LOCUS NC_015419 12403 bp DNA circular BCT 29-APR-2011 DEFINITION Clostridium botulinum BKT015925 plasmid p5BKT015925, complete sequence. ACCESSION NC_015419 VERSION NC_015419.1 GI:331268174 DBLINK Project: 66203 KEYWORDS . SOURCE Clostridium botulinum BKT015925 ORGANISM Clostridium botulinum BKT015925 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 12403) AUTHORS Skarin,H., Hafstrom,T., Westerberg,J. and Segerman,B. TITLE Clostridium botulinum group III: a group with dual identity shaped by plasmids, phages and mobile elements JOURNAL BMC Genomics 12 (1), 185 (2011) PUBMED 21486474 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 12403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (22-APR-2011) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 12403) AUTHORS Skarin,H., Hafstrom,T. and Segerman,B. TITLE Direct Submission JOURNAL Submitted (22-DEC-2010) Bacteriology, National Veterinary Institute (SVA), Sweden, Ulls vag 2, Uppsala SE 751 89, Sweden COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP002415. Source DNA and bacteria are available from Hanna Skarin, National Veterinary Institute, Sweden. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..12403 /organism="Clostridium botulinum BKT015925" /mol_type="genomic DNA" /strain="BKT015925" /db_xref="taxon:929506" /plasmid="p5BKT015925" /type="C" gene 121..447 /locus_tag="CbC4_8001" /db_xref="GeneID:10447571" CDS 121..447 /locus_tag="CbC4_8001" /codon_start=1 /transl_table=11 /product="putative prophage repressor" /protein_id="YP_004385884.1" /db_xref="GI:331268175" /db_xref="GeneID:10447571" /translation="MNERIKELRKLKGLNQSTFAKSLGLSQNHISSIEKGVRGLTTRT INDICRIYNVSPNWLINGTGDIFIDTTEQLYTNNEVKEFIEMFLQLDKETQQLIIQLT KKALNR" misc_feature 127..297 /locus_tag="CbC4_8001" /note="Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093" /db_xref="CDD:28977" misc_feature order(136..138,148..150,223..225) /locus_tag="CbC4_8001" /note="non-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28977" misc_feature order(145..147,220..222) /locus_tag="CbC4_8001" /note="salt bridge; other site" /db_xref="CDD:28977" misc_feature order(166..171,202..204,211..213,223..228) /locus_tag="CbC4_8001" /note="sequence-specific DNA binding site [nucleotide binding]; other site" /db_xref="CDD:28977" gene complement(1248..2546) /locus_tag="CbC4_8002" /db_xref="GeneID:10447559" CDS complement(1248..2546) /locus_tag="CbC4_8002" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385885.1" /db_xref="GI:331268176" /db_xref="GeneID:10447559" /translation="MGKSKQLVAKLKGGMDIGINNLKAGEEFKNYKTLCDCINVTVKK GGRNLKLQKQDLKRYFDWITEGRKIIIKEVYLEPKPKVDNRKNNGKSEGSRGNNNIYG KYVDNILIDYFIEHLKEHDNIVLNFTNREIAELTGMINLNYNITCNDKDNFYKYLFNS TTPVTRTAIRDVFRKVQNILKHTIDSSLNRLQKQGYIKFSKGYLLLEKQEDKNKTINR YAYDIETKAIRKVENDVLKEMGITIANKNYNDKLRKEYYKTVNERVKKVFKSDFDTKI KGYWTSYRIDTKEIQQAMNFTNTQLDEIDRLKIIDVTKYRKLKEVKVNSSKLKQELNE LIIQSVKNKINKDKIDIEQEINNPTLGLTNPIQPKWIIDRIDGKYLEDIEHVIKYVLQ LNAKSIKFELENIKAKEKIKEQKQQDQQNQDNDSWLNELD" gene complement(2859..3299) /locus_tag="CbC4_8003" /db_xref="GeneID:10447560" CDS