LOCUS NC_014333 14219 bp DNA circular BCT 20-JUL-2010 DEFINITION Bacillus anthracis CI plasmid pBAslCI14, complete sequence. ACCESSION NC_014333 VERSION NC_014333.1 GI:300885230 DBLINK Project: 50615 KEYWORDS . SOURCE Bacillus cereus biovar anthracis str. CI ORGANISM Bacillus cereus biovar anthracis str. CI Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group. REFERENCE 1 (bases 1 to 14219) AUTHORS Klee,S.R., Brzuszkiewicz,E.B., Nattermann,H., Bruggemann,H., Dupke,S., Wollherr,A., Franz,T., Pauli,G., Appel,B., Liebl,W., Couacy-Hymann,E., Boesch,C., Meyer,F.D., Leendertz,F.H., Ellerbrok,H., Gottschalk,G., Grunow,R. and Liesegang,H. TITLE The Genome of a Bacillus Isolate Causing Anthrax in Chimpanzees Combines Chromosomal Properties of B. cereus with B. anthracis Virulence Plasmids JOURNAL PLoS ONE 5 (7), E10986 (2010) PUBMED 20634886 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 14219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-JUL-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 14219) AUTHORS Klee,S.R., Brzuszkiewicz,E.B., Nattermann,H., Brueggemann,H., Dupke,S., Franz,T., Pauli,G., Appel,B., Liebl,W., Couacy-Hymann,E., Meyer,F.-D., Leendertz,F.H., Gottschalk,G., Grunow,R. and Liesegang,H. TITLE Direct Submission JOURNAL Submitted (11-SEP-2009) Goettingen Genomics Laboratory, Georg-August University Goettingen, Grisebachstrasse 8, Goettingen, Lower Saxony D-37077, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to CP001749. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..14219 /organism="Bacillus cereus biovar anthracis str. CI" /mol_type="genomic DNA" /strain="CI" /db_xref="taxon:637380" /plasmid="pBAslCI14" gene complement(105..449) /locus_tag="BACI_pBAslCI1400010" /db_xref="GeneID:9452479" CDS complement(105..449) /locus_tag="BACI_pBAslCI1400010" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787131.1" /db_xref="GI:300885231" /db_xref="GeneID:9452479" /translation="MAAKKKLEVIDLPIDISTPQATLQTRKTWLDAWKERKVDGKDMN TLNYALQGVSKDHELIQAEERIKIEWHRAETQREQLVHTKEKMEKQRERIEQLELLIT QYRCNFSALIIL" gene complement(465..719) /locus_tag="BACI_pBAslCI1400020" /db_xref="GeneID:9452458" CDS complement(465..719) /locus_tag="BACI_pBAslCI1400020" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787132.1" /db_xref="GI:300885232" /db_xref="GeneID:9452458" /translation="MVEELRKLEVEYNLGEYGIYACKWEEIQAFYKIGKLNDTQVTHI YNRKRLYDPSLLNTELVADEIVEKEEDPCRKIARELRRML" gene complement(757..1173) /locus_tag="BACI_pBAslCI1400030" /db_xref="GeneID:9452459" CDS complement(757..1173) /locus_tag="BACI_pBAslCI1400030" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787133.1" /db_xref="GI:300885233" /db_xref="GeneID:9452459" /translation="MASLKQLEKRLKKIQEQRIPKIDVMITDDREYAESYRSKAKECI IIIDDISATFDENFDVMEEYREESPEHYAMLMRLKAEDEEIALDKTSDLDKWVKGDIL YIRIGKRGTGGIEEIDLNQMSKGIRREITRGITEIH" gene complement(1173..1439) /locus_tag="BACI_pBAslCI1400040" /db_xref="GeneID:9452460" CDS complement(1173..1439) /locus_tag="BACI_pBAslCI1400040" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787134.1" /db_xref="GI:300885234" /db_xref="GeneID:9452460" /translation="MGEVIEIEKQKDRRIELFIEGKFTRQEFVNYFDSLARFFEGEYE GKGKEKIDEFIKAYKPKKVRRHQGKPHGNKRKQQILQVLRGGLE" gene complement(1488..1898) /locus_tag="BACI_pBAslCI1400050" /db_xref="GeneID:9452461" CDS complement(1488..1898) /locus_tag="BACI_pBAslCI1400050" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787135.1" /db_xref="GI:300885235" /db_xref="GeneID:9452461" /translation="MDYFTECKKYEEAKGFVKSHEEDFARFSQIYNDLCFWLPETIEI KGVDIDVKKVDERYGVNFREYDATIAINDSSYGGVTIHYVQEFISGSRSVIESAEIKR NEDVVHSISSGVTAEKLRDGIKEAYSMIKNGEIK" gene complement(1934..2347) /locus_tag="BACI_pBAslCI1400060" /db_xref="GeneID:9452462" CDS