LOCUS NC_015701 19059 bp DNA circular BCT 24-JUN-2011 DEFINITION Lactobacillus reuteri SD2112 plasmid pLR584, complete sequence. ACCESSION NC_015701 VERSION NC_015701.1 GI:338204606 DBLINK Project: 55357 KEYWORDS . SOURCE Lactobacillus reuteri SD2112 ORGANISM Lactobacillus reuteri SD2112 Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 19059) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (23-JUN-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 2 (bases 1 to 19059) AUTHORS Muzny,D., Qin,X., Buhay,C., Dugan-Rocha,S., Ding,Y., Chen,G., Hawes,A., Holder,M., Jhangiani,S., Johnson,A., Khan,Z., Li,Z., Liu,W., Liu,X., Perez,L., Shen,H., Wang,Q., Watt,J., Xi,L., Xin,Y., Zhou,J., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z., Zhang,L., Villasana,D., Johnson,A., Liu,J., Liyanage,D., Lorensuhewa,L., Robinson,T., Song,A., Song,B.-B., Dinh,H., Thornton,R., Coyle,M., Francisco,L., Jackson,L., Javaid,M., Korchina,V., Kovar,C., Mata,R., Mathew,T., Ngo,R., Nguyen,L., Nguyen,N., Okwuonu,G., Ongeri,F., Pham,C., Simmons,D., Wilczek-Boney,K., Hale,W., Jakkamsetti,A., Pham,P., Ruth,R., San Lucas,F., Warren,J., Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S., Bess,C., Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K., Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S., Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L., Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P., Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K., Petrosino,J., Highlander,S. and Gibbs,R. TITLE Direct Submission JOURNAL Submitted (06-JUN-2011) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP002847. Lactobacillus reuteri SD2112 Strain source, body site: Gastrointestinal tract Inquiries should be directed to microbe@hgsc.bcm.tmc.edu This is a reference genome for the Human Microbiome Project. This project is co-owned with the Human Microbiome Project DACC. Source DNA provided by Versalovic, J. (Department of Pathology, Texas Children's Hospital, 1102 Bates Avenue, Suite 830, Feigin Center, Houston, TX, 77030, USA). Funded by by 'Genomes and Genetics at BCM-HGSC' (U54 HG003273). ##Genome-Assembly-Data-START## Finishing Goal :: Finished Current Finishing Status :: Finished Assembly Method :: Newbler Assembler v. 2.3.10192009 Genome Coverage :: 63x Sequencing Technology :: 454 ##Genome-Assembly-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..19059 /organism="Lactobacillus reuteri SD2112" /mol_type="genomic DNA" /strain="SD2112" /culture_collection="ATCC:55730" /db_xref="HMP:00538" /db_xref="HOMD:tax_818" /db_xref="taxon:491077" /plasmid="pLR584" gene 361..720 /locus_tag="HMPREF0538_22286" /db_xref="GeneID:10865945" CDS 361..720 /locus_tag="HMPREF0538_22286" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650788.1" /db_xref="GI:338204607" /db_xref="GeneID:10865945" /translation="MFDYTTATRDQKEEFLQDKILICLQATKQPMTNAQIREYLLKHV DELPANVTKLTTSKKGSVYSDFQIRVNMSITSLYKGGLVDHPKRGVTELTQLGKSINL NTGRKHMHKLIVEGWQK" misc_feature 436..>660 /locus_tag="HMPREF0538_22286" /note="Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715" /db_xref="CDD:31901" gene 717..1304 /locus_tag="HMPREF0538_22287" /db_xref="GeneID:10865942" CDS 717..1304 /locus_tag="HMPREF0538_22287" /codon_start=1 /transl_table=11 /product="integrase" /protein_id="YP_004650789.1" /db_xref="GI:338204608" /db_xref="GeneID:10865942" /translation="MKQLVLPIKDSNILHEVQDTLLNNFRYGRRNYTIFQVGKATLLR VSDVLALRRNEIFNDDGTIKKNAYIRDKKTDKPNTLYLKPVNQDLIDYLQWLNENKIQ SDWLFPSIKHPDRHITEKQFYKIMAKTGDLLGINYLGTHTMRKTGAYRVYTQTNYNIG LVMSLLNHSSEAMTLKYLGLDQVSREQMLDKVSFD" misc_feature 723..1298 /locus_tag="HMPREF0538_22287" /note="DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213" /db_xref="CDD:193712" misc_feature order(846..851,933..935,1131..1139,1245..1247) /locus_tag="HMPREF0538_22287" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:29495" misc_feature order(846..848,933..935,1137..1139,1146..1148,1218..1220, 1245..1247) /locus_tag="HMPREF0538_22287" /note="Int/Topo IB signature motif; other site" /db_xref="CDD:29495" misc_feature order(846..848,1137..1139,1146..1148,1218..1220, 1245..1247) /locus_tag="HMPREF0538_22287" /note="active site" /db_xref="CDD:29495" gene complement(1770..1846) /locus_tag="HMPREF0538_nc22286" /db_xref="GeneID:10865943" ncRNA complement(1770..1846) /locus_tag="HMPREF0538_nc22286" /ncRNA_class="autocatalytically_spliced_intron" /product="Group II catalytic intron" /db_xref="GeneID:10865943" gene complement(1854..3236) /locus_tag="HMPREF0538_22289" /db_xref="GeneID:10865944" CDS complement(1854..3236) /locus_tag="HMPREF0538_22289" /note="COG: COG3344" /codon_start=1 /transl_table=11 /product="RNA-directed DNA polymerase" /protein_id="YP_004650790.1" /db_xref="GI:338204609" /db_xref="GeneID:10865944" /translation="MRQSQKTEQQADRLSRIGLENRKYTRARSTDYGEGKGMSVTIQD LVLDRNNLNQAYLRVKRNKGAAGIDDMTVNDLLPYLRENKTELIASLREGKYKPAPVK RVEIPKPNGGVRKLGIPTVVDRMVQQAVAQILTPIFERVFSDNSFGFRPHRGAHDAIA KVVDLYNQGYRRVVDLDLKAYFDNVNHDLMIKYLQQYIDDPWTLRLIRKFLTSGVLDH GLFAKSEKGTPQGGPLSPILANIYLNELDKELTRRGHHFVRYADDCNIYVKSQRAGER VMRSITQFLEKRLKVKVNPDKTKVGSPLRLKFLGFSLGVDHNGAYARPAKQSQQRVKK ALRLLTKRNRGISLTRMFEEIHRKMRGWLQYYSIGKLTDFIQRLDKWLRARIRQYIWK