LOCUS       NC_014556               8712 bp    DNA     circular BCT 05-OCT-2010
DEFINITION  Helicobacter pylori PeCan4 plasmid pHPPC4, complete sequence.
ACCESSION   NC_014556
VERSION     NC_014556.1  GI:308183744
DBLINK      Project: 53539
KEYWORDS    .
SOURCE      Helicobacter pylori PeCan4
  ORGANISM  Helicobacter pylori PeCan4
            Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
            Helicobacteraceae; Helicobacter.
REFERENCE   1  (bases 1 to 8712)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-OCT-2010) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   2  (bases 1 to 8712)
  AUTHORS   Kersulyte,D., Vasquez,J., Gilman,R.H. and Berg,D.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JUN-2010) Molecular Microbiology, Washington
            University Medical School, 4940 Parkview Place, Saint Louis, MO
            63110, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to CP002075.
            Annotation was added by the NCBI Prokaryotic Genomes Automatic
            Annotation Pipeline Group. Information about the Pipeline can be
            found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html. Please be
            aware that the annotation is done automatically with little or no
            manual curation.
            Bacteria is available from ATCC.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8712
                     /organism="Helicobacter pylori PeCan4"
                     /mol_type="genomic DNA"
                     /strain="PeCan4"
                     /isolation_source="gastric cancer patient"
                     /host="Homo sapiens"
                     /db_xref="taxon:765963"
                     /plasmid="pHPPC4"
                     /country="Peru"
     gene            240..1643
                     /locus_tag="HPPC_08199"
                     /db_xref="GeneID:9786687"
     CDS             240..1643
                     /locus_tag="HPPC_08199"
                     /codon_start=1
                     /transl_table=11
                     /product="F4"
                     /protein_id="YP_003927871.1"
                     /db_xref="GI:308183745"
                     /db_xref="GeneID:9786687"
                     /translation="MLKDYWECFNFLTYNDYEEWSNGEDFYSFIFPNCESKGEMNKDF
                     SKPNAVFLYKDLKTTLNDTDKPALKRRIMLKDTWGDDYIDFVLENDLTLCSGLSYRGR
                     YNDLAHAQQMNALIFDLDGVGLKEITAFFEVVKYCEKNEPNRYFWPIPRPTFVVLSGV
                     GLHVYYVFDKPIDLFPNIKLQLKAYKYALTFNIWRYKETSKEKETQYQSINQSFRMVG
                     SINEKHGNKIIAFKTGDRVSLEYMNQYVKEDKRVDILKRFRPSKYTLAETKIKFPEWY
                     ERVIVRGEQREKKKWHIKKDVYEWWKKRCEEPKGGHRYFFMMCMAIYAYKCDVSKQEL
                     EKDMLEVFEKLKDIPHTNPLTKRDVYSALESYDKGMACFKIKDIEILTALRIDRNRRN
                     CQTQENHLEIARAIRDVKQSRQGKTWNNKDGRPSKQNAVLLWRIKNPQGKKIDCHKET
                     NIDPKTIHKWWDTYTPN"
     misc_feature    <690..917
                     /locus_tag="HPPC_08199"
                     /note="AE_Prim_S_like: primase domain similar to that
                     found in the small subunit of archaeal and eukaryotic
                     (A/E) DNA primases. The replication machineries of A/Es
                     are distinct from that of bacteria. Primases are
                     DNA-dependent RNA polymerases which synthesis...; Region:
                     AE_Prim_S_like; cl01287"
                     /db_xref="CDD:194095"
     gene            complement(1697..2416)
                     /locus_tag="HPPC_08204"
                     /db_xref="GeneID:9786680"
     CDS             complement(1697..2416)
                     /locus_tag="HPPC_08204"
                     /note="COG3177 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="R2"
                     /protein_id="YP_003927872.1"
                     /db_xref="GI:308183746"
                     /db_xref="GeneID:9786680"
                     /translation="MLTKDLSKLIEKLNHERKNAIKNGIYHLIQIKFSYNSNRIEGSG
                     LTYEQTAHIFDKSALITEKNENIKLDDIFETINHFECVNYLLESYREPLSLEYFKTLH
                     KILKNNCSDEVIGDFKKRPNFVGNSTTTRPKLVESELTKLLKNYQRNLEVSLENIIDF
                     HVAFEKIHPFSDGNGRVGRLVMFKECLKNNIMPFIIENEHKAFYYRGIKEYDNTKGYL
                     KDTILQSQDNFNEMVSYFFSK"
     misc_feature    complement(<1781..2416)
                     /locus_tag="HPPC_08204"
                     /note="Fic family protein [Function unknown]; Region:
                     COG3177"
                     /db_xref="CDD:32990"
     misc_feature    complement(1871..2143)
                     /locus_tag="HPPC_08204"
                     /note="Fic/DOC family; Region: Fic; cl00960"
                     /db_xref="CDD:193989"
     gene            complement(2406..2681)
                     /locus_tag="HPPC_08209"
                     /db_xref="GeneID:9786681"
     CDS             complement(2406..2681)
                     /locus_tag="HPPC_08209"
                     /codon_start=1
                     /transl_table=11
                     /product="R4"
                     /protein_id="YP_003927873.1"
                     /db_xref="GI:308183747"
                     /db_xref="GeneID:9786681"
                     /translation="MLKDVEVGVKFYKELGKLEKQLAKYQSKVLEIKTQMKEIKKQYS
                     QAKKEEKKTKNLETLQAIKDVESGANFTKIDSLDELTNELKREIHAN"
     gene            2852..3187
                     /locus_tag="HPPC_08214"
                     /db_xref="GeneID:9786682"
     CDS             2852..3187
                     /locus_tag="HPPC_08214"
                     /codon_start=1
                     /transl_table=11
                     /product="F5"
                     /protein_id="YP_003927874.1"
                     /db_xref="GI:308183748"
                     /db_xref="GeneID:9786682"
                     /translation="MNINKQIIKSLRLSKEQWQTIQTQMQEKNLNFSQLVLNSLLTQN
                     SQTPTKSKKQKAIANKELVIELAKWGNNLNQIAKCLNTNKGVWDRLGLEQLIEISYQL
                     EQIRSKYVG"
     misc_feature    3035..3169
                     /locus_tag="HPPC_08214"
                     /note="Bacterial mobilisation protein (MobC); Region:
                     MobC; pfam05713"