complement(1934..2347) /locus_tag="BACI_pBAslCI1400060" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787136.1" /db_xref="GI:300885236" /db_xref="GeneID:9452462" /translation="MTKLQDLYKRREELGGYLKQGSDVQDEKKVESGLTNNIINDTEV TGTTERNARELELGITETMKAQAQHPLNLIKIGELSYFEPHKSKSQIFEEVVGMKYAQ YKEVAPDKNRRAAISFVENIPVENQLLREKQGRSL" gene complement(2363..2575) /locus_tag="BACI_pBAslCI1400070" /db_xref="GeneID:9452463" CDS complement(2363..2575) /locus_tag="BACI_pBAslCI1400070" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787137.1" /db_xref="GI:300885237" /db_xref="GeneID:9452463" /translation="MTTEELQAELEENRKWFANYKKQEVERELKEVNKQIAELEAKDA DRIEEECEKKDMAAINTAFDKGLNYL" gene 2851..3564 /locus_tag="BACI_pBAslCI1400080" /db_xref="GeneID:9452464" CDS 2851..3564 /locus_tag="BACI_pBAslCI1400080" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787138.1" /db_xref="GI:300885238" /db_xref="GeneID:9452464" /translation="MDFGRFSGQVSKELDVNGNTLRVWCLELENAGYKFERNNRQQRI YYEHDINILKEMKVLMSDGTRTLQEAISILLESSLSKDTDNAITHSINESVGSEATPF QRNNSAAGVAYAILEQTNEKVAELIKQQQTIALQNQEILNVIHKDNEEKRNVIQAVFE KQQQIIDQQQDIHLQNQSITKMYLEEREGRLKEGQEKNELKEQLSDMQVKMNEMLEYV HQQSEEKSKSFFSKFFSKK" misc_feature 2872..3045 /locus_tag="BACI_pBAslCI1400080" /note="Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600" /db_xref="CDD:194374" misc_feature order(2872..2874,2914..2916,2971..2979) /locus_tag="BACI_pBAslCI1400080" /note="DNA binding residues [nucleotide binding]" /db_xref="CDD:133389" gene 3894..4298 /locus_tag="BACI_pBAslCI1400090" /db_xref="GeneID:9452465" CDS 3894..4298 /locus_tag="BACI_pBAslCI1400090" /codon_start=1 /transl_table=11 /product="putative SpbB protein" /protein_id="YP_003787139.1" /db_xref="GI:300885239" /db_xref="GeneID:9452465" /translation="MKGDKRTRVSKPIIVGTLPQVIIDEYELKCDSNDVQMHPGVIKH IKKRHPGIYEQYSVNMKDIIENPDYVGRNPTEPNSVELIKLIDKHILIAVKLDPSGYL FLSSMYDMHNGPVKIEKRLNSERLKPFKDLLS" gene complement(4447..4830) /locus_tag="BACI_pBAslCI1400100" /db_xref="GeneID:9452466" CDS complement(4447..4830) /locus_tag="BACI_pBAslCI1400100" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787140.1" /db_xref="GI:300885240" /db_xref="GeneID:9452466" /translation="MLKPLRIQSRAVFGCLGVFHHSSSTSVTLRQSGFTQRISNCVED NCFTFARLPHSSQRLYFVFFNIIIIAFRCRLIEKVTTSDKKVNTKSHPLKKRMAYRSR IDGRAAYPTSLVTYLTDQIIDQERS" gene 5220..5281 /locus_tag="BACI_pBAslCI1400110" /db_xref="GeneID:9452467" ncRNA 5220..5281 /locus_tag="BACI_pBAslCI1400110" /ncRNA_class="antisense_RNA" /product="RNA-OUT" /note="RF00240" /db_xref="GeneID:9452467" gene complement(6157..6423) /locus_tag="BACI_pBAslCI1400120" /db_xref="GeneID:9452468" CDS complement(6157..6423) /locus_tag="BACI_pBAslCI1400120" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787141.1" /db_xref="GI:300885241" /db_xref="GeneID:9452468" /translation="MRLPTSNKLFALFSRTRLIRYTYYSRYYIQISTSNYLESFMYIR IAKLKAVSLSRSLVNRYELPGRDAAFLCSVHVELPEPTLKTDKT" gene 6612..6706 /locus_tag="BACI_pBAslCI1400130" /db_xref="GeneID:9452469" ncRNA 6612..6706 /locus_tag="BACI_pBAslCI1400130" /ncRNA_class="antisense_RNA" /product="ctRNA pT181 type" /note="RF00242" /db_xref="GeneID:9452469" gene complement(6972..8240) /locus_tag="BACI_pBAslCI1400140" /db_xref="GeneID:9452470" CDS complement(6972..8240) /locus_tag="BACI_pBAslCI1400140" /codon_start=1 /transl_table=11 /product="hypothetical GntR-type regulatory protein" /protein_id="YP_003787142.1" /db_xref="GI:300885242" /db_xref="GeneID:9452470" /translation="MEQTNQDLNKLTKLEYDKVPKFMRGAIGKKYGFNSLSRDIVGFL RNRMSVSVKNGWKEDGRYYVKASSKEMCDEFVTTNKTLDKALKIVEDIGYISSKKGFN SSKKFFIDFEIEARLNEEYLQWKEENKSVGMHTDKLTKSDSLGESTKLANNESECLNI NSLGNIPILNETSNDNSLGNSPNQFRKNSYLERSTLERRTKDIKTYTDVLEFVNICRR DFVHLKTMDEQELQGHAEKWYEAYDPEKEASIKTWIRACAEDLNESIEDPLHTSDVFT ERFYEDLEKKESIQENESPKVEKIQTPVGYVDVSVVDDIHNPFLDEEYLAMVDNTPIQ DSVHEVLEEINTITLDEEVKPVTSKSDKPKGSNLTYDDLERLAKLVKQANSGDQDAIM KCNSDRMEKYVGMNEFGFEIRSELYSLAAV" misc_feature