QWKKLKTKVTNLQKLGLSQRDAYVFASTRKGYWRTAHSKTLSYSLTNRKLEQLGLMNM SKTLQSIQCD" misc_feature complement(2298..2933) /locus_tag="HMPREF0538_22289" /note="RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651" /db_xref="CDD:73157" misc_feature complement(2298..2921) /locus_tag="HMPREF0538_22289" /note="Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078" /db_xref="CDD:143860" misc_feature complement(order(2307..2312,2448..2453,2457..2459, 2544..2549,2691..2708)) /locus_tag="HMPREF0538_22289" /note="putative active site [active]" /db_xref="CDD:73157" misc_feature complement(order(2451..2453,2547..2549,2691..2708)) /locus_tag="HMPREF0538_22289" /note="putative NTP binding site [chemical binding]; other site" /db_xref="CDD:73157" misc_feature complement(2544..2546) /locus_tag="HMPREF0538_22289" /note="putative nucleic acid binding site [nucleotide binding]; other site" /db_xref="CDD:73157" misc_feature complement(2013..2252) /locus_tag="HMPREF0538_22289" /note="Group II intron, maturase-specific domain; Region: GIIM; pfam08388" /db_xref="CDD:149448" gene complement(3795..4190) /locus_tag="HMPREF0538_22290" /db_xref="GeneID:10865946" CDS complement(3795..4190) /locus_tag="HMPREF0538_22290" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650791.1" /db_xref="GI:338204610" /db_xref="GeneID:10865946" /translation="MILPAKKYENRDKVKKDAIRARVTKAEKTEIQKWAKGAGEDVSA FLLNGAQSRHYALKKMPINIEDSTDFGNYSSASFGLLIDDLNDALSNIDSCLFENTKE KELYAQSIQWIIQRMKVSGEKYDSEHKND" gene 4773..5642 /locus_tag="HMPREF0538_22291" /db_xref="GeneID:10865947" CDS 4773..5642 /locus_tag="HMPREF0538_22291" /codon_start=1 /transl_table=11 /product="replication rep protein" /protein_id="YP_004650792.1" /db_xref="GI:338204611" /db_xref="GeneID:10865947" /translation="MVLMTVNKVVIKNKADIHPEDTVKYMVTNNYVHERKSLYTNHKA NIIKKGKGNYFNKNTGEKITKVKNSNLKIQNRQSLIRSYVNLRYTIEKYVTGSIYDEM YTLTYEKAQTSFKDLSHDFVTFMKRFKRYVKKNYPKVNLSWIRINEPHKDTINGKPKW HIHLIVIGLPFMKHHILEKLWGHGIVTITSYYKCNIHKVANYFTGFINKNDSDPESKK GRLKYYTSGTDLFSLSRGLHVPKWIQGTDQEIRKKHPGKIINETTIEIRDTNDNSLFN RFAYRDIESNKTK" gene 6865..7749 /gene="repB" /locus_tag="HMPREF0538_22292" /db_xref="GeneID:10865948" CDS 6865..7749 /gene="repB" /locus_tag="HMPREF0538_22292" /note="COG: COG1192" /codon_start=1 /transl_table=11 /product="replication-associated protein RepB" /protein_id="YP_004650793.1" /db_xref="GI:338204612" /db_xref="GeneID:10865948" /translation="MPTVLYGNMKGGVGKTTNSVMTAYQLARKGYKTLVCDLDPQANA TQLLRRTYGLQHGTDLKIEKTMMVALTEENIEPAIVNIMDNLYLLPSSEDFKNYPDFL EMKFMPDKEKILAGNSTTLQSEMAKVKEKRIAYFSKQLAKVHDQYDFIIIDVPPTLSI FTDSAIYATNFVIIVLQTQQRSLDGAETFFEYLQEMYNNYANIDFDIIGVLAVLLKNN AGLDSQILKDARVDFGDDMLFNQIIRHMERLKRYDRTGIAEKGLTKYDMHDTRLHYIY TKLTDEIIARLKDKGALN" misc_feature 6865..7737 /gene="repB" /locus_tag="HMPREF0538_22292" /note="ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192" /db_xref="CDD:31385" misc_feature 6871..>6987 /gene="repB" /locus_tag="HMPREF0538_22292" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042" /db_xref="CDD:73302" misc_feature 6892..6912 /gene="repB" /locus_tag="HMPREF0538_22292" /note="P-loop; other site" /db_xref="CDD:73302" misc_feature 6910..6912 /gene="repB" /locus_tag="HMPREF0538_22292" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:73302" misc_feature <7300..7497 /gene="repB" /locus_tag="HMPREF0538_22292" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042" /db_xref="CDD:73302" misc_feature 7321..7323 /gene="repB" /locus_tag="HMPREF0538_22292" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:73302" gene 7749..8123 /locus_tag="HMPREF0538_22293" /db_xref="GeneID:10865949" CDS 7749..8123 /locus_tag="HMPREF0538_22293" /codon_start=1 /transl_table=11 /product="replication-associated protein" /protein_id="YP_004650794.1" /db_xref="GI:338204613" /db_xref="GeneID:10865949" /translation="MAKYQFDKGTKRRSKPRPKPIDKTDISKPKITYNPLTVTDRVEN DLQHKKRSVGRPKTGRKSYKTVRLLTSTVLKINALENALGIKTQDATVDQAVDRVINS LTNDEMRAYKLWLEMFEKKEKE" gene complement(8192..8785) /locus_tag="HMPREF0538_22294" /db_xref="GeneID:10865950" CDS complement(8192..8785) /locus_tag="HMPREF0538_22294" /codon_start=1 /transl_table=11 /product="resolvase" /protein_id="YP_004650795.1" /db_xref="GI:338204614" /db_xref="GeneID:10865950" /translation="MKHMSMYAYVAGTTNNDINDKGSIACQIDFLKQTNVDYDAYFID TFTGVCQARFQLQKLLMVVKPGDMIDVMDVSNMTSNVRELCCLLDEIEDLQITIFSDE LEMGMSNSREPYYVAKMLCRADMVTMMQRSSNRKKMCQMTHQIDLHRDKSNKREITQQ DYQIYNLLMKSDYRTTQQATGLSRSTLYRLKKRIQKR" gene 8928..10934 /gene="sthIM" /locus_tag="HMPREF0538_22295" /db_xref="GeneID:10865951" CDS 8928..10934 /gene="sthIM" /locus_tag="HMPREF0538_22295" /note="COG: COG2189" /codon_start=1 /transl_table=11 /product="type III restriction-modification system DNA methylase" /protein_id="YP_004650796.1" /db_xref="GI:338204615" /db_xref="GeneID:10865951" /translation="MQIDTRLMEQVKDVLQQFGTKYITKDGSLKRNAVISDLDKYDKD LMVALLANNLIKDEYTEQIADTTVFKLNHFIEMFEYQEFWGNSFTKYANRIGLTSDDK FISDSDDVVLDFPYKDTVLKAGMTKDDVDKEVGADEPFLNETLAHSEISELFEPKVLV NAKLYDTEGEHKATNFDDNDNLVIKGNNLIALHSIAKKYAGKIKLIYLDPPYNTGSDS FKYNDRFSHATWLTFMKSRLEIAKTLMSDNGVIAIQLDDSEGPYLKVLTDSIFGRDNE LFTQYVLVRYANKTLKSDMDYHKQIEQIHYYKKNSNAEVKPNKDKVPYDYSKFCYEVK TTGKPSSSIMLGDKQVDIFTKDQVEFKKTSGNPEGLKEIWASGTILNGNSSGRFFRDY LSGRYKKDGYGVVYKVYDIGDDGNDYRFFTGPKKAGATKGKYYQGVPLDVKNGKTSQK LLPIPGFIDMAGSFGNDRLEGGVELRNGKKPEKLLKNIIKYFSNKNDYVMDFFAGSGS TLATAMKMSRKFIAIEQINEQIIKINKRLNNVIHGDQTGISKEVNWQGGGSFVYTELM KKNQGFLYDLQKATTIDELNAVYDRMKQGADLDFRVDLNKFENDSERASLPFEDQKKL LIKLLDKNQLYYNEANIDDADVRDLISDSDYRFNKSFYNGKESK" misc_feature 9048..9218 /gene="sthIM" /locus_tag="HMPREF0538_22295" /note="Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564" /db_xref="CDD:193081" misc_feature 9072..10640 /gene="sthIM" /locus_tag="HMPREF0538_22295" /note="Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189" /db_xref="CDD:32372" misc_feature 9534..