LOCUS NC_013453 17256 bp DNA circular BCT 22-NOV-2009 DEFINITION Staphylococcus aureus subsp. aureus ED98 plasmid pAVX, complete sequence. ACCESSION NC_013453 VERSION NC_013453.1 GI:262260515 DBLINK Project:41455 KEYWORDS . SOURCE Staphylococcus aureus subsp. aureus ED98 ORGANISM Staphylococcus aureus subsp. aureus ED98 Bacteria; Firmicutes; Bacillales; Staphylococcus. REFERENCE 1 (bases 1 to 17256) AUTHORS Lowder,B.V., Guinane,C.M., Ben Zakour,N.L., Weinert,L.A., Conway-Morris,A., Cartwright,R.A., Simpson,A.J., Rambaut,A., Nubel,U. and Fitzgerald,J.R. TITLE Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus JOURNAL Proc. Natl. Acad. Sci. U.S.A. 106 (46), 19545-19550 (2009) PUBMED 19884497 REFERENCE 2 (bases 1 to 17256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (29-OCT-2009) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 17256) AUTHORS Lowder,B.V., Guinane,C.M., Ben Zakour,N.L. and Fitzgerald,J.Ross. TITLE Direct Submission JOURNAL Submitted (30-SEP-2009) The Roslin Institute and Centre for Infectious Diseases, Royal (Dick) School of Veterinary Studies, University of Edinburgh, The Chancellor's Building, New Royal Infirmary, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, UK COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..17256 /organism="Staphylococcus aureus subsp. aureus ED98" /mol_type="genomic DNA" /strain="ED98" /sub_species="aureus" /db_xref="taxon:681288" /plasmid="pAVX" gene complement(125..376) /locus_tag="SAAV_c01" /db_xref="GeneID:8554475" CDS complement(125..376) /locus_tag="SAAV_c01" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283626.1" /db_xref="GI:262260516" /db_xref="GeneID:8554475" /translation="MVSVRKHFSNVYPNIEFHEADESHLDFPTKRSYFGYAKLKHNSL KQGYPIEIFQHDNLTKIVSIMEPDTWLQFRFRRNYGFKL" gene complement(1355..2929) /locus_tag="SAAV_c02" /db_xref="GeneID:8554453" CDS complement(1355..2929) /locus_tag="SAAV_c02" /codon_start=1 /transl_table=11 /product="primase C 1 family protein" /protein_id="YP_003283627.1" /db_xref="GI:262260517" /db_xref="GeneID:8554453" /translation="MLNINKIYDFILHGSIEKYKFKNSKATDLEKANFKATQPRNWRS ARIAVTPNKATLIDGLGLIIASEEALVQYGHKFSHWTPNPYNYLSKEKANIADVNTYK VLNRTKDNVKQINTFVLDVDEDIEYNELVQSLASAHINEGAELPNLYVKTPRGWHLYF VLDTPFYAKGIEKKAIKVAEKVHSSLAHAISKYLPVDNQCVSTGYFRLPTKDNVQLFT NQYCSKSYMVRWSKEYSEKHNLNQNVLYKSIANGQELTPEWVDYLLKEADVTSFGYGV GRNNAMFSVALYYYSKNIDMKVAESNIYAFNQRLNQPLSHKEVERVIKSAYSGRYGGA MREHVENLLEAFTDGQIAYSNSGVSINGFWKHKKERKDRVRSHFDERKADLERYLNEH TNKQKVFVKGSMSAIAKKLGMARSSLYAVFEKHINKGTIIKYTIKNGRYSETFIALKS VYIESLFEMVKSIKNKKESYITAIRHLVSSERNTHSLMVQNNGLLNEIENTLTYIDRH TQYIEGNEILYERFIS" gene complement(3321..3569) /locus_tag="SAAV_c03" /db_xref="GeneID:8554454" CDS complement(3321..3569) /locus_tag="SAAV_c03" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283628.1" /db_xref="GI:262260518" /db_xref="GeneID:8554454" /translation="MNENILLELCSKLKGIRKGKKYTQQEVADIIGINIWTVNRIENK KLEEVKLKTILRILDLYEITLYEFIEDNKDIVNRAYNK" gene complement(3582..4136) /locus_tag="SAAV_c04" /db_xref="GeneID:8554455" CDS complement(3582..4136) /locus_tag="SAAV_c04" /codon_start=1 /transl_table=11 /product="putative resolvase" /protein_id="YP_003283629.1" /db_xref="GI:262260519" /db_xref="GeneID:8554455" /translation="MAKIGYARVSTISQSLETQINLLKAEGCIKIFSEKVSGKKTNRS KLDECLKYLREDDVLVVTKIDRLGRTTKQLINLASWLQEHNIELKILDGNFNMNSPLG KMIFTVMSGFAELETDLNRERTLEGLNEAKARGRKGGRPGVTKDVKNYVMYLYNNTEL SGNEIARKTGVSRSTVYRIKRDFN" gene 4643..4774 /locus_tag="SAAV_c05" /db_xref="GeneID:8554456" CDS 4643..4774 /locus_tag="SAAV_c05" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283630.1" /db_xref="GI:262260520" /db_xref="GeneID:8554456" /translation="MYIIYLKKGFIDISKEGKMAKIGYARVSTKDQNLGSVVKLEKV" gene 4825..5379 /locus_tag="SAAV_c06" /db_xref="GeneID:8554457" CDS 4825..5379 /locus_tag="SAAV_c06" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="YP_003283631.1" /db_xref="GI:262260521" /db_xref="GeneID:8554457" /translation="MIKKEIRCFSNFATEPEFPLFNKEFGHLERDTIVGRRHGSAIIT LVERVSKMIITLRPLGRKATDIENALHSMFSALPSHIFKSITFDCGKEFSNWKTICNC