LOCUS NC_013888 12197 bp DNA circular BCT 21-FEB-2010 DEFINITION Methanocaldococcus sp. FS406-22 plasmid pFS01, complete sequence. ACCESSION NC_013888 VERSION NC_013888.1 GI:289193301 KEYWORDS . SOURCE Methanocaldococcus sp. FS406-22 ORGANISM Methanocaldococcus sp. FS406-22 Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus. REFERENCE 1 (bases 1 to 12197) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Bruce,D., Goodwin,L., Pitluck,S., Teshima,H., Detter,J.C., Han,C., Tapia,R., Larimer,F., Land,M., Hauser,L., Kyrpides,N., Mikhailova,N., Sieprawska-Lupa,M., Leigh,J., Whitman,W.B. and Woyke,T. CONSRTM US DOE Joint Genome Institute TITLE Complete sequence of plasmid of Methanocaldococcus sp. FS406-22 JOURNAL Unpublished REFERENCE 2 (bases 1 to 12197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (21-FEB-2010) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 12197) AUTHORS Lucas,S., Copeland,A., Lapidus,A., Cheng,J.-F., Bruce,D., Goodwin,L., Pitluck,S., Teshima,H., Detter,J.C., Han,C., Tapia,R., Larimer,F., Land,M., Hauser,L., Kyrpides,N., Mikhailova,N., Sieprawska-Lupa,M., Leigh,J., Whitman,W.B. and Woyke,T. CONSRTM US DOE Joint Genome Institute TITLE Direct Submission JOURNAL Submitted (02-FEB-2010) US DOE Joint Genome Institute, 2800 Mitchell Drive B310, Walnut Creek, CA 94598-1698, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. URL -- http://www.jgi.doe.gov JGI Project ID: 4086483 Source DNA and organism available from William B. Whitman (whitman@uga.edu) Contacts: William B. Whitman (whitman@uga.edu) Tanja Woyke (microbe@cuba.jgi-psf.org) Annotation done by JGI-ORNL and JGI-PGF Finishing done by JGI-LANL Finished microbial genomes have been curated to close all gaps with greater than 98% coverage of at least two independent clones. Each base pair has a minimum q (quality) value of 30 and the total error rate is less than one per 50000. The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. it is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..12197 /organism="Methanocaldococcus sp. FS406-22" /mol_type="genomic DNA" /strain="FS406-22" /db_xref="taxon:644281" /plasmid="pFS01" gene complement(439..858) /locus_tag="MFS40622_1837" /db_xref="GeneID:8805729" CDS complement(439..858) /locus_tag="MFS40622_1837" /note="KEGG: mja:MJ1489.1 hypothetical protein" /codon_start=1 /inference="similar to AA sequence:KEGG:MJ1489.1" /transl_table=11 /product="hypothetical protein" /protein_id="YP_003459242.1" /db_xref="GI:289193302" /db_xref="GeneID:8805729" /translation="MNDKITYFIDNTISIIKLTLMTYLVIAIGIMFQPLQYPTNISII FMVIIGIGLLFAFQFILGYGFDIYKQLSIEDRIEFYNYVVRKIFNILIEHSYYGLLLS TYNLFVYKKAIAIGLCCIATLGIITFWILGNKLIKNG" repeat_region 1357..1866 /note="CRISPRS" /rpt_unit_range="1357..1388" gene complement(2429..2734) /locus_tag="MFS40622_1838" /db_xref="GeneID:8805716" CDS complement(2429..2734) /locus_tag="MFS40622_1838" /note="KEGG: 1-aminocyclopropane-1-carboxylate synthase" /codon_start=1 /inference="ab initio prediction:Prodigal:1.4" /transl_table=11 /product="hypothetical protein" /protein_id="YP_003459243.1" /db_xref="GI:289193303" /db_xref="GeneID:8805716" /translation="MLNLFKKDKKEDYREKENYQSIHNVVKAHYDDFLANINNGMNGG