>9911 /gene="sthIM" /locus_tag="HMPREF0538_22295" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011" /db_xref="CDD:196296" misc_feature <10320..10490 /gene="sthIM" /locus_tag="HMPREF0538_22295" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011" /db_xref="CDD:196296" gene 10934..13567 /locus_tag="HMPREF0538_22296" /db_xref="GeneID:10865952" CDS 10934..13567 /locus_tag="HMPREF0538_22296" /EC_number="3.1.21.5" /note="COG: COG3421" /codon_start=1 /transl_table=11 /product="type III restriction-modification system restriction subunit" /protein_id="YP_004650797.1" /db_xref="GI:338204616" /db_xref="GeneID:10865952" /translation="MARKKTIPEEKIDLQLLNALNSTSLFSLKSSLEDNPLYITNNLK HKLRNYQMDAVHHLDAVLNMKDADQRNQLMFYMATGSGKTDIMAAIILYMFRAWGYQC FLFTTNTTAVVDKTIDNLVNSASAKYLYNNPLVIDGDHVTIKKVDRYPVNLEKDTIYI KLAGIQQLSNDYYAPRENGITKDSLARHKLVLLADEAHHFNVSTRSKKANREGLSWEH LLDEIRQLNHENKQLEFTATIDLHNPDIYHKYQNKIIAQYDLSHFINDGFSKKVYRLQ ANNSDENKMLNAVLLSQYRKRIAQNMSIPDFKPVILFKSNTIAESRAINETFLTMIDN LSAESLQQFIQNQNRSTQSEALSLAYKYWLNQDFGSTVTELKRDFSKFTTINANDSGS KNILDDESVSRRLNSLESPDNPIRSVFAVAKLSEGWDVLNLFDIVRIGEKNIKPKDTN AEAQLIGRGARYYPFVYHGKKSYTRRFDDRKPEIQLLERLYYHTINDPQYLENLRKSL DAIDLPVNEDTQYKVYTAKVKNSFKKTKAYKHGNIYYNKVIDVPESHYDSIQKYGFDP ETTGPIDMVDAVSERRYDTGADKNDTTSTTLEVAARFSNPQDKALIRTAVSFNNFYRF DSLKKYCPTLTSMREFLTSNEWLGNATIRVKVATGSPALTNEQRLTAVKKYLVRVQTA ISNNFKRSIGTNEFMPIAVNEVIQDYQKRVGDQFGKSALIGPDSMQGKDWYVYDYAIV DTLEKHFIDHINSIMPELTHQYGQAYLLRIDERTTDFKLHDFGENIFHYEGYMPDFIL YLENENFIYQIFLEPKGTPYIERDKWKEKLLERINPDNIKVLGEDEKVKIYGLKFYVE DDGKEDTHGLFQEMRDKNILQ" misc_feature 11063..>11296 /locus_tag="HMPREF0538_22296" /note="DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882" /db_xref="CDD:197446" misc_feature 11153..13495 /locus_tag="HMPREF0538_22296" /note="Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421" /db_xref="CDD:33227" misc_feature 11162..11650 /locus_tag="HMPREF0538_22296" /note="DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882" /db_xref="CDD:197446" misc_feature 11171..11185 /locus_tag="HMPREF0538_22296" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:28927" misc_feature 11516..11527 /locus_tag="HMPREF0538_22296" /note="putative Mg++ binding site [ion binding]; other site" /db_xref="CDD:28927" gene complement(14085..14381) /locus_tag="HMPREF0538_22297" /db_xref="GeneID:10865953" CDS complement(14085..14381) /locus_tag="HMPREF0538_22297" /codon_start=1 /transl_table=11 /product="lysophospholipase family protein" /protein_id="YP_004650798.1" /db_xref="GI:338204617" /db_xref="GeneID:10865953" /translation="MKILTGSRGDEVHEHLYENGQRRVGHRILKKNTVTNNGEFHPVP GNIVLIPLKGTVKLTTPDQECTIKNGQLAILGPTDSFYLTAIDDVEFVGVVDIK" gene complement(14400..14609) /locus_tag="HMPREF0538_22298" /db_xref="GeneID:10865954" CDS complement(14400..14609) /locus_tag="HMPREF0538_22298" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650799.1" /db_xref="GI:338204618" /db_xref="GeneID:10865954" /translation="MTKTYYRNKAKGSETMSQWILIALFLLAHPLMMLFMHKGMHGGS GSMGCCGNNTQQNSNNTEKPRKKVN" gene complement(14741..14932) /locus_tag="HMPREF0538_22299" /db_xref="GeneID:10865955" CDS complement(14741..14932) /locus_tag="HMPREF0538_22299" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650800.1" /db_xref="GI:338204619" /db_xref="GeneID:10865955" /translation="MTKTYYRNKAKGGETMSQWILVALCLLAHPLMMLFMHKGMHGGS GNNTQQNSNNTEKPRKKVN" gene complement(14940..17237) /gene="atkB" /locus_tag="HMPREF0538_22300" /db_xref="GeneID:10865956" CDS complement(14940..17237) /gene="atkB" /locus_tag="HMPREF0538_22300" /EC_number="3.6.3.4" /note="COG: COG2217" /codon_start=1 /transl_table=11 /product="copper-exporting ATPase" /protein_id="YP_004650801.1" /db_xref="GI:338204620" /db_xref="GeneID:10865956" /translation="MAWCSAKQKPKYKNLVGKSRAREFPHKELIFRLLTALLRTLIFR GSIIMANKEGHMNMKNMSAKNMENNESNMSHMDHDMTETDHSQMNMNHGDMDMAGADM MMHGGSMMHMGNLKVKFWVSVVLAIPVLLLAPIMGLNVSILSFSSPLIVGIIIVLFDT ALYFYGGMPFLKGAKAEIQNKSPEMMTLVTLGISVSYFYSLYAFIANNFLNPTNHIMD FSFELATLILIMLLGHWIEMNALMGAGNALQKMAALLPKTAHLVTDNGETKEVPVSDL KVGQAFQVRSGESIPADGVITAGESTVNEALVTGESAAVTKNVGDKVIGGTTNNNGTL TVKISGTGDSSYLSQVMKMVQNAQQAKSKAEDKADLVAKYLFYAALGVGIIAFFAWLP QGLATAMTIMVTVFVIACPHALGLAIPLVVSRSTTIGAQNGLLVRNRQAIEASQHVSH VLLDKTGTLTEGKFTVNALIPNDGIDETTLLSRLAALEINSTHPLAQAIITEAQAKNI EVVAAEKSQNIPGVGISGNVDGTDYMIVNGNYLTKQGIRFDEAAADKWAAKGNSVSFL LQGTQVQGMVAEGDTIKAGAKELISGLQRRGITPVMLTGDNPKAAEHVANLLGLTEFH AGLLPDDKQKIIADYQAKGNHVIMVGDGVNDAPSLAAADIGIAIGAGTDVAIDSADVV LVKSEPSDILHFLDLAKITNRKMVQNLWWGAGYNVVAIPLAAGVLSFIGIILDPAVGA AVMAMSTIIVAINAMGLTGEKIKNV" misc_feature complement(15021..16742) /gene="atkB" /locus_tag="HMPREF0538_22300" /note="copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511" /db_xref="CDD:188148" misc_feature