HDISIFFADPGTPSQRGLNEHSNGILRRSGLDKELDFNLVTDNHIISVAQKINHRPRK SLGYRTPLEVFMSFIEDDKLSSLI" gene complement(5555..5692) /locus_tag="SAAV_c07" /db_xref="GeneID:8554458" CDS complement(5555..5692) /locus_tag="SAAV_c07" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283632.1" /db_xref="GI:262260522" /db_xref="GeneID:8554458" /translation="MINTEKVNSLPLFTGELVNKINRGSLNIPFLSIVIFLIRVKVEN Y" gene 5879..6013 /locus_tag="SAAV_c08" /db_xref="GeneID:8554459" CDS 5879..6013 /locus_tag="SAAV_c08" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="YP_003283633.1" /db_xref="GI:262260523" /db_xref="GeneID:8554459" /translation="MEGINNKIKLIERISFGYRNFNNFKTCIMMIFSLYQVEKEDNQA" gene complement(6116..6433) /locus_tag="SAAV_c09" /db_xref="GeneID:8554460" CDS complement(6116..6433) /locus_tag="SAAV_c09" /codon_start=1 /transl_table=11 /product="staphostatin" /protein_id="YP_003283634.1" /db_xref="GI:262260524" /db_xref="GeneID:8554460" /translation="MSKYQLINIKDNNLEFSEKYWLHILQGVWRPEKISTKPLKITFN KNIFPIYICKEINEDSRRIILNNTDNTNIIIEIIIINHKKIIFNVLNKLSLGVTPKIT FIK" gene complement(6454..7653) /gene="scpA" /locus_tag="SAAV_c10" /db_xref="GeneID:8554461" CDS complement(6454..7653) /gene="scpA" /locus_tag="SAAV_c10" /codon_start=1 /transl_table=11 /product="extracellular thiol protease (staphopain)" /protein_id="YP_003283635.1" /db_xref="GI:262260525" /db_xref="GeneID:8554461" /translation="MAKKICNISTIVFVLAIGLILSLVFSLFFNNVNAEEASQKELPN QKNTKVNIDKKDIPSAVKKLAEDQYLSRVAALDKLSGEKNSSYTLGEAFKIYKFNQKS DGNYYFPVLNKEGKVVYVVTISPKIANDKNTSSNSDYTINVSPFLSKILNQYENQKFT ILTNTKGYFVVTEDNKIKHVLKTPYSGEKNSKNTMESPKNIDLKNFKQTASVTKPIIQ FENPKYGVRAQYVNQLKNFKIRETQGNNGWCAGYTMSALLNATYNTDRYNAEAVMRYL HPNLQGDDFQFTGLTPQEMMKYGKSQGRDTQYLNRMPSYNEVDKLTTNNKGIAILGSR VESTDGIHAGHAMAVVGNAELEGGQEVIMIWNPWDRGFMTQDAESNIIPVSNGDHYQW NSSIYGY" gene complement(8147..8485) /locus_tag="SAAV_c11" /db_xref="GeneID:8554462" CDS complement(8147..8485) /locus_tag="SAAV_c11" /codon_start=1 /transl_table=11 /product="putative transposase" /protein_id="YP_003283636.1" /db_xref="GI:262260526" /db_xref="GeneID:8554462" /translation="MFSALPSHIFKSITFDCGKEFSNWKTICNCHDISIFFADPGTPS QRGLNEHSNGILRRSGLDKELDFNLVTDNHIISVAQKINHRPRKSLGYRTPLEVFMSF IEDDKLSSLI" gene complement(8845..9096) /locus_tag="SAAV_c12" /db_xref="GeneID:8554463" CDS complement(8845..9096) /locus_tag="SAAV_c12" /codon_start=1 /transl_table=11 /product="putative plasmid replication-associated protein" /protein_id="YP_003283637.1" /db_xref="GI:262260527" /db_xref="GeneID:8554463" /translation="MIAMAGFLDNIKVVGQQKRGFLDDIDTSAVKYTENYKPMAKSST MRVDTLIKRRLSQMALDKDTSIKAISDKVLQEFLEKNNY" gene complement(9097..9888) /locus_tag="SAAV_c13" /db_xref="GeneID:8554464" CDS complement(9097..9888) /locus_tag="SAAV_c13" /codon_start=1 /transl_table=11 /product="chromosome partitioning ATPase" /protein_id="YP_003283638.1" /db_xref="GI:262260528" /db_xref="GeneID:8554464" /translation="MSVITIGNFKGGVGKTTVSTLLSYIGSERYDKRILLVDFDPQGN ATQIMKRTYPEAIDEKQTFIDALKTGELEDSIINLSTKLSLLPADSSLANLSDIIAKT DIIKKRYILKTVIDQIKKNYNFDYIFIDVPPTINSDFTNNAVYASDYIAMVFQTQQSA YESSLSFVNFLRDRKKESNLPFELIGAIPVLIKKNGNIDEYILEISKKTFSNALFKNQ IFQRERIKKFGAEGIRDKDVHDKRVLHMLEAIYKELIERIELIEG" gene 10018..11301 /locus_tag="SAAV_c14" /db_xref="GeneID:8554465" CDS 10018..11301 /locus_tag="SAAV_c14" /codon_start=1 /transl_table=11 /product="replication protein" /protein_id="YP_003283639.1" /db_xref="GI:262260529" /db_xref="GeneID:8554465" /translation="MSQSLRFTKLYKFLFEDPTFKTLPAKAKLLYALISERQSLSKAN AKQHGIQSQFIDNEGRLFSIYTNQELMTKLNMSKPTVIKLKKQLIEFGLLEDVRLGNN QPNRLYPKKPYDNYFYAYDVDEFYRLPHALFENPKYQSLAAESIIAYAIYLSRYEYSI YKNHFSDENGAVYCCFSNDNMANILDVSTRKVERIKKELIVSSLMINKRASFGKSNRL YISLPKASDDKEVKKCRTSYTYFSYTYSSDIDSNDMNDTYDNNIDEVHEINDSPQTNH SSHPNHQHNTEDTFNDQQVEQEMLLQHLPDYVQLNLKHFSNTEIRCIKSVLNKAKASY NHHAPVDERVTYEACTYAIGEALRRIKLLSRQKNENICDLEAYMMQTFKRVFVEHVLN DQQKLDDTKTKTHDISQFEPKNAFQSMAKRMFLDV" gene 11333..11566 /locus_tag="SAAV_c15" /db_xref="GeneID:8554466" CDS 11333..11566 /locus_tag="SAAV_c15" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283640.1" /db_xref="GI:262260530" /db_xref="GeneID:8554466" /translation="MNEKEIGIAFLNHFTQVEAYLEALGVPENHIADIKPIVIQNYPY