LOCUS NC_015700 12160 bp DNA circular BCT 24-JUN-2011 DEFINITION Lactobacillus reuteri SD2112 plasmid pLR581, complete sequence. ACCESSION NC_015700 VERSION NC_015700.1 GI:338202319 DBLINK Project: 55357 KEYWORDS . SOURCE Lactobacillus reuteri SD2112 ORGANISM Lactobacillus reuteri SD2112 Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 12160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (23-JUN-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 2 (bases 1 to 12160) AUTHORS Muzny,D., Qin,X., Buhay,C., Dugan-Rocha,S., Ding,Y., Chen,G., Hawes,A., Holder,M., Jhangiani,S., Johnson,A., Khan,Z., Li,Z., Liu,W., Liu,X., Perez,L., Shen,H., Wang,Q., Watt,J., Xi,L., Xin,Y., Zhou,J., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z., Zhang,L., Villasana,D., Johnson,A., Liu,J., Liyanage,D., Lorensuhewa,L., Robinson,T., Song,A., Song,B.-B., Dinh,H., Thornton,R., Coyle,M., Francisco,L., Jackson,L., Javaid,M., Korchina,V., Kovar,C., Mata,R., Mathew,T., Ngo,R., Nguyen,L., Nguyen,N., Okwuonu,G., Ongeri,F., Pham,C., Simmons,D., Wilczek-Boney,K., Hale,W., Jakkamsetti,A., Pham,P., Ruth,R., San Lucas,F., Warren,J., Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S., Bess,C., Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K., Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S., Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L., Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P., Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K., Petrosino,J., Highlander,S. and Gibbs,R. TITLE Direct Submission JOURNAL Submitted (06-JUN-2011) Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP002845. Lactobacillus reuteri SD2112 Strain source, body site: Gastrointestinal tract Inquiries should be directed to microbe@hgsc.bcm.tmc.edu This is a reference genome for the Human Microbiome Project. This project is co-owned with the Human Microbiome Project DACC. Source DNA provided by Versalovic, J. (Department of Pathology, Texas Children's Hospital, 1102 Bates Avenue, Suite 830, Feigin Center, Houston, TX, 77030, USA). Funded by by 'Genomes and Genetics at BCM-HGSC' (U54 HG003273). ##Genome-Assembly-Data-START## Finishing Goal :: Finished Current Finishing Status :: Finished Assembly Method :: Newbler Assembler v. 2.3.10192009 Genome Coverage :: 63x Sequencing Technology :: 454 ##Genome-Assembly-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..12160 /organism="Lactobacillus reuteri SD2112" /mol_type="genomic DNA" /strain="SD2112" /culture_collection="ATCC:55730" /db_xref="HMP:00538" /db_xref="HOMD:tax_818" /db_xref="taxon:491077" /plasmid="pLR581" gene complement(152..547) /locus_tag="HMPREF0538_22255" /db_xref="GeneID:10865976" CDS complement(152..547) /locus_tag="HMPREF0538_22255" /codon_start=1 /transl_table=11 /product="replication protein" /protein_id="YP_004650772.1" /db_xref="GI:338202320" /db_xref="GeneID:10865976" /translation="MMSPKSIARWQELKAKKLSGRTVPEDMEYKKLQMKHNADVLALN ELKWKAELAEAMLTLASNNDDLMQRLNSIINSQIGDDQKPFAKKDLHDFVTAFVAKIK QEQQEQSHAKPLGKNPLHDNEFPNGNNPD" gene complement(586..861) /locus_tag="HMPREF0538_22256" /db_xref="GeneID:10865961" CDS complement(586..861) /locus_tag="HMPREF0538_22256" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="YP_004650773.1" /db_xref="GI:338202321" /db_xref="GeneID:10865961" /translation="MSNINFKDYLNEQLKDPAFKKEFENETTKLESAIALTKVRKESG LSQRDLATVSDVPQSTIARIESGANTSIDTLTKIANALGKRLTVNFS" misc_feature complement(613..759) /locus_tag="HMPREF0538_22256" /note="Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093" /db_xref="CDD:28977" misc_feature complement(order(664..666,739..741,751..753)) /locus_tag="HMPREF0538_22256" /note="non-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28977" misc_feature complement(order(667..669,742..744)) /locus_tag="HMPREF0538_22256" /note="salt bridge; other site" /db_xref="CDD:28977" misc_feature complement(order(661..666,676..678,685..687,718..723)) /locus_tag="HMPREF0538_22256" /note="sequence-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28977" gene