VKRAGISFPENLHDFLYICSKYEKITVSKLVVDLLLFVLEDKERFNEFLKEKYGKKL" gene complement(2773..4047) /locus_tag="MFS40622_1839" /db_xref="GeneID:8805717" CDS complement(2773..4047) /locus_tag="MFS40622_1839" /note="PFAM: integrase family protein; KEGG: mmq:MmarC5_1487 phage integrase family protein" /codon_start=1 /inference="protein motif:PFAM:PF00589" /transl_table=11 /product="integrase family protein" /protein_id="YP_003459244.1" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="GI:289193304" /db_xref="GeneID:8805717" /translation="MGRNRPLHHQLKYAVMQSYRHRGQRRQFKQQWQELDKAYERGDI TFEEWLKEKSKIWFVASRGDFWRGNRHKEGYLDSLIKFANNFGRWIQNEFKVKRACDI TPEMTQLFLECKAKEGVRATTLKKYVSMIKALNLACAKTYGLKWNFKFAKGIYVPQHA LQQEARTIRIEPEDYKRVINSEYFQKSKSKAKIGIVLARHFALRVNEIAKLKYGDVVL DERAIPDSLKRFMVGKSIYNAYLIVKNSKHGLHRVIPAHTEKEYELLKSIKEHQIKNN ILDDVEIVGLDKDSVNAFFRRCLKNCGLNYYVEKGVNIHGLRKLRASELFLEKLKEIY TNVYAGKNMPLKKKIYLSFKKAGAYVDKYLGHENKSKGKQHLKREGRWDLIKKYQLDV LKPEDIAMALVECGLDYETALETVKEVLTDLN" gene 5388..5573 /locus_tag="MFS40622_1840" /db_xref="GeneID:8805718" CDS 5388..5573 /locus_tag="MFS40622_1840" /note="PFAM: regulatory protein MerR; KEGG: tsi:TSIB_2042 IS element ISTsi1 orfA, putative resolvase" /codon_start=1 /inference="protein motif:PFAM:PF00376" /transl_table=11 /product="regulatory protein MerR" /protein_id="YP_003459245.1" /db_xref="InterPro:IPR000551" /db_xref="GI:289193305" /db_xref="GeneID:8805718" /translation="MKYYSAREAAKILGVAHTTVIRWIEKGELKANIRKTLYRVYYQI PEDEVLRLKKRLEAQHD" gene 5698..8022 /locus_tag="MFS40622_1841" /db_xref="GeneID:8805719" CDS 5698..8022 /locus_tag="MFS40622_1841" /note="PFAM: MCM family protein; SMART: MCM family protein; KEGG: mfe:Mefer_1152 MCM family protein" /codon_start=1 /inference="protein motif:PFAM:PF00493" /transl_table=11 /product="MCM family protein" /protein_id="YP_003459246.1" /db_xref="InterPro:IPR001208" /db_xref="InterPro:IPR016027" /db_xref="GI:289193306" /db_xref="GeneID:8805719" /translation="MSPNEYIIDKIYNIFERERKKHPTYKESKYDKESEYKELIKFLV EKEEVNEAELMLKAKEIGLGRLYYNTFIAILKKYLNFIDIGEEDGYKVIKITNELRNV LNDDNESDESNFKIDMEFIIMQYEDLLRKYLKNYITVVGPEKLERKIRLSARDLSAEF GDMIDYAIESVDNYYQVVDYLTKLFNEVYYEITYEMGDFKVVLCDFPALEIDVNKINA EYVNKVVEFEANIIYASHVSVFVKKSVFQCPRCGKIVNVYLRDFFAKNSDKLVCNECN VKLQHIKDEEYTNFQELIVQGLPNEKGYIREQRVLYEDSDGVFSGYVKITGIVRTVPR SSKSKVYDLVVQAVDVEEIDNIAPRLTKKDIEDIKKIAKRKDVIDLLSDRLIPEIKGH SLVKKAVFLQQIRGVKKPGKRDKINILLITDPGIGKTVILRKIAEIPGNNYVSMPTST INSVFAIAEKKKSLSGESWTVKVGPVPKSIGTVCIDEFYIPKGDTTFYEAMEGDVIHF CKGGIDARLQSVCSFLCARNPRWGRFNPDVSVAEQIDIPAPLLSRFDLIFPIRDRADK EADKEIAEHIIDVHRAYLDKEVNKKIRLDYIKIDGVIIDFEFIVKYIFYARQLKPVMT GETKKKLVNWYVEMRKKHNITARQLEAAVRLAEAHAKAKLKDVVDVEDAEEAIGMITE CLKEIAYDPETGIFDIDKIMGVHSSERKKLDIVYNAIEELSHGSSEVLVGFDEILNFV EEKGINEKELERLLNKLKKFGDIDEPKPGRYRLI" gene 8074..8406 /locus_tag="MFS40622_1842" /db_xref="GeneID:8805720" CDS 8074..8406 /locus_tag="MFS40622_1842" /note="KEGG: mja:MJ1074 hypothetical protein" /codon_start=1 /inference="similar to AA sequence:KEGG:MJ1074" /transl_table=11 /product="hypothetical