LOCUS NC_015429 18513 bp DNA circular BCT 25-APR-2011 DEFINITION Lactobacillus buchneri NRRL B-30929 plasmid pLBUC02, complete sequence. ACCESSION NC_015429 VERSION NC_015429.1 GI:330370681 DBLINK Project: 66205 KEYWORDS . SOURCE Lactobacillus buchneri NRRL B-30929 ORGANISM Lactobacillus buchneri NRRL B-30929 Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus. REFERENCE 1 (bases 1 to 18513) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S., Chertkov,O., Detter,J.C., Han,C., Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Mikhailova,N., Pagani,I., Leathers,T.D., Mills,D., Liu,S. and Woyke,T. CONSRTM US DOE Joint Genome Institute TITLE Complete sequence of plasmid2 of Lactobacillus buchneri NRRL B-30929 JOURNAL Unpublished REFERENCE 2 (bases 1 to 18513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (22-APR-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 18513) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Goodwin,L., Pitluck,S., Chertkov,O., Detter,J.C., Han,C., Tapia,R., Land,M., Hauser,L., Kyrpides,N., Ivanova,N., Mikhailova,N., Pagani,I., Leathers,T.D., Mills,D., Liu,S. and Woyke,T. CONSRTM US DOE Joint Genome Institute TITLE Direct Submission JOURNAL Submitted (12-APR-2011) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP002654. URL -- http://www.jgi.doe.gov JGI Project ID: 4086509 Source DNA and organism available from Siqing Liu (Siqing.Liu@ars.usda.gov) Contacts: Siqing Liu (Siqing.Liu@ars.usda.gov) Tanja Woyke (microbe@cuba.jgi-psf.org) Annotation done by JGI-ORNL and JGI-PGF Finishing done by JGI-LANL The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. it is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). ##MIGS-Data-START## investigation_type :: bacteria_archaea project_name :: Lactobacillus buchneri NRRL B-30929 collection_date :: Missing lat_lon :: Missing depth :: Missing alt_elev :: Missing country :: Missing environment :: Host, Intestinal microflora num_replicons :: 4 ref_biomaterial :: NRRL B-30929 biotic_relationship :: Free living trophic_level :: Missing rel_to_oxygen :: Facultative isol_growth_condt :: Missing sequencing_meth :: WGS assembly :: Newbler v. 2.3 (pre-release) finishing_strategy :: Finished GOLD Stamp ID :: Gi02021 Funding Program :: DOEM 2007 Isolation Site :: Fuel ethanol production facility Cell Shape :: Rod-shaped Motility :: Nonmotile Temperature Range :: Mesophile Gram Staining :: Gram+ Diseases :: None Phenotypes :: Probiotic ##MIGS-Data-END## ##Genome-Assembly-Data-START## Finishing Goal :: Finished Current Finishing Status :: Finished Assembly Method :: Newbler v. 2.3 Genome Coverage :: 30x Sequencing Technology :: Sanger/454/Illumina ##Genome-Assembly-Data-END## COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..18513 /organism="Lactobacillus buchneri NRRL B-30929" /mol_type="genomic DNA" /strain="NRRL B-30929" /db_xref="taxon:511437" /plasmid="pLBUC02" gene complement(270..518) /locus_tag="Lbuc_2425" /db_xref="GeneID:10447610" CDS complement(270..518) /locus_tag="Lbuc_2425" /inference="similar to AA sequence:KEGG:pSF118-20_07" /note="KEGG: lsl:pSF118-20_07 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004399669.1" /db_xref="GI:330370682" /db_xref="GeneID:10447610" /translation="MSLDSFNHKKDEEMRESYETTLKDNKKDAVAFLKNISRKEVERK RSVTFSITESQLKKMDTAARKNGFKNRSEFLASIIDAI" gene complement(532..1338) /locus_tag="Lbuc_2426" /db_xref="GeneID:10447589" CDS complement(532..1338) /locus_tag="Lbuc_2426" /inference="protein motif:PFAM:PF01656" /note="PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: lsl:pSF118-20_08 putative plasmid partition protein" /codon_start=1 /transl_table=11 /product="Cobyrinic acid ac-diamide synthase" /protein_id="YP_004399670.1" /db_xref="GI:330370683" /db_xref="InterPro:IPR002586" /db_xref="GeneID:10447589" /translation="MKIITFTAIKGGVGKTTLTLNYGDWLAKHGKKVLLIDLDHQCNL TTVFEKTRRNNTIAEAFKENDNAQKVKIDSVGPNLDLIAGFIDLDVLGSYLENNSNKE MMLFMWFKNNSDSLSLTDYDYILIDTHPDFSTITKNAIAISNYLLSPITPSEHGYNAK FDLETRLEKFRKSLFDYRTGETYVDAKLFFIGNMIRHNTSMSRDLLKHIEGDETVATI IPERELFNKATARHASIFELANHDESILKQNQKFIEQADHLFQELANKTK" misc_feature complement(541..1338) /locus_tag="Lbuc_2426" /note="ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192" /db_xref="CDD:31385" misc_feature complement(<1216..1332) /locus_tag="Lbuc_2426" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042" /db_xref="CDD:73302" misc_feature complement(1291..1311) /locus_tag="Lbuc_2426" /note="P-loop; other site" /db_xref="CDD:73302" misc_feature complement(1291..1293) /locus_tag="Lbuc_2426" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:73302" misc_feature complement(805..>978) /locus_tag="Lbuc_2426" /note="ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042" /db_xref="CDD:73302" misc_feature complement(958..960) /locus_tag="Lbuc_2426" /note="Magnesium ion binding site [ion binding]; other site" /db_xref="CDD:73302" gene complement(1435..2028) /locus_tag="Lbuc_2427" /db_xref="GeneID:10447590" CDS complement(1435..2028) /locus_tag="Lbuc_2427" /inference="protein motif:PFAM:PF00239" /note="KEGG: lcz:LCAZH_p037 putative resolvase; PFAM: Resolvase, N-terminal; Resolvase, helix-turn-helix domain; SMART: Resolvase, N-terminal" /codon_start=1 /transl_table=11 /product="Resolvase domain protein" /protein_id="YP_004399671.1" /db_xref="GI:330370684" /db_xref="GO:0000150" /db_xref="GO:0003677" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR006120" /db_xref="GeneID:10447590" /translation="MAKIGYARVSSKEQHLDRQLAALKGVDKLFTDKLSGANTNRPEL QKMLAYIREGDIVLVTELDRLGRNNQELTKIMNTIQSKGATLDVLNLPSMTGIADPNL RQLMTNLIIELYKYQAESERKRIIERQQQGISLAKQQGKYHGRKPQYTQDDPRLQHAF KLYQAGMSDVDVARNTGIKRTTFIRYRKKYRIFKNEL" misc_feature