complement(2859..3299) /locus_tag="CbC4_8003" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385886.1" /db_xref="GI:331268177" /db_xref="GeneID:10447560" /translation="MFKNKKVLIIFTLITFLVCLCVVIYVSGRKDVPKLTVSYNEKNI QIGQGGYRWKSRGKFKEHSIDSYASILSKLSPGMKVSPNGQLKLNFDYQPKTITLGGG NTTDGKVINDNVINISDYGTGVYFLDCTWEEGNVTYVIYVDIHH" gene complement(3428..4120) /locus_tag="CbC4_8004" /db_xref="GeneID:10447561" CDS complement(3428..4120) /locus_tag="CbC4_8004" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385887.1" /db_xref="GI:331268178" /db_xref="GeneID:10447561" /translation="MIKVKKISKIILSAFLCTLAFSISSFASEVRTNTDKINVSQNSE NIRLITKEQYCKSIAKSRGISVKEVEKITNEIIANHKNSISQMDELSVSRSMRWGTTE PDGKGGYYNFGWVYKRVDAGGGMIVEASVPVIIYNYHSYAKEFIEVNVDDCYAHAVGS GSYTYQSFSAKAKLMNNKVHLNATGAVQIQTNVAKNIGISIPELASWGFSVSQDHYAR KTITISHVESLY" gene complement(4258..4707) /locus_tag="CbC4_8005" /db_xref="GeneID:10447562" CDS complement(4258..4707) /locus_tag="CbC4_8005" /codon_start=1 /transl_table=11 /product="putative RNA polymerase sigma factor" /protein_id="YP_004385888.1" /db_xref="GI:331268179" /db_xref="GeneID:10447562" /translation="MNNHYLTEDVFQETLVKAYEKINTIRDIRKFKTWIFSIAKNESL CWIKKYNIEILSEDSYLELLTCFSKNVPEELLLKSEMKVQIKKIIKVLKPVDQKIMYL KYYRDLTLNEISLMLDMNKNTVKTRHMRAKKKIYNHIVYDNNLYTFK" misc_feature complement(4561..>4707) /locus_tag="CbC4_8005" /note="Sigma-70 region 2; Region: Sigma70_r2; pfam04542" /db_xref="CDD:146937" misc_feature complement(4303..>4419) /locus_tag="CbC4_8005" /note="Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171" /db_xref="CDD:100119" misc_feature complement(order(4312..4314,4318..4323,4327..4335, 4339..4344,4348..4350,4378..4383,4399..4401)) /locus_tag="CbC4_8005" /note="DNA binding residues [nucleotide binding]" /db_xref="CDD:100119" gene complement(6632..7087) /locus_tag="CbC4_8006" /db_xref="GeneID:10447563" CDS complement(6632..7087) /locus_tag="CbC4_8006" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385889.1" /db_xref="GI:331268180" /db_xref="GeneID:10447563" /translation="MVSKATVSFAYVDDHIQNNTKDTAYELKENTLQDVLSQYNRRVF NCFLENSNDIGWFKTYLSNGDKTLTINIDVNSTIEVISEKDDKVVFTRKYGRSIAKQG EFKITENGVYYIKVKPNEEVNKIQNFTMLVGEPDYSRKYFTKILTKNYI" gene complement(7270..7767) /locus_tag="CbC4_8007" /db_xref="GeneID:10447564" CDS complement(7270..7767) /locus_tag="CbC4_8007" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385890.1" /db_xref="GI:331268181" /db_xref="GeneID:10447564" /translation="MDIGLLEKEVLTNGLNATSKKYKLKKDKIKKLLGNKVENDKKNI IEKNNTTNDIKKNTLKNNIKDNILDNDIVKEISTDDIIKDITNNNIDIDKLRMLIENT EEILRIVEKYKLHRIKITNDRSTVTTLRINEEVYGLVKEYSKKNNETITNIINCALIE YLESH" gene complement(8000..8542) /locus_tag="CbC4_8008" /db_xref="GeneID:10447565" CDS complement(8000..8542) /locus_tag="CbC4_8008" /codon_start=1 /transl_table=11 /product="putative resolvase" /protein_id="YP_004385891.1" /db_xref="GI:331268182" /db_xref="GeneID:10447565" /translation="MIYGYARCSTDNIKQDITRQTRELKALGVEKDNIYFEYASGTKV DREQLTRLMDIVVEGDIIVATEVSRITRSSKQLCEIIEFAKDKKIKLILGNFVVDCTK ELDPMTEGMLKMMGVFAELERNMISQRVRSGMANARSKGKVIGRPQTTIEDIPSNIIN AIELLKDKKLIRVNVLECVI" misc_feature