPFFSGAKGELKSRKPAMMMLITMGITVAYTYSVYATIMSLNGHMGMNFWFEL ATLIVIMLIGHLIEMKAIMGAGDALKDLASLVPKKAHLKSGKDVELSELKVGDLLLVK ENERIPADGLILSEAFVDESMITGESRAVNKKTNDLVYGGSLNQNQPFEMKVTTLGKD SFLNQVAELVKKAQAQKSNLENMADRVAGYLFYAALIVGIFSLIFWTISSNFSFALLL AVSVFVIACPHALGLAVPLVVSRLTSISAKNGLLIQNRTSLEKINTIKYALMDKTGTL TDGNFIVRNVINFTDETDILQIMAALEGSSTHPIAQSIVSAAKPLENLKVEAVENIPG VGIKGQVNQNFYQIVNYKYLRENQLSYDEQKIAQYLDLGLTVSFLINEQQDVLGFIAL GDSPKADAKAFINGLLAQGITPVMLTGDNKETAQKIASALNIPEFRAELKPEDKAEIV KEYQKKAGVLFIGDGVNDSPALATATIGFAIGAGTSVAISTADVVLVNSNPSDVLDMI NISKRMLRKMKQNLWFGAGYNIIAIPVAAGILYPFTGIYIDPLIAAVLMSISTVIVAI NAMGLRYDKK" misc_feature 7169..8857 /locus_tag="WKK_06887" /note="copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511" /db_xref="CDD:188148" misc_feature 7337..7981 /locus_tag="WKK_06887" /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122" /db_xref="CDD:189402" misc_feature <8393..8608 /locus_tag="WKK_06887" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391" /db_xref="CDD:197437" gene complement(9011..9538) /locus_tag="WKK_06892" /db_xref="GeneID:10963526" CDS complement(9011..9538) /locus_tag="WKK_06892" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA repair" /protein_id="YP_004717958.1" /db_xref="GI:339635259" /db_xref="GeneID:10963526" /translation="MSQNKEAENLDDIFLIKDKNKPKTNKERSSEEKARETKQIVDNL KKMQDPGKRWNEEQKNEVHYERNGLVRFESLTKQKLRKIKRGKSYQVFMENIDIYLDS NEVKLEIKKLLQDTKDYLLQGVFDVFDANRYLRGNIYFLVHKGSQLNDYERKILKSFK NKPYLKISLQSLVFV" gene 9907..10551 /locus_tag="WKK_06897" /db_xref="GeneID:10963527" CDS 9907..10551 /locus_tag="WKK_06897" /note="COG0640 Predicted transcriptional regulators" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_004717959.1" /db_xref="GI:339635260" /db_xref="GeneID:10963527" /translation="MFEQAVNYKNGLYKELSKIGKGLSSDRRLEILDLLTQAPKSVET IANGVGISVANASRHLQILKDSHLVKTKRKGNHIIYSLSSPKISDFVHLLTDIGNSEL SDMKTIQDKSDAQDNVKTISLKQAQEEYKNSFVLDVRPSDEYAAGHIQSAINVPLETL KESMPKLPKDQKIIVYCRGRLCANSNIATQILNRNGFDAVSLNSSYYDWNKITE" misc_feature 9964..10164 /locus_tag="WKK_06897" /note="Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090" /db_xref="CDD:28974" misc_feature order(9964..9969,9973..9975,9982..9984,9991..9996, 10003..10008,10015..10017,10105..10107) /locus_tag="WKK_06897" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:28974" misc_feature order(9967..9972,9982..9990,10027..10035,10060..10071, 10075..10080,10087..10092,10096..10101,10117..10125, 10138..10146) /locus_tag="WKK_06897" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28974" misc_feature order(10027..10029,10036..10038) /locus_tag="WKK_06897" /note="putative Zn2+ binding site [ion binding]; other site" /db_xref="CDD:28974" misc_feature 10297..10536 /locus_tag="WKK_06897" /note="Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158" /db_xref="CDD:29073" misc_feature 10435..10437 /locus_tag="WKK_06897" /note="active site residue [active]" /db_xref="CDD:29073" gene 10677..10958 /locus_tag="WKK_06902" /db_xref="GeneID:10963528" CDS 10677..10958 /locus_tag="WKK_06902" /note="COG0526 Thiol-disulfide isomerase and thioredoxins" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="YP_004717960.1" /db_xref="GI:339635261" /db_xref="GeneID:10963528" /translation="MSTIDKTLTLINFENNWCAQCYTQRPIINKISHDFNSYLNVRVV NSDAHPEPAKKYNVYSAPSTILLRDGKIVEKITRFIDQSQLTTLIKYYL" misc_feature 10689..10946 /locus_tag="WKK_06902" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947" /db_xref="CDD:48496" misc_feature order(10728..10730,10737..10739) /locus_tag="WKK_06902" /note="catalytic residues [active]" /db_xref="CDD:48496" gene 10972..11286 /locus_tag="WKK_06907" /db_xref="GeneID:10963529" CDS 10972..11286 /locus_tag="WKK_06907" /note="COG0526 Thiol-disulfide isomerase and thioredoxins" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="YP_004717961.1" /db_xref="GI:339635262" /db_xref="GeneID:10963529" /translation="MVKNLTDKDFVKETSTGVTLTDFWATWCPPCRMQGPIIEQLDKE IGDKVKITKIDVDANQKTPIAFGIMSIPTLIIKKDGQVVDKLVGLHSKDQLKTVLAQY TN" misc_feature 11011..11271 /locus_tag="WKK_06907" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947" /db_xref="CDD:48496" misc_feature order(11053..11055,11062..11064) /locus_tag="WKK_06907" /note="catalytic residues [active]" /db_xref="CDD:48496" gene 11307..11630 /locus_tag="WKK_06912" /db_xref="GeneID:10963509" CDS 11307..11630 /locus_tag="WKK_06912" /note="COG0526 Thiol-disulfide isomerase and thioredoxins" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="YP_004717962.1" /db_xref="GI:339635263" /db_xref="GeneID:10963509" /translation="MEQLSVMNKKEFDKKLKNGKYILVFMASWCPDCSFIKPHLPEIE QEFKDYTFISVDRDENTELAQELNIFGIPSFVIFRDGQEIGRLVNKDRKTKEEVENFI TNTIN" misc_feature 11334..11612 /locus_tag="WKK_06912" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947" /db_xref="CDD:48496" misc_feature order(11394..11396,11403..11405) /locus_tag="WKK_06912" /note="catalytic residues [active]" /db_xref="CDD:48496" gene 11849..12793 /locus_tag="WKK_06917" /db_xref="GeneID:10963510" CDS 11849..12793 /locus_tag="WKK_06917" /note="COG0492 Thioredoxin reductase" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="YP_004717963.1" /db_xref="GI:339635264" /db_xref="GeneID:10963510" /translation="MRKYDVVVIGAGPGGMTAALYAARANLNVAMLDRGIYGGQMNNT DDIENYPGFTTIKGPELGEKMYQGTVKAGVNFVYGDVQNVTVDDQQMKHIQTDSDELV ASAVIIATGSNNRKLGVPGEENFSGKGVSYCAVCDGSFFKGKNVTVVGGGDSAISEGL YLANVTDGVNVIHRRDQLRAQKVLQNRAFDNDKIDFTWNTSVTEILGDENHVTGVKIH NNQVGDDTTLDTDGVFVYVGNFPNSQIFNNLNITDQAGWIITNDQMETTIPGIYAIGD VRQKQLRQITTAVGDGGIAGQNAFEYFEAIKHRQTVKD" misc_feature 11858..12754 /locus_tag="WKK_06917" /note="thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292" /db_xref="CDD:162288" misc_feature 11858..>12181 /locus_tag="WKK_06917" /note="Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644" /db_xref="CDD:197445" misc_feature 12281..12493 /locus_tag="WKK_06917" /note="Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644" /db_xref="CDD:197445" gene 12812..13459 /locus_tag="WKK_06922" /db_xref="GeneID:10963511" CDS 12812..13459 /locus_tag="WKK_06922" /note="COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis" /codon_start=1 /transl_table=11 /product="protein-disulfide isomerase" /protein_id="YP_004717964.1" /db_xref="GI:339635265" /db_xref="GeneID:10963511" /translation="MEIKYWSDIACPFCYIGSNRMKRAMKEIGIYDTTELEFKSFELN PATPKETDEGYINHFTQGNKAMEPQAKKQMAYIEQMAHNDGLPMDLDSVVPTNTMDAH RIIKFAEAKNDPDLTERVIRRFYQVYFSDGQSISDHDVLLNAAMEAGLAKDEVEKVLN SNQYHQAVVNDEAEAQQSGIHAAPFFVINNKYAISGAQPYEVFVKALKGVQAEEN" misc_feature 12812..13453 /locus_tag="WKK_06922" /note="Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761" /db_xref="CDD:32627" misc_feature 12818..13432 /locus_tag="WKK_06922" /note="DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024" /db_xref="CDD:48573" misc_feature order(12842..12844,12851..12853) /locus_tag="WKK_06922" /note="catalytic residues [active]" /db_xref="CDD:48573" gene 13472..13600 /locus_tag="WKK_06927" /db_xref="GeneID:10963512" CDS 13472..13600 /locus_tag="WKK_06927" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004717965.1" /db_xref="GI:339635266" /db_xref="GeneID:10963512" /translation="MTEDKPQFNTIFGDNNDAAVCGPDGCNIAEHQKQTEDKKKTK" gene 13618..14949 /locus_tag="WKK_06932" /db_xref="GeneID:10963513" CDS 13618..14949 /locus_tag="WKK_06932" /note="COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004717966.1" /db_xref="GI:339635267" /db_xref="GeneID:10963513" /translation="MKFDYVVIGSGPSVYRFLLGMQNSGKKIAVVEKNRFGGICPNEG CEPKIFLEGAARATLTSMRLQGKGITQPAKLDWKELIQQKNKAMASFLNNMQSMYEGL GATTIKGEASFVDQHTIEVNNKKITADNFVIATGKKPHPLNIPGHEYLLTSTNLFELE DTPKNVAIIGSGYVGMEFATLLSAAGVKVTVIVRSGQPLEGFYSQHVHQLVDEMKNSL GINFIFNTNVTAVTEAQTGYEVQSANGNLGTFDKVINASGRVPEINALKLDNAGVEYS NRGIKVDKYLTTSANNIYAMGDIVDKTAPALTSTAQFEADYLSALLTNKTTEPLRYPV IGTVTFTFPQLAQAGISIDKAKEDSNYSIKDIDITQGDFLYAGTDDHARLSLVFDKQN HLVGAAEISQTAVDDINSLIPVMAIDVDPEVWKEKMLMAFPGLAYKIRTLI" misc_feature 13618..14943 /locus_tag="WKK_06932" /note="Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249" /db_xref="CDD:31441" misc_feature 14110..14355 /locus_tag="WKK_06932" /note="Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644" /db_xref="CDD:197445" gene complement(15722..15853) /locus_tag="WKK_06937" /db_xref="GeneID:10963514" CDS complement(15722..15853) /locus_tag="WKK_06937" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004717967.1" /db_xref="GI:339635268" /db_xref="GeneID:10963514" /translation="MKRLSLNKDPKATTNAWGPLINTITHHGLNSLKKGEIKFDDLK" gene complement(15861..16355) /locus_tag="WKK_06942" /db_xref="GeneID:10963515" CDS complement(15861..16355) /locus_tag="WKK_06942" /note="COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family" /codon_start=1 /transl_table=11 /product="putative NADH oxidase-related oxidoreductase protein" /protein_id="YP_004717968.1" /db_xref="GI:339635269" /db_xref="GeneID:10963515" /translation="MRILVEIYQGIRQVTKSNFIVGIKLNSSDFSSEGFSEDDSYRVI VKMSNLGIDFIKISGGNYERTKFLENSNGEAFFLKFSKKSQVSVNIPIMLTGGLSSQE AMENVVTNEGIAMVGSVRPFVLNPNSPEKMLSGIFEGLKLPHLTTGVKVIDNKLGHGG SSIL" misc_feature complement(15951..