complement(1453..2028) /locus_tag="Lbuc_2427" /note="Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961" /db_xref="CDD:32144" misc_feature complement(1633..2022) /locus_tag="Lbuc_2427" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768" /db_xref="CDD:58117" misc_feature complement(order(1828..1830,1837..1842,1999..2001, 2005..2007)) /locus_tag="Lbuc_2427" /note="catalytic residues [active]" /db_xref="CDD:58117" misc_feature complement(1999..2001) /locus_tag="Lbuc_2427" /note="catalytic nucleophile [active]" /db_xref="CDD:58117" misc_feature complement(order(1666..1668,1678..1683,1687..1692, 1843..1845)) /locus_tag="Lbuc_2427" /note="Presynaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(1660..1662,1669..1671,1678..1683, 1690..1695,1702..1704,1807..1812,1825..1827)) /locus_tag="Lbuc_2427" /note="Synaptic Antiparallel dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(1645..1647,1657..1659,1666..1668, 1678..1680,1687..1692,1699..1704,1750..1758)) /locus_tag="Lbuc_2427" /note="Synaptic Flat tetramer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(1645..1647,1657..1659,1666..1668, 1678..1680,1687..1689,1756..1758)) /locus_tag="Lbuc_2427" /note="Synaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(1642..1647,1663..1665)) /locus_tag="Lbuc_2427" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:58117" misc_feature complement(1468..1599) /locus_tag="Lbuc_2427" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569" /db_xref="CDD:119388" misc_feature complement(order(1471..1479,1483..1488,1588..1596)) /locus_tag="Lbuc_2427" /note="DNA-binding interface [nucleotide binding]; DNA binding site" /db_xref="CDD:119388" gene complement(2133..2552) /locus_tag="Lbuc_2428" /pseudo /db_xref="GeneID:10447591" gene complement(2602..3617) /locus_tag="Lbuc_2429" /pseudo /db_xref="GeneID:10447606" gene 3820..4191 /locus_tag="Lbuc_2430" /db_xref="GeneID:10447607" CDS 3820..4191 /locus_tag="Lbuc_2430" /inference="protein motif:PFAM:PF01022" /note="KEGG: bpf:BpOF4_20069 transcriptional regulator, ArsR family protein; PFAM: HTH transcriptional regulator, ArsR; SMART: HTH transcriptional regulator, ArsR" /codon_start=1 /transl_table=11 /product="transcriptional regulator, ArsR family" /protein_id="YP_004399672.1" /db_xref="GI:330370685" /db_xref="GO:0003700" /db_xref="InterPro:IPR001845" /db_xref="GeneID:10447607" /translation="MLSNKDTCEIYCYDEKKVNRIREELQKEDISSVSQLFKALADEN RAKITYALCQDGELCVCDVANIIGSTVATASHHLRTLHKQGIVKYRKEGKLALYSLDN EHIKQLMLITLAHKNEVKANV" misc_feature 3928..4146 /locus_tag="Lbuc_2430" /note="Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090" /db_xref="CDD:28974" misc_feature order(3928..3933,3937..3939,3946..3948,3955..3960, 3967..3972,3982..3984,4072..4074,4129..4134,4138..4146) /locus_tag="Lbuc_2430" /note="dimerization interface [polypeptide binding]; other site" /db_xref="CDD:28974" misc_feature order(3931..3936,3946..3954,3994..4002,4027..4038, 4042..4047,4054..4059,4063..4068,4084..4092,4105..4113) /locus_tag="Lbuc_2430" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28974" misc_feature order(3994..3996,4003..4005,4129..4131) /locus_tag="Lbuc_2430" /note="putative Zn2+ binding site [ion binding]; other site" /db_xref="CDD:28974" gene 4184..6103 /locus_tag="Lbuc_2431" /db_xref="GeneID:10447592" CDS 4184..6103 /locus_tag="Lbuc_2431" /EC_number="3.6.3.3" /inference="protein motif:TFAM:TIGR01525" /note="TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: sag:SAG1257 cation transporter E1-E2 family ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Haloacid dehalogenase-like hydrolase" /codon_start=1 /transl_table=11 /product="heavy metal translocating P-type ATPase" /protein_id="YP_004399673.1" /db_xref="GI:330370686" /db_xref="GO:0005524" /db_xref="GO:0046872" /db_xref="GO:0046873" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006404" /db_xref="InterPro:IPR006416" /db_xref="InterPro:IPR008250" /db_xref="GeneID:10447592" /translation="MSDQQAKLSEKVEREPFWKQKENIKVYISALLLVISWFLGEQLG EEHLLPMIGYAASILIGGYTLFIKGLKNLSRLKFDMNTLMTIAIIGAAIIGKWGEGAT VVILFAISEALERYSTDKARQSIGSLMDIAPKEALIRRGNEEMMIHVEDIQVGDIMIV KPGQKLAMDGLVIKGTSTLNQAAITGESVPVTKTIDDEVFAGTLNEEGLLEVKVTKRD EDTTISKIIHLVEEAQAERSPSQAFVDKFAKYYTPAIVLLALLIAVVPPLFGGDWSQW LYQGLAVLVVGCPCALVVSTPVAVVTAIGNAAKNGVLIKGGIHLEEAGHLKAIAFDKT GTLTKGIPAITDIVTYGGNENELLTVTAAIEKGSQHPLASAIVRKAEENGLNLNGVSV EEFQSITGKGVKAKVNNEMYYVGSPNLFEELHQTIESTIKERITRMQTEGKTVMVLGT EKEILSLIAVADEMRETSKEVISKLNHIGIETVMLTGDNQRTAEAIGKQVGVSDIKAD LLPEDKLNFIKELLGKHQSVGMVGDGVNDAPALAASSVGVAMGGAGTDTALETADIAL MADDLSKLPYTIKLSRKALAIIKQNITFSLAVKLVALLLVMPGWLTLWIAIFADMGAT LLVTLNSLRLLKVKG" misc_feature 4196..6055 /locus_tag="Lbuc_2431" /note="Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217" /db_xref="CDD:32399" misc_feature 4490..5149 /locus_tag="Lbuc_2431" /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122" /db_xref="CDD:189402" misc_feature 5558..5806 /locus_tag="Lbuc_2431" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391" /db_xref="CDD:197437" gene complement(6113..6409) /locus_tag="Lbuc_2432" /pseudo /db_xref="GeneID:10447593" gene 6445..7086 /locus_tag="Lbuc_2433" /db_xref="GeneID:10447608" CDS 6445..7086 /locus_tag="Lbuc_2433" /inference="protein motif:PFAM:PF00665" /note="KEGG: lca:LSEI_0347 transposase; manually curated; PFAM: Integrase, catalytic core" /codon_start=1 /transl_table=11 /product="Integrase catalytic region" /protein_id="YP_004399674.1" /db_xref="GI:330370687" /db_xref="GO:0003677" /db_xref="InterPro:IPR001584" /db_xref="GeneID:10447608" /translation="MILVPNFSIGAISYRDLVEMMRDRGIFVHHTTLMRWVQHYSPIM RALWRKRHRRTSKSWRMDETYIKIKGQWNYLYRAIDDQGLTLDFQLRKKRDFNSAYHF LKRLLKTYGLPHRLVTDQYGATLKAIKKLTREGCLHKGVHQCSKYRNNLIEQDHRFIK