complement(864..1226) /locus_tag="HMPREF0538_22257" /db_xref="GeneID:10865975" CDS complement(864..1226) /locus_tag="HMPREF0538_22257" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650774.1" /db_xref="GI:338202322" /db_xref="GeneID:10865975" /translation="MEDLEFEFYTRPNGHTEFAEYLDSLDVKAKAKLLARINMVATYG LSAGIQHNWVKPLEKNLYEIRSRVSNNQQRGLYFHVDGVHYVITHGFTKKTQKTPPRE INHAKKLRDEYFANRKEQ" misc_feature complement(894..1169) /locus_tag="HMPREF0538_22257" /note="Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470" /db_xref="CDD:194142" gene complement(1373..1960) /locus_tag="HMPREF0538_22258" /db_xref="GeneID:10865962" CDS complement(1373..1960) /locus_tag="HMPREF0538_22258" /codon_start=1 /transl_table=11 /product="integrase" /protein_id="YP_004650775.1" /db_xref="GI:338202323" /db_xref="GeneID:10865962" /translation="MKQLVLPIKDSNILHEVEDTLLHNFKAGRRNYTIFQVGKATLLR VSDLLALRRNEIFNNDGTIAKNAYIRDKKTGKPNTLYLKPVKQDLKDYFQWLNQQNLH SDWLFPSTKHPDRHITEKQFYKIMAKTGDLLGINYLGTHTMRKTGAYRVYTQTHYNIG LVMSLLNHSSEAMTLKYLGLDQVSREQMLDEVKFD" misc_feature complement(1379..1954) /locus_tag="HMPREF0538_22258" /note="DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213" /db_xref="CDD:193712" misc_feature complement(1430..1924) /locus_tag="HMPREF0538_22258" /note="Phage integrase family; Region: Phage_integrase; pfam00589" /db_xref="CDD:144254" misc_feature complement(order(1430..1432,1538..1546,1742..1744, 1826..1831)) /locus_tag="HMPREF0538_22258" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:29495" misc_feature complement(order(1430..1432,1457..1459,1529..1531, 1538..1540,1742..1744,1829..1831)) /locus_tag="HMPREF0538_22258" /note="Int/Topo IB signature motif; other site" /db_xref="CDD:29495" misc_feature complement(order(1430..1432,1457..1459,1529..1531, 1538..1540,1829..1831)) /locus_tag="HMPREF0538_22258" /note="active site" /db_xref="CDD:29495" gene 2209..2346 /locus_tag="HMPREF0538_22259" /db_xref="GeneID:10865963" CDS 2209..2346 /locus_tag="HMPREF0538_22259" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004650776.1" /db_xref="GI:338202324" /db_xref="GeneID:10865963" /translation="MSRRLGNRELPDSNLHTDFIILVVPNKHVKKSIKKVIALIRKMM K" gene complement(2563..4482) /gene="tetP" /locus_tag="HMPREF0538_22260" /db_xref="GeneID:10865964" CDS complement(2563..4482) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="COG: COG0480" /codon_start=1 /transl_table=11 /product="tetracycline resistance protein TetP" /protein_id="YP_004650777.1" /db_xref="GI:338202325" /db_xref="GeneID:10865964" /translation="MKIINIGILAHVDAGKTTLTESLLYASGAISEPGSVKKGTTRTD TMFLERQRGITIQAAVTSFQWHRCKVNIVDTPGHMDFLAEVYRSLAVLDGAILVISAK DGVQAQTRILFHALRKMNIPTVIFINKIDQAGVDLQSVVQSVRDKLSADIIIKQTVSL SPEIVLEENTDIEAWDAVIENNDKLLEKYIAGEPISREKLVREEQRRVQDASLFPVYY GSAKKGLGIQPLMDAVTGLFQPIGEQGSAALCGSVFKVEYTDCGQRRVYLRLYSGTLR LRDTVALAGREKLKITEMRIPSKGEIVRTDTAYPGEIVILPSDSVRLNDVLGDPTRLP RKRWREDPLPMLRTSIAPKTAAQRERLLDALTQLADTDPLLRCEVDSITHEIILSFLG RVQLEVVSALLSEKYKLETVVKEPTVIYMERPLKAASHTIHIEVPPNPFWASIGLSVT PLPLGSGVQYESRVSLGYLNQSFQNAVRDGIRYGLEQGLFGWNVTDCKICFEYGLYYS PVSTPADFRSLAPIVLEQALKESGTQLLEPYLSFTLYAPREYLSRAYHDAPKYCATIE TVQVKKDEVVFTGEIPARCIQAYRTDLASYTNGQSVCLTELKGYQAAVGKPVIQPRRP NSRLDKVRYMFQKIM" misc_feature complement(2572..4482) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480" /db_xref="CDD:30828" misc_feature complement(3760..4470) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168" /db_xref="CDD:133368" misc_feature complement(4432..4455) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="G1 box; other site" /db_xref="CDD:133368" misc_feature complement(order(4054..4056,4066..4068,4174..4179, 4246..4251,4303..4308,4408..4413,4420..4422,4429..4434, 4444..4446,4450..4452)) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="putative GEF interaction site [polypeptide binding]; other site" /db_xref="CDD:133368" misc_feature complement(order(3817..3825,4090..4092,4096..4101, 