>16355) /locus_tag="WKK_06942" /note="TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108" /db_xref="CDD:195791" misc_feature complement(order(15996..16001,16065..16070)) /locus_tag="WKK_06942" /note="phosphate binding site [ion binding]; other site" /db_xref="CDD:73384" gene complement(16463..16561) /locus_tag="WKK_06947" /db_xref="GeneID:10963516" CDS complement(16463..16561) /locus_tag="WKK_06947" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004717969.1" /db_xref="GI:339635270" /db_xref="GeneID:10963516" /translation="MTKEPVAPSVIPMPKNLRKLFNTPRELSKTGG" gene complement(16736..17569) /locus_tag="WKK_06952" /db_xref="GeneID:10963517" CDS complement(16736..17569) /locus_tag="WKK_06952" /note="COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)" /codon_start=1 /transl_table=11 /product="hydrolase, alpha/beta fold family protein" /protein_id="YP_004717970.1" /db_xref="GI:339635271" /db_xref="GeneID:10963517" /translation="MSYLQTKNQYITVEGLKIAYRELGQGKSQYPLVMLVHLAATMDN WDPKLIDNLAEKNHIIVMDLPGVGASEGKIAESIPCMADQAIAIIKALGYQKINLLGL SMGGFIAQEIVRLDANLVNTLTLAGTGPRAGIGVDKVTGVTFKHMANGFLHGADAKRY IFYNPDKAGKVEAHKVLDRLASRPKDAKDKDMKVSSFLKQLKAIKSWGKAEQDTLDFI KVPTFIVNGDNDVMVPTQNSYDMHEKIQDSKLIIYPDAGHGAIFQYAEEFVDELNNFL N" misc_feature complement(16757..17473) /locus_tag="WKK_06952" /note="Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697" /db_xref="CDD:193173" misc_feature complement(<16778..>16912) /locus_tag="WKK_06952" /note="Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031" /db_xref="CDD:197440" gene complement(17571..18578) /locus_tag="WKK_06957" /db_xref="GeneID:10963518" CDS complement(17571..18578) /locus_tag="WKK_06957" /note="COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases" /codon_start=1 /transl_table=11 /product="zinc-binding dehydrogenase" /protein_id="YP_004717971.1" /db_xref="GI:339635272" /db_xref="GeneID:10963518" /translation="MKAAQLTQYNKNNIKLELVDTPMPELGAQDVLVKVTAAGVNPVD NMISRGQIKLLIPYKLPQIAGNEVVGIVEKVGTQVTGFKVGDRVFARMPLDRIGAFAE YTAINYRALAHVPDYLTDVEAAAVPLTALTVMQALDLMGAKKGGTFFMTGGTGGVGAM AIPIAKAKGLTVITNGNIDNKARIMALGLNRFIDYKTEDYTQTLSQVDYVLDTLGGAE TEKQMSIMKKGGKLVNLSGMPNKAFAKRFGLPKWKQILFGLVGGKFDRMAKKYGVTYD FVFVESNGAQLQEVADLFSQLKIKPSIDTVYNFSQINEALDKVANGRSRGKTVITFGE K" misc_feature complement(17583..18578) /locus_tag="WKK_06957" /note="NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604" /db_xref="CDD:30949" misc_feature complement(17589..18578) /locus_tag="WKK_06957" /note="alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289" /db_xref="CDD:176191" misc_feature complement(order(17739..17747,17871..17876,17937..17942, 17997..17999,18039..18041,18045..18050,18105..18122, 18183..18185,18195..18197,18441..18443,18450..18458)) /locus_tag="WKK_06957" /note="putative NAD(P) binding site [chemical binding]; other site" /db_xref="CDD:176191" ORIGIN 1 tttagtatcc attattttct attttccttt ttgttgtatc agattcaggt acaagtatat 61 atagatattt tctaatgtca acaattttga ctcattatta ccaataatac ttagacgtat 121 tggttcgtaa cctatagcat aactttttat ttttatggat aaattttgga tccaccttaa 181 attccacttc acttacaaaa aataaggtgt aaaatcctta taaaacaaaa agtgatctaa 241 ggaatttctc ttagattact tttggactct ctgccaaatc ctgtcgatgg actgtaattg 301 gatagtataa agataaaact aaataaaagt cgtggagata accctcaaaa ttgaaccaaa 361 ttccaatctg gggttagcct catttgtaat tcttctgctc gtatactgaa aatccggact 421 gctttatttc tagggcataa tccgagataa tcaagtatag gagtttaata ggcgtcataa 481 ctcaacagtt gtgtcgcctt tttttgtgcc ttataattaa aggtgttaga atgcgtcata 541 acttaccgcc ataaatacag acccttttta ctgcaaaagt accaaatttg ctatataaaa 601 cagattggag aaataatatg aaatatggtt atgcacgagt gagcaccacc gatcaaaaac 661 tagaaaatca aattgagaac ttaaaaaaat caggcgctga aataatctat aaagaaaagt 721 ttactggtac gactactgaa cgtcccgaat ttaacaaatt gctgaatgaa cttaaaacag 781 acgacacgct aattgtgaca aaactagacc gctttgcacg caatactaga gaagcccttg 841 atataattga agacctattt aaacgtgaca tcaaaattaa tatccttaac atgggaataa 901 ttgataatac acccacagga caattgattt