protein" /protein_id="YP_003459247.1" /db_xref="GI:289193307" /db_xref="GeneID:8805720" /translation="MAVSYARIYELLLKYVKDEKKAMECYDVVVEVIKEIEREAREGV KDDLRDELATKKDIALLEEKMNSMEERILRYVDNKFNQIKILILITLFAVIVLNPYAY EIVKAILK" gene 8435..8653 /locus_tag="MFS40622_1843" /db_xref="GeneID:8805721" CDS 8435..8653 /locus_tag="MFS40622_1843" /note="KEGG: mja:MJ1072 hypothetical protein" /codon_start=1 /inference="similar to AA sequence:KEGG:MJ1072" /transl_table=11 /product="hypothetical protein" /protein_id="YP_003459248.1" /db_xref="GI:289193308" /db_xref="GeneID:8805721" /translation="MLENELATKNDIALLEERMNSMDEKILRYVDNKFYELDKKTDRI FYLIIVFMIVYVLTNPQVVGVIKLIFMK" gene 8672..9103 /locus_tag="MFS40622_1844" /db_xref="GeneID:8805722" CDS 8672..9103 /locus_tag="MFS40622_1844" /note="PFAM: zinc finger C2H2-type domain protein; KEGG: mja:MJECS06 hypothetical protein" /codon_start=1 /inference="protein motif:PFAM:PF00096" /transl_table=11 /product="zinc finger C2H2-type domain protein" /protein_id="YP_003459249.1" /db_xref="InterPro:IPR007087" /db_xref="GI:289193309" /db_xref="GeneID:8805722" /translation="MDIDKYIENLEIKKEGFFYKCPYCDYTNADLKVIKKHIKTKHLD EIKKEVEKMNKPKQKQNKQRRMPQRKQVKKEDDYKDYLLLFAHKKKCKIHLDNGMVVE GLVKAKDKYNIMVLDARADGKDVGRMIIQKGHIVALIPLEE" gene 9143..9586 /locus_tag="MFS40622_1845" /db_xref="GeneID:8805723" CDS 9143..9586 /locus_tag="MFS40622_1845" /note="PFAM: DNA polymerase beta domain protein region; KEGG: mvu:Metvu_0398 DNA polymerase beta domain protein region" /codon_start=1 /inference="protein motif:PFAM:PF01909" /transl_table=11 /product="DNA polymerase beta domain protein region" /protein_id="YP_003459250.1" /db_xref="InterPro:IPR002934" /db_xref="GI:289193310" /db_xref="GeneID:8805723" /translation="MNEKMLNKILNEFLNKCKEKFGDDLISIILFGSYARGTATEYSD IDLLIIVKNLPERRIDRYKIIKDIDLEFLKKYCIALSPILVKPEELSIKSINPLIYGI LTGYRVIYDKNNFWKNYLEKIRPIIKRTNPIFVDGEKEWKIAELI" gene 9562..9735 /locus_tag="MFS40622_1846" /db_xref="GeneID:8805724" CDS 9562..9735 /locus_tag="MFS40622_1846" /note="PFAM: HEPN domain protein; KEGG: mvu:Metvu_0399 hypothetical protein" /codon_start=1 /inference="protein motif:PFAM:PF05168" /transl_table=11 /product="HEPN domain protein" /protein_id="YP_003459251.1" /db_xref="InterPro:IPR007842" /db_xref="GI:289193311" /db_xref="GeneID:8805724" /translation="MENRRVNLSKFFLSMAEEDLEIAKILLETNHHSGSVFHSQQCIE KAFRNCYILDRQI" gene 9748..10380 /locus_tag="MFS40622_1847" /db_xref="GeneID:8805725" CDS 9748..10380 /locus_tag="MFS40622_1847" /note="TIGRFAM: DNA binding domain protein, excisionase family; PFAM: Resolvase domain; regulatory protein MerR; KEGG: mja:MJ0014 hypothetical protein" /codon_start=1 /inference="protein motif:TFAM:TIGR01764" /transl_table=11 /product="DNA binding domain protein, excisionase family" /protein_id="YP_003459252.1" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="GI:289193312" /db_xref="GeneID:8805725" /translation="MERHYTLKEAAKILGVSIKTLQRWDKAGKIKCVRTVGGKRRVPE SEIKRILGIKDDKQRKIIGYARVSSNTQKDDLERQIQLIKSYAEENGWKIQILKDIGS GLNEKRKNYKKLLKMVMNREVEKVIIAYPDRLTRFGFETLKEFFKSYGTEIVIINKRQ KALQEELVEDLITIVSHFAGKLYGMRSHKYKKLTKTVKEILREDNAKEEN" gene 10361..11671 /locus_tag="MFS40622_1848" /db_xref="GeneID:8805726" CDS 10361..11671 /locus_tag="MFS40622_1848" /note="TIGRFAM: transposase, IS605 OrfB family; PFAM: transposase IS605 OrfB; putative transposase IS891/IS1136/IS1341 family; KEGG: mfe:Mefer_0450 transposase, IS605 OrfB family" /codon_start=1 /inference="protein motif:TFAM:TIGR01766" /transl_table=11 /product="transposase, IS605 OrfB family" /protein_id="YP_003459253.1" /db_xref="InterPro:IPR001959" /db_xref="InterPro:IPR010095" /db_xref="GI:289193313" /db_xref="GeneID:8805726" /translation="MPKRKTKLPTEIVLTYKVRHGYNLDNLPNEFIKIAQKAVDIIWE NINWKEKKVKHRYKVGRKYKYYTTIRLIPEIPKDKTFKRELRSILLKNWNFASHYVDG AIKVAYSTIESWKSNYLNGKRGRNKPIFKRPFVRVKTTLIKYDKENGLIRITIKPRKE YLTLNIKNEWFFDKVRDFTIGEVILKDKEALITFKKPLNLSDKRILIGVDSNLKSLDL YHPEKGWIRIDLSELHRIKKVYDAIIDKLKSIYKKAPKRIGKLLKKYLNRRKNRVNDF INKLTSQLSKLFPNAIFVFEDLDKFNMYDDNSSFNRSLDRSSWREIARRLEYKSIVFY VNPHYTSKTCPVCGSKMKSQEGQVVKCDKCGVFDRQFVGCFNVFKRGVELVKEFLGGV GVPVAGVKGDDLLPNEPRGELNPMPPNPNVVYYVDLNGKYLKCL" gene 11695..12006 /locus_tag="MFS40622_1849" /product="hypothetical protein" /pseudo /db_xref="GeneID:8805727" gene 12010..12161 /locus_tag="MFS40622_1850" /product="hypothetical protein" /pseudo /db_xref="GeneID:8805728" ORIGIN 1 aggataagtt agaaattttc gaagtgcatg ccactgtttt atagagggta tattgccgat 61 tttataaaaa ataggcagtc attttgtata ataactaatt aagggaacat gttaaagaaa 121 gataaaatgg aaatgaaaaa ttatatccaa tagttgaaat gttatccaaa gtaaaagagc 181 atatttgtag aaaaatatac tctgaacaaa aatatacttg catacttgta tattctgcta 241 cctttccagt gaagataaca aaagttatat tctatagttg ccataactat gagtagaaaa 301 atagaggttg gtagttatgg agttatctaa caatgatgtg ttttttattg ccatggggat 361 ttatttgttc ctattgtttg ctattgcatt tatgacttat agatgggcta agagtgtaaa 421 actatctaaa acataatttt aaccattttt tattagctta tttcctaaaa tccaaaatgt 481 aattattcct aatgttgcta tacaacataa tccaatggca atggcttttt tatacacaaa 541 taagttgtat gtgcttagca ataacccgta atagctatgt tcaattagta tgttaaatat 601 ttttctaaca acatagttgt agaattctat tctatcctct atgcttagtt gtttgtaaat 661 gtcaaagcca tagcctaata taaattggaa agcaaataat aagccaattc ctataattac 721 catgaatata atgcttatgt tagttggata ctgcaagggc tggaacatta taccaatagc 781 tataactaag taagtcataa gagttaattt tattatggaa attgtgttat ctataaaata 841 ggttatttta tcattcatag caacaccatt aggggcttta cctttctatt tttctatatt 901 tctaaaggca tgattaaatt gttttaaaag tatataaact attaagatat ctccaaagtt 961 cagtatgtgt gtttaagcaa tttttgctat tattatgtgt ggtggtgttg gtctttagcc 1021 tcaaaggcaa actttggtta aaaaattccg gacactaaaa atgtaagtta tttaacatac 1081 atatttggtg tttttatcat gccactgctt gattaagtgc aagatttttt agaagtttaa 1141 agttgattaa cccacccctc cttcgaacct attttaaaca aatgcaattc gttataaaaa 1201 accagtatga gggtaataag cagtgttaaa ataggaactg cttaaatttc attaatgaaa 1261 caaaatgtat tacaaaaaaa gaaaaccaat tcccaccctc caagaggtct tattttaact 1321 ttatagttcc agcattacaa aaatgttatc taaaaggttt ccatcctcca agaggtctga 1381 ttttaacaac aaatatttat atacagctac agctttgttt agggtaagtt tccatcctcc 1441 aagaggtctg attttaacac gattatagtg aagagttaga gagcttttta attgaagttt 1501 ccatcctcca agaggtctga ttttaactga taaggaaatt aaagaagtta cagacgatgt 1561 agttaggttt ccatcctcca agaggtctga ttttaacacg cagtaaatat ataccttagt 1621 agattaaaag aatagtttcc atcctccaag aggtctgatt ttaacgcagt tttacgatgt 1681 