                     /db_xref="CDD:114439"
     gene            3177..5159
                     /locus_tag="HPPC_08219"
                     /db_xref="GeneID:9786683"
     CDS             3177..5159
                     /locus_tag="HPPC_08219"
                     /codon_start=1
                     /transl_table=11
                     /product="MobA-like protein"
                     /protein_id="YP_003927875.1"
                     /db_xref="GI:308183749"
                     /db_xref="GeneID:9786683"
                     /translation="MLVKFWGINQGGGDGDGSVNYLLNERVEQGTAKVLKGDANLTKS
                     LLLSLTQKHKACVGCLSFEEPDIDENLKHELIESFETTLLTEKMQGRYNILWVEHTDK
                     GRLELNFVIPRIDLITQKAFTPYYHSADITRIDIWKDYTNLKHAFTNPKDLEKQNTIQ
                     HHNTKTPQGKELLETYEKLDKLIQDNLGTLFNSRDDIINFLKANQCEVNRQGKDYISV
                     KLPNEPKAKRLKGFYYHETFRTIADIREQLSEVRQRESQREYPNSQRANNNHAELLRE
                     LENKLHERIEHKQRYYERLHQADPSNPRDFKEQPPGARESQQRTQQDYTSEVDRLRET
                     MLQKPNQKILTDALKFSHGVSRNGSNINGGILSHHSALQKQGIRAFTERKFAIQTANR
                     PIRQRQSAKILPTNTDQEIRRKNAEQLLKQVAERFNQRNRELTERERDLAQRKEQRDS
                     KFRERQKRAIDQARESYSRISKTKQRLLEIRGRNLELERELRNAIPNAQHIISQISSF
                     RESRESRIESINANIRTERSLAQKRFTDNVRTDFTTRITECSNQRARDFTSSIQRIEN
                     TIRDFRNNAQARVRTILHNLYARTRDAINTIKDIYRNAKERIRDFFQRADERLSKRME
                     QETRELHTKTTQLDRKIREHNQKIENERNYSRGYGR"
     misc_feature    <3354..3851
                     /locus_tag="HPPC_08219"
                     /note="Relaxase/Mobilisation nuclease domain; Region:
                     Relaxase; cl01584"
                     /db_xref="CDD:174650"
     gene            4420..5121
                     /locus_tag="HPPC_08224"
                     /db_xref="GeneID:9786684"
     CDS             4420..5121
                     /locus_tag="HPPC_08224"
                     /codon_start=1
                     /transl_table=11
                     /product="MobD-like protein"
                     /protein_id="YP_003927876.1"
                     /db_xref="GI:308183750"
                     /db_xref="GeneID:9786684"
                     /translation="MQNNCLNKLQNALINEIENLQNEKEILLKEKNSEIASLENDRNE
                     LLIKLEKVTAEFQKLSNDYLKLEAEILNLKESYETLSQTHNTLLAKFQALERAERAEL
                     NQLMQTLEQKEVSLKNDLQTMCEQILQQELQSAQIKEQETSQAQYKELKTQLEILETT
                     LKQELEQSYTTFMQEHETQLTQLKTSTETQKNELETSFNEQMNDFQNEWNKKQESFIQ
                     KQHSWIERLENTIKK"
     misc_feature    4597..>4854
                     /locus_tag="HPPC_08224"
                     /note="type I restriction enzyme EcoKI subunit R;
                     Provisional; Region: hsdR; PRK11448"
                     /db_xref="CDD:183141"
     gene            complement(5166..6668)
                     /locus_tag="HPPC_08229"
                     /db_xref="GeneID:9786685"
     CDS             complement(5166..6668)
                     /locus_tag="HPPC_08229"
                     /note="COG1132 ABC-type multidrug transport system, ATPase