4429..4446)) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:133368" misc_feature complement(4306..4341) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Switch I region; other site" /db_xref="CDD:133368" misc_feature complement(4318..4320) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="G2 box; other site" /db_xref="CDD:133368" misc_feature complement(4252..4263) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="G3 box; other site" /db_xref="CDD:133368" misc_feature complement(4201..4257) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Switch II region; other site" /db_xref="CDD:133368" misc_feature complement(4090..4101) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="G4 box; other site" /db_xref="CDD:133368" misc_feature complement(3817..3825) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="G5 box; other site" /db_xref="CDD:133368" misc_feature complement(3496..3747) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690" /db_xref="CDD:58081" misc_feature complement(2887..3231) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684" /db_xref="CDD:58278" misc_feature complement(2650..2874) /gene="tetP" /locus_tag="HMPREF0538_22260" /note="Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711" /db_xref="CDD:58064" gene complement(5128..5418) /locus_tag="HMPREF0538_22261" /db_xref="GeneID:10865965" CDS complement(5128..5418) /locus_tag="HMPREF0538_22261" /codon_start=1 /transl_table=11 /product="cell surface protein" /protein_id="YP_004650778.1" /db_xref="GI:338202326" /db_xref="GeneID:10865965" /translation="MLSRNNWKEQVRQQEPNKQRFTIKKLTIGVASVLIGFTFMGMSA SADAQTTSATGTQTGIASATDTTTPIAPSTTVPSYDGTKVVDTPFYNNAHVR" misc_feature complement(<5296..5385) /locus_tag="HMPREF0538_22261" /note="YSIRK type signal peptide; Region: YSIRK_signal; cl04650" /db_xref="CDD:189174" gene complement(5553..5819) /gene="acr2" /locus_tag="HMPREF0538_22262" /db_xref="GeneID:10865966" CDS complement(5553..5819) /gene="acr2" /locus_tag="HMPREF0538_22262" /note="COG: COG0798" /codon_start=1 /transl_table=11 /product="arsenical-resistance protein" /protein_id="YP_004650779.1" /db_xref="GI:338202327" /db_xref="GeneID:10865966" /translation="MKGINMKTSKNLLFMDRYMTLWVFLAMALGILSGFISPSLPKLI NSWSVGTTSIPIAIGLILMLYPPLTKVNYEKMGDVFSDKVDCKI" misc_feature complement(<5571..5786) /gene="acr2" /locus_tag="HMPREF0538_22262" /note="Membrane transport protein; Region: Mem_trans; cl09117" /db_xref="CDD:189190" gene complement(5867..6169) /gene="arsR2" /locus_tag="HMPREF0538_22263" /db_xref="GeneID:10865967" CDS complement(5867..6169) /gene="arsR2" /locus_tag="HMPREF0538_22263" /note="COG: COG0640" /codon_start=1 /transl_table=11 /product="arsenical resistance operon repressor" /protein_id="YP_004650780.1" /db_xref="GI:338202328" /db_xref="GeneID:10865967" /translation="MDYQKLANLLKVVAEPNRLKILEMLSCGEMCACNILDHFDFTQP TLSHHMKVLEDKGLVIVSKKSKWHYYSLNPDTTALIINGLTRTLSNTDNCMCKDAN" misc_feature complement(5927..6142) /gene="arsR2" /locus_tag="HMPREF0538_22263" /note="Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090" /db_xref="CDD:28974" misc_feature complement(order(5927..5932,5936..5941,5999..6001, 6089..6091,6098..6103,6110..6115,6122..6124,6131..6133, 6137..6142)) /gene="arsR2" /locus_tag="HMPREF0538_22263" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(5960..5968,5981..5989,6005..6010, 6014..6019,6026..6031,6035..6046,6071..6079,6116..6124, 6134..6139)) /gene="arsR2" /locus_tag="HMPREF0538_22263" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(5939..5941,6068..6070,6077..6079)) /gene="arsR2" /locus_tag="HMPREF0538_22263" /note="putative Zn2+ binding site [ion binding]; other site" /db_xref="CDD:28974" misc_feature complement(6252..6577) /note="potential frameshift: common BLAST hit: gi|325956240|ref|YP_004286850.1| arsenate reductase" gene complement(6252..6425) /gene="arsC3" /locus_tag="HMPREF0538_22264" /db_xref="GeneID:10865968" CDS complement(6252..6425) /gene="arsC3" /locus_tag="HMPREF0538_22264" /EC_number="1.20.4.