complement(15906..16562) /gene="atkB" /locus_tag="HMPREF0538_22300" /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122" /db_xref="CDD:189402" misc_feature complement(15261..15680) /gene="atkB" /locus_tag="HMPREF0538_22300" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391" /db_xref="CDD:197437" gene complement(17344..17775) /gene="copY" /locus_tag="HMPREF0538_22301" /db_xref="GeneID:10865957" CDS complement(17344..17775) /gene="copY" /locus_tag="HMPREF0538_22301" /note="COG: COG3682" /codon_start=1 /transl_table=11 /product="transcriptional repressor CopY" /protein_id="YP_004650802.1" /db_xref="GI:338204621" /db_xref="GeneID:10865957" /translation="MKDPKNVTITDSEWMVMRAIWTMGHATSRELIDAMNELEGWSAS TTKTLLHRLIQKQAVAQHGGSRPFTYKPVVGEKESMAAAADDLFDHMCAMRAGSTIAG VIQSRELSRADIANLQAILAEKAKTAPEEVQCNCLPGDQTC" misc_feature complement(17365..17754) /gene="copY" /locus_tag="HMPREF0538_22301" /note="copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698" /db_xref="CDD:131745" misc_feature complement(17407..17751) /gene="copY" /locus_tag="HMPREF0538_22301" /note="Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088" /db_xref="CDD:193654" gene complement(18036..18386) /gene="cadC" /locus_tag="HMPREF0538_22302" /db_xref="GeneID:10865958" CDS complement(18036..18386) /gene="cadC" /locus_tag="HMPREF0538_22302" /note="COG: COG0640" /codon_start=1 /transl_table=11 /product="transcriptional regulator CadC" /protein_id="YP_004650803.1" /db_xref="GI:338204622" /db_xref="GeneID:10865958" /translation="MKSKSADITCDQTLVETDKVMKVSEFLGKSRIKKYFYVLSKISD EKKLKIIFSLIAQESLCVCDIAYILGCSIATASHHLRMLYDADILDRQKKGKMVYYFI KDDDLKKILAQLDR" misc_feature complement(18069..18272) /gene="cadC" /locus_tag="HMPREF0538_22302" /note="Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090" /db_xref="CDD:28974" misc_feature complement(order(18126..18128,18216..18218,18225..18230, 18240..18245,18252..18254,18261..18263,18267..18272)) /gene="cadC" /locus_tag="HMPREF0538_22302" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(18087..18095,18108..18116,18132..18137, 18141..18146,18153..18158,18162..18173,18198..18206, 18246..18254,18264..18269)) /gene="cadC" /locus_tag="HMPREF0538_22302" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(18195..18197,18204..18206)) /gene="cadC" /locus_tag="HMPREF0538_22302" /note="putative Zn2+ binding site [ion binding]; other site" /db_xref="CDD:28974" gene complement(18403..19020) /gene="cadD" /locus_tag="HMPREF0538_22303" /db_xref="GeneID:10865959" CDS complement(18403..19020) /gene="cadD" /locus_tag="HMPREF0538_22303" /note="COG: COG4300" /codon_start=1 /transl_table=11 /product="cadmium resistance protein CadD" /protein_id="YP_004650804.1" /db_xref="GI:338204623" /db_xref="GeneID:10865959" /translation="MLGTIIAGVVTYWSTAIDLLIILMLFFAKVKDKKGVRDIYIGQF LGSGLLILVSLFFAVILHYVPDKRLLGFLGIIPVFLGIKALILGDSDGEKMANEKLKD TNQNNLIKTLIFITIVSCGADNVGLFVPYFISLALPKLLITLIVFLIMIFLLVFIAQK SVSIPTVGTVLEKYSRWFIGIVYIFIGGSVLIENGSIQLFINLIK" misc_feature complement(18409..19020) /gene="cadD" /locus_tag="HMPREF0538_22303" /note="Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300" /db_xref="CDD:34022" misc_feature complement(18412..18987) /gene="cadD" /locus_tag="HMPREF0538_22303" /note="Cadmium resistance transporter; Region: Cad; cl04177" /db_xref="CDD:141807" ORIGIN 1 aatattattt tggagtactc agattgaaac atcaagacac cttgagaatt ttctttaata 61 aatagtcaaa agccaaattt tatttgtagg tgtccagtaa taccaccaca agctaaaagt 121 attcactggc cattacctga tccggcacaa gcaaaaggca cacatgaaca aaaaatgttt 181 gtgtttcgac aaacgcgcga tgaaactaaa aaaacgtatt gtccaattag tttaggggct 241 atttttaata aataacccct taaaaacact attatatcaa gcccttgtat tctataatta 301 gaatataggg gctatttttt atattttaac tattattacc cctaaaagga gacgcttata 361 atgttcgatt acaccaccgc aacccgtgat cagaaagaag aatttttgca agacaaaatc 421 ctaatatgct tacaagctac taaacaacca atgacgaatg ctcagattcg agaatatctg 481 cttaagcatg ttgatgagtt gccagcaaac gtaactaagc taaccacttc caaaaaaggc 541 tctgtatact ctgatttcca gatccgtgta aatatgtcca ttacatcctt gtacaagggc 601 ggtctggttg atcatccaaa gcgaggagta accgaattga ctcaactcgg aaaaagcatc 661 aatcttaata ctggtcgtaa acatatgcat aaactaattg ttgaggggtg gcaaaaatga 721 aacaactcgt cctacccatc aaagacagca acattctcca tgaagttcaa gacacgctac 781 tcaataattt ccgatacggt cgccgtaact atactatctt ccaagttggc aaggcaacct 841 tgctccgagt gagcgatgtg ttagctctca gacgaaatga aatctttaat gatgatggaa 901 ctataaagaa gaatgcttat attcgcgata aaaagactga taaacccaac acactgtact 961 taaagccagt aaatcaggac ttaattgatt accttcagtg gttaaatgaa aataagattc 1021 aatctgattg gcttttccct tccattaagc accctgaccg acacattacc gagaagcaat 1081 tttacaagat catggccaaa acaggtgacc tacttggcat caattatcta ggtactcaca 1141 ccatgagaaa aactggcgcc taccgtgtct acacacagac caattacaat attggcttag 1201 tgatgagttt gctgaatcat tccagcgaag caatgacact gaaatatttg gggcttgatc 1261 aagttagtcg agaacaaatg ctagataaag tgagtttcga ctagtgatat ccttaaattc 1321 tcacaatagc aaaaaaggca acattatcta gcaattagag ataatgttgc ctttttaaca 1381 caaacaattc taaaaaagag aaaggagtaa tgaccaacct gattagtttc taaggaaaaa 1441 attattctta gaaaaatttt ttccttagaa actaaatagg caatactgcc aaaaatacta 1501 atatagaaag gagtccaacc aatggacttt aatgacaaca attttttaaa cgagattaac 1561 ccccttgatc ttaactcatc aattcctgca acaagagacc ttaaggactc