complement(7980..8189) /locus_tag="BACI_pBAslCI1400140" /note="Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970" /db_xref="CDD:148536" gene 8396..8451 /locus_tag="BACI_pBAslCI1400150" /db_xref="GeneID:9452471" ncRNA 8396..8451 /locus_tag="BACI_pBAslCI1400150" /ncRNA_class="other" /product="CopA-like RNA" /note="RF00042" /db_xref="GeneID:9452471" gene complement(8542..8940) /locus_tag="BACI_pBAslCI1400160" /db_xref="GeneID:9452472" CDS complement(8542..8940) /locus_tag="BACI_pBAslCI1400160" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787143.1" /db_xref="GI:300885243" /db_xref="GeneID:9452472" /translation="MTNTIYDDLKVVEKDIKGLGERAEQMYVENIDDNKQGSAEFIFE GLYNKVKNNVNGLDEDLYHTRNDMRRGVLSVIIKGVTKATGEAIQEVSELGNWEAYNA MDYLIEYSQTISKVYHNLNLIEMKMEKEEE" gene complement(9320..9508) /locus_tag="BACI_pBAslCI1400170" /db_xref="GeneID:9452473" CDS complement(9320..9508) /locus_tag="BACI_pBAslCI1400170" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787144.1" /db_xref="GI:300885244" /db_xref="GeneID:9452473" /translation="MNNEEKQLLESKFFWLVNGLNEMLEEANPNEGENATLDNVNIDH LLECVEWMHGVTNQLQNR" gene complement(9574..9786) /locus_tag="BACI_pBAslCI1400180" /db_xref="GeneID:9452474" CDS complement(9574..9786) /locus_tag="BACI_pBAslCI1400180" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787145.1" /db_xref="GI:300885245" /db_xref="GeneID:9452474" /translation="MTEKKSKAVTFFENRMRDYGVETMIEAKQIYNMMIAITKVAENK ELSEEQIKEWTDSAIKRGIEKRNKDR" gene complement(10068..12317) /locus_tag="BACI_pBAslCI1400190" /db_xref="GeneID:9452475" CDS complement(10068..12317) /locus_tag="BACI_pBAslCI1400190" /codon_start=1 /transl_table=11 /product="putative phage tail tape measure protein" /protein_id="YP_003787146.1" /db_xref="GI:300885246" /db_xref="GeneID:9452475" /translation="MEVFKIFGTLGLRDNEYRSGLSRAEQQGQRASNSINKGFKSTGS MFSGMGIAAGGFGAAMMGMAGTTVGVGAALAGIVSTGATYERTMSEVKAVSGANAEQM AELGTEARRLGASTSFSAKEAGEGMKFLAMSGMSTNDVLKSTEPMLRLAEAGALDLGQ AADIATNIMSSFGLKADSAGHTADVLAAAASKSNTNVQQMGEAMKYGAGAASTLGFDM EETAAAIMSMANRGLQGSIAGQAFATSLTRLAKPTKEMQKTMDGLGLSFFDSQGKIKP MIDIVKMLEDRTAGMSEQQKSATLSTLFGAEAFKNWAAVLGEGSEKLQQNEQMLRNSN GAATEMSNTMNDNLIGAWKNFTSAVSEVALQIYDVLGPALTDAVKWMTDLVTSFSTGG SNVGIFQGAFAALAEYFTPAMEGMRGVSESFANAFSSYGAVVVSVAGEVWNFIKGVFD IMKPYIMGAINEISSFTSSILNQIAGFWRENGQQISQAVSVAFSFIQSVISAVMPIIS FIISSTWESIKSVINGALNIIMGLIKVFASVLTGDWRGAWEGIKQILSGAWDAMWGIV GLWTGKITGLVSKFVPGLGTIFKPVTKLISEPFELAWKAVEKVVGWITKAWDGISGIL GKVKDGASALGGFVGGMLPGGRSAPVSAAPVNGFASGGIFKPNQERMIKIGDAKSYDE AVLPLNKGTLGEIGKKIAETMPFNQSYGSKPIQITNDIHIDGRRFARQTAVYMDEELG RRKARQVRV" misc_feature complement(11154..12086) /locus_tag="BACI_pBAslCI1400190" /note="phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760" /db_xref="CDD:188165" misc_feature complement(10074..>11255) /locus_tag="BACI_pBAslCI1400190" /note="Phage-related protein [Function unknown]; Region: COG5412" /db_xref="CDD:34971" gene 12380..12455 /locus_tag="BACI_pBAslCI1400200" /db_xref="GeneID:9452476" ncRNA 12380..12455 /locus_tag="BACI_pBAslCI1400200" /ncRNA_class="other" /product="suhB-like RNA" /note="RF00519" /db_xref="GeneID:9452476" gene 12623..13180 /locus_tag="BACI_pBAslCI1400210" /db_xref="GeneID:9452477" CDS 12623..13180 /locus_tag="BACI_pBAslCI1400210" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase" /protein_id="YP_003787147.1" /db_xref="GI:300885247" /db_xref="GeneID:9452477" /translation="MKYGYARVSTTNQDLESQIQTLQKEDCSVIYSEKFTGTKANRPE FNKLLAKLEDGDTLVVTKLDRFARSTVDAIQTVKELFDRGVKVHILNMGLVENTPTGR LVFNVMSAFAEFERDMIVERTQEGKAIAKQNPDFKEGRPRKYTKQQVEHAMKLLETHS YKQVEEMTGISKRTLIRRKKESESK" misc_feature 12623..13177 /locus_tag="BACI_pBAslCI1400210" /note="Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961" /db_xref="CDD:32144" misc_feature 12626..13000 /locus_tag="BACI_pBAslCI1400210" /note="Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768" /db_xref="CDD:58117" misc_feature order(12641..12643,12647..12649,12812..12817,12824..12826) /locus_tag="BACI_pBAslCI1400210" /note="catalytic residues [active]" /db_xref="CDD:58117" misc_feature 12647..12649 /locus_tag="BACI_pBAslCI1400210" /note="catalytic nucleophile [active]" /db_xref="CDD:58117" misc_feature order(12809..12811,12941..12946,12950..12955,12965..12967) /locus_tag="BACI_pBAslCI1400210" /note="Presynaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(12827..12829,12842..12847,12929..12931,12938..12943, 12950..12955,12962..12964,12971..12973) /locus_tag="BACI_pBAslCI1400210" /note="Synaptic Antiparallel dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(12896..12904,12929..12934,12941..12946,12953..12955, 12965..12967,12974..12976,12986..12988) /locus_tag="BACI_pBAslCI1400210" /note="Synaptic Flat tetramer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(12896..12898,12944..12946,12953..12955,12965..12967, 12974..12976,12986..12988) /locus_tag="BACI_pBAslCI1400210" /note="Synaptic Site I dimer interface [polypeptide binding]; other site" /db_xref="CDD:58117" misc_feature order(12968..12970,12986..12991) /locus_tag="BACI_pBAslCI1400210" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:58117" misc_feature 13037..13156 /locus_tag="BACI_pBAslCI1400210" /note="Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569" /db_xref="CDD:119388" misc_feature order(13040..13048,13139..13144,13148..13156) /locus_tag="BACI_pBAslCI1400210" /note="DNA-binding interface [nucleotide binding]; DNA binding site" /db_xref="CDD:119388" gene complement(13557..13883) /locus_tag="BACI_pBAslCI1400220" /db_xref="GeneID:9452478" CDS complement(13557..13883) /locus_tag="BACI_pBAslCI1400220" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003787148.1" /db_xref="GI:300885248" /db_xref="GeneID:9452478" /translation="MAAKKKLEVIDLPIDISTPQATLQTRKTWLDAWKERKVDGKDMN TLNYALQGVSKDHELIQAEERIKIEWHRAETQREQLVHTKEKMEKQRERIEQLELLID ELEDKK" ORIGIN 1 acctttaatt tattgaaaga gcaacgaatt tccgtttatc attaggttac tactatagta 61 ctaacttttt gttgacctct ggtatgttga gtactataat ggaattataa gataattaag 121 gcggaaaaat tgcaccggta ctgagtgatg agtagttcca actgttcgat gcgttctctt 181 tgtttctcca ttttctcttt cgtatggact aattgttcac gttgagtttc ggcgcgatgc 241 cattcaatct taatccgttc ttcagcttga ataagctcat ggtctttact cacaccttgt 301 agtgcataat tcaatgtatt catgtcttta ccgtcaacct tacgctcttt ccaagcgtct 361 agccacgttt tacgcgtctg tagcgttgct tgtggcgtac ttatgtcgat gggtaaatca 421 attacttcta atttcttctt agctgccata tcctctcctc cttcctataa catccttctt 481 agctccctag ctatctttct acagggatct tcttcttttt cgactatctc atcagcaact 541 aattctgtat ttaagagtga tggatcgtat aacctcttac gattgtatat atgtgttact 601 tgggtatcat ttagttttcc tattttatag aaagcttgaa tttcttccca cttacatgca 661 tatatcccgt actcacctag gttatattca acttctaatt tccgaagctc ctctaccata 721 aatttatggt acttcgtttc cggtgtaggc tcaccattaa tgtatttcag taataccacg 781 tgttatttcc ctccttatcc ctttactcat ttgattcaaa tctatttctt ctataccacc 841 tgtacccctt ttaccgatcc taatataaag gatgtcgcct ttgacccatt tatccaaatc 901 acttgtttta tccagtgcga tttcttcatc ttcagctttc aacctcatca gcatagcgta 961 gtgttcaggc gattcctcac gatactcctc cataacgtca aagttttcat caaatgtcgc 1021 tgaaatatca tctattatga tgatgcattc tttagctttt gaacggtatg actccgcgta 1081 ctctcgatca tcagtaatca ttacatctat cttaggtatc ctttgttcct ggatcttttt 1141 tagacgtttc tccagttgtt tgaggctggc cactactcta atccacctcg aagaacctgt 1201 aaaatttgct gtttacgttt attcccgtgc ggctttcctt ggtgtctacg caccttctta 1261 ggcttgtacg ctttaataaa ttcatcaatc ttttctttac ctttaccttc atactcaccc 1321 tcgaagaacc tagctagaga atcaaagtag tttacaaatt cctgtcgtgt gaacttccct 1381 tcaataaata gctcaatcct tctatctttt tgcttctcaa tctcaataac ttctcccata 1441 tggattacct ccctattaaa aaaataagag gaagcattac gccacctcta cttaatttca 1501 ccgttcttaa