LOCUS NC_010715 17207 bp DNA circular BCT 20-MAY-2008 DEFINITION Natranaerobius thermophilus JW/NM-WN-LF plasmid pNTHE01, complete sequence. ACCESSION NC_010715 VERSION NC_010715.1 GI:188584627 DBLINK Project:20207 KEYWORDS . SOURCE Natranaerobius thermophilus JW/NM-WN-LF ORGANISM Natranaerobius thermophilus JW/NM-WN-LF Bacteria; Firmicutes; Clostridia; Natranaerobiales; Natranaerobiaceae; Natranaerobius. REFERENCE 1 (bases 1 to 17207) AUTHORS Copeland,A., Lucas,S., Lapidus,A., Glavina del Rio,T., Dalin,E., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Chertkov,O., Brettin,T., Detter,J.C., Han,C., Kuske,C.R., Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N., Lykidis,A., Mesbah,N.M. and Wiegel,J. CONSRTM US DOE Joint Genome Institute TITLE Complete sequence of plasmid1 of Natranaerobius thermophilus JW/NM-WN-LF JOURNAL Unpublished REFERENCE 2 (bases 1 to 17207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-MAY-2008) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 17207) AUTHORS Copeland,A., Lucas,S., Lapidus,A., Glavina del Rio,T., Dalin,E., Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Chertkov,O., Brettin,T., Detter,J.C., Han,C., Kuske,C.R., Schmutz,J., Larimer,F., Land,M., Hauser,L., Kyrpides,N., Lykidis,A., Mesbah,N.M. and Wiegel,J. CONSRTM US DOE Joint Genome Institute TITLE Direct Submission JOURNAL Submitted (04-APR-2008) US DOE Joint Genome Institute, 2800 Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CP001035. URL -- http://www.jgi.doe.gov JGI Project ID: 4044106 Source DNA and bacteria available from Juergen Wiegel (jwiegel@uga.edu) Contacts: Juergen Wiegel (jwiegel@uga.edu) David Bruce (microbes@cuba.jgi-psf.org) Quality assurance done by JGI-Stanford Annotation done by JGI-ORNL and JGI-PGF Finishing done by JGI-LANL Finished microbial genomes have been curated to close all gaps with greater than 98% coverage of at least two independent clones. Each base pair has a minimum q (quality) value of 30 and the total error rate is less than one per 50000. The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. it is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..17207 /organism="Natranaerobius thermophilus JW/NM-WN-LF" /mol_type="genomic DNA" /strain="JW/NM-WN-LF" /db_xref="taxon:457570" /plasmid="pNTHE01" /note="type strain of Natranaerobius thermophilus" gene complement(115..4874) /locus_tag="Nther_2936" /pseudo /db_xref="GeneID:6314212" gene complement(4962..5192) /locus_tag="Nther_2937" /db_xref="GeneID:6314217" CDS complement(4962..5192) /locus_tag="Nther_2937" /note="KEGG: gka:GKP35 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911143.1" /db_xref="GI:188584628" /db_xref="GeneID:6314217" /translation="MSKRKAINQLLEDSDSNTKIQEYSEEEEGVNNNKTKKKATFELD SDLHTQLKIYAARQNKKMVDVVEEALKEYMKD" gene complement(5170..5946) /locus_tag="Nther_2938" /db_xref="GeneID:6314223" CDS complement(5170..5946) /locus_tag="Nther_2938" /note="PFAM: Cobyrinic acid ac-diamide synthase; KEGG: gka:GKP36 chromosome partitioning protein" /codon_start=1 /transl_table=11 /product="Cobyrinic acid ac-diamide synthase" /protein_id="YP_001911144.1" /db_xref="GI:188584629" /db_xref="InterPro:IPR001220" /db_xref="InterPro:IPR002586" /db_xref="GeneID:6314223" /translation="MGTTISFGIQKGGVGKTTTTAITSYILSKEHKTLAVDFDSQGNL TRFLTQQNIYNFTEKTVLEAVKAKDPRPYIYKISDNLHILPAEDFLATFSRFLYQEYQ GNKALLLKETLDVVREQYNYITIDLPPHLGDQTINGLSASDYAVVLLQSEPFALDALD RYLEVLMGVQKKANSNMKLIGILSTMLDSRAAIDSEIINKARKDYEDVVFETIIRRRN RIKEFSLFGIEERTKVDREALKYYKNFTKELISRVQKKGN" gene 6156..6617 /locus_tag="Nther_2939" /db_xref="GeneID:6314211" CDS 6156..6617 /locus_tag="Nther_2939" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911145.1" /db_xref="GI:188584630" /db_xref="GeneID:6314211" /translation="MKIIKEKAELYKQSREEVNRKIEVWENEIFDLVENKLQEIVSEI GSIEGLKVTVGESPMARSVRLTFGVGPYGKVDDEAFIKRGGSLLFIPKLNGGILVSTS SPSIESDERILVEEEKKPLENYNDPNKITEDKVEKHVEEFFDDLINWWDTL" gene 6819..7046 /locus_tag="Nther_2940" /db_xref="GeneID:6314214" CDS 6819..7046 /locus_tag="Nther_2940" /note="PFAM: helix-turn-helix domain protein; KEGG: lmo:lmo2408 hypothetical protein" /codon_start=1 /transl_table=11 /product="transcriptional regulator, XRE family" /protein_id="YP_001911146.1" /db_xref="GI:188584631" /db_xref="InterPro:IPR001387" /db_xref="GeneID:6314214" /translation="MRYPNCVSLHRQKKGITQEQLAREVDVSLNTIKNVEHGKTNPRV TTAIRISQVIGISVEELFAPKDQFISLKSER" gene complement(7565..9490) /locus_tag="Nther_2941" /db_xref="GeneID:6314215" CDS complement(7565..9490) /locus_tag="Nther_2941" /note="KEGG: drm:Dred_2131 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911147.1" /db_xref="GI:188584632" /db_xref="InterPro:IPR001637" /db_xref="GeneID:6314215" /translation="MQQGEEKIKQLKEFLAKFHGQDGEVYFQMVGDDHNPQIPKKDFN TGKLKEPKVTVDQLENVWDRLCNYHKQGYKVYFKLNSGGYLDKDIYNITAHCVDIDFH HEDDPEELEKKKNEKIEMLKNLPLPPSIIVVSPRGVHAYWLMQKQEDKTPKQIVQEIN QFKYVQDALAAYFNSCTGVNLLCQGMRLPSFKGKIIETSDRRYTQEELLRHYYAEPKP KKKKEKESNQKITNDIPSATPNTIDKPKTSQVAEEVYYNYHDFFEVAKQKDLREYIGL NVPLNENFSCIYHDDQKPSARMGISEKGHYRYRCFADGCGANNPYGLTIIDLMQLNGI TDFSQIIRTISETFNMKLISNEWCQKEKEKYIANMNFIKEEMTRENMYHTYQLFRHAI PIINEMLTMGITKVTPSLCSKDGLSMFFISNRYIAKRTKKWLERVNQYVNLLIWLGVF RLEQPSSNSKIYQDSVKRAEESGKEKAKEIGYKKEFSYNVISYYSMPNLYEIKQELEE KAEQLRKKYRYSISAMSEAYVANHQYPTEEIYAAEFTPNFKKSAMIRDKLLKKAKEQL GHKGYTCWQNFIRLKVKGKRVPREQVKIEFKRIEPILINELGCVKRKANKTLKQMYQL DGYPWIIVTPEVNQRVG" gene complement(9737..10216) /locus_tag="Nther_2942" /db_xref="GeneID:6314220" CDS complement(9737..10216) /locus_tag="Nther_2942" /note="KEGG: ddi:DDBDRAFT_0218840 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911148.1" /db_xref="GI:188584633" /db_xref="GeneID:6314220" /translation="MDELNQENEQLLQKNRQLEVELSEQESRLNKQLQNQKEIERQKN VELKELRDRLQKTENDCIGYKKAYEKWREKAKELSGEKEEDQGKWHDGMMRLEFKDGY AIGVYMLGISENQKPQDAERFAQMQIEEMQGVKELIGVTWSQGHGWTMIVRFEKNVF" gene