-" /EC_number="3.1.3.48" /codon_start=1 /transl_table=11 /product="arsenate reductase" /protein_id="YP_004650781.1" /db_xref="GI:338202329" /db_xref="GeneID:10865968" /translation="MTLCGDARDRCSVIPSQAQSVHWPLPDPAQAKGTPEQKMVVFRQ VRDEIKQLVKGLI" misc_feature complement(6258..>6425) /gene="arsC3" /locus_tag="HMPREF0538_22264" /note="Low molecular weight phosphatase family; Region: LMWPc; cl00105" /db_xref="CDD:193660" gene complement(6428..6577) /gene="arsC4" /locus_tag="HMPREF0538_22265" /db_xref="GeneID:10865969" CDS complement(6428..6577) /gene="arsC4" /locus_tag="HMPREF0538_22265" /EC_number="1.20.4.-" /EC_number="3.1.3.48" /codon_start=1 /transl_table=11 /product="arsenate reductase" /protein_id="YP_004650782.1" /db_xref="GI:338202330" /db_xref="GeneID:10865969" /translation="MAEGYGKALLKDQYECRSAGVEKHGLNPYAVEAMAEDGIDISQQ KSKLI" misc_feature complement(<6431..6577) /gene="arsC4" /locus_tag="HMPREF0538_22265" /note="Low molecular weight phosphatase family; Region: LMWPc; cl00105" /db_xref="CDD:193660" gene complement(6631..7695) /gene="acr3" /locus_tag="HMPREF0538_22266" /db_xref="GeneID:10865970" CDS complement(6631..7695) /gene="acr3" /locus_tag="HMPREF0538_22266" /note="COG: COG0798" /codon_start=1 /transl_table=11 /product="arsenical-resistance protein" /protein_id="YP_004650783.1" /db_xref="GI:338202331" /db_xref="GeneID:10865970" /translation="MSVYILGGATMKTSRNLSVMDRYMTLWVFLAMVIGILSGFIFPS LPKLINSWSVGTTSIPIAIGLILMLYPPLTKVNYGKMGDVFSDKKELTFSLIQNWVVG PLLMFALAIIFLRNYPSYMIGLIMIGLARCIAMVIVWNELAHGNNDYAAGLVAINSIF QIIFYSIYAYLFISILPKFFGIQTQTVNITMSEIAKTVFIYLGIPFILGISSRYLIIK SKGRGWFEDKYVPKISRITTWALLFTIVVMFSVKGARVVELPLDAVRVAVPLLLYFVL MFFITFWIAKKTGTSYSISATQSFTAASNNFELAVAVTVGIFGLSSGEAFAAVIGPMV EVPVMILLVDVALWIKRKFY" misc_feature complement(6658..7647) /gene="acr3" /locus_tag="HMPREF0538_22266" /note="Membrane transport protein; Region: Mem_trans; cl09117" /db_xref="CDD:189190" gene complement(7722..8033) /gene="arsR3" /locus_tag="HMPREF0538_22267" /db_xref="GeneID:10865971" CDS complement(7722..8033) /gene="arsR3" /locus_tag="HMPREF0538_22267" /note="COG: COG0640" /codon_start=1 /transl_table=11 /product="arsenical resistance operon repressor" /protein_id="YP_004650784.1" /db_xref="GI:338202332" /db_xref="GeneID:10865971" /translation="MDYQKLASLLKVVAEPNRLQILEMLSCGEMCACDILKNFDFTQP TLSHHMKVLEKEELVHVTKKGKWHHYSLNQDTAALLINGLSKTLSNTEDCICKITNKQ C" misc_feature complement(7815..8006) /gene="arsR3" /locus_tag="HMPREF0538_22267" /note="Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090" /db_xref="CDD:28974" misc_feature complement(order(7863..7865,7953..7955,7962..7967, 7974..7979,7986..7988,7995..7997,8001..8006)) /gene="arsR3" /locus_tag="HMPREF0538_22267" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(7824..7832,7845..7853,7869..7874, 7878..7883,7890..7895,7899..7910,7935..7943,7980..7988, 7998..8003)) /gene="arsR3" /locus_tag="HMPREF0538_22267" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28974" misc_feature complement(order(7932..7934,7941..7943)) /gene="arsR3" /locus_tag="HMPREF0538_22267" /note="putative Zn2+ binding site [ion binding]; other site" /db_xref="CDD:28974" gene 8270..8824 /locus_tag="HMPREF0538_22268" /db_xref="GeneID:10865972" CDS 8270..8824 /locus_tag="HMPREF0538_22268" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="YP_004650785.1" /db_xref="GI:338202333" /db_xref="GeneID:10865972" /translation="MMEEKLYTINEIIKDAGIARSTFDKFAEANNLRPVKTEKRGKKL YSLKDKEFVVSHYVSGKGKEEKEKFTNHKAERHDEVVDLLREQVQQLKRANEQLVHDN DILTDQLKVKDNQIAAAHQLTDQAQKLHLGLEKQVKALTGDADKPVVDGESSDINSSN NQQKPTDEPMGTKKATRKSWWHIF" gene complement(8829..9659) /locus_tag="HMPREF0538_22269" /db_xref="GeneID:10865973" CDS complement(8829..9659) /locus_tag="HMPREF0538_22269" /codon_start=1 /transl_table=11 /product="initiator RepB protein" /protein_id="YP_004650786.1" /db_xref="GI:338202334" /db_xref="GeneID:10865973" /translation="MVEMIFLKYDIFFLGGRIMAVVQNKKMDKTISNLLSRQNYLVTQ ANDLARSFGNLTTFEHKVLDYCFSFVKAEDTSDHTYTVQMIDIIRHLGLNSSGKNYQR VGEAFRALNTKTAIYLRTYKNGMNGILMTSLFDYIEIVEDGKIEFQFSKKVAPFVFEL KQNYYSFKLSELATVRSKYTLTLLKLWNANSMGKLQKATIRGSITEWQSWFLGTDDDG KPRKWSAGRFRQRVLGVSLKELGELYPKTIFYLTTEKKGRKVVGYTLDITPVKTTFQI " misc_feature complement(8859..9548) /locus_tag="HMPREF0538_22269" /note="Initiator Replication protein; Region: Rep_3; cl03080" /db_xref="CDD:186548" gene complement(9906..12032) /locus_tag="HMPREF0538_22270" /db_xref="GeneID:10865974" CDS complement(9906..12032) /locus_tag="HMPREF0538_22270" /codon_start=1 /transl_table=11 /product="replication protein" /protein_id="YP_004650787.1" /db_xref="GI:338202335" /db_xref="GeneID:10865974" /translation="MGDDNMSIKCTVTTDLQAKDKNGYSGIQKHVEHDKKINHTNQDI VFSETQFNQYDKSPKTRAAIDQWNNEHFKDYVEEHDKHQREKGHAERQYGSVKNYLKR KKKATAVLTIGNMEVQSKLMQQFCPKTSYQEEKLPDGTTHLVFKLKDQNGQPIPDNIA VAKQFYDCFNRALIKATNNNVGWKLNNNHQQWIHVGDYLHRGRYATNNDEMGISHIHY ELATFGMTRGGKKRAAHVTNSLNQALVSLHHAVTGKYCSGRDATKWFRTNMDQFALKC LEDELHKTYKVPQNKKILDFERKTKEDKTIQTGLSMEQLKAQHQEIADHQKAVQSLQD QADNLTNQKNDVQSQVATVTQNLKGIYEATTGHQAVDKDGNDLSPLEMANDITRAARS SQRDKQQAEKDADAAQEKQTAAENQQKQLEQQLTQQQQQLQTLQNQISDAEEQIKQRK LQRIKAAQKEIDQNDLLDNNDQPITVTEANVTQMEQELDSWRQEERDNWETDKQDYQD ELDNLNQEITTARTTKTELSTTNQQLTTQNQQLQNENTTVQNQINDYKNQLVDTIAEN APEHKVGSSLLNPNETAQPVISDIGRKQHLRQTLKYLMDTAIKVLQKIKIEAINLINE TTKVLITTPNTKPDHLHSAYIDPNTIQASIHPFSHLKEEQLENNPVLKLKKAILIANT EQLQRTNQQLKNNINKQLSQDNDLQR" ORIGIN 1 gaacacattt cctaataact atttatttac tttttgagat tacattcaaa aagtaaatgt 61 tacctttttc attaaaaggt aacgccaaaa taaaaaattc ccaatgcctt ttggcaaagg 121 gaatttttta caatccagct ttaacattta gttaatctgg attgttccca ttgggaaatt 181 cattatcatg taatggattc tttcccaatg gttttgcgtg actttgttcc tgctgctctt 241 gttttatttt agccacaaat gcagtcacaa aatcatgcaa atcttttttc gcaaatggct 301 tttgatcatc accaatttgc gaattaataa tgctgtttaa gcgttgcatt aagtcatcat 361 tattgctggc caaagttagc atagcttcgg ccaattccgc tttccatttt agttcgttta 421 aggctaaaac atcagcgtta tgtttcatct ggagcttctt atactccata tcttcaggaa 481 cagtacgacc actcagtttt ttggctttaa gttcttgcca acgggcaatt gatttagggg 541 acatcatgat aaaaacttct ttctattaag taattagatt aactattatg agaagttaac 601 agtcaatctc ttgcccaaag cgttagcaat tttggttaaa gtatcaatac tggtgttagc 661 gccgctttca attcgtgcaa ttgttgattg aggaacatca gaaacagtag ctagatctcg 721 ttgagaaagg cctgattctt ttctaacctt agttaatgca atggcactct ctaacttagt 781 tgtttcgttt tcaaattcct ttttaaatgc cggatccttt aattgttcat ttaagtagtc 841 tttaaaatta atgttgctca taattattgc tcctttcggt tggcaaagta ttcgtcacgt 901 aatttcttag catgattaat ttctcgtggc ggtgttttct gggttttctt agtaaagcca 961 tgggtaataa cgtagtgaac gccatcaacg tgaaaataaa ggccacgttg ttgattatta 1021 ctaacccgag agcgaatttc atagaggttc ttctccagtg gcttaaccca gttatgttga 1081 attccagcac taagtccata agttgcgacc atgttaatcc gtgctaataa ctttgcttta 1141 gctttaacgt caagactatc taaatattct gcaaattcag tatggccatt agggcgagta 1201 taaaattcaa attctaaatc ttccatgccc taatgatagc atatattgta tcaattatca 1261 atatatgcta tctagaacaa ctaccgtgct tcgcttgctg gactcgttaa tcagaacggt 1321 ttatgactaa acctaacctg attaacgagt gaattttttg gggggggagt gcttaatcga 1381 acttaacttc atcgagcatt tgttctcggc tgacttgatc cagacctaaa tattttaagg 1441 tcatggcttc tgaggaatga ttaagcagcg acatcactaa accgatattg taatgagttt 1501 gtgtgtagac ccggtaagcc ccagtttttc tcattgtgtg agtaccgagg tagttaatcc 1561 caagtaaatc gccagtttta gccatgattt tgtaaaactg tttttcagtg atgtgccgat 1621 cggggtgttt agtcgatgga aaaagccaat ctgagtggag attttgttgg tttagccact 1681 gaaaatagtc ttttaggtct tgtttaactg gttttaggta caaagtattg ggctttccgg 1741 tctttttatc ccgaatataa gcatttttag cgatagtccc atcgttattg aagatttcat 1801 tgcgtctgag agctaataaa tcggacactc ggagtaacgt tgccttgcca acttggaaaa 1861 ttgtgtaatt tcggcggcca gctttaaaat tatgtaggag agtatcttcg acttcatgca 1921 ggatattgga atctttgatg ggtaaaacga gttgtttcat gattaattgc tccttattta 1981 ggggctactt tttgtatata taaattaaaa gcccctatat tctgattgta gaatacaggg 2041 gcttattata tcaatgttct ttaggggcta tttataagaa atagccccta ctttaaaaac 2101 gatgaaaatt aatctttact ttttagtttc ccattcgttg ttatatatgg gaggaataaa 2161 