complement(8144..8539) /locus_tag="CbC4_8008" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768" /db_xref="CDD:58117" misc_feature complement(order(8327..8329,8336..8341,8516..8518, 8522..8524)) /locus_tag="CbC4_8008" /note="catalytic residues [active]" /db_xref="CDD:58117" misc_feature complement(8516..8518) /locus_tag="CbC4_8008" /note="catalytic nucleophile [active]" /db_xref="CDD:58117" misc_feature complement(order(8177..8179,8189..8194,8198..8203, 8342..8344)) /locus_tag="CbC4_8008" /note="Presynaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(8171..8173,8180..8182,8189..8194, 8201..8206,8213..8215,8306..8311,8324..8326)) /locus_tag="CbC4_8008" /note="Synaptic Antiparallel dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(8156..8158,8168..8170,8177..8179, 8189..8191,8198..8203,8210..8215,8249..8257)) /locus_tag="CbC4_8008" /note="Synaptic Flat tetramer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(8156..8158,8168..8170,8177..8179, 8189..8191,8198..8200,8255..8257)) /locus_tag="CbC4_8008" /note="Synaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature complement(order(8153..8158,8174..8176)) /locus_tag="CbC4_8008" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:58117" gene complement(8827..9696) /locus_tag="CbC4_8009" /db_xref="GeneID:10447566" CDS complement(8827..9696) /locus_tag="CbC4_8009" /codon_start=1 /transl_table=11 /product="putative epsilon-toxin type B" /protein_id="YP_004385892.1" /db_xref="GI:331268183" /db_xref="GeneID:10447566" /translation="MIKNIADAYKILPSVFCQSKNCEDIIEGSDSRVEDELRNGKYNF DIIGQSGLKPIGQPTITKNNTMYVGNTRLINETSLDQTMRTEIFSREETFTQSTKTIL GFNIGIKASGKFTAKFLESGVETSIEVSAQFNLSNDQTTTKSETVTFTIPSQDILVPS KSIIKVTAIFNKVSCNGKVQLPTTVRGYDYIDCWSTGVPNPGGHPCVSGTEKVPFGKL ARMANSSDFVPVANSDTEMTIMGIGEYSTDTATNFMLNIEQLDLNGDKLIKSNSYVIK PIIKVIDEKVITE" misc_feature complement(<9121..9540) /locus_tag="CbC4_8009" /note="Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318" /db_xref="CDD:146116" gene complement(9724..10563) /locus_tag="CbC4_8010" /db_xref="GeneID:10447567" CDS complement(9724..10563) /locus_tag="CbC4_8010" /codon_start=1 /transl_table=11 /product="putative epsilon-toxin type B" /protein_id="YP_004385893.1" /db_xref="GI:331268184" /db_xref="GeneID:10447567" /translation="MIESMESAYSKLLVPYYKYLANGRPYEEANSSILDELKAGRYHF NTEGAMGVSPIGEPLVTGNETLYVGNTVLTNNTSITRKMKSESFTKKVTFTGTNRTVM GLKVGWKSSVKVIAKFLGNGVEGTVEIGGDFNFGRETSQTNSKVLTYTLPSQDILVPP HSRVEVTSVFNKVTCSGKVQLQSTVKGQDFITLCFNNCDDHIDKDGTFRYVPFDELAK IANIQQFRPNEKGSGEMRVMGIAEYTAETATNFMIRLRQFDLRNKNIISSDSYNIKPI ISD" misc_feature complement(<9988..10404) /locus_tag="CbC4_8010" /note="Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318" /db_xref="CDD:146116" gene complement(11247..11924) /locus_tag="CbC4_8011" /db_xref="GeneID:10447568" CDS complement(11247..11924) /locus_tag="CbC4_8011" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385894.1" /db_xref="GI:331268185" /db_xref="GeneID:10447568" /translation="MKINKDYKSTTLTEFKKLVADYENLRGEEGSLQDYISTIDWFNF MCDNETSFIAMQNGDVYINTKDWDIDNTHAFKDLVSYEIYNDKLITHRLNGNSIYNKA YDLHGEDKEKCMGSGNRKLIKDNKYIIKAKEILDKYNSLGNIGDSIDLSNTIKQYAKL