ERFLFDDLGDVTNVIIPFSKVIGSNLFGNIGYK" gene 11576..11986 /locus_tag="SAAV_c16" /db_xref="GeneID:8554467" CDS 11576..11986 /locus_tag="SAAV_c16" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283641.1" /db_xref="GI:262260531" /db_xref="GeneID:8554467" /translation="MKWSLEQNFHGNAPNLKPQKIQGCLGFLKSLGWENWNQSYQTLD IGELYFSLLLDDKGHVITYMHEGGNGGGRHRIFTGKVCGAEYVRAARLTQFRLNKQKL AYYKNNWYLSNKLKILFKKVNCFKLFVSYILFMF" gene complement(12138..12812) /locus_tag="SAAV_c17" /db_xref="GeneID:8554468" CDS complement(12138..12812) /locus_tag="SAAV_c17" /codon_start=1 /transl_table=11 /product="transposase" /protein_id="YP_003283642.1" /db_xref="GI:262260532" /db_xref="GeneID:8554468" /translation="MNYFRYKQFNKGVITVAVGYYLRYALSYRDISEILRERGVNVHH STVYRWVQEYAPIVYQIWKKKHKKAYYKWRIDETYIKIKGKWNYLYRAIDAEGHTLDI WLRKKRDHQSAYAFIKRLIKQFGKPQMIITDQAPSTKVAMTKIVKVFKLNPNCHCTSK YLNNLIEQDHRHIKVRKTRYQSLNTAKNTLKGIECIYGLYKKNRRSLQIYGFSPCYEI SHMLAS" gene 13020..13145 /locus_tag="SAAV_c18" /db_xref="GeneID:8554469" CDS 13020..13145 /locus_tag="SAAV_c18" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283643.1" /db_xref="GI:262260533" /db_xref="GeneID:8554469" /translation="MTFIGNVVILVPFVLVAISENGNSSGEDNDFNRYGCMILKY" gene complement(13391..14074) /locus_tag="SAAV_c19" /db_xref="GeneID:8554470" CDS complement(13391..14074) /locus_tag="SAAV_c19" /codon_start=1 /transl_table=11 /product="caax amino protease family" /protein_id="YP_003283644.1" /db_xref="GI:262260534" /db_xref="GeneID:8554470" /translation="MYKNLNNIHQSHYLALIYIILLIIIPRYAILPFSNKLNINYDII NEWYFFVITTILMIYAIKIFKVKLQKDWLNIKNKKIGVFLTGIVGFFLILLLNVILIL IINQGRPVKSVNQNAIENISFLSQFFAPLLIVIIGPILEELLFRVYILEVLKNKIKLL PAILISISSFTVIHMHSLTEDWKTLIPYFSIGIVTVFIYLKKHNFYYILSIHVLNNLV AQIAIWFLQ" gene complement(14249..14587) /locus_tag="SAAV_c20" /db_xref="GeneID:8554471" CDS complement(14249..14587) /locus_tag="SAAV_c20" /codon_start=1 /transl_table=11 /product="pemK-like family protein" /protein_id="YP_003283645.1" /db_xref="GI:262260535" /db_xref="GeneID:8554471" /translation="MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWV LPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALDLKARQYNYKDELQDNLKNDILK AIKTYLKPTL" gene complement(14584..14943) /locus_tag="SAAV_c21" /db_xref="GeneID:8554472" CDS complement(14584..14943) /locus_tag="SAAV_c21" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003283646.1" /db_xref="GI:262260536" /db_xref="GeneID:8554472" /translation="MFLIFINYSTSYVFTLVTTFVMMNKRGLIIMAKSLKDLNKTSER VFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGG KYTELEVDWEERVGREI" gene 15424..16233 /locus_tag="SAAV_c22" /db_xref="GeneID:8554473" CDS 15424..16233 /locus_tag="SAAV_c22" /codon_start=1 /transl_table=11 /product="lysophospholipase" /protein_id="YP_003283647.1" /db_xref="GI:262260537" /db_xref="GeneID:8554473" /translation="MNYIKYIHSVDGTTLYVKVNENVNSSANIIICHGLAEHLDRYDE ISNYLQEKNFNIIRFDQRGHGRSGGKRTFYSNVNEIVEDLDAVINFTKEHYKGNIYLI GHSMGGYGSVLYSTKNPGKINGLIISGAVTRYNQKTFGDIDDTIDRNKYINYEIGEGV CSDTFELEKYRLDALTEKKVSYGLIYTVLEGVKGLVENAQYFDDNILILHGKDDGLVH YSDSLDFYKNISSSKKELHIYDGLQHEIFNERKKNKEIFSEIANWINNDLT" gene 16346..17077 /locus_tag="SAAV_c23" /db_xref="GeneID:8554474" CDS 16346..17077 /locus_tag="SAAV_c23" /codon_start=1 /transl_table=11 /product="caax amino protease family" /protein_id="YP_003283648.1" /db_xref="GI:262260538" /db_xref="GeneID:8554474" /translation="MKKTTIYFVLYFIISALGFGMLKKLGIEYNSLEIAVYALPMMII LSIFVYSIALNPYQKRKSSPIIHVKSLEYVVPLVILCDILIILELLYTGNFRPILVAQ LFLTFLIGFSEEFFFRKYIIEHILTKYKSKLLALITSSILFGLLHMANTFGGLTIENA ASQSMSATGVGLLYGLIYIFTKKIWMLVLLHMNVDFALFSSVINQSYLQAVPAFIVDI ILIFTVLKIIMYILKSIKSKNNKFL" ORIGIN 1 tatcaaaagc aacatcacta tacgtaaaac gtttgttggt ttctttccaa atctcctttt 61 cataattatc ccgatcttta aatttttgct ctctaatatc ttcatcagtc ttttttatag 121 cttttcataa cttaaaaccg taatttcttc taaatctaaa ttgtaaccat gtatcaggtt 181 ccataatact aactatctta gttaaattat catgttgaaa tatttctata ggataaccct 241 gttttaaaga attatgtttt aacttagcat aaccaaaata tgatctttta gtaggaaaat 301 ctaaatgact ttcatctgct