aattcatgcc 1621 ttggcaatgt taaatggatg cacgatgcaa gaatatttag aacaactcac ctcaacagaa 1681 attcatcact atgatatcca gaaattgtcc gattaccgta aactcaagtt ttatttcgat 1741 gcgcgctatc ttaaaaagta taatctaaaa tcgagtagga gataattgat tagttcaatt 1801 atcgacctct cacaccaccg tacgtacggt tccgtatacg gcggttcgac aacttaatca 1861 cattgaattg actggagcgt cttggacata ttcataagtc cgagttgttc cagttttcta 1921 ttagttagag aatagctcaa ggtcttactg tgtgcagttc gccagtagcc cttgcgggta 1981 ctagcgaaga catatgcatc acgctgggac agccccagct tctgtaagtt agttacctta 2041 gttttaagct tcttccattg cttccagata tactgtctta ttcgggccct caaccacttg 2101 tcaaggcgtt gaataaagtc agttagtttc ccaattgagt agtactgaag ccatccacgc 2161 atttttcgat gaatttcttc aaacattctt gtcagggata ttccacgatt acgtttagtt 2221 aataacctca atgctttctt tactcgttgt tgcgattgtt ttgctggacg ggcgtaggct 2281 ccattgtggt ctacacccaa cgaaaagcca agaaacttta accgtagcgg gctaccgact 2341 ttggttttat ctgggttcac tttaactttc aatcgctttt caagaaactg ggtaatgctt 2401 cgcattactc gttctccggc tcgttgactt ttaacataaa tgttacaatc atccgcatag 2461 cgcacaaagt ggtgaccacg tctagtcaac tctttatcca actcatttag atagatattc 2521 gccagtattg gtgacaatgg ccctccttgt ggggttcctt tttcactctt agcgaaaagc 2581 ccatggtcta agactccgct agttagaaac ttacgaatga gccttagtgt ccatgggtca 2641 tcaatatatt gttgaagata cttaatcatc aagtcatgat taacattatc aaaataggct 2701 tttaggtcta agtcgacaac tcttcgataa ccttgattat aaagatctac tacttttgca 2761 atagcgtcgt gagccccacg gtgagggcgg aagccaaaac tattatcaga gaaaacacgc 2821 tcaaagatag gtgtaagaat ttgggccaca gcttgttgaa ccattcggtc caccactgtt 2881 ggtattccga gttttcttac tccaccatta ggcttcggaa tttctacccg tttgactggt 2941 gctggtttat acttgccctc acgcaaacta gcgatcaatt ccgtcttatt ttctctgaga 3001 tatggcagaa ggtcattgac tgtcatatcg tcaatgcctg ctgccccttt atttctctta 3061 actcgcaaat aagcctgatt aaggttattg cggtccaaga ctaagtcttg gatagtgaca 3121 ctcatacctt taccttcacc ataatcggta ctacgcgccc ttgtgtactt tcggttttcc 3181 aaacctatcc tcgacaagcg gtcagcttgt tgttctgttt tctgcgattg tcgcacctga 3241 ttacacctcc gatataagtt acaagttatt gtcgttcagt ccttcatctg attactcaga 3301 ctactatgac ctcggctgac ttctggctta ctcaacgcta catcactgca ccgcttgttt 3361 ctgtggaaat taaacttatt cctcttgtcg gaaacgtgta ggccagatct ccccgggtaa 3421 ggatattaac tttcgtacca tgtcaccggt agctttactg aaagtaactt cgagtagtgt 3481 tggactttaa cttgtcatgc agtcttatcc agttagttcc agccttatag ctacttcttg 3541 ttcatcggtg cagtactttg ccttagactt ccttcagatt ccacctcgca gtggacaccc 3601 ttgtcctcag ctcatggttc cgactactac ggcccatagc ggactctcac cgcctagcta 3661 atacccatgc cgggcgcaca taaaaagaaa aaggttagct attattgcta acccttttct 3721 tttaccccgg ttttaagagt tattagaata atatatcctt taattttttc tttgcatatt 3781 atttccagtt gcgtttaatc atttttatgt tcagaatcgt atttttcccc cgaaactttc 3841 atcctttgaa tgatccattg gatggattga gcatataatt ctttttcttt agtattttca 3901 aataaacaag aatctatatt acttagtgca tcattcaaat catctatcaa caagccaaac 3961 gatgcagatg aatagttacc aaaatctgta ctatcttcga tattaattgg catttttttt 4021 agcgcatagt gtctagattg ggcaccattt aaaagaaagg cagaaacatc ttctccagcg 4081 cctttagccc acttttgaat ttctgttttt tcagctttag tcacgcgagc acgaatagcg 4141 tcttttttta ctttatcccg attttcatat tttttggctg gcaaaatcat tcctccaatt 4201 agcgtagcta cgctttaaac taagttatgt ttttttacgc agctacataa ttcatagtta 4261 aaagcgtaac tacctacatc ttcaaactaa attacttttt tcatcatgta gctacactat 4321 caatgattaa taatgtagct acgccttaat gtcacttcaa ctaaaaaaca caactacatt 4381 attattttat gatgtcgtag ctacactttc aacttctaaa agtgtagcta catcttcaaa 4441 ctaaactact ttttttcatc atgtaaccac actattaatg atagcgtagc tacattatca 4501 ttttttgatt ccgtaactac gttttcaatg ctgcaaaaaa agtaaaatta gttaatttgc 4561 tttaattcag actattgttt gctactttaa tatttagatg tatacattat gccgtttaaa 4621 gactaaaata aaaataagaa agctacaata gaggagttta aaattaaaag taaccaaaat 4681 agtaaccaat cgcaccacaa caacctttat cttgtaacta gatttaaaca atatgcctta 4741 caacaagggt taaaaaaaca ctattaaagg aaatggtatt aatgacagta aacaaagtag 4801 ttataaaaaa taaagctgat atccatcctg aagatactgt taaatacatg gttacaaata 4861 actatgtaca tgaaagaaaa agcctataca ctaatcacaa agcaaatatt ataaaaaaag 4921 ggaaaggaaa ttacttcaac aaaaatacag gtgaaaaaat aacaaaagtt aaaaactcaa 4981 atttaaaaat tcaaaatcgt caatcactaa ttagatccta cgtcaactta cgatacacaa 5041 tagagaaata tgttacaggt tctatctatg acgaaatgta cactcttact tatgaaaaag 5101 ctcaaacatc atttaaagac ctgagccacg attttgttac cttcatgaaa cgtttcaaac 5161 gctatgttaa aaagaactat cctaaagtta acttatcatg gatacgaata aacgaacctc 5221 ataaagacac aataaacggc aagccaaaat ggcatattca tctaatcgtc ataggacttc 5281 cttttatgaa gcatcacatt cttgaaaaat tatgggggca tggaatagtc acaatcactt 5341 catactacaa atgcaatatt cacaaagtag ctaattattt tactggcttc atcaacaaaa 5401 acgattctga tccagaaagc aaaaaaggac gactaaaata ctatacatct ggcactgacc 5461 tatttagctt gtctcgagga ttacacgtcc caaaatggat acaaggtaca gaccaagaaa 5521 ttagaaaaaa acatcctggc aaaattataa atgaaactac tattgaaatt agagatacaa 5581 acgataacag tctatttaat cgatttgctt accgcgacat cgaatcaaac aaaacaaaat 5641 aacaaaacaa tttaaaattg tatattatta ccagcaaccc aaaagtgagt attaagtctc 5701 ttagatgtac ttaatactca cttttgctat acccatcaac tgcgctaacc acttataaaa 5761 agcctactct accttaactc cccataaagt aactgcgtag catcatcatt acacttcgcc 5821 ttaatgtggc aaaaatgtaa tgacacaaca tcgtaacact agtcgcttat catcaatcaa 5881 tctactaata atcattacta gactcattga taatagcaac tcagacagat taagcgcatc 5941 cagcccttgc ccctaccatt attagagttt gatttgttca actgttttac ttaatttcaa 6001 