gtgaataata caaaattcaa ttgaaaataa aaaaggacat cttttcagat gtcccgccgg 2221 ctcggtaatc gggagctacc cgattccaat ttgcacaccg actttatcat tttggtcgtg 2281 cctaataaac acgttaaaaa atcaattaaa aaggtgattg ctctgattcg taagatgatg 2341 aaataatatt gctacttttt ctgcgctgac ttcggttggc gctttttatt cagaaacctt 2401 tataacaaat aggcttaaaa cataaaaaga agtattagct ctttgctttc ctgttgtaat 2461 attcgtctgt tcctggttca aaatagtttc tcctctctga tactgatttt atcaatgata 2521 tttcgcaata gccagcaatg aacgcttgca ttgcgcaaga cgttacatta tcttctgaaa 2581 catatagcgc accttgtcca ggcggctgtt tggacggcgg ggctggatga ctggcttgcc 2641 gacagcggcc tgataccctt tcagttctgt aaggcatacg ctctgcccgt tggtgtaaga 2701 ggccagatca gtacggtatg cctgtataca gcgggcggga atctcgccag taaagacaac 2761 ttcatccttt tttacctgga ccgtttcgat ggtggcacag tatttcggtg catcatgata 2821 agccctggaa agatattccc ggggcgcata gagggtgaag gagagataag gttccagcag 2881 ttgcgtccct gattccttca atgcctgttc caatacaatc ggggccaatg agcggaagtc 2941 cgccggcgtg ctgaccggac tgtaataaag cccgtattca aagcaaatct tacagtccgt 3001 tacgttccag ccgaacaagc cctgctccag cccgtaacgg ataccatccc tgacagcgtt 3061 ttgaaaactc tggttcaagt atcccagcga aacccggctc tcgtattgta caccggagcc 3121 aagcgggagt ggtgtaacag acagtccgat ggatgcccaa aacgggttgg gcggcacctc 3181 gatatggatg gtgtggctgg ctgctttgag cggccgctcc atataaatga cggtgggttc 3241 ctttaccact gtttcaagct tgtatttttc cgacagcaaa gcggaaacaa cctccaactg 3301 cacccggccc aaaaaagaaa gaatgatctc atgggtgatg gaatccacct cgcagcgcaa 3361 aagcgggtca gtatccgcaa gttgcgtaag agcgtccagc agccgttctc tttgcgctgc 3421 cgttttcggc gcaatcgacg tccgcagcat ggggaggggg tcctcacgcc accttttacg 3481 agggagccgg gttgggtccc ctaatacatc gtttaacctc acgctgtcgc tgggaaggat 3541 aacaatttca cccggataag cggtgtctgt ccgaacaatt tcccctttgg atggaatacg 3601 catctctgtg attttcagct tttctctccc ggccagggcc accgtatccc gcaggcgcag 3661 cgttccgctg tatagccgta gatagacacg ccgctggccg caatctgtat actccacctt 3721 gaaaacgctg ccgcataggg cggcgctccc ctgttcccca atcggttgga acagccctgt 3781 caccgcatcc atcaacggtt gaatgccaag gccctttttg gcgctgccat aatagaccgg 3841 gaacagggag gcgtcttgaa cccgccgctg ttcctcccgc acaagttttt cccggctgat 3901 tggttctcct gcgatatact tttccaataa tttatcgtta ttttcgatga ccgcatccca 3961 tgcttctatg tcggtatttt cctccaggac tatttccggg gacagcgaca ccgtctgctt 4021 gatgataata tcggcggaga gcttatcccg aacagactga accacgctct gcaaatcaac 4081 gccagcctgg tcgatcttgt tgataaagat aacggtggga atgttcattt tccgcagggc 4141 atggaacaga atacgggtct gggcctgcac gccatcttta gcggagatca ccaagatggc 4201 cccatctaaa acagccaaag agcggtacac ctccgccaaa aaatccatgt ggccgggcgt 4261 atccacaatg ttgactttac atctgtgcca ctggaaggaa gtgactgccg cttgaatggt 4321 aatcccacgc tgccgctcca aaaacatggt gtccgtcctc gttgtccctt ttttgacgct 4381 ccccggttct gaaatggctc cgctggcata tagcaggctc tccgtcaagg tcgtctttcc 4441 agcgtctaca tgggcaagaa ttccaatatt gattattttc atgtgattgt cctcccttta 4501 ctgccccgaa gggcataaaa atccccagca gtaaaatact tttaccactg gggatgataa 4561 tttgcggaca tacacatata cagcatacac ctgtttgtga gtgctgtttt tggggatatg 4621 tcaaaattga taaggcaaaa gtattcttta attgggtaca aaaaactaag cccctacaaa 4681 agggactatc ataatccttt gttcccacta tttgattata gttttattta agaatacctt 4741 gccgcatatt ttttactcct tttctggaat tgaatcatta tatcacatca gttttaggaa 4801 aacaagtata taaaagaaat ttttcttccc cttatatgta acaatcatac cggcttccta 4861 acgttcagaa tggtttctac tgtctgctgc ggtgtttggt tggaattgtc cagccaaaag 4921 ccgatccgtg gtgttgtctg cattttacta aatacaaatt caatgtatac agaaagaaat 4981 atataaggag tgggagggat tccgccgtag tcggcattgt aggaaaatcc aaaagtttag 5041 attttctcaa aatgcttatc ttttggtctt tggttcggaa tagtgtagtg ctggcggtct 5101 atctattgtt ttcggttgct tgcttcttta ccgtacatga gcattgttat aaaaaggtgt 5161 atcaactact tttgtaccat catagctagg tacagtggta gatggtgcaa ttggtgttgt 5221 tgtatcagta gcagatgcta tacctgtttg agtaccagta gcagatgtgg tttgagcgtc 5281 ggctgaagca ctcattccca taaatgtgaa accaatcaaa accgaagcaa ctccaatggt 5341 taatttctta atcgtaaacc gttgtttatt cggttcttgt tgccgaactt gttctttcca 5401 attattcctc gataacataa ttgaccctcc ataatattat ttattctaca ccctcaatat 5461 aatacaactc cttgaatctt tcaaacttat ttttcgtgga aatcgtttct