NKIQLKCNKQGNKFYLSTSNIQQILDTRDIVAYELNNSELYTVRFSTDGFSKYKLDSK LHSTYLS" gene complement(11927..12058) /locus_tag="CbC4_8012" /db_xref="GeneID:10447569" CDS complement(11927..12058) /locus_tag="CbC4_8012" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385895.1" /db_xref="GI:331268186" /db_xref="GeneID:10447569" /translation="MNDIEIHENDIIFENGMDWDSFYELVTNIELIQEYKNNEKEGK" gene complement(12070..12366) /locus_tag="CbC4_8013" /db_xref="GeneID:10447570" CDS complement(12070..12366) /locus_tag="CbC4_8013" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_004385896.1" /db_xref="GI:331268187" /db_xref="GeneID:10447570" /translation="MTLEEQLFWMELEHREKKAKQFNTSKVNLNAEGEELRQVLANMQ GKETISNREFKYILYCMDYNNWTLKEIIQATKQIERKSINVLQIVSCSKEILER" ORIGIN 1 tttattttgt attttatatc cttttgagat aaaattcaag tgtttattta tattatttat 61 aaaataatat tgttttgaga taattttaaa tgatacaata tcacaaagag gtgttattga 121 atgaatgaaa gaataaaaga attaagaaaa ttaaaaggtt taaatcaaag tacattcgca 181 aaatcacttg gactttctca gaatcatata tctagtatag agaagggcgt tagaggactt 241 acaacaagaa caataaacga tatatgtaga atatataatg tgagtccaaa ttggctaata 301 aatggtactg gagatatatt catagataca acagaacagc tttatactaa taatgaggtt 361 aaagaattta ttgaaatgtt tttacaatta gataaagaaa ctcaacaact tataattcaa 421 cttactaaaa aagctttaaa tagataaata aaaagaacta tgagtattta aatctaactc 481 gtatttagag tcagataatc ttactcacca atttattaaa aaggaggagc ttggaaataa 541 tttcgtagct ccaagtaaat ctcaagaaga tttagcaaag caaattataa gctcttagaa 601 ttgattatat tatgtttaat gataaattat acgctaatgc tactacattt catttagagt 661 gcaaattaac gaccatttta agccacttac aagcacttta aaatatatca atatctatta 721 ataaaagaag aattttattg actttattat ctacggctag tacaacattt aatgagccaa 781 taaagggtaa gttttcacct ttggacaatg ttgtctaacg ttatcttctt gagttatcaa 841 acccacaaat tgttggtttg attttttctg tttgtgtgat actaacttac ctcctatcaa 901 ataatctaat agggggtaat attaatccta ttgtgtgtgg ctcgtgtgct taatatatac 961 ctatcttctc catactatta cccctaatct ataatctaaa caattgcttg ttattgctta 1021 cttatcagcc atttacccta tcaatactaa tattaaataa acgctttaaa atgctctcta 1081 tttataaaat tgatattata tacttatcca ctattcatat cccttcatgg ctctgtaatt 1141 aattctgggg cacttttaca taccctttaa tggttttata cccttcgcct ttaaaatgcc 1201 ttaaaataca aacaaaccac atataaatta atatacgtgg tttgggttta atctaattca 1261 ttcaaccaac tatcattatc ttgattttgt tgatcttgtt gtttttgttc ttttattttt 1321 tcttttgctt ttatattctc taattcaaac ttaatagatt tagcatttaa ctgtaataca 1381 tactttatta cgtgttctat atcttcaaga tatttaccat ctattctatc tataatccat 1441 tttggttgta ttggattggt taatcctaaa gtaggattat taatttcctg ttcaatatct 1501 atcttgtctt tatttatttt atttttaaca ctttgaatta ttagttcgtt taactcttgt 1561 tttagtttag aactattaac tttaacctct tttaattttc tgtattttgt aacgtcaata 1621 attttcaatc tatctatttc atcaagttga gtatttgtaa aattcatggc ttgttgtatt 1681 tccttagtgt ctatcctgta acttgtccaa taacctttta ttttagtatc aaaatcactt 1741 ttaaatactt ttttaactct ctcatttact gtcttgtaat attcttttct tagtttatca 1801 ttataatttt tatttgctat tgtaatcccc atttctttta aaacgtcatt ctcaactttt 1861 ctaattgctt ttgtttctat atcataagca tatctattaa tagttttatt cttatcctct 1921 tgcttctcca ataataaata acctttacta aatttaatat aaccttgttt ttgtaatcta 1981 tttaaactac tatctatcgt