tcatgaaatt ctatatttgg ataaacattg ctaaaatgtt 361 ttctaactga aaccattaac tctttatccc ctgctaaata aaaacctaat ttgctatctt 421 tactttttcc tcgtctattt tctctataga ttaaaaaagt aaaccaagga tctccataaa 481 aaaaatcttt caaaaatatt tcttctagtc gaatgaatat ttttcaataa tttaaaaatt 541 ttatcagatt taggaaaatc tccctcataa gttaatattc tataatattc catatttttc 601 tgtattttaa ttattttcat aatatatcgc aacaacatag aaaatattat taatacaatt 661 gcaaaaattg caccagcgat cagtgatgct cgcgctgtga aaaatatgag tagtgaaagg 721 ataaggatat aggatatgaa taaggagagt tgtctaagaa gtttagacgt catatgtgga 781 tacctcccgt ttgtatttgg ttgtcaaggt acagtggata tgtcgccccc gcatttaaca 841 aataaaaaac aaagtcttct ccagttacga ttaattaaga tgatgatatt attctatgaa 901 taatgtaatc ttatttaatc taacaggaaa tagtcacgaa aaataccggg ttttatatcc 961 ttaattacat ttcaccttaa aaagactata aaaacaatat ttaatttgta tatcatgtta 1021 tgtgttatgt agttcattat ggtatggatt atgtaatgaa tttaatcaaa gcataatcta 1081 attatattaa tcttaataca tagtataata cgtcatatat tcacaccata atcaaacgca 1141 atatacaccc ataatatata attgttaatg gggagagatc tccattttgt taaaatattt 1201 taggtaattt ttaatttttt ggcgcctgct aattttaatt agtaggcgtt tttctattat 1261 tctacataac tacttaacta ctcacttata tatattattt acagaaacgc acaaacaccc 1321 tgatatatgt aatggcacat cggacaatta aaatttaact aataaaccgt tcatatagaa 1381 tttcattacc ttctatatat tgagtgtgcc gatctatata agtgagtgta ttttctattt 1441 cattcaacaa accgttattt tgtaccatta aactatgtgt atttctttca ctgcttacaa 1501 ggtgtcttat agccgttata tagctttctt ttttgttttt aatactttta accatctcaa 1561 ataaactttc aatatacacg ctttttaaag caatgaaagt ttctgaatat ctaccgtttt 1621 taattgtgta tttgataata gttcctttgt ttatatgctt ttcaaaaact gcatataaag 1681 atgatctagc cattcctaac tttttagcaa tagcactcat tgagccttta acaaacactt 1741 tctgcttatt tgtatgttca tttaaatatc tttctaaatc ggctttacgt tcgtcaaaat 1801 ggcttctaac acgatcttta cgctcttttt tatgtttcca aaagccattg atacttacac 1861 cactattgct atatgcaatt tggccatcag taaaagcttc taaaaggttt tctacatgtt 1921 cacgcattgc gccaccataa cgaccgctat aagcactttt aattactctt tcaacttctt 1981 tatgtgataa aggctgattt aagcgctgat taaaagcata gatattactt tctgctactt 2041 tcatatctat atttttagaa taataatata acgctactga aaacattgcg ttatttctac 2101 caacgccata tccaaatgaa gtaacatctg cttcttttaa caaataatca acccattcag 2161 gcgttaattc ttggccattg gctatactct tataaagtac gttctgattt aaattgtgct 2221 tttctgaata ctctttactc cagcgcacca tataagattt tgaacagtat tgatttgtaa 2281 ataactgaac attatctttt gtaggcaatc tgaaatagcc agtagataca cattgattat 2341 cgactggtaa atatttagaa attgcatgtg ctaagctact atgtactttt tcagctactt 2401 ttatcgcttt cttttctata cctttagcat agaacggtgt atctaataca aaatataaat 2461 gccaacctct aggcgtcttt acatacaaat taggcaattc agcgccttca ttgatatgcg 2521 ctgaagctaa gctttgaact aattcattat attcaatatc ttcatcaaca tctaaaacaa 2581 atgtattgat ttgttttaca ttatcttttg ttctgtttaa cactttatac gtattaacat 2641 ctgctatatt agctttttcc ttacttaaat aattatatgg attaggcgtc caatggctaa 2701 atttatgacc atattgaact aaagcttctt ctgaagcaat aattaagcct aaaccgtcta 2761 ttaatgtagc tttattaggt gtgacagcaa tacgtgctga tctccaattt cggggttgtg 2821 tagccttaaa attagctttt tctaaatctg tagctttaga atttttaaac ttatactttt 2881 ctatgcttcc atgtaatata aaatcataaa ttttattaat atttagcatt gtctgcacct 2941 cctaaacaaa aaagactgat aacacttgta agcgttacca gtccttgttt aggcgtccat 3001 atacatttaa agtagtcgag tagcgaagta gaaaagtaga aaagtagcgt ctttttcttt 3061 actttcttct ctcatgcccc tataatttag gtatacaaaa taatttaaaa atacctaaat 3121 cataaaggta tggaagaaga cccgaaaacc gtttgtatac gttagtgagg taacgtttca 3181 agcgctagaa gttaaaaatg ttggtagcaa ttttaacttt gcacgtggtc ttttttcata 3241 tctttttttg attaattcta gtataaactt ctatattgac gattgcaata attttggtac 3301 atttgcaaat aaattaaatg ttacttgtta tatgctctat ttactatatc tttattatct 3361 tctataaatt cataaagtgt gatttcatat aaatcaagta tacgtaaaat tgttttaagt 3421 ttaacttctt ctaatttttt attttcaatt ctgttcacag tccatatatt aattcctatt 3481 atgtcagcaa cttcttgttg tgtgtacttc ttacccttcc ttatcccttt aagtttagaa 3541 cataattcta ataatatatt ttcattcatc ttttttcccc cctaattaaa atcacgtttg 3601 atacgatata ctgttgatct acttacacct gtttttctcg caatttcatt acctgataac 3661 tctgtattat tgtatagata cataacatag ttctttacgt ctttcgtaac acctggtcgc 3721 ccgccttttc ttcctctagc