aactgtttcc 5521 aactgataaa caagttggta tatctaagtc ttctaaattt tacaatctac cttatcacta 5581 aatacatcac ccattttttc ataattaacc ttagttaatg gcgggtacag cattaagatt 5641 aagccaattg caatcggaat agacgtagtt cccactgacc aactgttgat caacttaggc 5701 aaggaagggg aaataaatcc acttaaaatc ccaagtgcca tagctaaaaa cacccatagg 5761 gtcatgtaac gatccataaa taataggttt ttcgacgtct tcatattaat ccccttcata 5821 tagataatta tctatgtttg cggtaaaaat aaaaggatta tcttttttaa ttagcatcct 5881 tacacataca attgtcagta ttggacagcg tacgggttaa gccgttaata ataagtgcag 5941 tagtgtctgg atttaatgaa tagtaatgcc attttgactt cttacttacg atgaccaatc 6001 ctttatcctc taatactttc atatgatgag aaagcgttgg ttgggtaaaa tcaaagtgat 6061 caagaatgtt gcaggcacac atttcaccac aggaaagcat ttcaagaatt ttaagtcgat 6121 ttggttcagc aactacctta agtaagttag ctaatttttg ataatccatt tacgttacct 6181 attatgtaat agttgtacat attgccataa ataatgctgt ttaaacaggg gtgattcatt 6241 acaaatagac cctaaattaa tcctttaact aattgtttaa tctcatcacg tacttgtcga 6301 aacactacca ttttctgttc aggagtacct ttagcttgtg cgggatcagg taacggccaa 6361 tgaacgcttt gggcctgaga aggaatcacc gaacagcggt ccctagcatc gccgcataaa 6421 gtcataatta aatcagcttt gatttttgct gactaatatc aatgccgtct tcagccatgg 6481 cctctactgc gtaaggatta agtccgtgtt tttcaacacc agcacttcta cattcatatt 6541 gatccttgag taatgctttg ccatatcctt cagccatttg gctacgacaa gaattaccag 6601 tacataggaa ataaatcttt ttcatagctt ttaatagaat tttctcttaa tccataatgc 6661 cacatcaact aacagaatca tcactggtac ttcgaccatg gggccaataa cggccgcaaa 6721 tgcttctcct gaacttaatc caaagatacc aacggtaacc gccacggcta attcaaagtt 6781 gttacttgca gcagtaaatg attgggttgc ggagattgaa taactagtac cagtcttttt 6841 agcaatccaa aaagtaataa agaacatcaa aacgaaataa agtaataagg gaacagcgac 6901 acgaactgcg tcaagtggta gttcaacgac ccgcgctcct tttactgaga acataactac 6961 tatagtaaat agtaaggccc aggtagtgat gcgactaatc ttcggaacat atttatcttc 7021 aaaccagccc cgacctttac ttttaataat caaataacgg gaactaatgc cgaggataaa 7081 tggaatacca aggtaaataa aaaccgtttt agcaatttca ctcattgtga tattcactgt 7141 ttgggtttga atcccaaaaa acttaggcaa aatactgata aagaggtagg cataaatcga 7201 gtagaaaata atttggaaaa ttgaattaat cgctactagc cctgctgcat agtcattatt 7261 accgtgcgca agttcattcc acacaatgac cattgcaatg catcgtgcca gaccaatcat 7321 aattaagcca atcatgtaac taggataatt tcgcagaaag ataattgcta atgcaaacat 7381 caatagtgga ccgaccaccc agttctgaat taatgaaaac gtaagctcct tcttatcact 7441 gaaaacgtct cccattttcc cataattaac cttagtcaat ggtggatata acattagaat 7501 taaaccgatc gcaattggaa ttgacgtcgt cccaaccgac cagctattga ttagcttagg 7561 taatgaaggg aaaataaagc cacttaaaat tcctattacc attgctaaaa atacccataa 7621 agtcatataa cggtccataa ctgataaatt tcttgatgtt ttcatagtag ctcctcctaa 7681 tatgtaaacg ctcatctatg tataaaacca agagaaaagg attaacattg cttgttagta 7741 attttgcaaa tgcaatcctc agtattagat aaggtcttag acagtccatt aataagtagc 7801 gcagctgtgt cttgatttag agaataatgg tgccacttgc cctttttagt tacgtggact 7861 agctcctctt tttctaatac tttcatatgg tgagaaaggg taggctgagt gaaatcaaaa 7921 tttttgagaa tatcacaagc acacatctct ccacaggaaa gcatttcaag gatttgtaac 7981 cgatttggtt ctgcaacgac ttttaacaaa cttgctagct tttgataatc catttacatt 8041 ccttctcaca tagacattta tctatatgat agattactct aacttagatg taaacctaag 8101 tagtggaatt ctttgcagtt aaagacctga aaggaagata ttaggaaaat aagcatgtaa 8161 taattattat cttcacatcg tatttccgtc atttagagcg gaattagata tgctacaatg 8221 taaataagca agttacactg ttttcgatgg tcggaagaag gtcgtaaata tgatggaaga 8281 aaagttatat accatcaatg aaattattaa agacgcaggt atagcccgct ctacatttga 8341 taaatttgct gaagccaata acttacgtcc agtaaagaca gaaaagcgag ggaagaagtt 8401 atattccttg aaagacaagg aatttgtagt ttctcactat gtaagtggaa aagggaaaga 8461 agaaaaagaa aaattcacta atcacaaagc cgaacggcat gatgaagtcg ttgatttact 8521 tcgcgaacag gttcagcaac ttaagagagc caacgaacaa ctcgtccatg acaatgacat 8581 tctgacagac caactgaaag ttaaagataa ccagattgca gccgcacatc agctaaccga 8641 ccaagcacaa aagttgcatc tcggactaga gaaacaggtc aaagccctca caggagacgc 8701 tgacaagccc gtagtggatg gcgaatcatc tgatataaat tcatcgaata accaacagaa 8761 gcccacagac gagcctatgg gcacgaaaaa agccacccgt aaatcgtggt ggcatatctt 8821 ttagtaagtt aaatttgaaa tgttgttttg