gtgcttcaaa atattttgca cttttctaaa tacatctctg 2041 atagctgtcc ttgttactgg tgttgtacta ttaaacaagt atttataaaa attatcttta 2101 tcattgcaag taatattata atttaaattt atcatgcctg ttaactctgc tatttctcta 2161 tttgtaaagt ttaaaactat attatcatgt tcttttaaat gctcaataaa ataatctatt 2221 aagatattat ctacatactt accatagata ttgttattac ctctactacc ttcactttta 2281 ccattattct tcctattatc aactttaggt tttggctcta gataaacttc tttaattata 2341 attttcctac cttcagttat ccaatcaaaa tatctcttta aatcttgctt ttgtagcttt 2401 aaatttctac cacccttttt aacagttaca tttatgcagt cacataatgt tttgtagttt 2461 ttaaattctt ctccagcttt tagattatta atacctatgt ccattccccc ctttaacttc 2521 gcaacaagtt gcttgctttt ccccaagggg aaacatctaa catttatcgc tttagggtac 2581 taatccaaaa cactatatat aattatttat atatttttat atacaagttt gaattagtac 2641 cctatattgt attctattac tattttttct attgtcaatg gtttactaat atttattttc 2701 atcttttagc accatttgta attaaaaaag ttaattacta tgggaagtat gtatctaatt 2761 catttattct aaatttaaaa atataataaa aatataaatc tcaactaata tctatttact 2821 attacaacac tttaaatatt attataataa tatattgcct aatgatgtat atcaacgtaa 2881 atcacataag ttacatttcc ttcttcccat gtacaatcta aaaagtacac tccagtccca 2941 taatctgata tatttataac attatcgttt atcacttttc catcagtagt atttccacca 3001 cctaaagtaa tagttttagg ttgataatca aaatttaatt ttaattgtcc attaggtgac 3061 actttcattc caggtgaaag cttacttaat atacttgcat aactatcaat tgaatgttct 3121 ttgaacttac ctctagattt ccacctataa cctccttgcc ctatttgtat atttttttca 3181 ttataactta cagttaactt cggaacatct tttcttccac ttacatatat aacaacacat 3241 aaacatacta aaaaagttat taaggtaaat ataattaata cttttttatt tttaaacata 3301 tatatcctcc ataatataaa ttatactcta cgtattataa tttatatttt cataactgaa 3361 ctaaatacaa tacaaaatag tataaaggtt gttcaataaa tttgaacaac ctttatacat 3421 acaattacta atataagctt tcaacatgac ttatagttat tgtttttcta gcataatggt 3481 cttgtgaaac actgaatccc caactagcta gttccggaat acttattcct atattttttg 3541 caacatttgt ttgtatttgt actgctcctg ttgcatttaa atgaacttta ttattcatca 3601 atttagcttt tgctgaaaat gattgataag tataacttcc acttcctact gcatgtgcat 3661 aacaatcatc tacattgacc tcaataaatt cttttgcata tgaatgatag ttatatataa 3721 ttactggtac actagcttca acaatcattc caccacctgc atctacacgt ttgtacaccc 3781 aaccaaaatt ataatatcca ccctttccat ctggttcagt agttccccaa cgcattgatc 3841 tagatactga taattcatcc atttggctta tactattttt atgattagca atgatttcgt 3901 ttgtaatttt ttcaacttct tttacagata tacctcttga tttcgcaatc gatttacaat 3961 attgttcttt agtaattagt cttatgtttt cactattttg tgacacatta attttatctg 4021 tattagtcct tacttcagaa gcaaaagaac taatactaaa tgctaaagta cataaaaatg 4081 cagataaaat tatttttgat atttttttca ctttaatcac ctcttaatat tattttttca 4141 tatataagat gattttcttt tgtaaaagtt tcacttttat gtagttttat atacaaatca 4201 taataaatta ctaatataca atatttttct tcatttattt ttacaagttt atatacatta 4261 tttaaatgta tacaaattat tatcatatac aatatggtta tatatctttt tctttgctct 4321 catatgacgc gttttaacag tatttttatt catgtctagc attaatgata tttcatttaa 4381 agttaaatca cgataatatt ttaaatacat tattttttgg tcaacaggtt ttaacacttt 4441 aataattttt tttatttgca ctttcatttc actttttagc aataattctt ctggaacatt 4501 tttcgaaaaa catgttaaca attctaaata actatcttca cttaaaattt ctatattata 4561 ttttttaatc cagcataaac tttcattttt tgctatagaa aagatccagg