                     and permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-type transport system, permease and
                     ATP-binding protein; putative membrane protein"
                     /protein_id="YP_003927877.1"
                     /db_xref="GI:308183751"
                     /db_xref="GeneID:9786685"
                     /translation="MQTIIAEQFSINIITQLANKFTKVKNLNFFENKDHTIKLNAIHN
                     GLYIRPLNYVSNLFFNLQRIIGLVSLFGILFSISIYLPFIMIFATVPCIFISNHIAKK
                     HSASIDKLQDQKESMQNYLYSGLDNQKNKDNLLFNFMLNFHHKFIENKELYINHFVKI
                     AQKNLMLTIYADILITTLSIALFFLMVFIILSKLIGVGAIAGYIQAFSSTQQQLQDLS
                     FYGKWFFAINKYFENYFCILDYKMPKPETQIKLEEKIHSITFENISFSYPNSKLIFEN
                     FNLSLHSDKIYALVGKNASGKTTLIKLLLGFYIPNSGQIIINNKYSLQDLELNSYHQQ
                     MSAIFQDFSLYAGYSIDDNLFMQNNPTREQLKQKREMLKSFDENFQNCLNDYSNALFG
                     TQYNGIDFSLGQKQRIATIRAFLKPSHCVVLDEPSSTIDPIIEKEFLDFIFKKSQSKI
                     ALIITHRMGSVKQADEIIVLDKGKLIEQGNFETLIKKQGLFSELYLKQQY"
     misc_feature    complement(5172..6662)
                     /locus_tag="HPPC_08229"
                     /note="ABC-type multidrug transport system, ATPase and
                     permease components [Defense mechanisms]; Region: MdlB;
                     COG1132"
                     /db_xref="CDD:31327"
     misc_feature    complement(5202..5903)
                     /locus_tag="HPPC_08229"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop NTPase; cl09099"
                     /db_xref="CDD:158411"
     misc_feature    complement(5775..5798)
                     /locus_tag="HPPC_08229"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(order(5301..5303,5394..5399,5649..5651,
                     5772..5780,5784..5789))
                     /locus_tag="HPPC_08229"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(5649..5660)
                     /locus_tag="HPPC_08229"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(5442..5471)
                     /locus_tag="HPPC_08229"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(5394..5411)
                     /locus_tag="HPPC_08229"
                     /note="Walker B; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(5376..5387)
                     /locus_tag="HPPC_08229"
                     /note="D-loop; other site"
                     /db_xref="CDD:72971"
     misc_feature    complement(5295..5315)
                     /locus_tag="HPPC_08229"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:72971"
     gene            complement(6923..8479)
                     /locus_tag="HPPC_08234"
                     /db_xref="GeneID:9786686"
     CDS             complement(6923..8479)
                     /locus_tag="HPPC_08234"
                     /note="COG4403 Lantibiotic modifying enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="lanthionine synthetase C-like protein"
                     /protein_id="YP_003927878.1"
                     /db_xref="GI:308183752"
                     /db_xref="GeneID:9786686"
                     /translation="MKKDTEPNRLRLYETLFNNWFDIEEIVSIEKYISRYRYILFRRM