RHRVRSASFQSIRTASATLSGVEIVHAIRKRTRRELSLIGFSVVDELEALLAA" misc_feature 6475..7062 /locus_tag="Lbuc_2433" /note="Integrase core domain; Region: rve; cl01316" /db_xref="CDD:194099" gene complement(7152..8978) /locus_tag="Lbuc_2434" /db_xref="GeneID:10447594" CDS complement(7152..8978) /locus_tag="Lbuc_2434" /EC_number="3.6.3.5" /inference="protein motif:TFAM:TIGR01525" /note="TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; KEGG: lca:LSEI_2799 cation transport ATPase; PFAM: ATPase, P-type, ATPase-associated domain; Haloacid dehalogenase-like hydrolase" /codon_start=1 /transl_table=11 /product="heavy metal translocating P-type ATPase" /protein_id="YP_004399675.1" /db_xref="GI:330370688" /db_xref="GO:0005524" /db_xref="GO:0046872" /db_xref="GO:0046873" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR005834" /db_xref="InterPro:IPR006404" /db_xref="InterPro:IPR006416" /db_xref="InterPro:IPR008250" /db_xref="GeneID:10447594" /translation="MKKNWQLMMVLAVSAIALVFAFVLKQPLIAQGLITVMGSIIALI MFWGMVKKIRSGNFGVDLLAITAVVATLAVGQYWAAMIVLLMLTGGDALESYAATKAS SELKQLLENAPTTAHRMVDGHVEDVDVEAVQVGETILVKPQEVVPVDGTVLAGESLVD EASLTGESKPVAKNAGSDIMSGTVNGDAALTVKVTQRAEDSQYQGIIKLVKESEARPA HFVRMADRYAVPFTLIAYVIAGLGWFFSGDPVRFAQVLVVASPCPLILAAPIAMVSGM SRNSRNGIIVKSGTTLEKLSEAKTFAFDKTGTVTRGILKVATILPQAGFSQDQLLKLA ASAEGQSTHILARSLADAVPTADRLPATDVSETTSFGVNATVDGRKVKVGKAEFAGTK ATVDTTAVYVNVDGQYAGAITFSDQIRPEAKETMTKLHELNDAKLIMISGDQQSIADK VAAQVGIDQVYAEQLPQQKIEVLDNVPKDGRPVVMVGDGVNDAPSLAIADVGIAMGAH GATAASESADAVVLRDDLAKVAAATLIAKETMAIAKQAVLIGIAICTGLMLIASFGVI PTIIGAMLQEVVDTVTILYALRARNGLHRQALVYPVRENKRA" sig_peptide complement(8913..8978) /locus_tag="Lbuc_2434" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probability 0.899) with cleavage site probability 0.528 at residue 22" misc_feature complement(7206..8756) /locus_tag="Lbuc_2434" /note="heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512" /db_xref="CDD:188149" misc_feature complement(8097..8735) /locus_tag="Lbuc_2434" /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122" /db_xref="CDD:189402" misc_feature complement(7407..7763) /locus_tag="Lbuc_2434" /note="Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391" /db_xref="CDD:197437" gene complement(9046..9966) /locus_tag="Lbuc_2435" /db_xref="GeneID:10447595" CDS complement(9046..9966) /locus_tag="Lbuc_2435" /inference="protein motif:PFAM:PF00665" /note="PFAM: Integrase, catalytic core; KEGG: lcr:LCRIS_00542 transposase" /codon_start=1 /transl_table=11 /product="Integrase catalytic region" /protein_id="YP_004399676.1" /db_xref="GI:330370689" /db_xref="GO:0003677" /db_xref="InterPro:IPR001584" /db_xref="GeneID:10447595" /translation="MGTSTLSRFQRGALAQLVNEGNKSYQVMADALGVAKATISYELD RVKPYDPELAQQDADRKRRNCGRRSMLTAALATLITNHLRLTWSPETIAAAYNLSTAS IYNWLNRGWLPFKLTDLPNRNVRQHRVSENRGKFTSGTSIEQRPTTVNQRLAFGHWEV DTVLSSRSESRSCLVTFVERKTRLLWAIKAPNRTAKALNTAFGKFMGAFGPQVKSITV DHGKEFANYQALEQDYQIKVYFCHPYSPWERGSNEYFNRRLRWFFPKKTNFSQVTTDE ILAALELINQRPLKIHHQQTAIERFRACSD" misc_feature complement(9064..9966) /locus_tag="Lbuc_2435" /note="Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826" /db_xref="CDD:32654" misc_feature complement(9187..9504) /locus_tag="Lbuc_2435" /note="Integrase core domain; Region: rve; cl01316" /db_xref="CDD:194099" gene complement(10186..11001) /locus_tag="Lbuc_2436" /db_xref="GeneID:10447596" CDS complement(10186..11001) /locus_tag="Lbuc_2436" /inference="protein motif:PFAM:PF00665" /note="PFAM: Integrase, catalytic core; KEGG: lca:LSEI_0773 transposase" /codon_start=1 /transl_table=11 /product="Integrase catalytic region" /protein_id="YP_004399677.1" /db_xref="GI:330370690" /db_xref="GO:0003677" /db_xref="InterPro:IPR001584" /db_xref="GeneID:10447596" /translation="MLDVSTSGYYAWRRALPKRNAKERQYRQRIKHFFDQGQGTYGPK RICGLLRKNGNKASYHRVARLMADGGLYSTLRCRHPKSLTDSRLARQGDYPNLVKHQS FKPFEALSSDITQTTTSEGKAYICQIRDLTSNLVLAHQISNHMDTDLVLATLKQAHQR WALPETCIFHSDRGSQYTAKAVTKLVNQYHWQRSFSALGIPGDNAWSESFFAIMKKEL IYQIQFKDINDLRAQVFAYIETFYNRVRVQARLDYLAPVAWLSLYDQASQKVA" misc_feature complement(10234..10998) /locus_tag="Lbuc_2436" /note="putative transposase OrfB; Reviewed; Region: PHA02517" /db_xref="CDD:177368" misc_feature complement(10348..10701) /locus_tag="Lbuc_2436" /note="Integrase core domain; Region: rve; cl01316" /db_xref="CDD:194099" gene complement(11067..11348) /locus_tag="Lbuc_2437" /db_xref="GeneID:10447597" CDS complement(11067..11348) /locus_tag="Lbuc_2437" /inference="protein motif:PFAM:PF01527" /note="PFAM: Transposase IS3/IS911family; KEGG: lcb:LCABL_21370 transposase IS3/IS911 family protein" /codon_start=1 /transl_table=11 /product="transposase IS3/IS911 family protein" /protein_id="YP_004399678.1" /db_xref="GI:330370691" /db_xref="GO:0003677" /db_xref="GO:0004803" /db_xref="InterPro:IPR002514" /db_xref="GeneID:10447597" /translation="MTYSRNRYDQDFKKNAVRLSFNSSKPVKIIASELGVPESALYRW RKLYTEDGKQTPFASLEAENRSLKRENAELALERDMLKKAAAYFASLQK" misc_feature complement(11130..11336) /locus_tag="Lbuc_2437" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116" /db_xref="CDD:186341" gene 11429..11923 /locus_tag="Lbuc_2438" /pseudo /db_xref="GeneID:10447598" gene complement(11966..12556) /locus_tag="Lbuc_2439" /db_xref="GeneID:10447609" CDS complement(11966..12556) /locus_tag="Lbuc_2439" /EC_number="5.99.1.2" /inference="protein motif:PRIAM:5.99.1.2" /note="PFAM: Toprim domain; KEGG: lcz:LCAZH_p024 protein TrsI, topoisomerase 1A-like protein; SMART: Toprim domain; DNA topoisomerase, type IA, domain 2" /codon_start=1 /transl_table=11 /product="DNA topoisomerase" /protein_id="YP_004399679.1" /db_xref="GI:330370692" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR006171" /db_xref="GeneID:10447609" /translation="MTTVILAEKPSQARSYVQAFQKSTKKQGYYTVSDPVLPENTLVT