ttacaatttt tagcgccttt gcgcaatttg 961 aacgagatat gattgtgaca agaacacatg agggaaaaga atatgccaaa aggaacgacc 1021 cttattttca tgagggacgc ccacaaacct acacagatga acaaatacgt ttagcctatg 1081 agttgcgtca acaaggcatg acatacaaaa tgattgctag aaaaacaggc ataagtgaac 1141 gaacgcaaca aagacgattt aaagatatat gatagcatat catgatgtgc tatgttgtta 1201 atgccagcta aattataccg tgaaccctct atcaaaagtt gcccacttta ctagcatacg 1261 aacaaattgt gtgagaaaat tattgactta acttgattca tcttatgaaa acaaaaaaat 1321 atcacaataa aatatgtcta caagtttaaa cgtatcgtat caagctatat ctaattggga 1381 acgtgggaaa agttatccgg atatctccaa tattattatg atttcagatt tgtacaatat 1441 ttcattggat gaactgatta gagaagataa aaactataaa gacatgttac ttgaaaagaa 1501 agtatcaggc atcgtcgata cgatacttaa tgttattttt ttcttgtgcg ctgtaatgat 1561 attaatttac atgattatcg aaaataaact cacctcagca aattcttttt atatcattct 1621 ggcaatctta gttataatcc ataccagcat tgatttatta aaattgttac caaaaaaaac 1681 gtgtagtttg ctcacaggga attttggatt caaattaata cgatgaggga catatcagca 1741 ttcaaaataa gttgagatag atacagatac tatctcaact tattttttat gtggttaagc 1801 tgacaccagc ttgccccacg cgggtagcgt tctgcatgac atgctctcac tgaaagtgat 1861 cctgcaatga taaattgccc cgtcacggcg tgacccgccg gaggttttac aagccggata 1921 agtggcgctg taaaatagca gtttccccag tacgaagggg aaaagctacg gtcatcgctt 1981 gtcgatgaca cgcctcgcag agcctgtcca aaatattatt ttggtataac aggctatacc 2041 agatttttaa cggtgttata ctggtcttgg aaaacctttt ttgaggaggc atttttgatg 2101 gcgcatttaa agaaaaatac ccgtggcgca gtacccggtt tagcggttca ctttgaacgt 2161 aaaaccgatc atcacaccaa caaagaaatt gatgtgtcga aaacctatct gaatcaagag 2221 ctcatggctg atggttctga tatgctttca cgcttcaatg cgcgtttaaa tgacgtttat 2281 tgcatgaaaa gagacgatgt aaaggcgtta gcgacttgga ttgtcacttt acctgaagaa 2341 ctcgcagaat cgccctacga gcaacagagc gccttttttg aagcaaccac taattttttg 2401 aatgaccgtt atggtcaaga aaatgccgtg gccgctgtcg tgcattatga cgagacaacc 2461 cctcacttgc actatgcctt tgtcccggta gtttttgatg ataaaaaggc acgttataaa 2521 gtatccgcta aagaagtgct cacgcgtcat gatctgcaaa cctttcatga ggatttagat 2581 cagcatttaa aaaaggtgct acccttttat gaacgaggga ttttaaataa caaaacctta 2641 ccgtttgaga atgtcgctga aatcaaaaaa tacaatgatc agtttaatgc cttaaaaacg 2701 gaactagccg atattgaaga caacattcgt gcgaaacagg cagtacttaa aatcacggat 2761 caagccttaa cggaagtaga cttagccgaa aaacaaattg atgcctttaa acaagactta 2821 tctaaaaacc tctttggtaa gacggtgctt aaacctgatg acttagatcg ctttaaaagt 2881 gtgttagcca cgatgaagaa agccaccttg caaagccagc atgagacgga agaactcaag 2941 caaacgttag gccaagtcaa agcgcaatta gctgacatcc aagctgatta tcaaaaccta 3001 aaagaaacgc atcaagcgct acagaagcgg caacgagaac agcaacagat ggattatgct 3061 atgcgtgaca tgcttaaaaa tgattatggt gtcgacaaga tagcccatac tgatgtggag 3121 gcccggtatg ttctttataa gctggatcat gaaaaactca ctcaaaataa aaaagtagcc 3181 cagtcctggt taaaaacact gacgacagct agagcagatc cagatacgaa aatagcgcca 3241 actagattag atcgcggtat tgaacaagtt aaagcattaa tcaatcgaat cattgaatta 3301 acgcgtgata tttttaaggg gccaagtctg taacgttata acggcttatt tgcccgtata 3361 agccttttta gccatgtgac gtagaaataa tcattaaata gattaaaacg tcgctattgg 3421 cttaataagt ggcaatctat gttagataac taggtatccg gcatttgaaa tgattcaaaa 3481 caaaaagaac actctgtacg aaatttatgt gcaccagtgt tctttttgtt ttgtttttta 3541 ttgaatcaat aaaaaggcgg agcctattat aagtttatct tttatatttt aatcttttgt 3601 tcttttgcgc agttataaag tcagtattat caagggttta caagattatg tacccacaaa 3661 aaactatgta tacacccaca aaatactatg tatacaccca caaaatacta tgtatacacc 3721 cacttctcat ttagataagt gggtgtatag gttataataa aaagcataaa gaaattcccg 3781 actaaaagtt tttctttata cttatccaac aacacgccca aaggagcgta tttatatgtc 3841 aattatacca gaatcaaaga caaggcaggt acacaccttg aatgagttat caaaacgaaa 3901 agtcgtcgaa cataacagtt taatcacttc aattgccaaa atggataaga caccactcaa 3961 aatgtttgag ttggccgttt ctctaataga tacggaaaat ccccccgaag atcagacggt 4021 ttatttatca aagcgagagt tgtttgcttt ttttcaagtt gatgatagca acaaacatag 4081 tcgttttaaa gaagccgttg aaaaaatgca gaaacaagct ttttttcaga ttaaaaaaga 4141 acaagataaa ggctttaaat ttattagtat tgtaccgatc ccgtatgtgg aatggacaga 4201 ttataatgac gaagtaaaaa ttgaatttca tcgtgaaatt atgccttatc taattaatct 4261 caaaaataat tttacgcaac atgctttgtc agatattgca gaattgaaca gtaagtatgc 4321 aataattttg tatcgttggt tatcgatgaa ttacaatcaa tacgagcatt acagcgttaa 4381 aggtggacgg agagaggaac aggttgaaag ttaccgtaat cccgaaataa gcatgcgaga 4441 tttacgtcaa atgacagata caattgatga atataaacga tttgatcatt ttgaaaaaag 4501 agtactgaat gaaccattgt cagaaattac taaacacaca actttcaatg taacttacga 4561 aaagctcaaa