atttaatcaa aaggaattct agtttccatc ctctaagagg tctgatttta acccaaccaa 1741 tagaaaaaat aataaatgct gataagaggt ttccatcctc taagaggtct gattttaacc 1801 attttagaaa gttatttgtt aatatcatgt gttatgtttc catcctctaa gaggtctgat 1861 tttaacaggg caatcatcga caatatagtt ttaattacca ttcttatatt taagcttttt 1921 ggaaccatat ttttctaagt atagatgaca tcttttattt ataaatccaa cgctatataa 1981 gcttttttct tatatacaaa atagaggatt tttatatttc taaatttgaa gatttaactt 2041 attggttgga gaaattttat ttagcttatt atttaacctt aacttttaaa aatctaaatg 2101 atttaataaa cctaaatatt ccgaataatc aaactaccat atccttagaa attaaataaa 2161 aatcctctaa attagcaaat atcaaatagt tattaccttt attaaattca aagttcattc 2221 ggcgagacag ccacaacact acaataaaca actaaatcaa acaaataaaa atatcaaaaa 2281 acccatataa atatttttgt tctttttaaa ttattctttc taaatcatat tgtttaagtg 2341 caggttgaat ttttttgaac actatatcca aaacatgtag gcagtggcat agctattaat 2401 ccagatgcca ctgccaatat acaacaatct ataatttttt accatatttt tcttttaaaa 2461 actcattaaa tctctcctta tcctctaaaa caaataatag taaatctaca actaatttac 2521 taactgttat tttttcatac tttgagcaaa tatataaaaa atcatgcaaa ttttcaggaa 2581 aggaaatccc agcccttttt acccctccat tcatgccatt gttaatattg gctaaaaaat 2641 catcatagtg agctttaaca acgttatgaa tgctttgata attctctttt tctctataat 2701 cttctttttt gtcttttttg aacaaattca gcattaatta ccacctttta attattttat 2761 aaacagtggc atttaattca agtcagttag cacttctttg acagtttcca aagcagtttc 2821 ataatccaat ccacactcta ctaatgccat tgctatatcc tctggcttta aaacatccaa 2881 ttgatacttt tttatcaaat cccatcgacc ttctcttttt aaatgttgtt ttccctttga 2941 tttattctca tgccccaaat atttgtcaac ataagcccca gcttttttaa aggataagta 3001 aatcttcttt ttcaatggca tatttttgcc agcataaaca ttagtgtata tctccttcaa 3061 cttctctaaa aacaattctg aagctctcaa ttttctcaat ccatgaatat taaccccttt 3121 ttcaacataa tagtttaatc cgcagttttt taaacatctt ctaaaaaatg cattaacact 3181 atctttatcc aagcctacaa tttcaacatc atctaaaatg ttgtttttta tttgatgctc 3241 tttgattgat ttgagcaatt catactcttt ttcagtatga gcagggatta ctctatgtaa 3301 tccatgtttt gagtttttga caattaaata agcattatat attgatttcc caaccataaa 3361 acgctttaat gagtctggaa tagctctttc atctaaaaca acatctccat attttagttt 3421 tgcaatttca ttcactctca aagcaaaatg tcttgctaaa acaatgccaa tctttgcttt 3481 gctctttgat ttttggaaat actcactatt gataaccctt ttataatctt caggttctat 3541 ccttatggtt cttgcttctt gttgtagtgc atgctgagga acataaatcc cctttgcaaa 3601 tttaaaattc cattttagcc cataagtttt agcacaggct aaattcaatg ctttaatcat 3661 tgaaacatac ttttttaatg ttgttgctct aactccctct tttgctttgc attcgaggaa 3721 aagttgagtc atttcaggag ttatatcgca agctctttta actttaaatt cattttgtat 3781 ccatcttcca aagttatttg caaattttat taaggagtct aagtatccct ccttatgcct 3841 attcccacgc caaaaatccc cccttgaggc tacaaaccaa atttttgatt tttctttgag 3901 ccattcttcg aaggtaatgt ctcccctctc ataagctttg tctaattcct gccattgctg 3961 tttaaattgt cttctttgcc ctctatgcct ataggattgc atgactgcat actttagctg 4021 gtgatgtaaa ggcctattcc tacccattaa atcccaccaa attttaccac aattggttaa 4081 tataaatatt ttgtattcgc taaataaaca attataacaa tgtgtatttg taaaatgtgc 4141 ttacacactt tgtattaacc ttagtttctc ccaaattgtg ttgttttttg tggtgtgcat 4201 ggtttgtttg tttatattta tccatttgga ataaccaata atcgaggcag tcctaacccg 4261 tcgtgggtaa ttgccattac ccacgacggc taccgccctc aggaataaac aatgccccca 