YGLGHLVELATPDKYDQKYQQWALSNLPIFPDKYKFVVSASKKDQFKVVKDLLKKADT IIVATDSGREGSNIAWSIMIQAQIDVKKKTIKRLWLNSLEKDAIITGFKNLGDWHKDY LAYKEAQTRQISDWLIGMNGSPLYTLLLRQKVLVQS" misc_feature complement(12098..12553) /locus_tag="Lbuc_2439" /note="TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362" /db_xref="CDD:173782" misc_feature complement(order(12221..12223,12227..12229,12233..12235, 12521..12523,12530..12535)) /locus_tag="Lbuc_2439" /note="active site" /db_xref="CDD:173782" misc_feature complement(order(12191..12196,12200..12205,12224..12226, 12230..12232,12512..12514)) /locus_tag="Lbuc_2439" /note="putative interdomain interaction site [polypeptide binding]; other site" /db_xref="CDD:173782" misc_feature complement(order(12227..12229,12233..12235)) /locus_tag="Lbuc_2439" /note="putative metal-binding site [ion binding]; other site" /db_xref="CDD:173782" misc_feature complement(12224..12226) /locus_tag="Lbuc_2439" /note="putative nucleotide binding site [chemical binding]; other site" /db_xref="CDD:173782" misc_feature complement(<11969..12160) /locus_tag="Lbuc_2439" /note="DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986" /db_xref="CDD:143769" gene complement(12653..14713) /locus_tag="Lbuc_2440" /db_xref="GeneID:10447599" CDS complement(12653..14713) /locus_tag="Lbuc_2440" /inference="protein motif:PFAM:PF03389" /note="PFAM: MobA/MobL protein; KEGG: lps:LPST_P0018 nickase" /codon_start=1 /transl_table=11 /product="MobA/MobL protein" /protein_id="YP_004399680.1" /db_xref="GI:330370693" /db_xref="InterPro:IPR005053" /db_xref="GeneID:10447599" /translation="MAIFHMSFSNISAGKGRSAIASAAYRSGEKLFDDKEGRHYFYAR SVMPESFILTPKNAPEWASDREQLWNEVEKKDRKSNSRYAKEFNVALPVELSESEQKE LLTKYVQENFVDEGMVADVAIHRDHPDNPHAHVMLTNRPFNPDGTWGQKTKTEYILDS HGNKTKTPAGNVRNRKIWLVDWDKKEKITEWRHNWAVSVNQVLEQKNIPDRISEKSFE NQGIDEVPTQHEGINSKRHERKEFNQQVKDYRKAKASYKNNQEKAINRGHLDSLSKHF SFNEKRVVKELSHELKTYISLENLDDKRRMLFNWKNSTLIKHAVGEDVTKQLLTINQQ ESSLKKADELLNKVVDRTTKKLYPELNFEQTTQAERRELIKETNSEQTVFKGSELNER LMNIRDDLLTQQLLTFTKRPYVGWKLLMQQEKEVKIELKYTLMIHDDNLESLEHVDQG LLEKYSPIEQQKITRAVKDLRTIMAVKQVIQTQYQEVLRRAFPKGDLDGLPLTKQEQA YTAVMYYDPTLKPLKVETMEQWQSNPPQVFSTQEHQLGLAYLSGQLSLDQLENHHLQR VLKHDGTKQLFFGECKVDPTIKNSQIEKIQKQLKEQQAKDDQYRKANIGHYQPLNYKP VSPSYYLKTAFSDAIMTVLYARDEDYQRQKQERGLKETEWEMTKKQRQHQTRNRHEDG GMHL" misc_feature complement(13994..14665) /locus_tag="Lbuc_2440" /note="MobA/MobL family; Region: MobA_MobL; pfam03389" /db_xref="CDD:112214" gene 14983..15192 /locus_tag="Lbuc_2441" /db_xref="GeneID:10447600" CDS 14983..15192 /locus_tag="Lbuc_2441" /inference="similar to AA sequence:KEGG:LPST_P0019" /note="KEGG: lps:LPST_P0019 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004399681.1" /db_xref="GI:330370694" /db_xref="GeneID:10447600" /translation="MSQSNLEKQEAKLKQLNQKIKAEKNKIEQRLGKQIISQANLDYA NLSNDQIKLLAKQFSEFLKVKSVDH" gene 15215..15493 /locus_tag="Lbuc_2442" /db_xref="GeneID:10447601" CDS 15215..15493 /locus_tag="Lbuc_2442" /inference="similar to AA sequence:KEGG:LPST_P0020" /note="KEGG: lps:LPST_P0020 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004399682.1" /db_xref="GI:330370695" /db_xref="GeneID:10447601" /translation="MSNQYEKLVEQQARLKQKIEREDFKLRQSKYYENRQSRKARSRR LIQKGALLEKYFQANNLSVEQTEELLKTFADYVNAHKPDKLKNDQPNN" misc_feature 15230..15427 /locus_tag="Lbuc_2442" /note="Protein of unknown function (DUF3847); Region: DUF3847; pfam12958" /db_xref="CDD:193431" gene complement(15483..16163) /locus_tag="Lbuc_2443" /db_xref="GeneID:10447602" CDS complement(15483..16163) /locus_tag="Lbuc_2443" /inference="similar to AA sequence:KEGG:LCAZH_p004" /note="KEGG: lcz:LCAZH_p004 putative ATPase" /codon_start=1 /transl_table=11 /product="putative ATPase" /protein_id="YP_004399683.1" /db_xref="GI:330370696" /db_xref="GeneID:10447602" /translation="MIDKPQYIIVAGINGAGKSTLYDTFPVLFDKTKRINADELLRQM GGDWHKDSDNLKAMKEEIKQLHYALDHQQSIHVETTLAGRGKAQLNLIDKAHKNGFEV TLLYVALRDENLAIQRVNERVQKGGHGVPVATIKKRYQQSKHNLPLVAFKSDKVMIYD NSEKFTSVYAREKGQVFKNDLRHFPWINQNITYPEKVQKQLQNFADQNPEVKPKNDPE NKNDRPSY" misc_feature complement(15636..16151) /locus_tag="Lbuc_2443" /note="P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099" /db_xref="CDD:158411" gene complement(16160..16351) /locus_tag="Lbuc_2444" /db_xref="GeneID:10447603" CDS complement(16160..16351) /locus_tag="Lbuc_2444" /inference="similar to AA sequence:KEGG:LCAZH_p003" /note="KEGG: lcz:LCAZH_p003 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004399684.1" /db_xref="GI:330370697" /db_xref="GeneID:10447603" /translation="MNMKDTITINDFFEIAKETDLKDLLDKSLHEPDPEKRKVYDALY TYFLDKRQDEVIKRKDFVR" gene complement(16392..16673) /locus_tag="Lbuc_2445" /db_xref="GeneID:10447604" CDS complement(16392..16673) /locus_tag="Lbuc_2445" /inference="protein motif:TFAM:TIGR02384" /note="KEGG: lcz:LCAZH_p002 addiction module antitoxin, RelB; TIGRFAM: RelB antitoxin; PFAM: RelB antitoxin" /codon_start=1 /transl_table=11 /product="addiction module antitoxin, RelB/DinJ family" /protein_id="YP_004399685.1" /db_xref="GI:330370698" /db_xref="InterPro:IPR007337" /db_xref="GeneID:10447604" /translation="MAVKEKKRVQVQIDKELADNTEAVLSQLGLNPTTAINMFYKRIV ADAALPFKPALSEAERANLSLLKATKETPVTEFKDAKEVADWLNDPDED" misc_feature complement(16407..16649) /locus_tag="Lbuc_2445" /note="RelB antitoxin; Region: RelB; cl01171" /db_xref="CDD:186367" gene complement(17076..18176) /locus_tag="Lbuc_2446" /db_xref="GeneID:10447605" CDS complement(17076..18176) /locus_tag="Lbuc_2446" /inference="protein motif:PFAM:PF06970" /note="PFAM: Replication initiator A, N-terminal; KEGG: lsl:pSF118-20_06 putative replication initiation protein" /codon_start=1 /transl_table=11 /product="replication initiator A domain