ttttaaattt 4621 tcgtatatct ctaattgtat taattttttc atatgccttt actaaagttt cttgaaatac 4681 atcctcagtt aaatagtgat tattcatgat agaatatata aatttatata aatctttata 4741 tattggaaaa aggtgtttct cgaagtgctt tcgctcaagt atattaatca attccataat 4801 aatctccata ttctttaatt ttacagtaat acctatatat tatcatttta tgtaaaatta 4861 tcaaatatgt ataattctaa gtaactatta aaagattaat attatttatt tcaataacta 4921 acataggata cgagatggct ttagattgga gtgttttgga tatagttatc ccttaaaaaa 4981 gggattgtaa ctattaatgt atggctttga gttgtcatgc cccatcaata ctatgcttgt 5041 cttaaagtgc tttaatatcc tatatcatgc ccatagaata cccactattt agtagttaca 5101 cagttaccgt ctttcgacca tgaaacctcc gcaagtttat ttatactggt tgcttgtcca 5161 ccagttgacg tctactattt tatataagca tagaaagtaa atagtatccg aatagatttt 5221 atacgtcggc tctatcacac catgatttat agtgtcagtt ccacatagag aataaaacag 5281 tacttaccat tattatctcc cttccataat tagcacatgg acatgctcca tatattttta 5341 tacctatatg gtagtaattt aaattgcttt tatttgctat tctaaagttt tttattatct 5401 aagtaatgaa tctaacgtgt agccctctta acattctcta atgtgctata caatagaaaa 5461 caagccacgt ctatatattt ttaagcatta aaaaagcacc tcttaggata ctacctaaaa 5521 agtgcttgaa attctcttat aaatttgtta tactttattt cataattgaa taaagtaatt 5581 ataagttctt tctaacggct tttatgtgtt ggtagcacat actaagtttg gcttatatac 5641 aatgttggta gcattatata taagagttga aagggctttt tattttgttt ttatgtaata 5701 gattataaca taattctttt aaaatggaaa ttttttttta taaacattaa aattttcacc 5761 cttcaaataa aacatattag tatgttatta aacaactctc aatattcaat tgtattaaaa 5821 ataaaatttt gaaacttatt aaattcttat aatccactct aatgtgtaac cctcttaacg 5881 ttctctagtg tgctatacaa tagaaaacaa gccacgtcta tatattttta agcattaaaa 5941 aagcacttct tagtacgttc atactaaaaa gtgcttgaaa ttcatttatt aattatgtat 6001 aatctattct ataattaaat agtaattaat aagtcttttc taacgttctt ttatgtattg 6061 cagtacatat ttgaatcggc ttacaagctc aattgcagtt gaatttgtaa gagttgaaag 6121 ggctttttat tttgttttta tgtaatagat tataacataa ttcttttcaa atggaaattt 6181 ttttgtctat attaaaattt ttatttttca gatgaaacat aattttttat ataaaataaa 6241 taatactatt aaaaaggtaa aattctatat ttagaatctt acctttttag taatattatt 6301 taatatttat ccctgcaaag atatgtaaat ctaattgaag gttgtaaagc atatactcca 6361 tcaacatctg atgcagaatg tttaaatgac caattagttt ttaatttaac tggtgcattt 6421 atatttaaaa tgtttttatc aaaatatgag acaccaggta cattaatcca ttggctatta 6481 taagatttaa tatatcttac tttattataa gcatcatatc tattagtttc agttccatta 6541 agagatactt ctaatactat agcttcatta ggaattgtat cttcatatga taaatcaaag 6601 tttactgtat cggatgtcgt ataatttgaa tttatatata atttttcgtt aatatttttg 6661 taaaatattt tcttgaatag tctggttctc caactaacat agtaaaattt tgtattttat 6721 tcacttcttc atttggcttt acctttatat agtaaactcc gttttctgtt attttaaatt 6781 cgccttgctt tgctatgctt cttccatatt ttcttgtgaa tacaacctta tcatcttttt 6841 cagaaataac ttcaatagta ctattaacgt ctatgttaat tgttaatgtc ttatctccat 6901 tagaaagata tgttttaaac catccaatat cattagaatt ttctaaaaaa caattaaata 6961 ctcttctgtt atattgtgat aatacatctt gtaatgtgtt ttccttaagt tcataagcag 7021 tatcttttgt attgttttga atatgatcat ctacatatgc aaaagaaaca gtagctttgc 7081 taaccataaa tggtataaat aataataagc tcaataataa gtgctttaaa aattttttca 7141 taattttcct cctgaaattc aagtagtata ttataccatt tcgtatataa tattaaaaac 7201 tttatatatt atatatattc