4321 atatatcgat taattcacat attgaaacat cctgctctcc acggatgtgg agagccgaaa 4381 ggttcctgga gggtcgccct ttatggcatg ggcagtcccc ctcccagccc ctcactctgc 4441 cacaccccca acggagtgtg ggtcatcggt catcggagct aatttattgg aataaactaa 4501 tattttgata tatagttgtt tcaatatata ctataacgac attttcatac atttgtgtat 4561 ttaaaatagt tctcctcctt gtccctcctt aacttctatt gcaccccacg tgattaattt 4621 aaaagaaaca ttatagtttc tgtaatagag agtatatata actatcgcat ccacaaaaaa 4681 caaaactgcc aattttttgg gaaaatcaag gaatcattag ccccattttc gggaaaaata 4741 ccaattaaat ctcaatttag aggtattagg gagagtatga ggaaaagaac tgttcagtat 4801 atgtgaaata acataattat ggtatatagt atattcggga caatgaggag ttttggagat 4861 ttgaggaatg tcaaggagtt attaccccta tttttcggag aataacgagg atttttgaga 4921 ttttaacaat ggttgtgttt attgtatgca caaccatcga aattggaaaa aatcataaaa 4981 tcataggggt tgaaaaactc aatttcttat ctggatggaa tatgccttat ctgttgagta 5041 ttgatagata tatacggata aaagtcttat ccgacagata agattagatt aaaacagata 5101 aggttcttat ctgttagata aaaacaattc caaacagata agaacggata agaatagata 5161 gagacagata agaacggata agaatagata aaacaggata aggttattac taaacagata 5221 aaggaatata agttgagata tatattttgg atatctggct atagtagtat gacttaatta 5281 tctctagcta cctttctgag ctaaagttcg gagctttgta atagatatag caaagtatat 5341 atatccaatg ttacaatata acaataaacc attaagttgt gattgttatg aagtattatt 5401 ctgccagaga agctgcaaaa atcttgggtg tagctcatac tactgtaatt cgatggattg 5461 aaaagggaga attgaaagct aacattagaa aaacgttata tagagtatat tatcagattc 5521 cagaggatga agtgttgaga ttaaaaaaaa ggctggaagc ccagcacgat taacatttgg 5581 gagtattgta cgattacgtt aggacacaag agtgttctaa tagagattca cagtggttta 5641 ttaaaaattt tgcacgatta cgtataggat atctaccaaa gttttaaggt gatgtgcatg 5701 tccccaaatg agtatattat tgataaaata tataatattt tcgaacgtga gaggaaaaag 5761 catcctacct ataaagaaag caaatatgat aaagaatcag aatataagga attaataaag 5821 tttttagtag aaaaagagga ggtaaatgaa gctgaattga tgctaaaggc aaaggaaata 5881 gggcttggaa ggttgtatta caacacattc attgcaatat taaaaaaata tcttaatttt 5941 attgatattg gagaagagga tggttataag gttattaaaa tcacaaatga attaagaaat 6001 gttttaaatg atgataatga aagtgatgaa tctaatttta aaatagatat ggaatttatc 6061 ataatgcaat atgaagactt gttaagaaaa tatttaaaga attatattac tgttgttggt 6121 cccgagaagt tggaaaggaa gattaggctt tctgcaaggg atttatctgc agagtttggg 6181 gatatgattg attatgccat tgagagtgtt gataattatt atcaggtagt tgattatttg 6241 acaaaattat ttaatgaggt atattatgag ataacttatg aaatgggaga ttttaaggtt 6301 gttttgtgtg attttccagc attggaaatt gatgttaata agattaatgc tgaatatgtt 6361 aataaggtag tagaatttga agcaaacata atttacgcgt ctcatgtttc tgtttttgtg 6421 aaaaagagtg ttttccaatg tccaagatgt ggaaaaatag ttaatgtgta tctcagggac 6481 ttttttgcaa aaaatagtga taagttggta tgtaatgagt gtaatgtaaa attacagcac 6541 attaaagacg aagaatacac aaactttcag gaattgattg ttcaggggct acctaacgag 6601 aaggggtata taagggagca gagagtgttg tatgaagact ctgacggggt ttttagtgga 6661 tatgtgaaga ttacaggtat cgtcaggaca gttccaagga gttcaaaatc caaagtttat 6721 gatttggttg ttcaggcagt ggatgttgag gagattgata acattgctcc aagattgaca 6781 aagaaggaca ttgaagatat taaaaagatt gctaagagga aggatgtcat tgatttatta 6841 tcagatagat taatcccaga gattaagggg cattcacttg taaaaaaagc tgttttctta 6901 caacaaatta ggggggtgaa aaaaccagga aaaagggata aaatcaacat tctcttaatt 