protein" /protein_id="YP_004399686.1" /db_xref="GI:330370699" /db_xref="InterPro:IPR010724" /db_xref="GeneID:10447605" /translation="MDQSNFNFTNAKRAYEVKFYALPQILLQGEKYKDLSDSAILLYS VLRDRLSYSLSNNWVDENNNVYFIYTNNELKDLRNWSNNKINKIKHELMDANLLYQKH MGFNPRSGKNEPNRLYLADLEVTAKDVYIKREPLKSPEPLGTSGLLKKRNPHDTVEPL GTSGLLKKRNPHDTVSDTSESLGTSGLLKKRQDLDYTNNLDTNRYNIDTQKLDFSTAN FSSAELETQNRDLVTHANDFLTDEDSGLPVFLEPEAVQLLSFWCRTPQQMRRFIGIIL NAKYRVEKDHKDIGVLIPLDDEELKPLMTKALRRYFNALRSNEKHIKNVESYLYGTMQ NLFGVWWNKQAAREYAAKHPEEQNTDNERSWN" misc_feature complement(17901..18125) /locus_tag="Lbuc_2446" /note="Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970" /db_xref="CDD:148536" ORIGIN 1 cttggcggtc taaatcgtct gaatctaagt agctcgctat tagctacttg ctaaacctaa 61 aatccccgat tcctcgtgaa tcggggattt ttctgtttag cttgatctat ttattcggtt 121 gttaaattaa tcttagtcta gcatagcgct tacctacagg caaccgtatt tggtttagtg 181 cactttacta gtttttacct aatcacaaat taatcaagcg aacaaattgc gtatttactt 241 gtttgattaa ttatttattt atttaactgc taaattgcat ctatgattga agctaagaat 301 tctgaacgat ttttaaatcc gttttttcgg gcagccgtat ccattttttt aagttgactt 361 tcagtaattg agaaggtcac agatcgctta cgctctactt cctttcggct gatatttttc 421 aaaaatgcga ctgcatcttt cttgttgtct ttcaatgtag tttcgtaact ttctctcatt 481 tcttcgtctt ttttatggtt gaatgaatct aaactcataa tctaactctc cttacttggt 541 tttatttgct aattcttgaa aaagatgatc ggcttgttct atgaactttt gattttgctt 601 taaaatggat tcatcatgat tggctaattc aaatattgaa gcgtgccttg cagtagcttt 661 attaaagagc tctctttcag gaattatagt tgcgactgtt tcatcgcctt ctatgtgttt 721 tagcaaatcg cgagacatgc ttgtattatg tctaatcata ttaccgataa agaaaagctt 781 tgcgtcaacg taagtttcgc cagttcgata gtcaaaaagt gattttctga atttttcgag 841 tcgtgtttct aggtcaaact tggcattgta gccatgttca ctgggtgtaa tgggactaag 901 caggtaatta ctgatagcaa tagcgttttt agtgatggtg ctaaaatctg ggtgcgtatc 961 aattaagata tagtcatagt cggttaagct taatgaatcg gagttgtttt taaaccacat 1021 gaacaacatc atttctttgt tactgttatt ttctagataa cttcctaaaa catctaggtc 1081 tataaaaccg gctattaaat ctagattcgg tccgacactg tcaattttta ctttttgagc 1141 attgtcattt tctttaaacg cttcagcgat ggtattgttt cgtcgtgttt tttcaaaaac 1201 ggttgttaaa ttgcactgat ggtctaaatc tattaataga accttcttac catgtttggc 1261 taaccaatca ccataattta aagtcaaggt tgttttacca acaccaccct tgatagcagt 1321 aaaagtaata atcttcatct tgatacctcc ttcatctagc ttaattatat cattagtaga 1381 caaataaata aacaaacaat ttattaaata attaagctga caattaactc aattttaaag 1441 ctcattttta aagattctat attttttgcg atatctgata aaggtcgtcc gtttaatccc 1501 tgtattacgg gcaacatcta catcactcat gcctgcctga taaagtttaa aagcatgttg 1561 caagcgggga tcgtcttggg tgtattgggg tttgcgtcca tgatatttgc cctgctgctt 1621 ggccagagaa atcccttgtt gttgacgctc aataatccgc ttacgctcac tttcagcctg 1681 gtacttatac agttcaataa tgagattggt catgagttga cgtaaattgg ggtcagcaat 1741 ccccgtcatg gacggtaaat tcaacacatc taaggtggca cccttacttt gaatggtgtt 1801 catgatctta gttaattcct ggttgtttct gcctaagcga tctaattcag tgaccaggac 1861 aatatctccc tcacgaatat aggccagcat tttttgcagt tctggccgat tagtgttagc 1921 tccacttaat ttatccgtaa ataatttatc aacgcctttt aaggccgcta gctgtcgatc 1981 taaatgttgc tctttggaac tcacacgcgc ataaccaatt ttagccattg tcagcacttc 2041 cttttggaca gttctaatga acatttgtaa cccctagcat agcacagaaa cgagaaagtc 2101 caatagggta taccctagtg gccgtaaagc gctcagtgag aattattaat tgaatttatt 2161 gtttcactgt atttaacacc taatgcttct tcatctggaa ataaggtttc tcgtgaatat 2221 cctagatgcc ttaattcttt ttggatcaaa tctttatagg tagctggaac aattattttt 2281 tgaggttcgt attgctgagt tatcatattt tgaattgtag aaatagaagt tgtttcaaga 2341 aagggctgaa acataaaata accatgttgt gctttaattc ggggattgat ttgggaagca 2401 gttacaaaaa agcactctgt aaataatttt gtaaagtcaa ttggctttac ataagctttg 2461 caactatctg ctttcaaaat ctctaataat cggcaaactt gtggactatt atttaactgc 2521 atatatttcg gataaattag ttcctcaatt tttaagtcaa gtgcaacgat gataacgaat 2581 tcttgatagt ggtctaggct gttacgccat gcatcggtag taatcgcatg ggcgaagata 2641 gttcagaata cgtctgggac gatggttcag tgcggattgg actgcttgaa tttcaaccag 2701 ggtaactgct ctgagagact tccctttcgg gaagaattcc ctaagcagtc cattggcgtt 2761 ctcgtttgtg ccacgctccc aaggcgagta cggatgtgcg aagtaaatct gggttccaac 2821 aatctctgat aacttggcaa actcggaacc attgtcaaaa gtgatactct caaattcctt 2881 ggctccgtag tcgtcgatcg tgtcctgcaa ggctttaagg caggtgcccg catgatagtc 2941 aggaatcttg acgatgatct cagtctggct gtaccgttct gtgagcgtca ttaatgctgg 3001 ctcatcagct aagcgaatac ctttgaccaa gtcgcctttc caatgtccca cgcctgtgcg 3061 gtcattcacg gccgcaggac gcaactcgat tgagtcgccg tattcttctt attcttgcgc 3121 ttgtgggcgt tcttatagcc tttgatgcgg cgtcggagct tcttgggaag tgtcatgttg 3181 tctagctcaa gcagcccggc gtcgatgtag cgatacacag ttgtcgttga agggcaagcc 3241 ttgccctggt cgcgatagaa gtgtacgaag ctatcaacgc tgtgtacgcg cggcttacga 3301 gtaagcttcc tggcgagagc cttgaagaac gcacggccgg tcttaagaaa ggcgtagtga 3361 ccggttctat cgcgtttacg gtcgtgcatg gcttgggcag tttccgcaag atagacttga 3421 tgcgagtgac gcttcgagtc gagctgagtt acagatccac gcgtgatttc tcgtgagatt 3481 gtcgctttac tgcgatgaag cttctgtgca atcacggtcg cggtgtcgcc agcagcctga 3541 agggcctgaa ttgtagcacg gtcgctaaaa ctgagttgtt ggtaatgctt gtgggtatta 3601 gtctgagagt gggtcatgaa gattcctgct ttcttgttta gctagcacta acaagaatag 3661 gtcttcatgg cctttatggt ctagtcgtca gggtgttgca cttgaattgt aaactggaga 3721 aacgattatt tctacaaaac attcaaataa gtatttcaat gttttggaaa aaggggtata 3781 atatattcaa atgaatattt gaatgataat ggagtgatga tgttgagtaa taaagatact 3841 tgtgaaattt attgttatga cgaaaaaaaa gtcaatcgaa tacgagaaga gttacaaaaa 3901 gaagatatat ctagtgtttc ccaattattt aaagcacttg cagatgaaaa tagggcaaaa 3961 attacctatg ccttatgcca agatggggag ttatgcgtgt gtgacgttgc gaatatcatt 4021 ggttccactg ttgcaacagc gtcccatcac ttacgaaccc ttcacaaaca agggattgtg 4081 aagtatcgaa aagaaggaaa attggcgctt tattcactag ataatgaaca tatcaaacag 4141 ttaatgctta ttactttagc tcataaaaat gaggtgaaag ccaatgtctg atcaacaagc 4201 aaaattatct gaaaaggtag agcgtgaacc tttctggaag caaaaagaaa acattaaggt 