aaagggcgga gtattgatag tattgtcttt catatcacta aaaaacaagt 4621 ggcagatgat attagttaca agctagatga tcccgtttat atcgagggca agatccgtca 4681 agaagaaaca gaagatatgt tgactgttaa ggcaataaaa agtccctata caaagttact 4741 tatggagcag tttttattgt catatattga tttaacggat actactattt tgtcagggtt 4801 acagaaaaat gtttatccac tttatgacga attaaaagag tcacgtggtt taaagggcgt 4861 gaaagaacac ttagcctata tcagagacaa acaagatgac tattcgaaaa agaatattgc 4921 taagtatctt aaaaaatcga ttgaacagta tctaccaatc gttaaaaggc aggatataga 4981 tcatgagtga aaatttaaaa acaattcgag aacttgctga ggagttaggt gtttcaaaac 5041 aggcgataca atatcatata aagtcgctga caaacaaaac aaggcaaaca aacgacaaag 5101 gtatagttgt tttatcttta gaagaacagc attttataag gtctaaggtc gacaaacaga 5161 caaacaaaaa caagacaaat aaacagacaa atgacaaaca aacagacaaa gagacaaagt 5221 gggatatcca caactattta attagtgaac ttgatgaagt taagaaaaat agagataaac 5281 aattagcagt taaggataag caactagaaa ataaagattc gcaaatagct caaatgcaaa 5341 acttactaga ccagcaacaa cggctagcct tacaggacaa gcaactgctc gaagaataca 5401 aggcagaaat taaggacttg aaagccttaa cgatggcacc gcatgatgat ggtgaaaaag 5461 aagtgacgtc agacaaacaa ctggaacctg aaaatagcac cccggagtca caacctaaac 5521 ctaaaaagtg gtggcgtttt ggtaaatagt tacaactaaa aaagaaaaga agactagtta 5581 aatggcggga tgctcttatg ctagatttac ggacagattt tcttctgccc tgtaaactaa 5641 tagcatagga gcatttttta atatgattcg atacaaaaaa gaatttaagc agtctcttgt 5701 tgagatgcac aatcaaggcc gttcatatac tgatctatcc gctgaatacg gaccttcggt 5761 cgactcaatc cgtaactggg tcaagttgta cgcggtccac gaagtggacg gcgaaaaatg 5821 gacgcaagct gatgtaaacg cattacaaaa aggaaaacga caaacttcgc gaagaacttg 5881 agattttaaa aataaggaat tctaaaatca ataaaagtaa atcaatggta accttataat 5941 tagtattggg taaagatagg aaaacaaagg caataatagc tggttacatt tatttaaaaa 6001 agacttgaca agaatggttt acaatagtaa acttatctca aacgtttacg tttacgcatg 6061 tagacaataa ggagggaagg agggaaagag aatgagtaca atagtagtta accctcatat 6121 cacagatgct gaatgggaag ttatgcgtgt agtctgggcg aatggtcgag tgactagtaa 6181 agaaatcatc tccatattga aagaaaaaat ggactggaaa caagccacta tcaaaacgct 6241 cttaggtcga ctggttgaaa aaggcgtact aaatacagag caagaaggta gaaaatttat 6301 ttatactacc aatattgaag agaaagaagc cgtaggaaat tatacagacg atattttcaa 6361 ccgtatttgt cgaaagaatg tcgggaatgt agtagggagt atcattgaag atcatgtctt 6421 aagcttcgat gatatccagc gactagaaga aatattagag atgaaaaaag ctttcgcagt 6481 agaagaagtg gattgtcagt gtacagaagg gcaatgcgat tgccatttac atcatcatgg 6541 agaataagta gcgaaaaaat tggagaataa atcgtttgcc atagaagggg ttgaatctgt 6601 agaggttgat ttagcgacta aaaaagcagt acttgaaagt caaacagaga ttgataccga 6661 aacgctcaat gctgctttag cagaaactaa ctattcagta ttaagtgcat aaagtacgaa 6721 taccatttat tcatagatag tagatagaga taaagtatag aacccttttc atgagaatta 6781 tatgcagtgt tagatgagaa aattctaaaa ctttaaaatc agtctctaat ataataagga 6841 ggaattaaaa atgaggaata acaaacaaca ttcgtcacat agtcatcata atcacggcga 6901 catggatcac tcaaaacacg accataatga aatggaacat agtcagatgg atcacggcaa 6961 gatgaatcat agtgcgatgg atcacagtga aatggatcat ggaggacaca tgatgcatat 7021 gggtgatatg agtaaaaagc tcaaagtggc tatcattctt atgattccgc ttctactcat 7081 ttcaccaatc gcgggcttta ctatccttaa attccccgga agtgaaattt tgcaacttat 7141 ccttggtaca attatcttct tttactctgg gactcctttt tttagcggag caaaaggtga 7201 attaaaaagc cgtaagccag ccatgatgat gctgattaca atgggaatta ccgttgccta 7261 tacttattct gtttatgcca caattatgag tcttaacgga catatgggca tgaacttctg 7321 gtttgaactg gcaactttaa ttgtcattat gttgattggt cacctgattg agatgaaagc 7381 aatcatgggt gctggcgatg cattgaaaga tttagcaagc cttgttccca aaaaagctca 7441 cttaaaaagt gggaaggatg tggagctttc agaactaaaa gttggcgatt tgcttttagt 7501 gaaagaaaat gaaagaattc ctgcagatgg ccttatatta agtgaagcgt tcgttgatga 7561 gtcaatgatt actggtgaaa gccgagcagt caataaaaaa acaaatgacc ttgtttatgg 7621 tggttccctc aatcaaaacc aaccatttga gatgaaagtc acaacccttg gaaaagattc 7681 atttctcaat caagtggccg aattagtcaa gaaagcccaa gctcaaaaat ctaatttgga 7741 aaatatggct gacagagtgg ctggttacct tttctatgct gcacttattg tcggtatctt 7801 ctcattaatt ttttggacaa ttagttctaa ctttagtttt gctcttcttc ttgcggtttc 7861 tgtttttgta attgcatgtc cacacgcttt aggtcttgcg gttccacttg ttgtttctcg 7921 cttaaccagt atttctgcta aaaatggttt attaattcag aacagaacct ctttggaaaa 7981 aataaataca attaaatatg ccttaatgga taaaacagga acattaactg acggtaattt 8041 tattgtccgt aatgttatta attttactga tgaaacagac attctccaaa tcatggcagc 8101 acttgaagga agttccactc acccgattgc tcaatcaatc gtttcagctg ctaaacctct 8161 tgaaaatcta aaagttgaag cggttgaaaa tattccagga gttggaatta