acgggagtga tgtcgagtgt atatccgaca 8881 accttccgtc cttttttctc tgtcgtaaga tagaatattg tctttggata aagttctccc 8941 agttctttta agctaacgcc tagaacccgt tgccgaaaac gaccagcgct ccattttcgc 9001 ggctttccgt catcatcagt gcctagaaac cagctttgcc attctgtaat acttcctcta 9061 atagttgcct tttgaagttt gcccattgaa ttagcattcc aaagcttaag caaagtcagc 9121 gtatacttcg agcgcacagt tgccaattct gagagcttaa acgagtaata attctgcttt 9181 agttcaaaaa caaatggggc aacctttttg ctgaactgga attcaatctt cccgtcctca 9241 acaatctcaa tgtaatcaaa gagcgaagtc attaaaattc cattcatacc atttttgtac 9301 gtccggagat aaatggctgt tttagtgttt aatgctcgaa atgcttcacc tactcgctga 9361 taattcttcc cagaactatt cagccccaga tggcgaataa tatcaatcat ctggacagtg 9421 tacgtatggt cactggtatc ttcggctttc acaaagctaa agcaatagtc aagcaccttg 9481 tgttcaaatg ttgttagatt accaaatgac cgcgcgagat cattagcctg tgtaactaaa 9541 taattttggc gactaagtaa gttgctaatg gttttatcca ttttcttgtt ctgaacaaca 9601 gccataattc tgccccccaa aaaaaatata tcatatttta agaatatcat ctctaccata 9661 tttgtgcaat ccatggcatt aatgacgtac taaaatggca ttaatgacgt actaaaatgg 9721 cattaatgac gtactaaaat ggcattaatg acgtactaaa atggtattta ttttcgccga 9781 aaccctttaa tctcaagggt ttcgtacccc tctaatgtat attaaatgta ataataatgt 9841 atttacttaa tgtatgacct tggcaaactg agtaaaaaat aaactcatac taaaaaatta 9901 tagtttcaac gttgtagatc attatcttga ctaagttgct tattaatgtt gtttttaagt 9961 tgctgattag tccgttgtaa ttgttcagtg ttagcaatta atatagcttt ctttagttta 10021 agaacaggat tattttccaa ttgttcctct tttaggtgac tgaatgggtg aattgatgct 10081 tgaattgtat ttgggtctat atatgcactg tgcaaatgat ctggttttgt attaggtgtt 10141 gttattaaaa cttttgttgt ttcattgatt aagttaatag cttcaatctt gattttttgg 10201 agaaccttga ttgcagtatc cataaggtac tttagggttt ggcgtaagtg ttgtttacgt 10261 ccaatgtcag aaataactgg ttgagctgtt tcattggggt ttagtaatga tgatccaacc 10321 ttatgttcag gtgcattctc agcaatggta tcgactaatt ggtttttgta gtcgttaatt 10381 tggttttgta cggttgtatt ctcattctgg agttgctgat tctgggtggt taattgttgg 10441 ttggtagttg ataattcagt tttggtagta cgggcagtag ttatctcttg gtttaggtta 10501 tcaagttcat cttgatagtc ttgtttatct gtttcccaat tatctcgctc ttcttgacgc 10561 caggaatcta attcctgttc catttgggtt acattagctt cggttactgt aattggttga 10621 tcgttgttat cgagtaagtc gttttggtca atttcttttt gggcggcttt gatacgctgg 10681 agcttgcgct gcttaatttg ttcttcagcg tcgctaatct gattttgcag ggtttgtaat 10741 tgctgctgtt gctgggtcag ttgttgttcc aattgcttct gttggttttc agcagctgtt 10801 tgcttttctt gggctgcatc agcgtctttt tcagcttgtt gtttatccct ctgagagctt 10861 ctagcagccc ttgtaatgtc gtttgccatt tctaagggtg aaaggtcgtt accgtcttta 10921 tcgaccgcct gatggcctgt ggtggcttcg tagatgccct ttaggttctg agtgacggtt 10981 gctacttgtg actggacatc attcttttgg ttagttaagt tatcagcttg gtcttgtaat 11041 gactgaactg ctttttggtg gtccgcaatt tcctgatgtt gagcttttaa ctgttccatg 11101 gaaagcccgg tttgtatggt cttatcttcc ttggttttac gttcaaaatc gaggattttt 11161 ttattttgcg gcactttata ggtcttatgt agttcatctt ccaggcattt taaggcgaat 11221 tggtccatgt tagtccgaaa ccatttcgta gcgtcacgtc cggaacagta tttacctgta 11281 acggcgtgat ggagacttac taaggcctga ttgagtgaat tagtcacgtg agcggctcgc 11341 tttttaccgc ctctggtcat gccaaaggta gctagttcat aatgaatgtg agagattccc 11401 atttcatcgt tattggtggc gtagcgtcct cggtgtaaat aatcgccaac gtgaatccat 11461 tgttgatgat tattgtttag cttccagcca acattgttgt tagtagcttt aattagggct 11521 cgattgaaac aatcataaaa ctgcttggca actgcaatat tatctgggat tggttgtccg 11581 ttttggtcct ttaatttgaa aactaggtgc gtagtaccgt ctggcaactt ttcttcctga 11641 taggaagtct tgggacagaa ttgttgcatc aatttgcttt ggacttccat attgccaata 11701 gtcaggacag cggtggcttt ctttttccgt ttaaggtagt ttttaacgct gccatactgc 11761 cgctcagcgt gtcctttttc tcgttggtgc ttatcgtgtt cctcaacata gtctttgaaa 11821 tgttcattgt tccattggtc gattgctgct cgtgttttcg gagatttatc atattgatta 11881 aattgagttt cgctgaacac aatatcttgg ttagtgtgat taatcttttt atcatgttca 11941 acgtgctttt gaatgccaga ataaccgttc ttatccttgg cttgtaagtc agttgttacc 12001 gtgcatttaa tcgacatatt atcatcaccc atatcgtagt tttgctacca tcattgtaac 12061 atattcggta ataagtaaag tggttaactt atccaattta ctagctccct agtcaaaatg 12121 gagtaatcca ttttgtcggt cgctctgctg agggcattag //