tttcgcttcg tttaaacctt caagagttct ttctctattt 3781 aaatctgttt ccagttctgc aaagccactc attacagtaa atatcatttt tcctagtggg 3841 ctattcatat taaaatttcc atctaatatt tttaattcta tattgtgttc ctgtagccaa 3901 cttgctaaat ttattaattg tttagttgtg cgtcctaatc tatcaatttt agtcacaact 3961 aatacatcat cttcccttaa atattttaag cactcatcta atttacttct atttgttttc 4021 ttgccactta ctttttcaga aaatatttta atacaacctt cagcctttaa taagttaatt 4081 tgtgtttcta agctttgact gattgttgaa actcttgcat agcctatttt agccaaaata 4141 tcgcctactt cctttataaa tagctttaat atgaacgatt gtgtgtgcgt ttacgtataa 4201 tgggcttcaa aatatttttt cgcggcgtct gagggcttct ctcagcttgg tcaaaaaccc 4261 tttttacctt taattttgac actttgattt taacacatat tttgaccagg cacgaatata 4321 gttaaaggct tatagaattt attcagttct acaagccttt aatccttaca aatagcactt 4381 attcaagcat attttttatt attttatttt acttattgaa atatattatt ttctaatgtc 4441 ataccctggt caaaaccgat cggttttgac taggttatgt tagaaacagt actttttgac 4501 tgtctataaa acggaggttt atagacaaca gtaactaaaa tatattataa agtacgaaga 4561 aggatagtaa atcccttata tttaaggtgt ttattatcct ttttatattt aatacaatgt 4621 ctatttactt atctataaat caatgtatat aatatactta aaaaaaggtt ttatagacat 4681 tagtaaggag gggaaaatgg ctaaaatcgg ttatgctaga gtttcaacta aagatcaaaa 4741 cttaggttct gttgtaaagt tagaaaaagt atagctaatc atcattttat catgtcagtg 4801 ttcgtttaac tagctaacac tgaaatgata aaaaaggaaa ttagatgttt ttctaacttt 4861 gcaacagaac cagaatttcc tttattcaat aaggagtttg ggcatcttga aagagatact 4921 attgttggtc gtcgtcatgg tagtgcaatc attactttgg tagaaagagt ctccaagatg 4981 attatcacct tgcgaccctt aggtcgtaag gcaaccgata tagaaaatgc tctgcactca 5041 atgttttcag ctttaccttc tcatatattt aaatcaatta cttttgattg tggtaaggag 5101 ttttcaaact ggaaaacaat atgcaactgt catgatatat ctatattttt tgctgatcca 5161 ggcacgccat cacagagagg cttaaatgaa cattctaacg gaatacttag acgcagtgga 5221 ttagataaag aactagattt caatttagta acagacaatc atatcatcag tgttgctcaa 5281 aaaatcaatc atcgtcctag aaaatcttta ggttatagaa caccattgga agtatttatg 5341 agtttcatcg aagatgataa actgtccagc ttaatttgat aatctaaaat cttaaaaaat 5401 aaaggaataa taacaaaagt acacaaagtc attttccaat ccaatataaa aagcataatt 5461 atggaaccaa taattgttaa tacattaggt aaagtaatgg gaaccttatg tgatataaaa 5521 gtatttataa cctttgtatc gtctactatc ctacttaata attctccact ttcactcgaa 5581 tcaaaaaaat aactatgctc aaaaaaggta tgtttaatga acctctattt attttgttta 5641 ctagctctcc cgtaaataat ggtagcgaat ttactttttc agtattaatc attatgctat 5701 gtatctcatt tagaaatcac cccaaaggtt atgcaataag acgaaattta ttaatcgttt 5761 gaattctgtt agtagaaagt ctataagtaa agatatctag aaagttgtta actattatag 5821 gaagaatcaa agaattctaa gaaatacaat ttatcatcca gtatttaata atagatttat 5881 ggaaggaatt aataataaga taaagttaat tgaacgaatt tcttttggct acagaaattt 5941 taacaacttc aaaacatgca tcatgatgat tttcagttta tatcaagttg aaaaagaaga 6001 caaccaagcc taatattgga ctggttgcct aaaaataaat actctcagaa ttattattta 6061 aaatagttta ttagtatcta aaaatcataa aattgaaaga gttactttaa gctgtttatt 6121 tgataaaagt aattttaggt gttactccta aagataactt attcaacaca ttgaaaataa 6181 tctttttatg gttgattata attatttcta taataatatt agtattgtcg gtattattta 6241 aaattatcct ccttgaatct tcattaattt ctttacatat atatattgga aaaatatttt 6301 tattaaaagt tatttttaaa ggttttgttg aaattttttc tggtcgccat actccttgga 6361 gtatatgaag ccaatatttt tctgagaatt ccaaattatt atctttaata ttaattaatt 6421 gatatttact cataagtttg cctttttata ttattaatac ccataaatag aactattcca 6481 ttgataatga tctccattag atactggaat aatattactt tcagcatctt gagtcataaa 6541 accacggtcc caagggttcc aaatcataat cacttcttgt ccaccttcta attctgcatt 6601 accaactaca gccatagcat gtcctgcatg aataccgtct gttgattcta cacgacttcc 6661 taaaatagca atgcctttat tattagtagt caatttatca acttcattat aagatggcat 6721 tctattaaga tattgagtat ctctaccctg tgatttccca tacttcatca tttcttgagg 6781 tgttaaacct gtaaattgga aatcatcacc ttgtaaattc ggatgtaaat atctcattac 6841 tgcctcagca ttataacgat ctgtattata agttgcattc agtaatgctg acattgtata 6901 tccagcacac caaccattat taccttgtgt ttctctgatt ttaaagtttt ttaattgatt 6961 gacatattgt gctcggactc catatttggg attctcaaat tgtataatag gttttgtaac 7021 tgaagctgtt tgtttaaagt tttttaaatc aatatttttg ggggattcca tcgtattttt 7081 agaattcttt tcaccactat atggagtttt taatacatgt ttaattttat tatcttctgt 7141 