complement(10337..10906) /locus_tag="Nther_2943" /db_xref="GeneID:6314218" CDS complement(10337..10906) /locus_tag="Nther_2943" /note="KEGG: btl:BALH_p0038 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911149.1" /db_xref="GI:188584634" /db_xref="GeneID:6314218" /translation="MKLEDHITLSEAEQKTGVPARTIRRYIQKHGQYIPFEKQDRKYM IAEYALPMITKIRELYDQGMTVAQVDQKLDNDGDSMLVEVDRVTESSAMDGKKLKEFF QAVLNEHDKKLDQKVKQSEERILNQIQEEQRQIYNSNQLDHQKTRKKLEEEIANIEEI KKLNKTIEELRNEMKELKKPWWKKIFRKD" gene complement(11002..11481) /locus_tag="Nther_2944" /db_xref="GeneID:6314216" CDS complement(11002..11481) /locus_tag="Nther_2944" /note="TIGRFAM: DNA binding domain protein, excisionase family; PFAM: regulatory protein MerR; KEGG: sen:SACE_5645 excisionase/Xis, DNA-binding" /codon_start=1 /transl_table=11 /product="DNA binding domain protein, excisionase family" /protein_id="YP_001911150.1" /db_xref="GI:188584635" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR010093" /db_xref="GeneID:6314216" /translation="MNEKMLTVEEVAEQAGVHVESVRRWIRSGRLPASLPSRYHGYQV KEKDLQDFLQKKNKVQQKGQIEAEQVLRSLADAYNKYQQDEYLRIAYGVAELSGLLPD FQKRWSSGQSDFEIDRLLEQRETVLRNLEKNLGEKTRAKEEKTLKKIEGKLILKHYS" gene complement(11561..12511) /locus_tag="Nther_2945" /db_xref="GeneID:6314221" CDS complement(11561..12511) /locus_tag="Nther_2945" /note="KEGG: mta:Moth_0361 phage integrase" /codon_start=1 /transl_table=11 /product="phage integrase" /protein_id="YP_001911151.1" /db_xref="GI:188584636" /db_xref="GeneID:6314221" /translation="MSNPLEQQLEKLYRHCRQGSKGYRIDSVKRAKEFARYIHDEYKV QNFKNIKDQHVASFVKYQQDKGNSDATIKNKLSSIRFFHDQVSNPRHQISDNKTLQEK YDFKFNKTPEIKEEVNRAWHEKEVDKAVEVATEMGREDVKDAITLAKNTGLRISEVTC MERRQAEQALKTGVMPVDRGTKGGRERVVPINTNSEREREVREVLEKRLSETERGGRL FTEYDQKAHQATRSIQDFLINNQDKFATVEGIELRGSTGDGSTNLNFHGLRYCYAQER KDELLNEHLGDRQKAAEDLSLEMGHNRTDVLRTYLAGESL" gene complement(13634..14074) /locus_tag="Nther_2946" /db_xref="GeneID:6314210" CDS complement(13634..14074) /locus_tag="Nther_2946" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911152.1" /db_xref="GI:188584637" /db_xref="GeneID:6314210" /translation="MGEQEKKTKACDSCKEEIKQDASACPYCGEKQVSKGAVVGCLVI IALIVIGVAIFLFNIIGNGEGVAILQAVDFAEEAIGYDMSYDHDDLVVNEIHEDYYQV NGKISRVHDNKHFRMQSQVEFLEDKDKWRLRYLNIDGDVVHDSR" gene complement(14100..14576) /locus_tag="Nther_2947" /db_xref="GeneID:6314222" CDS complement(14100..14576) /locus_tag="Nther_2947" /note="KEGG: aoe:Clos_2622 hypothetical protein" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911153.1" /db_xref="GI:188584638" /db_xref="GeneID:6314222" /translation="MTKKTQLILVGIILILGMTVHAIYEELNDKQEKTDNDKEQKEEV QVSITEEVKTETTKIIEDYNEVVDTTIEKEANDITLYLVIHREADAKQLGEDFIRSFA SNASIHGEGDIEGPDSESLGGIWEHYSGDIYIGYDADPFLHGVIQDTRDNIRWFEI" sig_peptide complement(14100..14168) /locus_tag="Nther_2947" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probability 0.882) with cleavage site probability 0.783 at residue 23" gene complement(14609..14797) /locus_tag="Nther_2948" /db_xref="GeneID:6314219" CDS