acagagcatc gcgaaaactc gagaaaatcg cttaatagta gggttgtccg tcgcattttc 6061 tggacttcca gccacttctt taaggattgt aagtcctagg gtttagcata ccatttgttt 6121 accacaggat tgtacgtctc agtcccacgt gtgtttcgag gtgctaccaa cacagtacag 6181 ctgttttcga gtcaaacggg tgcggcccaa aaagaaaagc acacagcctt ttagccatgt 6241 gcctagtttt ttggtttatg ttaaattcaa tcacttgaaa ttagctacat ttctcctata 6301 attaattcat agatagaaat gacaaaccac tagctacgcc cattagctaa ttggttgcct 6361 gttgtgtact tccaatacat ggcaggcttt ttctttttgc tctaaaatat tcaattttga 6421 aataaatatt ttgtttcgac tcttaaatta cactatttat tgcacaaagt aaatacttta 6481 aaataagctg tagtacggta tttataaacc acaattattt attgtagtaa aatatttatt 6541 gtagtttata aataatagta gtaagcaaat aacttactac tatttcaaag gtgattatat 6601 caacgtttaa aaaaataagc ttgtaatttg tttactacag taaataattg tagtagataa 6661 atattttact ataattattt atctagtttt cccattattg tatttattta ctacacttaa 6721 tcgatatcta taattaactg ttatagttcc tttaccaatt aagattaatc cgagttgtag 6781 taaagtaatt atagtaacta gaattttttt gttgtaaact tagtttaaag taactaaacc 6841 tattattatg ggaggtgact accaatgcca actgtactat acggaaacat gaagggtggc 6901 gtaggcaaaa ctactaatag tgttatgacc gcataccaat tagcaagaaa gggctataaa 6961 acattagttt gcgatttaga tccacaagca aatgctaccc agttactacg aagaacttat 7021 ggattgcagc atggcactga tttaaaaatt gaaaaaacaa tgatggtagc tttaaccgaa 7081 gaaaatattg aacctgctat tgttaatatt atggataatc tgtatcttct tccttcgtca 7141 gaagacttta aaaattatcc tgatttctta gaaatgaaat ttatgcctga taaagaaaaa 7201 attctagccg gtaatagcac aaccttgcaa agcgaaatgg ctaaagtaaa agaaaaacga 7261 attgcttatt tttcgaaaca actggctaaa gtacatgacc aatatgattt catcattatc 7321 gatgtaccac caacgctttc aatttttaca gattcagcaa tatatgctac taattttgtg 7381 atcattgttt tacaaaccca acagcgttct ctagatggag ctgaaacatt ttttgaatac 7441 ctgcaggaaa tgtacaataa ttatgccaat attgactttg atattattgg agttttagca 7501 gtcctactta aaaataatgc tggtttagat agtcaaattt taaaagatgc tcgcgttgat 7561 tttggcgacg atatgctatt taatcaaatt attagacaca tggaaagatt gaaacgatac 7621 gatagaacag ggattgctga aaaaggatta accaagtatg acatgcatga cacacgtcta 7681 cactatattt acacaaagtt aacagatgaa attattgctc gattaaagga taaaggagca 7741 cttaactgat ggctaaatat caatttgata agggcacgaa aagaaggtca aaaccaaggc 7801 ccaagccaat agacaagacc gatatttcaa agccaaaaat aacttataat cctcttactg 7861 taaccgacag agttgaaaat gatctgcagc ataaaaaaag atcagtagga aggccaaaaa 7921 caggtcgaaa atcatacaaa acagttcgtt tattaacaag tactgtgttg aagattaatg 7981 cgttggaaaa tgctcttgga attaagacac aagatgctac tgtagatcaa gccgttgacc 8041 gagtaattaa ttcattaact aatgatgaaa tgcgagctta taagctgtgg cttgaaatgt 8101 ttgaaaaaaa agaaaaagaa taggtaagat cataaaattt tgaaaaaata ggtactacta 8161 aatttaaaat ttagtagtac ctattttttg attaccgttt ctgaattcgt tttttcaatc 8221 gataaagcgt tgacctagat aggcctgttg cctgttgagt agttctatag tcgctcttca 8281 taagcagatt gtaaatctgg taatcttgtt gtgtaatctc tcgtttattg cttttatccc 8341 tatgcaaatc aatctgatgt gtcatttgac acatcttttt tctattagag gaacgttgca 8401 tcatagtaac catatctgct cgacagagca tcttagctac ataatacggt tcacgactgt 8461 tactcatacc catttctagc tcgtcgctaa aaattgttat ctgaaggtct tcaatctcgt 8521 cgagtaagca acataattca cgcacgttag acgtcatatt tgatacgtcc attacatcta 8581 tcatatcgcc aggtttcaca accataagta atttttgcag ttgaaatcgt gcctgacaca 8641 ccccagtgaa tgtgtcaata aagtaagcat cataatccac attggtttgt ttaagaaaat 8701 caatttgaca cgcgattgaa cctttatcat taatgtcatt attagtggtt ccagccacat 8761 aagcatacat tgacatatgt ttcatatcct ttctatttta ttttttgtat taacagtcta 8821 aataaaaaaa tttgaaacat ggtatgaaac aaaataacta catcagttcg cataacataa 8881 attggtataa taagaagaaa taataattac tagaaaaggt agatatgatg caaatagata 8941 ctagattaat ggagcaggtt aaagatgttc ttcagcaatt cggtactaag tatataacca 9001 aagatggttc tctaaaacgt aatgccgtta ttagcgacct tgataaatat gataaagact 9061 taatggtagc attgttggcc aacaatctta ttaaagatga atatactgaa caaatagctg 9121 atacaacagt attcaaatta aatcacttta ttgaaatgtt tgaatatcaa gagttttggg 9181 gtaatagttt taccaaatac gccaaccgaa ttggccttac cagtgatgat aaattcatta 9241 gtgactcaga cgatgttgta ttagatttcc cctataaaga tactgttcta aaagcaggta 9301 tgactaaaga tgatgttgat aaagaagtcg gggctgatga accttttttg aacgaaacat 9361 tagctcattc tgaaattagt gagttatttg aaccaaaagt attagttaat gcaaaactat 9421 acgatacaga aggcgaacac aaagctacca attttgatga taatgataat ttagtaatta 9481 agggcaataa tttaatcgct ctacatagta ttgccaaaaa gtacgccgga aaaattaaac 9541 tcatttattt ggatccaccc tataacacag gatctgattc ctttaaatat aatgatcgat 9601 ttagtcatgc tacttggctc acgtttatga agagtcgatt ggaaatagca aaaacgctaa 9661 tgtctgataa cggggtcatt gctatccaac tggatgattc tgagggacca tatctaaagg 9721 tactgacaga ctcaatattt ggtcgtgaca atgaattatt cacgcaatat gtgttagtcc 9781 gatatgctaa taagacattg aaatcagata tggattatca taaacaaata gaacaaatcc 9841 attactataa aaaaaattct aatgctgagg taaaacccaa caaggacaaa gttccatatg 9901 attattcaaa attctgttac gaagttaaaa cgactgggaa accttcttca tcaattatgc 9961 ttggcgataa acaagttgat attttcacta aagaccaggt tgagtttaag aaaacctccg 10021 gtaatccgga aggtcttaaa gaaatatggg cttctggaac aatcttaaat ggtaattcct 10081 ctggaagatt ttttagagat tatttaagtg gccgttataa aaaagatggt tatggtgtgg 10141 tctataaagt ttatgatata ggcgatgatg gtaatgacta tagattcttt acaggtccaa 10201 agaaagcagg agctactaaa ggaaagtatt atcaaggagt tcccctagat gttaaaaacg 10261 gtaaaactag tcaaaagtta ttgcctatac caggcttcat tgatatggca ggttcatttg 10321 gaaacgatcg tcttgaagga ggcgtcgaat taagaaatgg aaaaaagcct gagaaattat 10381 tgaaaaatat