aactacaaaa taaccttttg tattggttaa aattgtgaat ttctgatttt catactgatt 7201 taatattttt gaaagaaacg gagaaacatt aattgtataa tcactatttg aacttgtatt 7261 tttatcgttt gcaattttag gagagattgt aacaacatat actactttac cttctttatt 7321 taacacaggg aaatagtaat taccatcact cttctgattg aatttataaa ttttaaatgc 7381 ttcacctaat gtgtaagatg aatttttttc tccggataat ttgtcaagtg ctgctacacg 7441 tgaaagatat tgatcttcag ctagcttttt aactgccgat ggaatatctt ttttatcaat 7501 attaactttt gtattttttt gatttggtag ttctttttgt gatgcttcct cagcattcac 7561 attattaaaa aacagactaa ataccaaact aagtattaaa ccaattgcaa gaacaaagac 7621 aatcgtacta atgttacata tttttttagc catagaaaac actccttttt atttttgtaa 7681 ctctttcatt attaatataa cactctttct gcttttttat tatttttttc ctaaatgttt 7741 atattaacga catatttgta taaaatatta attgataacg aaaatatttt tattaactta 7801 atacctcaat aatcttattg aataaattta ttgaggtgta caatgacagt tggggctaag 7861 tttaaacact ttaattaagt tagacattga ccctctgcat caatacacta tttataatag 7921 ttttattatt tttttcttct aaatttgata taaaattagt attatattct taaaattacg 7981 gataattttt ttgacgatat acttattatc tattgctttt aatatttcag atatatcacg 8041 ataattcaat gcgtacctta agtattagcc tacgcctata gtgatgacat tcttatcgaa 8101 ttatttatac ttcgaaagat taaatatttt ttaagatttt agattatcaa attaagctgg 8161 acagtttatc atcttcgatg aaactcataa atacttccaa tggtgttcta taacctaaag 8221 attttctagg acgatgattg attttttgag caacactgat gatatgattg tctgttacta 8281 aattgaaatc tagttcttta tctaatccac tgcgtctaag tattccgtta gaatgttcat 8341 ttaagcctct ctgtgatggc gtgcctggat cagcaaaaaa tatagatata tcatgacagt 8401 tgcatattgt tttccagttt gaaaactcct taccacaatc aaaagtaatt gatttaaata 8461 tatgagaagg taaagctgaa aacattgagt gcagagcatt ttcggttctg ttgcaaagtt 8521 aaatttatag tataatttta actttgcaac agaaccggat ttactaattg aatggtgtaa 8581 atatcaagat gaagatgttt atgaacgcta taaaaatcat gaattaccag ggcaaaaaat 8641 aatatttgca aaaaatatat attctagctg ctacaaaata acaaaaaaga gtgcgttctt 8701 attaaagaat gcactcttta aacttctcta tattagaatt aaagaactta aaaataatga 8761 tttgaaaact aattggtcta tgataatgag ataatttctt ttgtaaaatc aaatctgaac 8821 atctaaaaaa ctaaaccact tctattaata attatttttc tctaaaaatt cttgtaaaac 8881 tttatctgat attgccttta tggacgtgtc tttgtctaac gccatttgac taagtcttct 8941 ttttatcaga gtatcaactc tcatagtcga acttttagcc attggcttat aattttctgt 9001 atacttcact gctgaagtgt ctatgtcatc taaaaatcct cttttctgtt gtcctacgac 9061 tttaatatta tctaaaaatc ctgccattgc aatcacctat ccttctatta attctattct 9121 ttcaatcaat tctttatata tcgcttctaa catatgcaaa actcttttat catgaacatc 9181 tttatcccta ataccttctg caccgaattt cttaattctt tctctttgaa atatttgatt 9241 tttaaacaga gcatttgaaa aagtcttttt agatatttcc aatatatatt catcaatatt 9301 accatttttc ttgattaata caggtatcgc acctattaat tcaaacggta aatttgattc 9361 tttttttcta tctcttaaaa aattaacaaa tgataaactg ctttcatacg ctgattgttg 9421 tgtctggaat accatagcaa tgtagtcgct tgcatataca gcattatttg taaaatctga 9481 atttatcgtt ggtggtacat ctataaaaat gtagtcaaaa ttataatttt ttttaatttg 9541 atcaataacc gttttaagta tatatcgctt ttttataata tctgtttttg caataatatc 9601 tgacaaatta gctagtgaag aatctgcagg taataaagat aatttcgttg ataaatttat 9661 aatactatct tctaattccc ctgttttaag agcatctata aatgtttgtt tttcatctat 9721 tgcttctgga tatgttcttt tcataatttg ggtagcgttc ccctgaggat caaaatcaac 9781 taatagaatt cttttatcat acctttcaga gccaatatat gataataaag ttgatacagt 9841 agtttttcct acccctcctt taaaattacc aatagttata actgacatat acaacactcc 9901 ttactgttat aatataatat attataacag taacttgtga catgtcacaa gttactgtta 9961 tacaattcca aaaaatcaac tctaacaaaa acaaataagg aaagaggttt ttttattatg 10021 tctcaatcac tacgttttac aaaactatac aaatttttat ttgaagatcc tacatttaaa 10081 actttaccag cgaaagccaa attgctctat gcattaattt ctgagcgtca aagcttatcg 10141 aaagctaatg ctaagcaaca tggcattcaa tcccaattta tcgataatga ggggcgtttg 10201 ttctccattt atacgaatca agaactgatg acgaaactta atatgtcgaa accaacggta 10261 atcaaactaa aaaaacaatt gattgaattt ggtttattag aagacgtgcg tctcggtaac 10321 aatcaaccga atcgtttata tcccaaaaag ccctatgata actatttcta tgcctatgat 10381 gttgacgaat tttatcgtct tcctcatgct ttatttgaaa atcccaaata tcaatcttta 10441 gcggctgaat ctatcattgc ttatgcgatt tatctgagtc gttatgagta tagtatctat 10501 aaaaatcatt tctcggatga aaatggtgca gtctattgtt