                     EFFLVPTIAKLIFDAKQNKIPNAYEYYFNDTKIILNKLHEIGILNRVRSNLVNFTILT
                     KNTIEKSIEALLLSKIISCKNDIKSIEVEFSDLHSLVFTSILVTIKKNRKFFIKSSLT
                     DPSKVFYDVCKILNIHTKKKSVYWQSDLLNVADYIEYDPDVKDIEFFYKRVAELMAVS
                     ATLNLTDIHLENLLVSDGLPVILDFETLFTFKETSSGLIDNTITDVEATLFIEPVQEL
                     INNNTLDNKRRSIISGLQGGEVRNKSFLYPFVINDGSDEFRVSYRKLSHYQSHNRISS
                     NKTIIQPHLYSKIITNSFTETMLEICKNRQKLLDILNENYLSNFKYRHILRPTSFYSF
                     ISVRSWQPKEYINWDTYWNKIELTLDNQQVNCFSKNAKKQIVQYEIQTIQKGLVPLFY
                     RDINTCNLYTADSQTIKNAFRKPLIKNIKSKISQISDEYIHQNVLSIEESLNLSRSIN
                     QEEKNIGWIR"
     misc_feature    complement(<6977..8281)
                     /locus_tag="HPPC_08234"
                     /note="LanC-like proteins. LanC is the cyclase enzyme of
                     the lanthionine synthetase. Lanthionine is a lantibiotic,
                     a unique class of peptide antibiotics. They are
                     ribosomally synthesized as a precursor peptide and then
                     post-translationally modified to contain...; Region:
                     LanC_like; cl04955"
                     /db_xref="CDD:195013"
ORIGIN      
        1 aattacgcta gaatagggaa aaacaatatt gataaatata agccccctag tgtcagcttt
       61 agctgacgat aaatatcaaa ctagagcata gctctagttc accgattaca tgggacttgt
      121 aaggcaatat catgtggttt tttatttaat ggtatttatt gttttaaaaa gttaaatttt
      181 aagaaaaaat aacaataaaa gtgaatttct aaatgaaatg atagattgga ggtcatggaa
      241 tgttaaaaga ttattgggag tgttttaatt ttttgactta caatgattat gaagaatgga
      301 gcaatgggga ggatttttat agttttattt ttcctaattg tgagagtaag ggtgaaatga
      361 ataaggattt ttctaagcca aatgctgtgt ttttgtataa agacttaaag acaactctaa
      421 atgataccga taaaccagct ttaaaacgcc gtataatgct taaagacact tggggcgatg
      481 attatattga ttttgtgcta gaaaacgatt taacgctatg tagcggctta agttataggg
      541 gtaggtataa tgacttagct catgctcaac aaatgaacgc tttaattttt gatttagatg
      601 gggtagggtt aaaagaaatt accgcttttt ttgaagtggt taaatattgt gaaaaaaacg
      661 agcctaacag atatttttgg cctataccta gaccgacatt tgttgtttta agtggggtag
      721 gtttgcatgt gtattatgtg tttgataagc ctatagattt atttccaaat atcaaactcc
      781 agcttaaagc ttataaatac gctcttacat tcaatatttg gcgttataaa gagactagca
      841 aagaaaaaga aactcaatat cagtcaatca atcaatcttt tagaatggta gggagcatta
      901 acgaaaagca tggcaataag attatcgcct ttaaaacagg cgatagagtg agtttggaat
      961 acatgaacca atatgtcaaa gaagataaaa gagtggatat tttaaagcgt tttagaccga
     1021 gcaaatacac cttagcagag actaaaatta aatttcccga atggtatgag agagtgatag
     1081 ttaggggcga acaaagagaa aaaaagaaat ggcatattaa aaaagatgtg tatgagtggt
     1141 ggaaaaagcg ttgtgaagag cctaagggag ggcatcgcta tttttttatg atgtgtatgg
     1201 ctatttatgc ttacaaatgc gatgtatcca agcaagagct agaaaaggat atgttagaag
     1261 tttttgaaaa attaaaagat ataccccaca ctaacccctt aactaagcga gatgtttata
     1321 gtgcgttaga gagctacgat aagggtatgg cgtgttttaa aattaaggat attgaaatcc
     1381 ttacggcgtt aagaattgat aggaataggc gaaattgtca aacccaagaa aatcatttag