tattaaatat tttagtaata aaaatgatta tgttatggac tttttcgctg 10441 gtagtggctc aacgttagct acagcaatga aaatgagtcg aaaatttata gcaatcgaac 10501 aaattaatga acaaatcata aaaatcaata aacgattaaa taatgttatt catggtgatc 10561 aaactggtat ttccaaggaa gttaattggc aaggtggcgg ttcatttgtc tacaccgaac 10621 ttatgaaaaa gaaccaggga tttctttatg accttcagaa ggcaactacc attgacgagc 10681 ttaatgcagt ttatgaccga atgaaacagg gtgctgatct agattttcgt gtcgacttaa 10741 ataaatttga aaatgattct gaacgtgctt ctctaccatt tgaagatcag aaaaagctgt 10801 taatcaagct acttgataag aaccaacttt actataacga agccaatatt gatgatgcag 10861 acgtccgtga cctgatctcg gatagtgatt atcgattcaa taagagcttc tacaacggga 10921 aggagtcaaa gtaatggctc gtaaaaaaac aatacccgaa gaaaaaattg atctccaatt 10981 actaaatgct cttaacagca ccagcctttt ttcactcaaa tcatccttag aggataatcc 11041 cctttacatt actaataatc taaaacacaa actccgtaat taccaaatgg atgctgtcca 11101 tcacctcgat gcagtactca acatgaagga tgctgaccaa cgtaatcagt tgatgtttta 11161 catggccaca ggatctggaa agaccgatat tatggccgca attatcctgt atatgtttcg 11221 tgcctggggt tatcaatgct tcttgtttac cactaataca actgctgttg tcgacaagac 11281 tattgataac ttagtaaata gtgcttctgc taagtacctt tacaacaatc cattagttat 11341 tgatggcgat catgttacga ttaaaaaagt cgaccgatat ccagtaaatc ttgaaaagga 11401 tacaatatat atcaaacttg ctggcattca acaattatca aatgactatt acgcccccag 11461 agaaaatgga attaccaagg attcactggc aagacataaa ttagtcctgc ttgccgacga 11521 agcacaccac tttaatgttt ctactcgcag taagaaagct aatcgggagg gacttagttg 11581 ggagcatttg cttgatgaga tcaggcaatt aaatcatgaa aataaacaac ttgaatttac 11641 tgcgactatc gatcttcata atcctgacat ttaccacaag tatcaaaata agatcattgc 11701 acaatatgat cttagccact tcattaatga tgggttttcc aaaaaggtct accggcttca 11761 agcaaataat agtgatgaaa ataagatgct caatgctgta ctcttatcac aatatcggaa 11821 gcgtattgct caaaacatga gtattcccga ctttaagcct gtaatcttgt tcaaatcgaa 11881 tacaatcgct gaatcaaggg ctatcaacga aacctttttg acaatgattg acaacctatc 11941 agcagaatcg ttgcaacaat ttatacagaa tcaaaaccgt tcaacgcaaa gtgaagcact 12001 cagtcttgct tacaagtatt ggctaaatca agattttggt tctacagtaa ccgagttaaa 12061 acgcgatttt agcaagttta caacgattaa cgcgaatgac tctggaagta agaacattct 12121 tgatgacgaa tcagtttcaa gaaggctcaa ttctttggaa agtcctgaca acccgattcg 12181 ctctgtcttc gccgttgcta agttgagtga aggttgggac gttttgaacc tctttgacat 12241 cgtccggatt ggcgaaaaaa atatcaagcc taaagataca aatgctgaag cccagcttat 12301 tggacgtggt gccagatact atccattcgt ttatcacgga aagaagtcat atacgagaag 12361 atttgatgac cgtaaaccag aaattcagct tttggagcgt ttgtactacc acactattaa 12421 cgatccacaa tatctggaaa atcttagaaa atcactagat gcaattgatc tacctgttaa 12481 tgaagatact caatacaagg tgtacaccgc taaagtaaag aattcgttta agaagaccaa 12541 agcatataag catgggaata tttactataa taaggtcatt gacgttcctg aatcgcatta 12601 cgattctatt cagaagtacg gcttcgatcc tgaaacaact ggaccaattg atatggttga 12661 tgctgtttct gagcgaagat acgatactgg tgcggataag aacgatacca cctctacaac 12721 acttgaagtt gctgctagat ttagcaatcc tcaagataag gcacttatac gtacagccgt 12781 gtccttcaat aacttctacc gttttgactc ccttaaaaaa tactgtccta ctttaacaag 12841 catgcgagaa ttcttaacta gcaatgaatg gttagggaac gccaccataa gagttaaggt 12901 agcaaccggt tctcctgctc taactaacga acaacgatta acagcagtta aaaagtattt 12961 agtccgtgtg caaacagcaa tctctaataa cttcaaacgc tctattggta ctaacgagtt 13021 tatgcctatc gccgttaatg aagttattca agattatcaa aagcgtgttg gtgatcaatt 13081 cggcaagagt gccttaatag gccctgattc gatgcagggc aaagactggt atgtctatga 13141 ttatgcgatt gtagataccc ttgaaaagca ctttattgac catatcaata gtattatgcc 13201 tgaactaaca catcagtacg ggcaagctta tctactacgt attgatgaac gtacaactga 13261 tttcaagtta catgattttg gtgagaatat tttccattac gaaggatata tgcctgactt 13321 tattctttac cttgagaatg agaactttat ctatcagata ttccttgaac ctaaagggac 13381 accttatata gaaagggata aatggaagga aaaacttctg gaacgaatta atcctgacaa 13441 tattaaagtc ctaggtgaag acgaaaaagt taagatctat ggcctgaaat tctatgttga 13501 agatgatggc aaagaagata cccacggttt attccaagag atgcgcgaca agaatatctt 13561 gcagtaacct catgagtggt aaactattcg attcatgata taatgtttat agagattaag 13621 tcgttatgag gttcatagcg caacacaaaa gcccccagca aggtccgaag atgctgaggg 13681 cttttattgt gggcttgtgc cgttcgatta ctcgttaatg gtgtcggttg ttaagccacc 13741 agctgaacca tactacgatg agcgaactaa cgagcgagat taagtcgttt aaaaggtcca 13801 tagccaccac cccctctcta tcacgacaag gggacgaacg acaatattaa gtatagcaac 13861 ttctaagcga tctgaaagta ttaagattct gacctgaaaa cgtggagagt gtaacatctg 13921 ttaatgttag tgcggtaact aaagtaggca tatttctctg cgttaatttc aactttgtct 13981 cctccatttt tttgaaatac actttattaa aatagtcata tgtgtcgtaa atatggagaa 14041 gccagcatat ataaaaaaga gtgccatgtg acactctttt tgagctattt aatatcaaca 14101 acaccgacaa attcaacatc atcaattgca gttaagtaaa aactatcagt tggtccaagt 14161 attgcaagtt gaccattttt gattgtacat tcttgatctg gtgtggtcag tttcaccgtc 14221 ccttttaagg gaatgagaac tatatttcca ggtacagggt gaaattctcc gttgtttgtc 14281 actgtatttt tctttagtat acgatgacca acccgtcttt gaccattttc gtaaaggtgt 14341 tcatggacct catcaccgcg actaccagtt aatattttca tataatatat actcccaagt 14401 taattgactt ttttacgtgg cttttcagta ttattggaat tttgttgagt gttgtttcca 14461 cagcagccca tactaccaga gccaccgtgc atacccttgt gcataaatag catcatgagt 14521 gggtgtgcta gaagaaaaag ggctatcaga atccattgtg acatagtttc acttcctttt 14581 gctttgtttc tataataagt ttttgtcatc acttgtttgt cactgtattt ttctttagta 14641 tacgatgacc aacccgtctt tgaccatttt tgtaaaggtg ttcatggacc tcatcaccgc 14701 gactaccagt taatattttc atataatata