4261 ctatatttca gcgttattac ttgtgattag ttggtttttg ggcgagcaat taggagaaga 4321 acatcttctt ccaatgatcg gctacgcagc atccatttta attggtggat atacactgtt 4381 tattaaaggt cttaaaaatc taagcagatt aaaattcgat atgaatacgc tcatgacgat 4441 tgctattata ggtgctgcga tcattggtaa atggggtgaa ggcgcaacag ttgttatcct 4501 attcgctatc agtgaagcgt tagaacgtta ttcaacggat aaagctcgtc aatctattgg 4561 atcattaatg gatattgccc caaaagaagc attaattcgg cgtggaaatg aagaaatgat 4621 gattcacgtt gaagatattc aagttggaga cattatgatt gtaaaacctg gtcaaaaatt 4681 agcaatggat ggattagtta ttaaaggtac atctacacta aatcaggctg ctattactgg 4741 ggaaagtgtt ccagtaacaa aaacaattga tgatgaagtg tttgcaggaa cattgaatga 4801 agaagggtta cttgaagtta aagtaacaaa acgagatgaa gatactacta tttcaaaaat 4861 tattcatctt gtagaagaag ctcaagcaga acgatcacct tctcaagcat ttgtcgataa 4921 atttgcgaaa tactatacac cagctattgt gcttttagct cttttaattg cagttgttcc 4981 tccattattc ggtggagatt ggagccaatg gctttatcaa ggtttagctg tgttagtagt 5041 tggttgtccg tgtgctttag ttgtttcaac tccagttgcc gtagttactg caatagggaa 5101 tgcggcaaaa aatggtgtgt taattaaagg tggtatccat ttagaagaag caggacactt 5161 aaaagccatt gcttttgata aaacaggaac attaacaaaa ggtattcctg ctataacaga 5221 catcgtgacg tatggtggaa atgaaaatga attgcttaca gttacagcag ccattgaaaa 5281 aggatcacaa catccacttg cttcagccat tgtaagaaaa gcagaagaaa atggattgaa 5341 tttaaatggt gtttcggttg aagagttcca atctattaca ggtaaaggtg taaaagcaaa 5401 agtaaataac gaaatgtatt atgtaggaag tccaaatctg tttgaagaat tacatcaaac 5461 aattgaaagt accatcaaag aaagaattac tcgtatgcaa acagaaggaa aaaccgtaat 5521 ggttttagga acggaaaaag aaattctttc gttaattgcc gtagcagatg aaatgagaga 5581 aacatcaaaa gaagttatta gtaaattgaa tcatatcgga attgaaacag taatgctgac 5641 tggtgataat caaagaaccg cagaagcaat tggaaaacaa gtcggtgttt cggatattaa 5701 agctgattta ttaccagagg ataagctgaa tttcattaaa gaacttcttg gaaaacatca 5761 aagtgtagga atggttggag atggtgttaa tgatgcacca gcacttgcag cttcttcagt 5821 tggtgtcgca atgggtggtg ctggaacgga tactgcatta gaaacggctg atattgcttt 5881 aatggctgat gatttaagca aattgccata tactatcaaa ttaagccgta aggctttagc 5941 aattatcaaa caaaacatta ccttctcttt agccgttaaa ttagtagcat tactattagt 6001 tatgcctggt tggttaactt tatggatagc aatttttgcc gatatgggag caacgttact 6061 tgttacacta aacagtttac gactattgaa ggttaaaggg tagattgcaa atttaatccg 6121 aatttttgga caaatttgtc agcataacct gatacggtgt ttgccagtcg agtattttaa 6181 gcggtcgctg gttaatttgg agtaacgtcg tcgttaaatc ttgagcacta atgtgctcaa 6241 aacgagtccc tttaggataa aaataacgta aattccgatt aaagcgttca ttactaccac 6301 gttcagctgg cgtataagca tggcagtaat aggtcttaac accatattgt gattcaagtg 6361 atactagccc actaaactca gtgccacggt ccacagtaaa gttgtgcacc gtgctcctat 6421 actgaaattt ggtaccaaaa tctaatgatt ttggtaccaa atttcagtat aggagcaatc 6481 agttatcgag atctagttga aatgatgcgc gaccgtggta ttttcgtgca tcacacaacc 6541 ctcatgcgtt gggtacaaca ttactcaccg attatgcggg ctctatggcg taagcgccat 6601 cggcgcactt ccaaaagttg gcgtatggat gagacctata tcaagatcaa aggtcaatgg 6661 aattacctct accgtgccat tgatgatcaa ggtcttacgc ttgattttca actgcgcaag 6721 aagcgtgact ttaactcggc ctatcatttt ctcaaacgcc ttttaaagac ctatggtctt 6781 ccacatcgat tagtgactga tcagtacgga gcgaccctaa aggcaattaa aaagcttact 6841 agggaaggct gtctgcacaa aggtgtgcat cagtgctcca aatatcgcaa taatttgatt 6901 gaacaggacc accgattcat taaacgtcat cgtgtccgct cagcaagctt tcaaagcatt 6961 cgaaccgcta gtgcaacgtt gagcggtgtg gaaattgttc acgcaatacg caaaagaacc 7021 cgacgagagt taagtctcat cgggttctca gtcgtggacg aattagaagc attgttagct 7081 gcataacctt caacatagga tcaatagctg gttagatggt catctctcag actgtttgca 7141 ccagatcctg attatgctct tttattttct cgaacaggat acacaagtgc ctgccgatgc 7201 aaaccatttc gcgctcgcag agcatagaga attgtcacgg tatcgacaac ttcttgcagc 7261 attgcgccaa taattgttgg aatgacaccg aagctggcga ttaacatcaa acctgtacaa 7321 atcgcaatgc cgatgaggac cgcttgcttg gcaatggcca tggtttcctt agcaattaaa 7381 gtggccgcag caactttcgc caaatcgtcg cgcagaacca cggcatcagc cgattcgctt 7441 gccgcggttg ccccatgtgc acccattgca atgccgacat cagcaatcgc caatgaaggt 7501 gcatcattga caccatcacc aaccatcaca actggccggc catccttagg gacgttatcc 7561 aaaacttcaa tcttctgttg tggcaattgt tccgcataga cttggtcaat gccgacctgt 7621 gccgccactt tatcagcgat tgactgctgg tcgccagaaa tcataatcag cttagcatca 7681 tttaattcgt gcagtttcgt catcgtttct tttgcttctg gacgaatctg atcggaaaat 7741 gtgatcgcac ctgcgtactg gccatcaaca ttcacataca cggcagtcgt atcaaccgta 7801 gccttcgtcc cagcaaactc ggctttaccg accttgactt tgcggccatc caccgtggca 7861 ttaacgccaa agctagtggt ttccgacaca tctgtcgctg gcagccgatc agctgtcggc 7921 acagcatctg ccagtgaacg cgccaaaata tgagtcgatt gaccttccgc acttgcggct 7981 agcttcaaaa gctgatcctg tgagaaaccg gcttgtggca aaatcgtcgc aacttttaaa 8041 ataccgcgtg tcacggtgcc ggttttatca aaggcaaagg ttttagcttc acttaacttt 8101 tctagcgtag tccctgactt gacaatgatc ccgttgcggc tattacgact catgccggag 8161 accatcgcaa ttggcgcggc cagaatcagc ggacaaggcg aggccacaac caatacctgt 8221 gcaaagcgaa ctgggtcgcc agagaagaac cagccaagac ccgcaatcac ataagcaatc 8281 aacgtaaatg gtaccgcata acgatcagcc atccgaacaa aatgtgctgg ccgcgcttca 8341 gattccttaa ccagtttaat aatcccttga tactgactat cttcagcccg ttgcgtgacc 8401 ttaacagtta gggcagcgtc accattgacg gtcccagaca taatgtcact acctgcgttt 8461 ttggcaaccg gtttagattc acccgtcaaa ctggcttcat ccaccaaact ctcacctgcc 8521 aaaaccgtac catcaactgg cacgacttcc tgcggcttaa ccaaaatcgt ttcgccaact 8581 tggacggcct caacgtcaac atcttcaacg tgtccatcaa ccatacgatg cgcggttgtc 8641 ggtgcatttt cgagtaattg ctttaattca ctgcttgctt ttgttgctgc gtagctttca 8701 agcgcatcgc caccagtcag catcaataac acgatcatcg cagcccaata ctggccaacc 8761 gccaaggtgg caacaaccgc cgtaatggca agcaagtcaa cgccgaagtt accagaacga 8821 attttcttca ccatgcccca gaacataatt aaagcaatga ttgaccccat caccgtgatc 8881 agcccttgcg cgatcagtgg ttgctttaaa acgaaagcaa agactagcgc aatggcactt 8941 acagcaagca ccatcattag ttgccagttc tttttcatca ctgccacccc ctttttctaa 9001 gcattccaat tctaattatt acagacgaga tggcaaatta caagtttaat