tcatgctata ggcttcttta attccgtccc ttaatttctc ggctgtaaca 1561 ccagaagaga tagaatgaac aacatcttca ttacgtttaa tttccgccga ttcaatcact 1621 gatctcgatc ctgaaatgaa ttcttgaaca tagtgaattg ttaccccacc ataactacta 1681 tcattaatag caatagttgc atcatactct cggaagttga caccatatcg ctcatcaacc 1741 ttcttcacgt ctatatctac acctttgatc tcgattgttt ccggtaacca aaaacaaagg 1801 tcattgtaga tttgactaaa acgtgcaaaa tcctcctcgt gacttttaac gaatcccttc 1861 gcttcctcat acttcttaca ttcagtaaaa tagtccatta tttatctacc ttccctattt 1921 aaagttgcaa ttctcacagt gatcgccctt gtttctctcg taataactga ttttctacag 1981 gaatattttc aacaaatgat atggctgcac gtctattttt atcaggagca acctccttgt 2041 attgtgcata cttcataccg acaacttcct caaaaatctg acttttcgat ttatgtggtt 2101 caaagtatga taactcgcca attttaatca agttaagagg atgctgagcc tgtgccttca 2161 tcgtttccgt aatccctagc tccaactccc tcgcatttcg ctctgtcgtg cctgtaactt 2221 cagtatcatt aatgatgtta ttcgttaatc ctgattcaac ttttttctca tcctgtacgt 2281 ctgaaccttg ttttagatat ccccccagtt cttcacgacg tttgtataag tcttgtaatt 2341 tagtcattgt tttcatcctt ccttatagat agttcaaacc tttatcgaat gccgtgttga 2401 tagctgccat atctttcttc tcgcactctt cctcaatacg atccgcatcc ttcgcttcta 2461 gttccgcgat ttgcttatta acttctttta gttcgcgctc aacttcctgt tttttataat 2521 tagcaaacca ttttcgattt tcttctaatt ccgcttgcaa ttcttctgtc gtcataaatc 2581 atcctcctct actacttgtc actcagtacc gttgcaattt ttccgcctta attatcttat 2641 aattccatta tagtactcaa cataccagag gtcaacaaaa agttactact atagtagtaa 2701 cctaatgata aacggaaatt cgttgctctt tcaataaatt aaaggtgaag ttaataacag 2761 cattagtgac ttagcattaa cggtgttata atggtgctac aatgcatcaa taatgccgtt 2821 ataaggtgag agaataggag ggattccaca atggactttg gaagattttc gggacaagtt 2881 agcaaagaat tagacgtcaa cggaaataca ttacgtgttt ggtgtttaga actagaaaac 2941 gctggatata aattcgaacg gaataatcgt cagcaacgga tttattacga acatgatatt 3001 aatatcctta aagagatgaa ggttttaatg tcggatggga caagaacctt acaagaagcg 3061 atatctatat tgctagaatc atctctttct aaagataccg ataacgcaat aacgcatagc 3121 attaacgaaa gtgttggtag tgaagcaaca ccatttcaac gcaataacag cgccgccggg 3181 gttgcttatg ctatattgga acaaaccaat gaaaaagtgg ctgaattaat aaaacagcaa 3241 caaactattg ctctgcaaaa tcaagaaatt ctaaatgtta tccataaaga caatgaggaa 3301 aagcgaaatg ttattcaggc tgtctttgaa aagcaacaac agataatcga tcaacaacaa 3361 gatatacatt tacagaatca gagcataaca aaaatgtatt tagaagaacg tgaaggaaga 3421 ttgaaggaag gccaagaaaa aaacgaactg aaggaacaac tctctgacat gcaagtaaaa 3481 atgaatgaaa tgttagagta tgttcatcag caaagcgaag agaaaagtaa atcattcttc 3541 agtaagttct tctctaagaa ataactaaat attaaatcgc ctcctggatc ttaacccact 3601 tatgcctcac caatcgtttc cgtgaggaag ttagatgcaa taaataatac aaagacctat 3661 ggattccggg agtgaaaata ggacatagta agtatatcta ggttcatgtt cttacaaaga 3721 ttacgcttgt tttctcttta atccgacggc atttttttac gcttttttat tcctcatctt 3781 actttaatga aatatagtcg ctgtatatgt ttatttaaac gtggctcatg ccccagctca 3841 aactctcatt tatggtaaaa taaagatata aagagacgag atgagggaga aatttgaagg 3901 gtgataaaag aacaagggta agtaaaccaa taattgtggg cactctgccg caagtgatta 3961 tagatgagta tgaattaaag tgcgattcaa atgatgtcca aatgcatccc ggtgttataa 4021 aacacataaa gaagagacat cccggtattt atgaacaata ttccgttaat atgaaagata 4081 tcatagagaa tccggattat gtaggaagaa atcctacaga gcctaatagt gtggaattga 4141 taaaactcat agataaacat atattaatcg ctgtaaaact agacccaagt ggttatttgt 4201 tcttatcatc tatgtacgat atgcataacg gccctgttaa aattgaaaaa cgcttaaata 4261 gcgaacgttt aaaaccgttc aaagaccttt taagttaact tagagtttac aattcataaa 4321 gttgtgatac aatgagtata gatattacat gcaacaagtt cttaggtgta gatgtatcaa 4381 atgcatcaga attcgcataa taatagttag gatctatgag gtgagaaagg ttcctcacgc 4441 gcttatctaa cttcgttctt gatcaattat ttggtccgtt aggtaagtta ccagagatgt 4501 aggatacgcc gccctgccat cgatcctaga acggtaagcc attcgttttt ttaacggatg 4561 gctttttgta ttgacttttt tatcgctagt ggttactttt tctatcaaac gacaccgaaa 4621 ggcgatgatt attatgttaa aaaacacgaa atataaacgc tgcgaggaat gtggcaatcg 4681 agcaaacgta aaacaattat