tactcccaag ttaattgact tttttacgtg 14761 gcttttcagt attattggaa ttttgttgag tgttgtttcc agagccaccg tgcataccct 14821 tgtgcataaa tagcatcatg agtgggtgtg ctagaagaca aagggctacc agaatccatt 14881 gtgacatagt ttcacctcct tttgctttgt ttctataata agtttttgtc atcacttaat 14941 tacacgtttt taatcttttc accagtcaat cccatcgcat taattgccac gataattgtc 15001 gacatcgcca tgaccgcagc accaacggct gggtctagaa tgattccaat aaatgacaac 15061 acaccggcag cgagtggaat tgcgacaaca ttgtagcctg ctccccacca gagattttga 15121 accattttcc gatttgtgat tttagccaaa tcaagaaaat gtaaaatatc gctgggttct 15181 gatttaacca acacaacatc agcggaatca atggcaacat cggttccggc gccaattgca 15241 attccaatat cggccgcggc aagacttggt gcgtcattta cgccgtcacc aaccatgatg 15301 acgtgattgc cctttgcttg ataatcagca ataatctttt gcttatcatc tggtaatagg 15361 cctgcatgga attcagtcaa tcctagtaag ttagcaacgt gttccgcggc ttttggatta 15421 tcgccagtga gcattacggg ggtaattcct cgcctctgaa gaccactaat taattcctta 15481 gctcccgctt tgatggtgtc gccttcggca accattcctt gaacttgggt gccctgcaat 15541 aggaagctaa cggaattacc cttagcagcc catttatcag cagcggcctc gtcaaacctg 15601 atcccttgct tcgttaaata gttaccatta acaatcatat agtcagtgcc atcaacatta 15661 ccggaaatac caacgcccgg aatattttga gacttttcag ccgcaacgac ctcaatgttc 15721 ttcgcttggg cttcagtaat gattgcttgg gccagcggat gagtcgaatt aatttcaagg 15781 gcggccagtc ggcttaataa cgttgtttcg tcaatcccat catttggaat caatgcattc 15841 actgtaaatt taccttctgt taacgtgcca gttttatcca agagaacgtg gctaacatgt 15901 tgacttgctt caatggcttg gcgatttcga actaatagcc cattttgagc gccgatagta 15961 gtagaacgag aaaccactaa tggaatcgct aatcctaatg catgcgggca agcaatcacg 16021 aagacggtca ccatgatcgt cattgcagtc gccaatccct ggggtaacca ggcaaagaaa 16081 gcaataatcc caacaccaag tgccgcgtaa aatagatact ttgcaactaa atcagcttta 16141 tcttctgctt tagatttagc ttgctgggca ttttgaacca ttttcattac ttgagaaaga 16201 tagctggagt caccagtacc actaatttta accgttagcg tcccgttatt gttggttgta 16261 ccaccaatga ccttatcgcc aacgttcttg gtaacggcag cagattcacc ggttaccagt 16321 gcttcattca cggtcgactc cccagccgta ataacaccat cggctggaat actctcacct 16381 gaacgcactt ggaaagcttg accaactttt aaatcagata ctggcacttc ttttgtttca 16441 ccattatctg taactagatg ggccgtctta ggcaacaggg ccgccatctt ttgtaaggca 16501 ttcccagccc ccatcaatgc attcatttca atccagtgtc ctagaagcat aattaaaatc 16561 agggttgcaa gttcgaacga aaaatccatt atatgatttg tcgggttcaa gaagttgttg 16621 gcaataaatg cgtacaaact gtagaaatac gaaacggaaa ttccaagggt tactagcgtc 16681 atcatttcag gagatttatt ctgaatttcc gctttagccc cctttaaaaa tggcattccg 16741 ccataaaagt aaagtgctgt atcaaacaaa acgatgataa tgccaacaat tagcggtgaa 16801 ctgaaactaa ggatggaaac gtttaaaccc atgattggtg ctaacagtaa aactggaatc 16861 gctaagacaa cggagaccca aaatttaact ttcaaattcc ccatatgcat cattgagcca 16921 ccgtgcatca tcatgtcggc cccagccata tccatatcac cgtgattcat gttcatttgg 16981 ctgtgatccg tttcggtcat atcgtgatcc atatgactca tatttgattc attattttcc 17041 atattcttag cactcatgtt tttcatgttc atatggccct ctttatttgc catgattatc 17101 gaccccctaa aaataagtgt gcgtagcaaa gcggttagaa gccggaatat aagttccttg 17161 tgtggaaatt cccgggctcg ggattttccc accagattct tatatttagg cttctgcttt 17221 gcggagcacc atgccactat atgaatgaga attacgacaa aagttcataa gtttccgcca 17281 tcaggaatcc cagattctgg atttttgtgc agcaatccta aaagtaaaca gaacaccaca 17341 gtcttaacac gtttgatcac ctggcaagca gttacactga acttcttcgg gcgctgtttt 17401 ggccttttca gctagaatcg cctgtaagtt cgcaatatcc gcccgtgaga gttcccttga 17461 ctgaataacg ccggcaattg ttgaaccagc ccgcatcgca cacatatggt caaacaaatc 17521 atctgccgct gccgccattg attccttctc gccaacaacc ggcttatacg tgaatggtcg 17581 actgccgcca tgctgcgcaa ccgcctgttt ttgaatcaac ctgtgaagta gcgttttggt 17641 tgttgaagct gaccagcctt ctaattcgtt catagcatcg attagttcac gactagtcgc 17701 atgtcccatt gtccaaattg ctctcataac catccattca gaatcggtga tggttacatt 17761 ctttggatcc ttcaattggc ttcctccatt aattgaatta taagtttaca tttgtagtct 17821 cttaatgctt attagtttac aactgtagtc acaataatgc aacctttctg ccagaaaata 17881 ccatgacact aaaaaaacgc ctagataata ttccagacgt ggtttgatac gatatattaa 17941 attacgttag ttgctagttt gtaacattcc catgacttct aaattatggg tcagcataat 18001 tactttctct tcttaaggga agcacttaag tcaattcacc tgtcaagttg agcaagtatt 18061 tttttcagat catcatcttt tataaagtag tacaccattt tccccttttt ttgacggtct 18121 aaaatgtcag catcatacag cattcttaag tgatgagaag cggttgcaat actacagcct 18181 aaaatatatg caatatcaca aacacataac gattcctgag cgattaaaga gaaaatgatt 18241 tttaactttt tctcatctga gattttagac aatacataaa agtatttctt aatacgtgat 18301 ttacccaaga attccgagac cttcattact ttatctgtct caaccaatgt ctgatcacaa 18361 gtaatgtcag cacttttgct tttcatagaa tcactctgcc tattatttaa ttaaattaat 18421 gaaaagttga attgatccat tttcgatcaa aacggaacca ccaataaaga tataaacgat 18481 tcctataaac caacgactat atttttcaag aactgtacct acagttggaa tactaaccga 18541 cttctgggca ataaaaacta ataagaaaat cattatcaaa aacacgatta aagttattaa 18601 taactttggt agtgccaaac taataaagta aggtacaaat aatccaacat tatcagcacc 18661 acagctcaca atagtaatga aaatcaaggt tttaatcaaa ttattttgat ttgtatcttt 18721 caatttttca ttagccattt tttcaccgtc tgaatctccc aaaattaaag cctttattcc 18781 caaaaagaca ggaattattc ctagaaaacc taataatcgt ttatcaggaa cgtaatgtaa 18841 aatgacagca aagaacaaac taactaatat caaaagccca gacccaagaa attggcctat 18901 ataaatatct ctaacaccct ttttatcttt aactttcgca aaaaaaagca tcagaattat 18961 taataagtca atagcagtac tccagtaagt caccacacca gcaataattg ttcctaacat 19021 ttcttatttc ctccaaaata atattcaaat atatatttg //