gtttctctaa tgacaatatg 10561 gcaaacattt tagatgtgag tacacgaaaa gtagaacgta tcaaaaaaga attgattgtt 10621 tcgagtctaa tgattaataa gcgtgcatct tttggtaaat cgaatagatt atatatttca 10681 ctccctaaag ctagtgatga caaggaagtt aaaaaatgtc gcactagtta tacttatttt 10741 agttatactt attctagtga tattgattct aatgatatga atgatacgta tgataataat 10801 attgatgaag tacatgaaat aaatgattca ccacaaacaa atcattcaag tcatccaaat 10861 catcaacaca acacagagga tacgtttaac gatcaacaag tcgaacaaga gatgttactt 10921 caacacttac cagactatgt acaattgaac ttaaaacatt ttagtaatac tgaaattcgt 10981 tgtattaaat ctgtactgaa taaagcgaaa gccagttata atcaccacgc acctgtagat 11041 gaacgtgtta cgtatgaagc ctgtacctat gctattgggg aagctttacg acgtatcaaa 11101 ctattaagcc gacaaaaaaa tgaaaatatc tgcgatctag aagcctacat gatgcaaaca 11161 tttaagcgtg tctttgttga acatgtgctg aacgaccaac agaaacttga cgatactaaa 11221 acaaaaacgc atgatatttc acaatttgaa ccgaaaaatg cgttccaatc gatggcaaaa 11281 cgtatgtttc ttgatgtttg ataactttaa tatttaggaa ggagagatag ttgtgaatga 11341 aaaagagata gggattgcgt ttttgaacca ctttacgcaa gtggaggctt atttagaggc 11401 tttaggtgtg cccgaaaacc atatcgcaga tattaagccg atagtcattc agaactatcc 11461 ctatgaacgc tttttgtttg atgatttagg cgatgtaacg aatgtgatca ttcccttttc 11521 taaagtcatt gggagtaact tatttgggaa tattggctac aagtagtttg acttagtgaa 11581 atggtcgcta gaacagaact ttcatggtaa cgcgcctaac cttaaacccc aaaaaataca 11641 aggctgttta ggttttctaa aatcgttagg ttgggaaaat tggaatcaaa gttatcaaac 11701 attggatatt ggagaactct attttagttt gctacttgat gacaaagggc atgtgataac 11761 ctatatgcat gaaggtggca atggcggcgg tagacatcga atatttactg gtaaagtctg 11821 tggtgcagaa tatgtcagag ctgcgagatt gacacaattt agattaaata aacaaaaatt 11881 ggcatattat aaaaataatt ggtacttgag caacaaatta aagatattat ttaaaaaggt 11941 gaattgtttc aaattgtttg tttcgtatat tttatttatg ttttgaaagg agtatctttt 12001 catgaaaaaa atattattat tagtgagcac atgtttatta tatttagatt gtcaaattaa 12061 gctggacagt ttatcatcgg ttctgttgca aagttagaaa aacatctaat ttcctttttt 12121 atcatttcag tgttagttta actagctaac atatgactga tttcgtagca tggcgaaaat 12181 ccatagatct gaagagacct acggttcttt ttatataatc cgtaaataca ttcaatgcct 12241 ttgagtgtat tttttgccgt attgagactt tgataccttg tctttcgtac cttaatatga 12301 cgatgatctt gttcaatgag gttattgaga tatttagatg tgcaatgaca gttagggttc 12361 agcttaaaca ctttcactat tttagtcatt gcaaccttcg ttgaaggtgc ttgatctgta 12421 attatcattt gaggtttacc gaattgttta ataagacgct taataaacgc atatgctgat 12481 tgatgatctc gttttttacg caaccaaatg tctaatgtat gtccttctgc atcaatggca 12541 cgatataaat agttccattt tccttttatt ttgatatacg tctcatcaat acgccatttg 12601 taataagctt ttttatgctt tttcttccaa atctgataca caatcggtgc atattcttga 12661 acccaacgat agactgttga atgatgaaca ttgacaccac gttcccttaa tatttcagat 12721 atgtcacgat aactcaatgc atatcttaga tagtagccaa cggctacagt gataacaccc 12781 ttgttaaatt gtttatatct gaaatagttc atacagaaga ctcctttttg ttaaaattat 12841 actatcaatt caactttgca acagaaccct agcaagttaa tacgaagtat tattttaaac 12901 atgagtctag aggtttattt tttaactttg caacataact gttttagata tatgtgtagg 12961 agtaaaactt ttttgcgaag aataagtata taaataaatt ggagataagt ataattacat 13021 tgacgtttat aggaaatgta gttattttgg ttccatttgt acttgtagcg ataagtgaga 13081 atggtaatag tagtggagaa gataatgatt ttaataggta tggttgtatg attttaaaat 13141 attagctatc aaaaaatatt tttatagaga aaataataaa aaacatctag atcagtttgt 13201 accttgaaat ttgaaatcaa taaaaaaacg accactaaca cctcatagct attatactac 13261 aaatattgtg gtcgttctga agacttcatt catttggagg tgaggcataa gtactcgtgg 13321 gggatatcct aacctctctt ttttgaattg tgtattttga tgttgataat aaactaaaat 13381 actgctgttt ttattgtaaa aaccaaatag caatttgagc tactaaatta tttagtacat 13441 ggatagagag tatataataa aagttgtgtt tttttaaata aataaaaact gttactatgc 13501 ctattgaaaa ataggggatt aatgtcttcc aatcttctgt taaactatgc atatgtatta 13561 ccgtaaaaga cgatatagaa attaatattg cagggagtaa tttaattttg tttttaagaa 13621 cttctaaaat atatactctg aaaagtaatt cttcaagtat aggtccaatg ataacaatta 13681 ataatggtgc aaaaaattga gataaaaatg aaatattttc aatggcattt tggttaacac 13741 tctttactgg tctgccttga ttaataatta atataagtat tacatttaaa agaagaatta 13801 gaaaaaagcc tactattcct gtaagaaaga caccaatttt tttgttttta atatttaacc 13861 aatctttctg tagttttact ttaaatattt taatggcata