aagggcaagt 8221 taatcaaaac ttttatcaaa ttgttaacta taaatatctt cgtgaaaatc aactttctta 8281 tgatgaacaa aagattgctc aatatttaga tttaggttta actgtatctt tcctaatcaa 8341 tgaacaacaa gatgttttag gatttattgc cttaggagat tctcctaaag cagacgcgaa 8401 agcctttatt aatggtttat tagcccaagg aattacccct gttatgctca cgggtgataa 8461 taaagaaact gctcaaaaaa ttgctagtgc actaaatatt cccgaattta gagcggaatt 8521 aaaacctgaa gataaagcag aaattgtgaa agaataccaa aagaaagccg gcgttctttt 8581 cattggtgat ggtgtcaatg attccccagc tcttgcaact gctacgattg gttttgcgat 8641 tggagcagga acttcggttg ctatcagtac cgctgatgtc gtcctagtta actccaatcc 8701 aagtgacgtc ctggatatga ttaatatctc caaacgtatg cttagaaaaa tgaaacaaaa 8761 cctctggttt ggagcaggct ataacatcat tgctattcct gttgcagcgg gtattcttta 8821 tccatttaca gggatttata ttgatcctct cattgcagca gtcctgatgt caatctcaac 8881 cgtgattgtc gcaatcaacg cgatgggatt gaggtatgat aaaaaataga agagcacatg 8941 ctcttctatt tttttcatac taattatgaa acttttatca cttaaatata cttaaagatt 9001 aactatgata tcacacaaat actaatgatt gtaatgatat ttttaaatat ggtttatttt 9061 taaatgattt tagaatcttt cgttcataat catttaattg actcccttta tgaactaaaa 9121 aataaatatt acctctaaga taacgattag catcaaaaac atcaaagact ccttgaagta 9181 aataatcttt agtatcttga agcagttttt ttatttctaa tttaacctca ttagaatcaa 9241 gataaatatc tatattttcc ataaacactt gatagctttt tcctctttta atttttctta 9301 gcttttgttt agtaaggctt tcaaatctaa cgagtccatt tctttcatag tgaacttcat 9361 tcttctgttc ttcgttccat ctctttccag gatcttgcat ctttttaaga ttatccacaa 9421 tttgcttagt ttcccttgct ttttcttcac tgcttctttc tttatttgtt ttaggtttat 9481 tcttatcttt gattaaaaat atatcgtcta aattttctgc ctctttattt tgactcatta 9541 gttctcttcc tttttgctca gaagtcaata aattggacta tttttattca gttacttagg 9601 caacatttga gatacgattg cgattataaa aattaatata ccaaccaatg gctgcttgga 9661 agactgacat attagcctcg atatcatcga ataactaaat acagaaaaat acaataaata 9721 ttatcggact agggactata ctaggaaaca tcagtacatt ccttaaatca gggtctataa 9781 ttataggatg actcctaaat ctaaaaagac aaggcccatt aatttattaa ctaataatat 9841 tgaatttcaa tttcatagga aaactggtaa actattcaac acaatagttg aaaaggtgga 9901 aagaaaatgt ttgaacaagc agttaactac aaaaatggac tatataaaga actatctaaa 9961 attggtaagg ggctaagcag tgatcgacga ttagaaattc ttgatctttt aactcaagca 10021 cccaaatcag ttgaaactat tgccaacggg gtcggaataa gtgtagctaa cgcctcacgc 10081 catctacaaa tattgaagga cagtcatctg gttaaaacaa aacgaaaagg caatcatatt 10141 atttatagcc ttagttctcc caaaattagt gattttgtgc acctattaac cgatattggc 10201 aacagtgaac tttcagatat gaaaacaatt caggataaat cagacgctca agataacgtt 10261 aaaaccattt ccttaaagca agctcaagaa gaatacaaaa atagctttgt ccttgatgta 10321 cgaccttctg atgaatatgc agcaggccac atacaatcgg caattaatgt cccattggaa 10381 acattaaaag aatcaatgcc caaattacct aaagatcaaa aaattattgt ttattgccgt 10441 ggaagactat gtgctaattc caacattgcc acacagatct taaatagaaa tggttttgac 10501 gcagttagtt taaattcaag ttactatgat tggaataaaa taacagaata aacagtttaa 10561 gcacgattta gtcatttatt gattaaatcg tgcttttata ttgacttaca aaaagtatgt 10621 gatattatta aactattcaa gcaaacaatt gaataattga aaggcggtga cataacttgt 10681 ctactattga taaaacgcta accttaatta attttgagaa taattggtgc gcccagtgtt 10741 acacgcagcg accaataata aataagatta gccatgactt taattcatat ttaaacgttc 10801 gggtagtgaa ttcagatgct cacccagaac cagcaaaaaa atacaatgtt tattccgcac 10861 ccagtactat tttgctgcgt gatggaaaaa tcgttgaaaa aattacccgt tttattgatc 10921 aatcacaatt aacaacttta attaaatatt acctataaag gagcgactct tatggttaag 10981 aacttaactg acaaagactt tgtgaaagaa actagtaccg gtgttacatt aactgatttt 11041 tgggctactt ggtgtcctcc atgtcgaatg caaggaccga ttattgaaca acttgataaa 11101 gaaattggcg ataaagtcaa aattactaaa atagacgtag atgcaaatca aaaaacacca 11161 atagcatttg gaattatgtc tattccaacc ttaattatca aaaaagatgg ccaagtagtt 11221 gataagctgg ttggcctcca cagtaaggac caacttaaaa ccgttcttgc tcaatatact 11281 aattaggtta agaggggaga agctgaatgg aacaactatc agtaatgaat aaaaaagaat 11341 ttgataaaaa actgaagaat ggaaaatata ttttagtttt tatggcttct tggtgccctg 11401 attgtagctt tatcaagcct catctaccag agattgaaca agaattcaaa gattacactt 11461 tcatcagtgt cgatcgtgat gagaataccg aattggctca agaactaaat atctttggta 11521 ttccaagctt cgttattttt agagatgggc aagaaatcgg aagacttgtc aataaagatc 11581 ggaagactaa agaagaagtc gaaaatttca ttaccaacac tattaactaa tgaagaagtt 11641 ttttactatt cttggcggta tggggacgtt agcaactgaa agttatgtcc gactccttaa 11701 taagaaaact gaaacccata aagaccaaga ctatttagat tatatagtgg gtaaccatta 11761 ttgatgcaca agaagtcatt gttaatcgtt cattggataa gggattagcg ttacgtgacg 