atcaataata ttacatatat gaaaaatata atatattaaa 7261 atgttatctt taatgacttt ctaaatattc tattaatgca caatttatta tatttgttat 7321 agtttcatta ttcttttttg aatactcctt caccaatcca tagacttctt cattaatcct 7381 caatgtagtt actgtggatc tatcattagt tatttttatc ctatgcaact tatacttttc 7441 aacaattcta agtatctcct cagtgttttc aattaacatc cttagtttat ctatatctat 7501 attattattt gtaatatctt ttataatatc atctgttgaa atctctttca caatatcatt 7561 atctaaaata ttatctttaa tattattttt taaagtattc tttttaatat cattagttgt 7621 gttattcttc tctatgatat tttttttatc attctcaacc ttattcccca gtaacttttt 7681 aatcttatct tttttcaatt tgtacttttt agatgtagca tttaagccat ttgtaagtac 7741 ttccttctcc agtaacccaa tatccattcc ccacacctca tatttttata atatttctat 7801 atgtaatatt ataccatatt attgattgtg ttatcgctga aattctagta atggtctgtg 7861 acttggtgta ctctaccttc tcccaataac ttaaatttaa tcaaatatga gtaagtaccc 7921 ccctgtatgt aattaagcaa taaaaaaaga aggtattatc cttctataat ttttatatac 7981 ttatctaatg ttggtcgact tatattacac attctagcac attcactctt attaattttt 8041 tgtcctttaa taattcaata gcattaataa tattacttgg aatatcttct atggttgttt 8101 gtggtctacc tattaccttc cccttggatc ttgcattagc cattccactt ctaactcttt 8161 gacttatcat gtttctttct aactctgcaa atacacccat catctttaac ataccttctg 8221 tcattgggtc taactctttt gtacaatcaa ctacaaaatt tcctaatatt aatttaatct 8281 tcttatcctt agcaaactct ataatctcac ataactgttt acttgaacgt gtgattctac 8341 ttacttcagt ggcaactata atatcacctt caacaactat atccataagt cttgttaatt 8401 gctctctatc aacctttgta ccacttgcat actcaaaata tatattatcc ttttcaacgc 8461 ctagtgcttt taattctctt gtctgtcttg ttatatcttg ttttatatta tccgttgaac 8521 atcttgcata tccgtaaatc atattattaa tacacccttt cgtttacaat ctctatgaat 8581 agaatatcat atcctaatcg atttgtaaac aaaatggttg tttgatttca tttacacatt 8641 ttcaatataa aaatactttt aaaccctcat ttgttggtta actttcacac tcctaattaa 8701 tgtcttgttg tgtaaaggaa aagagatgtt tttatttaca cgagtaagac ataagtattt 8761 ttgttttact tttttcttgt aatcatataa ataagaagcc atgaaaggct tcttatttgc 8821 tttttatcat tcagttataa ctttttcatc aataacttta ataataggtt ttataacgta 8881 actattactt ttaatcaatt tgtctccatt tagatctaat tgctctatat taagcataaa 8941 gttagtagca gtatcagtag aatactctcc tattcccata attgtcattt ctgtatccga 9001 atttgctacg ggtacaaagt ctgaggaatt agccattcta gccaatttac caaatggtac 9061 tttttccgta ccacttacac aaggatgacc acctggattt ggcactcctg tagaccaaca 9121 atcaatataa tcatatcccc ttacagtagt cggtaattgg acttttccat tacaactaac 9181 tttattaaat atggctgtaa ctttaattat agattttgat ggaactaata tatcttggga 9241 tggaattgta aacgtaacag tttcggattt agttgtagtt tgatcattac tcaaattaaa 9301 ctgtgctgat acttctattg aagtttctac tccactttcc agaaacttag cagtaaattt 9361 tccagaagct tttattccta tattaaatcc taaaatagtt ttagtagact gagtaaaggt 9421 ttcttctcta gaaaaaattt cagtcctcat tgtttgatct aaactagttt cattaattaa 9481 tctagtgttt ccaacataca tagtattatt tttagtaatc gtcggctgtc caataggttt 9541 aagtcccgac tgacctataa tatcaaaatt atattttcca tttcttaatt catcttctac 9601 tcttgaatct gatccttcaa taatgtcctc acagttttta ctttggcaaa aaacacttgg 9661 taatatttta taagcatccg ctatattttt aatcataaaa aaactcctta tattaaatta 9721 aatttaatca ctaataattg gttttatatt ataactatca gatgaaatta tatttttatt 9781 tcttaaatca aattgtctta gtcttatcat gaaattagtt gcagtttcag