cttccacaca attcgaaatc cgttgtgtaa atcctgattg 4741 tcgtaacgtc acgctggtag aggaggaatg gtggaaaact cctaaacagc cgaaaaccgc 4801 tctagattga attctaagcg gttttaacac taattaatgc ttttatactt aaaggaggat 4861 gttatccagt ggtaaataag ctaggtatga caaaagaaca ggagcaacgc ttcttagatc 4921 caattattaa atacatgaaa gaaaacccac atttattcaa agaatctcca aaagagagca 4981 aaatcaagac tcaaaaggag gttcttaaat gaaaaaaatg aatctaacga gagaacaagc 5041 gcaaaggttt tgtgatccta ttatcgattt tttacaacgt aatccaaaaa tagcgaaaaa 5101 gattctccga aaaatagagg aagaaaaaaa gaagtttaag taagaccgcc cgaactaata 5161 ctacaactga ataaatctca tatattacta tttaatttct atacaacaac agaaactcca 5221 atttcataac acctacttat ggataatctt acttttagta agtaggtgtt atgaaattct 5281 aggtgaaaat agtggtgaaa tacctgatga ataaaagttc accattgaag tgaaacttcg 5341 ctatattacc ttttttcaaa atagaactgc ataataccag cgtttctaca actaaatcat 5401 atagatctat aaaagttcac cactactttc accataataa tcacctaagg tttcacttct 5461 tcccccttgc tcttatcgca ttccttaata ttcaggtcta ccttatcttc ttctttttta 5521 tctgacttaa acaactccgg attcttcctc ataaaatcaa tcagtggttc acaaaacctt 5581 tgagcatgtt cccccttaag tatgatcttc atcctcaatc cccctctatc ttagttaatg 5641 gtagtcactt cggtactcta cttttttagc taatcggggt taaaatcctt taaatctctt 5701 gactttcggt tttgagggtt tttatcatgc tgaagcgaag ttaggaaaac ggctgctgaa 5761 gacagacttg tcccctactc tgaaagaaaa ctaaaaaagt aatctaacag aataggagag 5821 ataagcgtct atgttttttt acatgccttg cttgtcagtg ttccgtgtgc atatagaccc 5881 tattcactta acagttttca ccgtacacga cctctgccta agacttgtcc actacacaaa 5941 gccacccctg tgcgacaagt tgatcgtgct ccctagcacc ttaatgctaa tggctaccac 6001 ccgaaccttt aaaggtagtt ctcacctacc ctcaccagac gaatagggat ccagtgaggg 6061 gtgctgttct tgtagaggta tactaagtac ctcccgcacg accaacagca agccacaacg 6121 taacgcgttc ccattaacta tgtaatagca cgtaagctac gttttatcag tttttaacgt 6181 gggttcaggc aattccacgt gaacggaaca caaaaaggcg gcatctctac caggaagctc 6241 gtaacgattc acaagacttc tagatagaga taccgccttt aatttagcta ttcttatata 6301 cataaacgat tccaaataat tactagttga aatttgtata taataacggc tataataggt 6361 gtatctaata agccttgttc gcgaaaacaa ggcaaataac ttatttgagg ttggtagcct 6421 catataggtc gaagtcctgt atggctgtac aggattaagt cattctcgct aaaggttggt 6481 agccgatagc atatgagagt ggcttttttc atttccgttc tattaagtta ctgctaattt 6541 taccgctatg tttctattaa atcaacgaaa atttgataag gttcatcaga aacatcaata 6601 tttgcgacat aaaacgttgc taaagctcaa ctcgaaattg agttcagttg aaataggtgt 6661 caacaagatg tggtagtggt tttaacctct tcatattgag agagttaact ttttagccac 6721 cccttttatt tcagtggctt gtgccgatgg ttttagtcta tgacatacgt gtcgtacact 6781 aactttagga gggaaatcaa ttcccttcta acctcctata agtaaattaa caccttgttc 6841 atttactctc tgccacgccc gatcttcctg catataccca tattctatta atgtaggtat 6901 cgccacgttt ggcggttctt ccctgtaaaa cgacaaaaag gcatgtccat attgggacac 6961 acctctcgtc atcacaccgc tgctaacgaa tacaattccg acctaatctc gaaaccaaac 7021 tcgttcatac ctacatactt ttccattctg tcagagttac acttcataat cgcatcttga 7081 tctccactat tcgcttgctt aactaactta gctagtcttt ctaagtcatc ataggtcaaa 7141 ttactaccct taggcttgtc agatttactt gtaacaggtt ttacttcctc atccagtgta 7201 attgtattga tttcttctaa aacctcgtga acgctatctt gtataggtgt attatctacc 7261 atagctaaat actcttcatc caagaatgga ttgtgaatat catcaacaac acttacgtct 7321 acatatccta ctggagtttg aattttctcc acttttggcg attcattctc ttgtatagat 7381 tcttttttct ctaggtcttc atagaatctc tctgtgaata catctgatgt gtggagtgga 7441 tcttctatac tctcatttaa atcttccgca catgctctaa tccacgtttt gatgcttgct 7501 tctttttcag ggtcatatgc ttcataccac ttctcagcat gtccttgtaa ctcctgttca 7561 tccattgttt ttaaatggac gaagtcacga cgacagatgt ttacgaattc caaaacatca 7621 gtatatgttt taatatcttt agtacgtctt tctaaagtac ttctttctag ataggagttt 7681 ttcctaaact gattaggaga atttcctaaa ctgttgtcgt tactggtttc gttaagtata 7741 ggaatatttc ctaaactgtt gatattaagg cattcacttt cgttatttgc tagtttagta 7801 gattctccta aactgtcact tttggtcaac ttgtcggtat gcattccgac acttttgttt 7861 tcttctttcc attgtagata ctcttcgtta