11821 actaataagt agattggagt gaaatttaat gaggaaatat gatgtagtag tgattggggc 11881 cggtcctggt ggaatgaccg ctgccttata tgcagcacga gctaatttaa atgtagcaat 11941 gcttgatcgc ggtatttatg gtggacaaat gaacaacacc gatgacattg aaaactaccc 12001 tggttttaca acaattaagg ggcctgaact tggtgagaaa atgtatcaag gaaccgttaa 12061 ggccggagta aattttgtat acggtgatgt ccaaaacgtt accgttgatg atcaacaaat 12121 gaagcatatt caaaccgata gtgacgagtt agtagcaagc gcagtaatta ttgcaacagg 12181 atctaataat cgaaaattag gtgtaccagg tgaagaaaat ttctccggaa aaggggtttc 12241 ttactgtgca gtatgtgatg gttctttctt taaaggaaag aacgtgactg tagttggcgg 12301 tggtgattca gcaatttctg aaggattgta cttagctaat gtcactgatg gagttaatgt 12361 cattcatcgt cgcgatcagt tacgggcaca aaaggtatta caaaatcgtg cttttgataa 12421 cgataagata gatttcactt ggaatactag tgtgacagag attttaggtg atgaaaatca 12481 tgttactgga gtaaaaattc ataacaatca ggtcggtgat gatacaactc tagacactga 12541 tggagttttc gtttacgtcg gtaactttcc aaacagccaa attttcaata atttaaatat 12601 taccgatcaa gctggttgga ttataactaa cgatcaaatg gaaacaacaa ttcctggaat 12661 ctatgcaatt ggtgatgtcc ggcaaaagca actgcggcaa attacaactg cggttggcga 12721 tggtggtatt gctgggcaaa acgcctttga atatttcgaa gccataaagc atcggcaaac 12781 ggttaaagat taaagagagg aaaattactt tatggaaatc aaatattggt cagacattgc 12841 ttgccccttt tgttatatcg gttctaaccg aatgaaacga gcaatgaagg aaattggtat 12901 ttatgacaca actgaattag agttcaaatc attcgagctt aaccctgcaa caccaaagga 12961 aaccgatgaa ggatacatta atcacttcac tcagggaaat aaggcaatgg agccacaggc 13021 caaaaagcaa atggcttaca tcgaacaaat ggcgcataac gatggtctac caatggatct 13081 tgacagtgta gtacctacaa atactatgga tgcgcaccgg attattaaat tcgcagaagc 13141 taaaaatgat cctgatttga ctgaacgagt aattagacgc ttctaccaag tttactttag 13201 tgatggtcaa tcgatttctg accatgatgt gctattaaat gcggcaatgg aagctgggct 13261 tgctaaagac gaagtagaaa aagtgcttaa ttctaaccaa tatcatcaag ctgtggtcaa 13321 tgacgaggca gaggctcaac aatccggtat tcatgctgca cctttttttg taatcaataa 13381 taagtatgca attagtggtg ctcaaccata tgaagtcttt gttaaagcct taaagggcgt 13441 tcaagcagaa gaaaattagg aggaatttac gatgaccgaa gataagccac aatttaatac 13501 aatatttggc gataataatg atgctgctgt atgtgggcca gacggttgta atatcgctga 13561 acatcaaaag caaactgagg ataagaagaa aacaaaataa atggaggaaa gctataaatg 13621 aagtttgact acgttgttat tggcagtggg ccatcagttt atcgtttcct attgggaatg 13681 cagaatagcg gaaagaaaat cgcggttgtt gaaaagaatc ggtttggcgg aatttgccct 13741 aacgaaggct gcgaacccaa gattttctta gaaggagcag cacgagcaac cttaacttca 13801 atgcgtttgc aaggtaaggg aattactcaa ccagctaagc ttgactggaa agaacttatt 13861 cagcaaaaga ataaggctat ggcgtcattc ctaaataata tgcaaagtat gtatgaaggc 13921 ctgggtgcga ctaccatcaa gggtgaagca tcatttgttg atcaacatac cattgaagtt 13981 aataataaaa aaatcactgc tgataatttt gtaatcgcaa ccggaaaaaa gccgcatcct 14041 cttaacattc ctggccacga gtacctactt actagtacta acctttttga actcgaagat 14101 actccaaaga acgtcgcaat tatcggaagt ggttacgttg gtatggaatt tgctacattg 14161 ttgtctgctg ccggggttaa agtaacagtt attgttcgat ccggccaacc actagaggga 14221 ttttacagcc aacacgttca tcagttagtt gatgaaatga aaaactcact tggtattaat 14281 tttatattta acacaaatgt tacagctgtt accgaagcac aaactggcta tgaggttcaa 14341 tcagctaacg gcaaccttgg cacttttgat aaagttatta atgccagtgg tagagttcct 14401 gaaattaatg cattgaaact tgataatgct ggtgtagagt acagcaaccg cggaattaaa 14461 gttgataaat atttgaccac atcagcaaat aacatttacg caatgggcga tattgttgat 14521 aaaaccgcac cagcattaac ctctacggca cagtttgaag cagactactt aagtgcctta 14581 cttactaata aaacaactga acctcttagg tacccagtaa ttggaaccgt tacgttcaca 14641 ttcccccaac tcgctcaagc tggaattagt attgataaag caaaggaaga cagtaattat 14701 tcaattaaag atattgatat tactcaaggt gactttcttt atgctggaac agatgatcac 14761 gcacgattat cattagtctt tgacaagcaa aatcatctcg tgggcgctgc tgaaattagc 14821 caaacagcag tagatgatat caattcacta attcctgtta tggcaattga tgttgatcca 14881 gaggtttgga aagaaaagat gctaatggct ttccctggtt tagcatataa aattagaaca 14941 ttaatttaac aacaagaggg tctatttgtg ataataactt cttaaaaatc ctattaaaac 15001 agcccctaac aaatcaactt gtcttgttag aggctgtttt ttatttaaat aatataatag 15061 cccttggaat gcaaggctaa atcgaatagc taatcattac tatatagagg cgtaatcatt 15121 actatataga ggcgcataca tactttgttt ctcaattttg gctaggtatg ttataatgaa 15181 tgcagaaaaa ggaagccttg cgctaacaag acttcccgtg tagagccgta taagacggtg 15241 gcattaatta acgattgaac ataaccgcta gcttgccaga gctaaggcgg ttattttttt 15301 tgctgatttt taataaactc aacaactaat gctagtaagg cgactataaa agtgccaaac 15361 atgaacataa gctgtaaagc gtccgatacg gacacttggg ctactccttt