6961 acagaccctg ggattgggaa gacggttatt ttaagaaaga ttgcggagat tccaggtaat 7021 aattatgtga gtatgccaac ttcaacgatt aacagtgttt ttgcaattgc agagaagaaa 7081 aagagcctat ctggagaaag ttggactgtg aaagttgggc ctgttccaaa gtcaattgga 7141 actgtatgta ttgatgaatt ctacattccc aaaggagata ctacatttta tgaggctatg 7201 gagggggatg taatccattt ttgtaaagga gggattgatg caaggttgca atcagtttgt 7261 agctttcttt gtgcgagaaa cccaagatgg ggaagattta atccggatgt ttctgtagct 7321 gaacagattg atatcccagc tccattgctt agcaggtttg acttgatttt cccaattagg 7381 gatagggcag ataaagaggc tgataaggaa attgcagaac acattataga tgtgcatagg 7441 gcttatttag acaaggaagt taataaaaag attagattag attacattaa gattgatgga 7501 gtgataattg actttgagtt cattgtaaaa tacattttct acgcaaggca gttaaaacca 7561 gttatgactg gggaaactaa gaaaaaatta gtaaattggt atgtagagat gaggaaaaaa 7621 cataacatca ctgcaagaca gttagaagcg gccgtaagat tggctgaagc tcatgcaaaa 7681 gcaaaattga aagatgttgt tgatgttgag gatgcagagg aggcaattgg aatgataaca 7741 gaatgtttaa aagagattgc ttatgaccca gaaactggaa tattcgatat tgacaaaata 7801 atgggagttc atagtagtga aaggaaaaag ttagatattg tgtataatgc catagaagag 7861 ctttcacatg ggagttcgga ggttttagtt ggttttgatg aaatcttaaa ttttgttgaa 7921 gaaaaaggaa taaatgagaa ggaattggaa agattgttaa acaagttgaa aaagtttgga 7981 gatattgatg aaccaaaacc gggaaggtat cggttgatat aatatataat ataatatata 8041 ttatatgttg tatctgctgg tggaggtgtt ggtatggcag tctcctatgc taggatatat 8101 gagttgttac ttaaatatgt taaggatgag aagaaggcta tggaatgtta tgatgtggtt 8161 gttgaggtaa taaaggagat tgagagagag gctagggaag gggttaaaga tgatttgagg 8221 gatgagttgg ctactaagaa ggatattgcc cttttggagg aaaaaatgaa ttctatggag 8281 gagaggattt taaggtatgt tgataataaa tttaatcaaa taaaaatatt gatactaatt 8341 accttatttg ctgtaattgt tttgaatcct tatgcttatg aaattgtaaa ggccatattg 8401 aaataatttt ttcattgagt gttggtgtta ttcaatgtta gaaaatgaat tagccactaa 8461 gaatgatatt gccctattgg aggagaggat gaattctatg gatgagaaga ttttaaggta 8521 tgtggataat aagttttatg aattggataa aaagactgat agaatctttt atttgattat 8581 tgtgttcatg atagtgtatg tattgacaaa tcctcaagtt gtgggagtta taaaattaat 8641 ttttatgaaa taatagaata agagggatat aatggatatt gacaaataca ttgaaaactt 8701 ggagataaag aaggagggat ttttctataa atgtccttat tgtgattata ctaatgcaga 8761 cttaaaagtt ataaaaaagc atattaaaac taagcattta gatgagataa agaaagaggt 8821 tgagaagatg aataaaccaa agcaaaagca gaataagcag aggaggatgc cacagaggaa 8881 gcaagtaaag aaggaggatg attataagga ttatttgttg ttatttgctc ataagaagaa 8941 gtgtaaaatc catttggaca atggcatggt tgttgagggc ttggttaagg caaaggataa 9001 gtataatatt atggttttag atgcgagggc tgatggcaag gatgttggta ggatgataat 9061 tcaaaagggg catattgttg ctctaattcc gttagaggaa taagtatggg aaaatagtag 9121 ttatgcaagg ggagggtcaa aaatgaatga aaaaatgtta aacaaaatcc taaatgaatt 9181 tttaaataaa tgtaaggaga aatttgggga tgacttaata tcaattattt tatttggttc 9241 ttatgcaaga ggaacagcta cagaatattc tgatattgat ttgttgatta ttgttaaaaa 9301 cctaccagaa aggagaattg ataggtataa aattataaaa gatattgatt tagagtttct 9361 taaaaaatat tgtatagcct tatctccaat cttggtaaag ccagaagaat tatcaattaa 9421 atcaataaat ccgttaatat atggaatttt aactggttat agagtaattt atgataaaaa 9481 taatttttgg aaaaattatc ttgaaaaaat aagaccaatt attaaaagaa caaatccaat 9541 atttgttgat ggggagaaag aatggaaaat cgcagagtta atttaagtaa gttttttcta 