ccgaacaagc 9061 acggaatctt tcaatggcag tctgttgatg atgtattttt aatggtcgtt gattaattag 9121 ttcaagtgct gctaggatct catcagtcgt tacttggcta aaattggtct ttttcgggaa 9181 gaaccagcgt aaccgtctat taaaatattc attggaacct cgctcccatg gtgaatatgg 9241 atggcaaaaa taaactttga tctgataatc ctgttctaag gcctgataat tggcaaactc 9301 tttaccatga tcaacagtaa tggattttac ttggggaccg aaggccccca taaacttgcc 9361 aaaggcggtg tttagagcct tagccgttct attaggggct ttgatggccc atagaagtcg 9421 ggtcttacgt tctacgaatg taaccagaca tgatcgtgac tcacttcgac tagaaagcac 9481 cgtatctact tcccaatgac caaaagctaa ccgttgatta acagttgttg gccgttgttc 9541 gatggaagtc ccacttgtaa atttcccacg attttcgctc actcggtgct ggcggacatt 9601 ccgattgggt agatcagtca atttgaaggg gagccagcca cgattaagcc aattataaat 9661 tgacgcagtg ctcaagttat aagcggccgc aatggtttct ggtgaccagg ttaatcgtaa 9721 gtgattggta attaaagtcg ctaatgctgc agtcagcatc gaacgacgac cgcaattccg 9781 ccttttgcga tctgcatctt gctgagctaa ttctggatca taaggtttaa cccggtccaa 9841 ctcatagcta atcgtagctt tggcgacgcc taaggcgtca gccattactt ggtaagattt 9901 attcccctca ttgaccagtt gtgctagtgc gccacgttga aaacgtgata aagtagatgt 9961 acccaaagta atcactccct atattggttg gaattagcta ctaccattgt aagtgattgc 10021 tttgggcttt ttaatttctg ttcggattaa ttatagaatt tgccagatta catatttaaa 10081 gttaccaccc tcaagacaaa aaagcctgtc ctttcttgtt aaaagggact ttgcatatca 10141 taccatacta tctagaggga agtcatcact ttttcggaca gtttgctaag cgactttttg 10201 tgaagcttgg tcatacaagg aaagccatgc tactggtgca agatagtcta agcgtgcttg 10261 tacccttacg cggttgtaaa aggtctcgat gtaagcgaag acttgcgctc tcagatcatt 10321 gatatcttta aattgtatct gataaatgag ctctttcttc atgatggcaa agaagctttc 10381 gctccaagcg ttatcacccg gtattcccaa tgctgagaag ctacgttgcc aatgatattg 10441 gttgaccaac tttgtcactg ctttggccgt gtattggcta ccacggtcac tatgaaaaat 10501 acacgtttct ggcaaagccc acctttggtg ggcttgttta agtgtcgcta agactaaatc 10561 cgtgtccata tgattggata tttgatgagc taacactagg ttgctggtca aatcccttat 10621 ttggcaaatg taagcttttc cttctgatgt tgtcgtctgt gtaatgtcac ttgataaggc 10681 ttcaaacggc ttaaaagatt ggtgtttcac tagattggga taatcacctt gacgagcaag 10741 tcggctatcg gtcaaactct tcggatgacg acaacgtagc gttgaataca gaccgccatc 10801 agccatcaga cgggcaactc ggtgatagga agctttatta ccatttttac gcaataaacc 10861 gcagatgcgt ttgggcccgt aagtgccctg tccttgatca aaaaagtgtt tgattcgttg 10921 acgatattgc ctttctttgg cgtttcgctt tggcaaagct ctccgccaag cataataacc 10981 actcgttgat acgtctaaca aacgcgccca ccttaccaca gaaacagagg tttccctcaa 11041 cataaaagca tacttatcgc tgggggttac ttctggagac tggcaaagta ggcggcggct 11101 ttttttaaca tatcacgctc caatgctaat tcggcatttt cacgttttaa ggaacggttc 11161 tcagcttcta aagaagcaaa cggcgtttgc tttccatctt cggtatatag cttccgccaa 11221 cgatacaggg cactttcagg aacaccaagt tcggaggcaa tgattttaac tggtttggaa 11281 gagttaaaac tcaaacgtac cgcatttttc ttaaaatctt ggtcgtagcg attgcgtgaa 11341 taggtcattt tgaggactcc tttcggataa atcaattctc ttatgtttct gtccgaaatt 11401 ctagtacaga cccagagtac tctaacaact gaatcaacct gattactcta aaagttggcg 11461 tatggatgag acctatatca agatcaaagg tcaatggaat tacctctacc gtgccattga 11521 tgatcaaggt cttacgcttg attttcaact gcgcaagaag cgtgacttta actcggccta 11581 tcattttctc aaacgccttt taaagaccta tggtcttcca catcgattag tgactgatca 11641 gtacggagcg accctaaagg caattaaaaa gcttactagg gaaggctgtc tgcacaaagg 11701 tgtgcatcag tgctccaaat atcgcaataa tctgattgag caagatcacc gttttattaa 11761 gcggcaacaa gttcgttccg caagttatca gagcactcgg acagcagcta ggacattata 11821 cggcattgaa accatgcatg cgatacacaa agaaagccga aagaagccag gcctcttcgg 11881 cttttcagcg tatcaagaag tcgaccaatt gttagcggca taggctacaa ccactaaaca 11941 cagtcacttt gatctacgct taatttcaac tttgcaccag aaccttttgt cttaataaca 12001 aagtatataa gggactacca ttcataccga tcaaccaatc actaatttga cgggtttggg 12061 cttctttata agccaaatag tctttgtgcc aatcaccaag atttttaaag ccggtaataa 12121 tggcgtcttt ttccaaacta ttcagccata gccgcttaat ggtcttcttt ttaacgtcaa 12181 tctgggcttg gatcatgatt gaccacgcaa tattagagcc ttcccgaccg ctatcggtgg 12241 caacaataat ggtatcggcc ttctttaaca ggtctttgac gaccttgaat tgatcttttt 12301 tactagctga caccacaaac ttgtatttat cggggaaaat cggtaaatta gataaggccc 12361 attgctgata tttctgatca tatttatccg gtgtggctag ttcaactaaa tgtccgagac 12421 catacgtcac aagcgtattt tcgggcaaaa cagggtcgct aaccgtatag taaccctgtt 12481 tttttgtgct cttttgaaag gcttggacgt atgaacgggc ttgactaggt ttttcagcta 12541 agataacagt ggtcatgttc gttcactcct tgtgattaag tttctgttct aattctgttc 12601 taccttgttc agccgctttt aaccaggttt aacggtgcat tttttattcc gattacaagt 12661 gcatgccacc atcctcatgc cggtttcgag tttggtgttg ccgttgcttt ttcgtcattt 12721 cccactcggt ttctttcagt ccacgttctt gcttttgccg ttggtaatct tcatcacgag 12781 catatagaac agtcatgatc gcatcactaa aggccgtctt taagtagtag cttggactaa 12841 ctggcttgta atttagcggt tgataatgtc caatatttgc ttttctgtac tggtcgtcct 12901 tggcttgttg ctcttttaac tgcttttgga ttttctcgat ttgactgttc ttaatcgttg 12961 gatcgacttt gcattcgcca aaaaagagtt gtttagtgcc atcatgcttt aaaacccgtt 13021 gtaagtgatg attttctaac tgatctaagc taagctgtcc cgacaaataa gctaacccta 13081 attgatgttc ttgggtactg aaaacctgtg gtggatttga ttgccattgt tccattgttt 13141 cgacttttaa tggctttaaa gttggatcat agtacatcac ggctgtataa gcctgttcct 13201 gtttagtcaa tggcaatcca tctaaatcgc ctttgggaaa ggcccttctt aaaacttcct 13261 ggtattgcgt ttgaataact tgcttaacag ccatgattgt tcgcaaatct ttgactgcgc 13321 gagtaatctt ttgctgttcg attggtgaat atttctctag taacccttga tcgacgtgtt 13381 ctagactttc taagttatcg tcatgaatca tcagcgtata tttcagttcg attttgactt 13441 ccttttcctg ttgcattaat aacttccagc caacgtatgg ccgtttggta aaggtcaata 13501 attgttgtgt caacaaatca tcacgaatgt tcattaaacg ttcgtttaat tcactaccct 13561 tgaaaactgt ttgttcgcta ttggtttcct taattaattc tcgtctttca gcttgcgtgg 13621 tttgttcaaa attaagctct ggataaagtt ttttagtcgt gcgatcaacc actttattta 13681 agagttcatc tgcttttttg agtgagcttt cttgttggtt aattgtcaat aattgtttag 13741 tcacatcttc accaaccgca tgtttaatta aggtactgtt tttccaatta