     1441 aaatagcaag ggctataaga gatgttaaac agagccgaca gggaaagact tggaataata
     1501 aagatggtag acccagcaaa cagaatgcgg ttttgctatg gcgtatcaaa aacccacaag
     1561 gcaaaaaaat tgattgccat aaggaaacaa atatagaccc aaagaccatt cataagtggt
     1621 gggacactta cacaccaaac tagaattagt ctcaatacga gtaaaaccta tgctaagaga
     1681 gtagaagtga aacagactat ttagaaaaga aatagctaac catttcattg aaattgtctt
     1741 gactttgcaa aatggtgtct ttcaagtagc cttttgtgtt gtcatattcc ttgatgcccc
     1801 tgtagtaaaa ggctttgtgt tcgttttcta tgatgaaagg catgatattg ttttttaagc
     1861 attctttaaa catcactaat cgccccaccc taccattgcc atcgctaaaa gggtgtatct
     1921 tttcaaaagc cacatgaaaa tctatgatgt tttccaaact cacttcaagg ttgcgttggt
     1981 aattttttaa aagttttgtt aactcgcttt caaccaattt gggtcttgtt gtggtgctat
     2041 tgcctacaaa attagggcgt tttttaaaat caccaataac ttcatcagag caattatttt
     2101 ttaagatttt gtgtaaggtc ttaaagtatt ctaaactcaa aggttctcta taactttcaa
     2161 gtaagtaatt tacgcattca aagtgattga tagtttcaaa aatatcatca agtttgatat
     2221 tttcattttt ttcagttata agagcagatt tatcaaaaat atgagcggtt tgttcataag
     2281 tcaaaccgct tccttcaatg cgattagagt tgtaagaaaa tttgatttgg atcaagtggt
     2341 aaatgccatt tttgatagca ttctttcttt cgtgattcag tttttctatg agtttagata
     2401 aatccttagt tagcatgtat ttctcttttt aactcatttg taagctcatc taaactatca
     2461 atttttgtaa aattagcccc actctctaca tcttttatcg cttgtaaagt ctctaaattt
     2521 ttagtttttt tctcttcttt cttagcttga gaatattgct ttttaatctc tttcatttgt
     2581 gttttaattt ctaaaacttt actttgatac ttagctaatt gtttttctaa tttgccaagc
     2641 tccttataaa atttaacccc tacttctaca tctttcaaca tctcagctcc ttgtgttaaa
     2701 caacattgta gtcccattat atctaaaact cagtcaatct atgctaaact acaattaaaa
     2761 gggcaagcat atattttgta atacaatatt acaaaatagc ttgcaatggg gtaatccccc
     2821 ttgaccccct aaaaatcaaa taagggaaca agtgaatata aacaaacaaa ttattaaaag
     2881 tcttaggtta tctaaagaac aatggcaaac tatccaaact caaatgcaag aaaaaaattt
     2941 aaacttctct caattggttt taaactctct tttaactcaa aactcacaaa ctccaacaaa
     3001 atctaaaaaa caaaaagcga ttgctaataa agaactagtt attgaattag ctaagtgggg
     3061 aaacaattta aaccaaatcg ctaaatgtct caacactaat aaaggagtat gggatagatt
     3121 aggtttagaa caactcatag aaatcagtta ccagttagaa caaataagat ccaagtatgt
     3181 tggttaaatt ttggggcatt aatcaagggg gcggcgatgg tgatgggagc gttaattact
     3241 tgcttaatga aagggtagaa caaggcacag ctaaagtttt aaagggcgat gctaatctaa
     3301 ctaaaagcct tttactctct cttactcaaa aacacaaggc atgcgtaggg tgtttatcct
     3361 ttgaagagcc tgacattgat gaaaatctca aacacgaatt gatagaaagt tttgaaacca
     3421 ctttattgac tgaaaaaatg caagggcgtt acaacatttt atgggtagaa cacacagaca
     3481 aggggcgttt ggagttgaat tttgttatac ctagaattga tttgataact caaaaagcct
     3541 ttacccccta ttaccatagt gcagacatca cacgcattga catttggaag gattatacca
     3601 acttaaaaca cgcctttact aaccctaaag acttagaaaa acaaaacacc attcaacacc
     3661 acaacacaaa gaccccacaa ggcaaagaac ttttagaaac ctatgaaaaa ctagacaagc
     3721 ttatacaaga caacttagga acgctattta atagccgaga tgacatcatc aattttttaa
     3781 aggctaatca atgcgaagtt aatagacaag gtaaggatta tatcagtgtc aagctaccca