9601 tctatggcag aggaggattt ggaaatagca aaaattttat tggaaacaaa tcaccactct 9661 ggttctgtct ttcactctca acagtgtatt gaaaaagcct tccgaaactg ttatatatta 9721 gatagacaaa tatagacatt gatggttatg gagcgacatt atactctaaa agaagcggca 9781 aaaatcttag gagtttcaat taaaacatta caacgttggg ataaggcggg aaaaattaaa 9841 tgtgttagaa cggtaggagg taaaagaaga gttccagaga gtgaaataaa acgaatctta 9901 ggaataaaag atgacaaaca aaggaaaatt atcggatatg caagagtgtc atcaaacact 9961 caaaaagatg atttagagag gcaaatacaa ttaataaaat cctatgcaga ggaaaatggt 10021 tggaaaatac aaatattaaa agacattggt agtggtttaa acgaaaagag gaagaattat 10081 aaaaaacttt taaaaatggt tatgaatcgg gaggttgaaa aagtaataat cgcttatcca 10141 gacagattaa caagatttgg ttttgaaacg ttaaaagagt tttttaaatc ttatgggact 10201 gaaattgtaa ttataaacaa acgacagaag gcactacaag aagaattagt tgaagatttg 10261 ataacgattg tttcccactt tgcaggaaag ctttatggaa tgcgttctca caagtataaa 10321 aagcttacca aaacagttaa agaaatctta agggaggata atgccaaaga ggaaaactaa 10381 actcccaacg gaaattgtat taacttataa agttagacat ggttataact tagacaacct 10441 accgaatgaa tttataaaaa tagcccaaaa ggcagttgat attatttggg aaaacatcaa 10501 ctggaaggaa aagaaggtaa aacatcgata taaggtgggg agaaaatata aatattacac 10561 taccattcga ttaattccag agattccaaa ggataagact tttaaacggg agttaaggag 10621 tatcctacta aaaaattgga atttcgcatc acattatgtc gatggtgcta taaaagtagc 10681 ttactctaca atagaaagtt ggaagtcgaa ttatttgaat ggtaagaggg ggaggaataa 10741 gccaatattc aaaagacctt ttgttagggt taaaacaact ctaataaaat acgataaaga 10801 aaatgggctg ataagaatta caataaaacc gagaaaggaa tatttaactc taaatattaa 10861 aaatgaatgg tttttcgata aagttagaga tttcaccatt ggagaggtta ttttaaagga 10921 caaagaagca ttaataacat ttaaaaaacc attaaattta tccgataaga ggattttaat 10981 tggagttgat agtaatctaa aatcactcga tttatatcat cctgagaaag gttggattag 11041 gattgatttg tctgaattgc ataggataaa gaaggtttat gatgctataa ttgataagtt 11101 aaagtcaatc tataaaaaag ctccgaagag gattggcaaa ttattgaaaa aatatcttaa 11161 taggagaaaa aatcgagtta atgattttat taataaattg acttcacaac tgtcaaaact 11221 ctttccaaat gcaattttcg tttttgagga tttggataag tttaacatgt atgatgataa 11281 ttcgagtttt aataggagtt tggataggag tagttggagg gagattgcga gaaggttgga 11341 gtataagagt attgtttttt atgttaatcc tcattatact tcaaaaacct gtcccgtatg 11401 cgggagtaaa atgaagtccc aagagggaca ggttgttaag tgtgataagt gtggtgtttt 11461 tgatagacaa tttgttggtt gttttaacgt gtttaagagg ggtgttgaat tggttaaaga 11521 atttttaggc ggagttgggg ttcccgtggc tggggtgaag ggtgatgatt tactccccaa 11581 tgaacccaga ggggagttga acccaatgcc acccaatccc aacgtggtct attatgttga 11641 tttaaatgga aaatatctca aatgcctata attgtccata aatgaccacg ttgggaagac 11701 cccattaaat ctgtattaat tttatttgga gtttttataa aaacacatta tgtttcaacc 11761 ctgctggtaa ggaatttgga taacttcgat gaatattgga aaggaagatt tgaaagttta 11821 ttacctataa taagggagtt agaaagacat tgggctttgc cccgatatcc tgaaccaatg 11881 ggggaggatg tgtggaatcc actggagaaa tatacaaaag aggatgctga agaatgctta 11941 aaaaatgcag aggaagtttt aaaagttgtt aaagaatttt taaaagaaaa atataattta 12001 gagtaagagt ttaaagaaag ttatgaaatt gaagacataa caataaacaa aaaagttaga 12061 agttttcact taaacaaaat attttattct taaatccaca aaaagggatt ttaaaatctc 12121 aaagttattt gatttggaat gttatagaga ggttgttatg aagttgattc agagactgaa 12181 ctttaattcc aaagttc //