tatcatcaaa atagttgtaa 13921 taacaaaaaa ataccattca ttaattatat cgtaatttat atttagtttg tttgaaaacg 13981 gtaatattgc gtatctgggg ataatgatga gtagtattat ataaattaaa gctaaatagt 14041 gactttggtg aatgttattt aaatttttgt acatggaaat ctcctgaatt ttttataatt 14101 actaagtatt tgtttaaaag ttatttggat ttgctttgta ttcccatttt aagaagcaaa 14161 gaagtttata aaggtataat aaatactata ttttgccctg ttacgaaatt aaatctatag 14221 tatactttta gctttgcaac aaaatccttt ataacgttgg cttaagataa gtttttatcg 14281 cttttaatat atcatttttt aaattgtcct gtagttcgtc tttatagttg tattgacgtg 14341 cttttaggtc taaagcgcgt atttgaacag tgtctatcac accagatact aatccttttt 14401 ttgttttaag ttggatatct gttggataac gtaaaccccg agttgttatg ggtaaaaccc 14461 aaacaaaatt agtgccatca atactcatct gattatttat cactaagcag ggccttacgt 14521 tatgcttttc acgtccacga gttggattta aatcaatgta gagtatgtca aattgtttaa 14581 tgttcatatt tctcggccaa ctctttcttc ccaatctact tctaattctg tatactttcc 14641 accactttga aagaaatttt taattctatc ttcaatagac tccttttttt tagtaatgaa 14701 caaaccacca ttcatttttt gaacttcaac tgtatctcct atatcaaaat tagctaacct 14761 gatagttttt ttacttaaac tgattgcttt actgtttcca tttttaaaaa ctcgttccga 14821 agtcttgttt aagtctttta atgatttagc cattattatc agcccccttt tgttcatcat 14881 aacaaatgta gttaccaaag taaatacata tgaagttgaa taatttataa aaatcaaaaa 14941 catcgctttt actatcctcg actgcatttt ttacaaaggt gaaaagtaaa tatttaattt 15001 ttcgtttaag gtaatcgttt tcttaacttt ctagtatgac gataattttg ctcaatgagt 15061 tcgttaaggt atttatattt ataatgacag ttaatattaa ggttaatatc ttgaattaat 15121 tcggacattg cccttcttat ttaattttga tatatatctt atcaacatac agtttaaagt 15181 taaccctaag ttctctttcc atatatcaca ataactcaac gtctatctta atcaacaatc 15241 atcaactata tcgttgctac ctttatcaaa ttgtttatag ctgcagtagt tcatgtagaa 15301 tatttctttg tgttaatacc ataccataaa attaactttg caatagaatc tatatttata 15361 attattttac ccatttatgt taattaatgg taaaataatt ataaatatag agaggttaaa 15421 agaatgaact atataaaata tatacatagt gtagatggaa caactttata tgttaaagtg 15481 aatgaaaatg taaatagtag cgctaatatc attatatgtc atggattagc agagcattta 15541 gatcgctatg acgaaatttc aaactatttg caggagaaaa attttaatat tataagattt 15601 gatcaacgag gacatggaag gtctggagga aaacgaactt tttatagcaa tgtaaatgag 15661 atagttgagg acttagatgc tgttattaat ttcaccaaag aacattataa aggtaatatc 15721 tatctgattg ggcatagtat gggaggatat gggtctgtac tttattctac taaaaaccct 15781 ggaaagatta atggtttaat tatatctgga gcagtaacaa ggtataatca gaaaactttt 15841 ggagacattg atgatacaat tgatagaaat aagtatatta attatgaaat tggagaggga 15901 gtgtgtagtg atacttttga gttagaaaaa tatagattag atgcattaac tgaaaaaaag 15961 gtatcttacg gcttgatata cactgttttg gaaggtgtaa aaggcttagt ggaaaatgct 16021 caatattttg atgataatat tttaatttta catggcaaag atgatgggtt ggttcattac 16081 agtgactctt tagattttta taaaaacatt tcttcttcaa aaaaagaatt acatatttat 16141 gatggtttac aacacgaaat ttttaacgag agaaaaaaga ataaagaaat tttttcggag 16201 attgcaaact ggataaataa tgatttaact tgagaatccg attgataaat ttgaataagt 16261 cggttctgtt gcaaagttta aaaataagtg tccagcttta tctttaaaag ttttacttca 16321 gaagaaatta gaaaggatta ttttgatgaa aaaaacaaca atatattttg ttctatattt 16381 tattataagc gctcttggtt ttggtatgtt gaaaaaatta gggatagaat ataatagttt 16441 ggaaattgca gtatatgccc ttcctatgat gataattttg tcaatatttg tttactcaat 16501 agctttgaat ccctatcaaa aaagaaaaag ttctcctata atacatgtaa aatcattgga 16561 atatgtggtt ccattggtta tattatgtga tatattaata attttagaat tattatatac 16621 tggtaatttt agacccatat tagtggcaca gttattttta acctttctta ttggtttttc 16681 agaagaattc ttctttagaa aatatattat tgaacatata ttgactaaat acaaatcaaa 16741 actgttagcc cttattactt cttctatact ttttggttta ctacatatgg caaatacctt 16801 tggtggctta actattgaaa atgctgcttc tcaatctatg tcagctacag gagtaggatt 16861 attatatggt ttaatatata tattcacaaa aaaaatatgg atgttggtat tattgcacat 16921 gaacgttgat ttcgctttat tttcgtctgt aataaatcaa tcatatttac aagcagtacc 16981 agcctttatt gtggatatta ttttaatttt tactgtttta aagataatta tgtatatact 17041 caagtcaatt aaatctaaaa ataataagtt tttatagagg atacatagaa atattacggt 17101 tctgttgcaa agttaaaaat catataatat aaatacagag aaatgagaaa ataaccaaat 17161 ctcccgaaat aatctattgt tattgcagca ttttgtttat tgattttgta tagatttgta 17221 tactaattta actttgcaac agaaccctta ttgttg //