     3841 acgaacctaa agccaaacga ttgaaaggat tttactacca tgaaacattc agaactattg
     3901 cagacattag agagcaactt agcgaagtta gacagcgaga gagccaacga gaatacccaa
     3961 actctcaaag agctaataac aatcatgcag aactactgcg agagcttgaa aacaaattac
     4021 acgagcgtat tgaacacaaa caacgctact atgaaagatt acaccaagct gatccaagca
     4081 acccaagaga ttttaaagaa cagccacctg gagctagaga aagccaacaa agaacacaac
     4141 aagactatac aagcgaagtt gatagactta gagaaacaat gttacaaaaa cctaaccaaa
     4201 aaatccttac tgatgccctt aaattttctc atggggttag tcgtaatggg agcaatatca
     4261 atgggggcat actttctcat cattctgccc tacaaaaaca aggaattaga gcttttacgg
     4321 aaagaaaatt tgcaattcaa acagcgaata gaccaattag acaacgccaa tctgcaaaga
     4381 ttttaccaac caataccgac caagaaataa ggagaaaaaa tgcagaacaa ttgcttaaac
     4441 aagttgcaga acgctttaat caacgaaata gagaacttac agaacgagaa agagatcttg
     4501 ctcaaagaaa agaacagcga gatagcaagt ttagagaacg acagaaacga gctattgatc
     4561 aagctagaga aagttacagc agaatttcaa aaactaagca acgattactt gaaattagag
     4621 gcagaaatct tgaacttgaa agagagctac gaaacgctat cccaaacgca caacacatta
     4681 ttagccaaat ttcaagcttt agagagagca gagagagccg aattgaatca attaatgcaa
     4741 acattagaac agaaagaagt ctcgctcaaa aacgatttac agacaatgtg cgaacagatt
     4801 ttacaacaag aattacagag tgctcaaatc aaagagcaag agacttcaca agctcaatac
     4861 aaagaattga aaacacaatt agagatttta gaaacaacgc tcaagcaaga gttagaacaa
     4921 tcctacacaa cctttatgca agaacacgag acgcaattaa cacaattaaa gacatctaca
     4981 gaaacgcaaa agaacgaatt agagacttct ttcaacgagc agatgaacga ctttcaaaac
     5041 gaatggaaca agaaacaaga gagcttcata caaaaacaac acagctggat agaaagatta
     5101 gagaacacaa tcaaaaaata gaaaacgaga gaaattatag tcgtgggtat gggcggtaag
     5161 tcgctttaat attgttgctt caaatataat tcagaaaata agccctgttt ctttataagg
     5221 gtttcaaagt tgccctgttc tataagtttg cctttgtcta acacaataat ttcatcagcc
     5281 tgtttgacgc tacccatgcg gtgtgtaatg attaaagcaa tcttagattg cgatttttta
     5341 aaaataaaat ccaaaaactc tttttctata atggggtcaa tagtgctgct tggctcatct
     5401 aaaacaacac aatgacttgg ttttaaaaag gctcttatag tggctatgcg ttgcttttga
     5461 cccagagaaa aatctatccc attatactgt gttccaaata atgcgttgct ataatcatta
     5521 agacaatttt gaaaattttc atcaaaagat tttagcattt ctctcttttg ctttaattgc
     5581 tctcttgtgg ggttgttttg catgaaaaga ttatcatcaa tgctataccc agcataaaga
     5641 gaaaaatctt ggaatatggc actcatttgt tggtggtagc tgtttagctc taaatcctgt
     5701 aacgagtatt tgttattgat aataatttga cctgaatttg ggatataaaa ccctagcaat
     5761 aatttaatca gcgtggtttt tccgctagca ttcttgccga ctagtgcata aattttatca
     5821 gagtgtaaag agagattaaa gttttcaaaa ataagttttg aattaggata agagaaacta
     5881 atattttcaa atgtaatgct atggattttt tcttctaatt tgatttgtgt ttctggtttt
     5941 ggcattttgt aatctaaaat acagaaataa ttttcaaagt atttattgat agcaaaaaac
     6001 cactttccat aaaatgataa atcttgtagt tgctgttggg tagagctaaa tgcttggata
     6061 tacccagcaa ttgctcccac accaattaat tttgaaagga taataaaaac cattagaaaa
     6121 aatagtgcga tacttagagt ggtgattaaa atatcagcat atatggtaag cattaagttt
     6181 ttttgggcga ttttcacaaa atgattgata tataattctt tgttttcaat aaatttatga
     6241 tgaaaattta gcatgaagtt aaataacaag ttgtccttat ttttttggtt atctaatcca