agtcgtgctt ctatctcaaa atcaataaag 7921 aacttcttag aagagttgaa gcccttttta ctactaatgt aaccaatgtc ctctacgatt 7981 ttcagggctt tatcaagtgt tttattagtc gtcacaaact catcgcacat ctccttagat 8041 gacgccttaa cgtaatacct tccgtcctct ttccaaccgt tcttaacgga aacgctcatt 8101 ctgtttcgta ggaagccaac gatgtcacga gatagtgagt tgaaaccgta tttcttacca 8161 atagcaccac gcataaattt aggcacttta tcgtattcta actttgttag cttgtttaag 8221 tcttgattag tttgttccat ttaaaaacct cttttcgaat tttaggtaca acgaaataga 8281 ggtattgtat aggtaataca taattgttat aataaaggta tcttaaatgt acggtatcaa 8341 aaggagaaac ctacattgat tagatttatc taaacaattt tatacaatat gccttgagaa 8401 cgtcttatac cttccagtcg ccaaacttag ataggtatag ggcgtttttt cgttgtctat 8461 accctattat actatgattc tactaagcaa aaaagggttc tcagaggaac ccttttagtg 8521 gtatattacc atgtgcactt tttactcttc ctctttttcc atcttcattt cgataaggtt 8581 gaggttatga tataccttgc taatcgtttg agagtactct attaagtaat ccatcgcatt 8641 gtatgcttcc cagttgccta actcagatac ctcttgaatt gcttcacctg tagcttttgt 8701 aacaccttta atgattacgg acagaacacc gcgtctcata tcattacgag tatgatataa 8761 atcctcatct aatccattca cgttattttt aactttattg tataaacctt cgaaaatgaa 8821 ttctgccgac ccttgcttgt tgtcatcgat attctctaca tacatttgct ccgcacgttc 8881 acccagacct ttaatatcct tctctactac ttttaaatca tcataaattg tgtttgtcat 8941 attaattacc tcttccgttt gatagtttat ttattatata tcatcattta cctttataaa 9001 aagattggtc tactatccaa cgccctcaac gttgagggct cacttactga gtagagcgca 9061 atcttacgct tttctctctt agatcagctt aattttcagc caaccactta ctgagacgcg 9121 cccaacgttg gaccaatctc ttttgagtgt ccccaaagtt ggcgacccat tactaacctt 9181 ttatcgtttt actaccttgc gcaaacactc tacggccaat atacttaata ctggaagtgc 9241 aaatgctaac atgaaccaca ttgctgttgt gaatgacatt tgtacgctcc tttctagctc 9301 actatgccag tagtgggctt tatctatttt gtaattgatt tgttacgcca tgcatccact 9361 cgacacattc taaaagatga tcgatgttca cgttatccaa cgttgcattt tcaccctcat 9421 ttggattagc ttcttctaac atttcattca acccatttac caaccaaaaa aacttgcttt 9481 ctagtaactg tttttcttca ttattcattt tgaatacctc caagttgtgg tttatgaacc 9541 gattaggtaa aaagagaagg gctattgccc cgtttatcta tctttatttc tcttttctat 9601 acctctctta atcgctgagt cagtccactc tttaatttgt tcctcactca attccttgtt 9661 ctctgctact ttcgtaatgg caatcatcat gttgtaaatc tgtttcgcct caatcatcgt 9721 ttctacaccg taatctctca tacgattctc gaagaatgtg acagccttac ttttcttctc 9781 tgtcatccca ttaacaccac cttacataaa atagtataca taggtttatg aaccatgtaa 9841 aggtggttta tgaacttttt tagttaattt aaatagtttc ctatttatac attttcaaaa 9901 cttttttaaa gagattgata gtattgtgac gaaaagggtt tgtatatcat taactacctt 9961 gtgtcactta ctagatgatg gtataataaa tgtatacttc catctaatca ccatagtaac 10021 tataaaagaa acaaagcccc tttccattac ggattggggc tttttgttta tactcttact 10081 tgtctcgctt ttcttcttcc taattcctca tccatatata ctgccgtttg tctcgcaaaa 10141 cgtcttccgt caatatgaat atcattcgtt atttgaatag gcttagaacc gtatgattga 10201 ttaaatggca ttgtctcagc aatcttttta ccgatttctc ctaaagtgcc tttattcaac 10261 ggtaataccg cttcatcgta actcttagcg tcaccaatct taatcattcg ttcttggtta 10321 ggtttaaaaa taccacccga agcgaatccg tttactggcg ctgctgatac aggagcgctt 10381 cttcctcccg gcaacattcc cccaacaaat cctcctaaag cactagctcc atctttaact 10441 ttacctagaa tgccgctgat accatcccat gcttttgtaa tccatccgac taccttttcg 10501 accgctttcc aagctaactc gaatggctca gaaattagtt ttgttacagg tttgaaaatt 10561 gttcctagac cggggacgaa tttggaaaca agtccagtta tcttacctgt ccataatcca 10621 acaattcccc acatagcgtc ccacgcacct gaaagaattt gcttaatacc ttcccacgca 10681 ccacgccagt caccagtcag tacagatgcg aatactttaa taagccccat aatgatgttt 10741 aacgcgccgt taatcactga tttaatagat tcccacgtac tagatatgat gaaagatata 10801 ataggcatta cggccgaaat caccgattgg ataaagctaa acgctacaga caccgcttga 10861 gaaatctgtt gtccattctc tctccaaaat ccagctattt gatttaatat gcttgatgtg 10921 aatgatgaaa tctcattgat agctcccatg atgtaaggtt tcattatgtc gaatacacct 10981 ttaatgaagt tccacacctc tcccgcgaca ctgaccacca cagctccgta tgacgagaat 11041 gcatttgcga aactttcgga aacgcctctc