cagtatattc 9841 tgcaattccc ataactctca tttctcctga acctttttca ttaggtctaa attgttgaat 9901 atttgctatt ttcgctaatt catcaaatgg aacatatcta aatgtgccat ctttatctat 9961 atgatcatca cagttattaa aacaaagtgt aataaaatct tgacctttca cagtagattg 10021 taactgaact tttcctgagc aagtaacctt attaaataca gaagttactt ctactctaga 10081 atggggtgga actaatatat cttgagatgg aagtgtatac gttaaaacct ttgaattagt 10141 ttgagatgtt tctcttccaa agttaaaatc accacctatt tctacagttc cttcaacacc 10201 attacccaaa aattttgcaa taaccttaac agaacttttc caccctacct ttaatcccat 10261 tacagttcta ttagttccag taaaagtaac ttttttagta aaactttcag atttcatttt 10321 acgagttata cttgtattat tggttaatac agtattccca acatataaag tttcattacc 10381 agttactagg ggttctccta taggtgaaac tcccatggcc ccctcagtat taaaatgata 10441 tcttcctgct tttaattcat ctaatattga tgaattagcc tcttcataag gacgtccatt 10501 agctaaatac ttataatacg gaacaagtaa tttagaataa gctgattcca tactttctat 10561 cataaaaaaa ctccttaaac taatatatta actaactgta attttaaaat tatagtcagt 10621 taatatatta tatttattaa ctcaacaaaa tgttttacat agaattccat ttttcgactt 10681 ttttttaaaa gctctaaaac ttatatgatt ttcagattta ctttaattaa ataattctta 10741 atttcaaaat aacttctaat taaatatttt aatatatcaa taatattatc gaataaacta 10801 ttccatatgc tgaaaccctt atatatcaac gctttgagac tctcgtgttt tttaataggt 10861 tagttttaga atatacatga aatacgatac acgctagtaa taccaacgct ttgaagctat 10921 tttgctaaag tagtatcgaa taaaaagaat agtatccaac tataacactt caaaccctct 10981 tgttataata tattaagtta aattatattg taaaaataaa aaaggaattc atatttattt 11041 atagaacatt aatattaacg caataaaaca tattatacta agtgtttcag tattcccaac 11101 tagtacctca aaaggttcta tgaataaatt ttccctgttt aagtgaatac ttatatgacc 11161 ccatatataa agaatgtgcg ctgatttctt tatatatggg gttatttata tttatatata 11221 ctaaaaaagc caatagaatt aatctattag cttaaatatg ttgaatgtaa tttactatct 11281 agtttatact tactaaaacc atctgtgcta aaccttacag tatacaactc actattattt 11341 aattcatatg ctactatatc tctagtatct aagatttgtt gtatattgct tgtacttaaa 11401 taaaacttat tgccttgctt attacatttt aactgtatct tatttaactt tgcatattgc 11461 tttattgtat tgcttaaatc aattgaatct cctatatttc ccagtgaatt atatttatct 11521 aatatttctt tagctttaat tatatattta ttatccttta tcaactttct attgccacta 11581 cccatacact tctctttatc ttctccatgt agatcataag ctttattata aatactatta 11641 ccattaagcc tatgtgtaat caatttatca ttatagattt cataactaac caaatcttta 11701 aatgcatggg tattatctat atcccaatct tttgtattta tatacacatc tccattttgc 11761 attgcaataa agcttgtttc attgtcacac ataaaattaa accaatctat tgtactaata 11821 tagtcctgta agctaccttc ttcccctctt aaattctcat aatcagcaac caacttttta 11881 aattctgtta atgttgtgct tttataatcc ttatttattt tcatgtttat ttaccttcct 11941 tctcattatt cttgtactct tgtataagtt caatattagt tactagttca taaaaactat 12001 cccaatccat tccattctca aaaataatat cattctcatg tatttctata tcattcatat 12061 gtatttctcc tatctttcta atatctcttt actacaactt actatttgca acacatttat 12121 gcttttacgt tctatctgtt ttgtagcttg tattatctct tttagagtcc aattgttgta 12181 atccatacaa tacaatatgt atttaaattc tctattactt attgtttctt tgccttgcat 12241 attagctaat acttgcctta attcctcacc ttctgcgttt agattaactt tgcttgtatt 12301 aaattgtttt gctttctttt ctctgtgttc taattccatc caaaataatt gttcttctaa 12361 tgtcatctat tgttgtctca cctcttttta tctctttgtg ata //