aatagcatgc 13801 gccgcttatc atctaagttc tccaaactga tataagtttt cagttcatgg cttagctctt 13861 taactacccg tttttcatta aacgagaagt gtttacttag gctatctaaa tgacctctat 13921 tgattgcttt ttcttggtta tttttataac tggctttggc cttgcgatag tccttaactt 13981 gttgattaaa ttcttttctt tcatgccgct tactattgat tccctcatgt tgagttggaa 14041 cttcatctat tccttgattt tcaaaggatt tttcgctgat ccgatcggga atattttttt 14101 gctctaaaac ttgattgaca ctaaccgccc aattgtgccg ccattcagtt attttttctt 14161 ttttatccca atcaaccaac caaatttttc ggtttcttac attccctgca ggggtcttag 14221 ttttattacc atgactatct aaaatgtatt cggtttttgt tttctgtccc caagtaccat 14281 cggggttaaa tgggcgattg gttaacatca catgagcgtg cggattatct gggtggtcgc 14341 gatgaattgc cacgtcggct accatgccct catcaacaaa attttcttgc acatattttg 14401 tcagtaattc tttctgttcg gattcactta attctaccgg tagagccacg ttaaactctt 14461 ttgcataccg tgagtttgat ttacgatctt tcttttcaac ttcattccac aactgctctc 14521 gatcactggc ccattctggt gcattttttg gcgtcaaaat aaagctttct ggcataaccg 14581 agcgggcata aaaatagtgg cgaccttcct tatcatcaaa tagcttttca ccacttcgat 14641 aagcggcact ggcaatcgca cttcgtcctt taccagcact aatattacta aaactcatgt 14701 gaaaaattgc catgtcgttc accaccttta tttgggttta tgggtttgat tttgttgtcg 14761 ccatcggcga cttctaatac aggttttaat gggtttagca caacgtcatc aaagatgacg 14821 tgtaagtgcg cattgacctc gtttcacttg gtcttctgat tctcttaact ttaacttagt 14881 gtatgccttc cgcttcgcta tttcaacttt tatcctttga cttaacgttt cctatatgat 14941 atagtgtcga tgattatttc taatatgatt ggagggatcg ttatgtctca aagtaactta 15001 gaaaaacaag aagctaaatt aaaacagctt aatcaaaaga ttaaagctga aaaaaataag 15061 attgaacaac ggctaggtaa acaaatcatc agtcaagcca atttagatta tgctaatttg 15121 tctaacgatc agattaagct tttagctaag caattttctg aatttttaaa ggtaaagtcc 15181 gtagatcatt agccatacga gatggggaaa ttccatgtct aatcaatatg aaaaactagt 15241 cgagcaacaa gcgcgtttaa aacaaaaaat tgagcgggaa gattttaaat tacggcaatc 15301 taaatactat gaaaatcggc aatcccgcaa agcccgttct cgccgactaa ttcaaaaagg 15361 ggctttatta gaaaagtact ttcaagctaa taacctctcg gtcgaacaaa ccgaagaact 15421 tttaaaaaca tttgctgatt atgttaacgc ccataaaccg gataaattaa aaaacgatca 15481 acctaataac taggccgatc gtttttattt tctggatcat ttttaggctt tacttctggg 15541 ttttgatctg caaaattttg taactgcttt tgcacctttt ctggataagt aatattttgg 15601 tttatccaag gaaaatgcct caaatcgttc ttaaaaactt gtcccttctc tcttgcataa 15661 acagaggtaa acttttcgct attatcatag atcatgacct tatcagattt aaaggccact 15721 aatggcaaat tatgtttgga ttgctgataa cgtttcttga tcgttgctac tggaacaccg 15781 tggccacctt tttgtacccg ttcgttgacc ctttggatag ctaaattttc atctcgcaaa 15841 gcaacatata ataaagtcac ttcaaagcca tttttgtgag ctttgtcaat caaattgagt 15901 tgagctttgc ctctacctgc cagtgttgtt tctacgtgaa tactttgctg gtgatctaaa 15961 gcatagtgta gttgtttgat ttcttctttc atggctttta agttgtcact atctttatgc 16021 caatcgccac ccatttgtct taaaagttca tcagcgttaa tccgttttgt tttgtcaaac 16081 aagacgggaa atgtatcgta tagcgtactt tttcctgctc cgttaatacc agcaacaatt 16141 atatattggg gtttatctat caacggacaa agtcctttcg cttaataacc tcatcttgcc 16201 ttttatctaa aaagtaggta tataaagcgt catatacttt gcgcttttct gggtctggct 16261 catgtaatga cttatcaagt aaatctttta aatcagtttc tttggcaatt tcaaaaaagt 16321 cattaattgt gattgtatct ttcatgttca tcacacttcc aagttattaa tttatttaat 16381 ctgataagcc attagtcctc atctggatca ttgagccaat cagcgacttc tttagcgtct 16441 ttgaactctg ttactggtgt ctctttggta gcctttaaaa ggcttaaatt agctctttcg 16501 gcttcgctca gggctggttt aaacggtaat gctgcgtcag ctacgatccg cttataaaac 16561 atattgatcg cggtagttgg gtttagacct aactggctta aaacggcttc ggtattatct 16621 gccaattctt tgtcaatctg gacttgtacg cgtttctttt ccttaactgc catgattttc 16681 tcgcccccct ttattactac tcacattata ctaatctttg agtaccatct caattagcct 16741 gcttctttaa aagttgtgaa tttaagtttg ctgtcctttc cgcaatggca cttatacaac 16801 gttcctaaag tgcccgtaag cgcattttaa aactcgttta atataattat gctctatctg 16861 tttaaaacag cttaaatggc cttatatagc tttttagttt taagcacgct catcgttagg 16921 gtgtttggcc gcatattctc tagccgcttg tttattccac caagcgccaa ttcagccact 16981 caaggtgtct atttttgctt ctaagcgatt ttaaagcgat tttaataaat tatgcatgta 17041 acacttaaaa cggcttaaat gagcttatac ggcgtttaat tccaagaacg ctcattgtca 17101 gtgttctgtt cttcggggtg tttggccgca tattctctag ccgcttgttt attccaccaa 17161 acgccaaata ggttttgcat ggtgccgtac aagtagcttt ccacgttctt gatgtgcttc 17221 tcattgcttc taagggcgtt aaagtagcgt ctcaaggctt tagtcatcaa aggtttaagt 17281 tcttcatcgt ccagtgggat tagaacccca atatctttgt gatctttctc aactcggtac 17341 ttagcattta agataatgcc aatgaagcgc cgcatttgtt gtggggtacg gcaccaaaaa 17401 ctaagtagtt gcacagcttc gggttctaag aaaaccggta agccactgtc ttcatcagtt 17461 aagaagtcat tagcatgggt caccaaatct cggttttggg tttctagttc tgctgatgaa 17521 aaattggctg tggaaaagtc caacttttga gtatctatat tatatctatt agtatctaaa 17581 ttattagtat agtctagatc ttgtctcttt ttgagaagtc cgcttgtacc aagggattca 17641 gacgtatcag aaacggtatc atgcgggttt ctctttttga gaagtccgct tgtaccaagg 17701 ggttcaacgg tatcatgcgg gtttctcttt ttgagaagtc cgcttgtacc aaggggttca 17761 ggcgatttta atggctctcg cttaatataa acgtcttttg ctgttacttc caaatctgcc 17821 aaatataatc tatttggttc gtttttgcct gatcttggat taaaccccat atgtttttga 17881 tacaaaaggt tcgcgtccat taattcgtgt ttaatcttat tgattttatt atttgaccag 17941 tttcgtaaat cttttagttc attgtttgtg tatatgaaat atacgttgtt attttcgtca 18001 acccaattat tgcttagtga gtaacttaga cgatcgcgta acaccgaata aagtaaaatg 18061 gcactatcgc taagatcctt atatttttcc ccttggagta agatctgcgg caaagcgtaa 18121 aactttactt cataggccct tttagcattt gtaaagttga agtttgattg atccataata 18181 aaagctccct ttcttaactg acacacgtcg tcttaaagag agttgctaaa acatctgact 18241 tgttttaaaa tacaaatctg atatgcttta actgaattac aaagcgaaca ttggacgtga 18301 tcggctttgt aaattcaccg gcatgtgtct attctgggtt gcccatacgg caactttttt 18361 taatttctaa caacaaaaat ggactaaata gcattggtta gccacttagc ccattggatt 18421 caatttgttt ttaactatcc ttcacttgtc ccataggact ggtttgcggt ataattaacc 18481 tacaaattaa gaacaatgtt cagacgattt taa //