ataccttcca ttgctggtgt gaagtattct 11101 gccaatgctg caaaagcacc ttggaatatc cctacattag aaccaccagt gctgaatgag 11161 gtaactaagt ctgtcatcca tttaacagca tccgttaacg ctggccccag cacatcgtat 11221 atttgtaacg caacttccga gacagccgaa gtgaagttct tccatgctcc tattaagtta 11281 tcattcatag tattggacat ttccgttgct gcaccattcg aattacgtaa catctgttca 11341 ttctgttgta acttctcgct accttcacca agtaccgctg cccagttctt gaacgcttct 11401 gctccgaata atgtcgatag tgtcgctgat ttctgttgtt ctgacattcc tgctgttcgg 11461 tcttctagca tcttcacgat atcgatcatt ggtttgatct taccttgaga atcgaagaag 11521 gataatccta atccatccat tgtcttctgc atctcttttg taggtttagc cagacgtgtt 11581 agagaggttg caaatgcttg tcctgcaata gaaccttgta acccccggtt tgccatagac 11641 atgatggctg ctgctgtctc ttccatatcg aacccaagtg tagatgctgc acccgcgccg 11701 tatttcatcg cttctcccat ttgttgaacg tttgtattag atttagacgc cgctgccgct 11761 aatacatctg ctgtatgacc cgcgctatcg gctttaagac caaatgaaga cataatgttt 11821 gttgcgatgt ctgctgcttg tcctagatct aacgctcctg cttctgcaag acgtaacatt 11881 ggctctgttg atttcaatac atcgtttgta ctcataccac tcattgcgag gaacttcata 11941 ccttctcctg cttctttagc cgaaaatgat gtacttgccc ctaaacgacg cgcttctgta 12001 cctagttctg ccatttgttc agcattcgca cccgaaaccg ctttaacttc actcattgtt 12061 ctttcgtagg tagcgccagt agaaacgata ccagcaagtg ccgcaccgac accaactgtt 12121 gttccagcca tacccatcat cgctgcaccg aatccacctg cggcaatacc cataccactg 12181 aacatgctgc cagtactctt gaaaccttta ttgatagagt ttgaagcgcg ttgtccttgt 12241 tgctctgcac gacttaaacc tgatctatat tcattgtctc tgagacctag tgtcccaaaa 12301 attttaaaaa cctccactta ttaatctccc tctcacgttt gttatttggc atattttatc 12361 tctcctcttt tttgactcct tcacataaca aaagggcact agcacaaagc taatgcccca 12421 gttagtggag gaaaataata aagaactaga attcaatttg taatgatatt tgttgtgtct 12481 ctattatacc aactaattga ccggtgttca attaaaaaag tgccataact taaaagtatt 12541 gtcaccgaat tagcaacgtg ataaaatcag tgcatgccct tgtgtcatat cttggtgaca 12601 taagtaaaag gagagaaacc cgatgaaata cggatatgcc cgcgtgagta caactaatca 12661 agatttagaa tctcaaatac agacactgca aaaggaagat tgctctgtta tctactcaga 12721 gaaatttaca ggaacgaaag ctaatcgccc ggagtttaat aagctattag caaagttaga 12781 ggatggagat actcttgtag ttaccaaatt agaccgtttc gcacgttcta cagtagatgc 12841 aatccaaacc gttaaagagc tgtttgacag gggtgttaaa gtccacattc ttaatatggg 12901 acttgttgaa aatacaccta caggaagact tgtatttaat gttatgagtg cctttgctga 12961 gttcgaaaga gatatgatcg tggagagaac acaggaaggt aaagcgatag ctaaacagaa 13021 tcctgacttt aaagaaggac gaccaagaaa gtatacaaaa caacaagtag aacacgctat 13081 gaagcttctg gagactcatt catacaaaca ggtggaggaa atgaccggta ttagtaaacg 13141 tacgctcata agacgaaaga aagagtctga aagcaagtaa tacccaaacc taattttgtc 13201 gaaaaagctc atcttttatt tattgagtca attggacaag tatgagataa ttaattgtcc 13261 taaaggggaa tggataaacg aatggcaaat gaatcgattc aaggttaagg tactctcact 13321 cttcaaattc atttaagaag gtgaagacat ttgctaaagt ttaagttcaa aaagtctcct 13381 aaagatggta tcgagctaga gtttcattgt gagttaccta cattaatcgg agcaacaaca 13441 atcatagaat tcatcagaca gtatttaaat atataaaaca aaaaagaaga ggtaggattc 13501 gtccgcttct tcttttttgt ttatccgcct atatacaggg agggggtacc cctattttat 13561 tttttatcct ctagttcatc gatgagtagt tccaactgtt cgatgcgttc tctttgtttc 13621 tccattttct ctttcgtatg gactaattgt tcacgttgag tttcggcgcg atgccattca 13681 atcttaatcc gttcttcagc ttgaataagc tcatggtctt tactcacacc ttgtagtgca 13741 taattcaatg tattcatgtc tttaccgtca accttacgct ctttccaagc gtctagccac 13801 gttttacgcg tctgtagcgt tgcttgtggc gtacttatgt cgatgggtaa atcaattact 13861 tctaatttct tcttagctgc catatcctct cctccttcct ataacatcct tcttagctcc 13921 ctagctatct ttctacaggg atcttcttct ttttcgacta tctcatcagc aactaattct 13981 gtatttaaga gtgatggatc gtataacctc ttacgattgt atatatgtgt tacttgggta 14041 tcatttagtt ttcctatttt atagaaagct tgaatttctt ctcacttaca tgcatatatc 14101 ccgtactcac ctaggttata ttcaacttct aatttccgaa gctcctctac cataaattta 14161 tggtacttcg gttccggggt aagctcacca ttaatgtatt tcagtaaaaa cacggggta //