cctagaatgt 15421 gagtttatag tttttacacc ataagcacca ccccctttaa ggaaatagcc accgccttaa 15481 cttctctact caaactatta tacaggataa cgtataattt acctattgat gattaatgct 15541 cttatatcct gaattgctat gtttctattt tcaatataaa tataattatc agacatgttt 15601 tcaatgaacc tagatatatt tttttggttt catgattgaa gttagtctca tctaattgaa 15661 tagtcgcagt ataataattg gcaatgaaaa atgtaataaa aaagaatata ttaaccattt 15721 tttatttcaa atcgtcaaat ttaatttcgc cttttttcag actatttaat ccatgatgag 15781 taattgtgtt gattaaagga ccccatgcat tcgtggtagc tttaggatcc ttatttaagg 15841 ataatcgttt catctgttgc tcataatatg ctagacccac catgccccaa tttattatcg 15901 ataactttta caccagttgt taaatgtggt aattttagac cctcaaaaat tccagacagc 15961 attttctcag gggaattcgg attgagaaca aatggtcgta cactccccac catggcaatt 16021 ccttcgtttg tcactacatt ttccatggct tcttggctgc tcaaaccgcc tgtaagcata 16081 atagggatat tgactgatac ttgagatttt ttagaaaact ttaaaaagaa cgcttctcca 16141 ttactatttt caagaaactt ggttctttca taatttcctc ctgaaatttt aataaagtca 16201 atacctaaat tagacatttt gacgattact ctatatgaat catcttcact aaatccttcc 16261 gaactgaagt cactggaatt cagtttgatc ccaacaataa aattagattt agttacttgg 16321 cgaatacctt gatatatttc aaccaaaatt cgcattatat tttctaaatt atctccataa 16381 aaatctgttc gcttattatc tgctggagag agaaactggt ttttcagcga tacaacttgt 16441 tgtcacaaat ttttgaataa cattaaccac ctgttttaga caattcgcga ggagtattaa 16501 ataatttacg tagattctta ggcattggaa tcacacttgg cgcaaccggt tctttcgtca 16561 tagaacgtgg agtatgttta ccagaatggt taatttgcag aataaatttt gtattatttt 16621 cagtgccagc ttgtgcccat ttttttgtct gtttgttgat ccaccactac attacttggt 16681 tcaccaatat tttacgctcc cggatttagt gtagagactt aagttatttc aataactaat 16741 taagaaaatt atttaattca tcgacaaact cctcagcata ttggaagatg gcgccgtgac 16801 cagcatcagg atagatgatg agtttgctat cctggatttt ctcgtgcatg tcgtaggagt 16861 tctgcgttgg aaccataaca tcgttgtctc cgttgacaat gaatgtcgga actttgataa 16921 aatcaagcgt gtcctgctct gcctttcccc aactcttgat agctttcaac tgcttcaaga 16981 aactggatac tttcatatcc ttgtccttgg catctttcgg acggctagcc aatctatcta 17041 aaactttgtg cgcttcgact tttcctgcct tgtcaggatt atagaaaata taacgtttgg 17101 catccgcacc gtgtaaaaag ccatttgcca tgtgtttgaa ggtcacacca gtcaccttat 17161 caacaccgat acccgcacgt ggaccagttc cagctaaagt caaggtattg acaagattgg 17221 catcaagtct gacaatttct tgggcgataa agccgcccat ggaaagacca aggagattga 17281 ttttttggta acccagcgcc ttgataatag caatggcttg gtctgccatg caaggaatgc 17341 tttccgcaat tttcccctca ctggcaccaa cacctggcaa atccatgaca atgatgtggt 17401 tcttttctgc taggttatca atgagttttg gatcccaatt gtccatggtc gctgccaaat 17461 gcaccaacat gacaagcgga tattgtgact taccttgtcc aagttcacgg taggcgattt 17521 tcaagccttc gacggtgatg tattgatttt tcgtttgtaa gtatgacatt ttatttttct 17581 ccgaaggtga taacggtctt accacgtgaa cgtccatttg cgaccttgtc taaggcctcg 17641 ttaatctgtg agaagttata aacggtatca attgatggtt tgatttttag ttggctaaag 17701 aggtctgcaa cttcttgaag ctgggcaccg tttgattcaa cgaagacgaa atcataagta 17761 accccatatt tcttagccat tctatcgaat ttaccaccca caagaccgaa caagatttgt 17821 ttccacttag gtagtccgaa gcgtttggca aaggctttat ttggcatgcc acttaggttg 17881 acgagtttac cgcctttttt cataatgctc atttgttttt cagtctcagc accgcccaat 17941 gtatccaaaa cataatccac ctggctgagt gtttgcgtgt aatcctcagt tttgtagtcg 18001 ataaaacggt tcagccccag cgccataata cgcgctttat tgtcaatatt cccgttggtg 18061 atgacggtca gccccttagc ttttgcgata ggaatcgcca tggcaccgac accacctgta 18121 ccacccgtca taaagaaggt accgcccttt ttcgcgccca tcaggtcaag cgcctgcata 18181 accgtaagag cagtcaaggg caccgctgct gcctcaacat ccgttagata atctgggaca 18241 tgggctagcg ctcgataatt aatcgccgta tactcggcaa atgcaccgat acggtcaagc 18301 ggcatgcgtg caaagacacg gtcaccaact ttaaatcctg tcacttgcgt gcctactttt 18361 tctacaatcc caacgacttc attaccagca atttgtggga gtttgtaggg aatgaggagc 18421 ttgatttgtc ctcgtgaaat catgttatca actggattga ctcctgcggc tgtgactttg 18481 acaaggacat cttgagcgcc aagttcaggc atcggtgtgt caacgagttc aagtttgata 18541 ttgtttttat tatattgggt taattgtgct gctttcatgg agatttcctt ttcttaattg 18601 attttataca tatcagtgat taaatctgac aaattttctt ggttgaggcg attgagaagg 18661 ctggcttctg cgtcttcaaa gactgggctg agcacctgtt cgatacgact accgactgga 18721 cagttgggat tggcatcttc gtggacgtgg agcagagttt tttctggata gactgcttgg 18781 tagacttctt ttaaggaaat atcagcgggt tcttttacta ggtaaaaacc agacttccct 18841 tgttggctag caatcagacc tgcttgcttt agcaagagag tgatctttcg gatatgactg 18901 gcattggtgt tgactgactg agctagattt tctgatgatg gtgtcttttc tgtttcagaa 18961 atgtatatta aaatgtgtag cgctactgaa aa //