     6301 gagtataggt aattttgcat actctctttt tggtcttgaa gcttatctat ggaagcacta
     6361 tgtttttttg ctatatgatt ggagatgaaa atacaaggca ctgttgcaaa aatcattata
     6421 aagggtagat aaatactaat ggaaaataat atcccaaaca gactcacaag ccctataatg
     6481 cgttgcaagt taaaaaatag attactgaca taatttaggg gacggatgta tagaccgtta
     6541 tggatagcgt taagcttaat agtgtgatct ttgttttcaa aaaaatttag atttttaact
     6601 tttgtgaatt tattagcaag ctgagtgatg atgtttatag aaaattgttc agcaataatg
     6661 gtttgcaagc ttgatgaaat tcctgagaac acatgcgtta aaaacagcaa ggctccccat
     6721 agtagcaaag ttggtaacag caagctgtat tcaaaatgcg tatgattttg caataggtct
     6781 accacaatat caatcaatct tatcataaca agaatattta tagatggaat aatgccgata
     6841 aatagcactg taattgatgc caacacaaca cattttggtg agcttttata gagtaaaatg
     6901 aaagtcctta gaggaatgct ttttatcgta tccatccgat atttttctct tcctggttga
     6961 tggatctgga taaatttaag ctttcttcta ttgataaaac attttgatga atgtattcat
     7021 cggatatttg actaatttta ctttttatgt ttttaattag cggtttccta aaagcatttt
     7081 ttattgtttg tgaatccgct gtatacaggt tgcatgtatt gatatcacga tagaataatg
     7141 ggacaagtcc tttttgtatg gtttgtattt cgtattgaac gatttgtttt ttggcattct
     7201 ttgagaaaca atttacttgt tggttatcca gtgttagctc aatcttattc cagtaagtgt
     7261 cccagttaat atattcttta ggttgccaac ttctgacaga tataaaacta tagaatgatg
     7321 ttggtctcag gatatgtctg tatttaaaat tagataagta gttttcatta agaatatcta
     7381 ataatttttg tctgtttttg caaatttcaa gcattgtttc tgtaaaggaa tttgtgatta
     7441 tttttgagta gagatgcggt tgtataatag ttttattaga tgatattcta ttatgtgatt
     7501 gataatgact taattttcta tagcttaccc taaactcatc gctaccatca ttaatcacaa
     7561 atgggtagag aaaacttttg ttcctaacct cgccaccctg taacccagaa ataatacttc
     7621 tcctcttatt gtcaagtgtg ttgttattga taagctcttg aactggttca ataaataatg
     7681 tggcctcaac atctgttata gtgttgtcaa taagaccaga agatgtttct ttgaatgtaa
     7741 ataatgtctc aaaatctagt attactggta atccatcaga gactaacaag ttttctagat
     7801 ggatgtcggt aagatttaat gttgcagaaa cagccattaa ttctgcaact cttttgtaaa
     7861 aaaactctat atcctttaca tcagggtcat attcgatata gtcagctaca tttagtaagt
     7921 ccgattgcca atatacactt ttcttttttg tgtgtatatt taatattttg catacatcgt
     7981 aaaatacttt tgatgggtct gttagtgagg atttaataaa aaattttctg ttttttttga
     8041 ttgttactag tatggaagta aaaacgagcg aatgcaaatc actaaactct acttcaatgc
     8101 tcttaatatc gtttttacaa gaaataatct tggatagcaa gagtgcttct attgattttt
     8161 ctatagtatt ttttgttagg atagtaaaat tgacaaggtt tgagcgaact ctgtttaaaa
     8221 taccaatttc atgcagtttg tttagaatta tttttgtgtc gttaaagtag tattcatatg
     8281 cgttgggaat tttattttgc ttagcatcaa atattagttt agcaatggtc ggaactaaaa
     8341 agaactccat tcgtctgaaa agtatatatc tatacctaga tatatacttt tctatagata
     8401 caatttcttc aatgtcgaac caattgttga agagagtctc atacaatctt aaacgatttg
     8461 gttctgtatc tttcttcatt gagctcactt cagccagtca caagttccac tagcacaaca
     8521 agccgtagaa tctccaaaaa agaaatgagt ctcaataata tcaaaactaa tttcatctaa
     8581 tccagtgtaa aagttttcta attccataat ttacctccgg ttttttgctt aaactaaaac
     8641 gatacaaatt atatcattag agatgaataa ttattataaa agtaatatca gtaataagta
     8701 ttgtgtgtag at
//