complement(14609..14797) /locus_tag="Nther_2948" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911154.1" /db_xref="GI:188584639" /db_xref="GeneID:6314219" /translation="MKEMYIKGDTYEKQKSCFTELGITDYEGYFVSEYEFIGQEEVVQ YYGYSGDTWGEFIISVEN" gene complement(14951..15559) /locus_tag="Nther_2949" /db_xref="GeneID:6314213" CDS complement(14951..15559) /locus_tag="Nther_2949" /note="PFAM: Resolvase domain; KEGG: bcz:pE33L54_0049 recombinase" /codon_start=1 /transl_table=11 /product="Resolvase domain" /protein_id="YP_001911155.1" /db_xref="GI:188584640" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="GeneID:6314213" /translation="MNNYYGYIRVSTDEQNESRQLQALKQFEKDHEVKLTIFMDKLTG KCFSEREQYQALKKVVAPGDVIVIKELDRLGRTYDQIKQELTEFRNINVQVVILDLPT FTDVKDQKLGKLLNNLMVELLSYFAEKEHERITERVREGVRQAQKEGKPIGRPKRKLP KNFSKWYPEWKNGDMTAVEFARIMGVSKPTIYRYIRHYENHN" gene complement(16034..16729) /locus_tag="Nther_2950" /db_xref="GeneID:6314209" CDS complement(16034..16729) /locus_tag="Nther_2950" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001911156.1" /db_xref="GI:188584641" /db_xref="GeneID:6314209" /translation="MSDLKEAVAKAKSSKKKRNKPIIILVLLLVLSIGMNLYLAYPYI YTYFFGRPLIGFEYLQSEMSFFEGALTDLIDEVENDQSGREQDNTDYETHRELWSDVV NHSRNIQRVAGSMNNDPTFLLSGISRDNLETLTGEIRNAHGLLAYYKVKAAARTDEEF FQFENDELEDLRAIAKVHELVVDKIEVNPAYDGNVGGEIIYEPDLFDSLKKPNEYIRN RRSEEKLYPGNIN" sig_peptide complement(16034..16156) /locus_tag="Nther_2950" /note="Signal predicted by SignalP 3.0 HMM (Signal peptide probability 0.799) with cleavage site probability 0.773 at residue 41" ORIGIN 1 ttgcctttta tagccctcat tttggcgcat attggctttt tctttctata aaggtccaat 61 aacctttgta gctaaataaa aagggtatac aagccaaata aaatgggggt aaaattaatt 121 gctttcatct atatctaaat ccggtaattg attaacaatt ctttgagttt ctagacttaa 181 ggttactaat cttttaatta gatcaactat atatcgtgga tcgtcatgct cttctaacca 241 tttgtttgga tcattaacta tgccactctt cttgtccttt ttaacctgat aacggtctat 301 tacccattca attggagatt tacctcctac ttggtactca taaacctcta atggaatgtt 361 cttcagttta attttgtcgt tatagacaat aaccgactta tcattctttt tgtctttctt 421 accaaaacgt attttattga cttcatatgt ttctggatca tcagggtcgc cttttattta 481 tttgatcaaa cagaggaaga ttttcgtaat acaagtgcaa ctcagctaac cttcttccag 541 cgtcactaaa tgatctaaag tcttcggttg aagtaacaaa aggaatgtgc ggcaatgttc 601 tttttaaatt gtgtttatat ctttctctat aatcaggaga atgtaacaag ccgtaaacat 661 agtaaaagat atcttcttta gttacatcta aaccataacg ttttctgtat tcatttaatg 721 cccaatccgt aacgtttttt tgacatatat aatgctctcc agagggtgct gtaatataac 781 ttccattatc caagttctcc tctttaaaaa gacttccttt atcagtttta tatatgtaga 841 atgggaaagc ttgtgtatca cctaccaaat gtagatctgg aatattatca accattaaaa 901 cagaaaagtc ttttgtgccc ccaggtgctt gaatagtaat aactagatta tcaatattag 961 gctcaggaaa aagaattggt aacaaataaa tactattatt aaataaatta ctaaaataga 1021 cccattcttt aacaaaagga cgatacgttg agattaaggt attaccatac tcttgattat 1081 aatattctcc ttttaataac tttttcttta aatctcctga ccatgaaatt ttagtcggat 1141 cattattaac tgtatcttgt aaattatttg atgttatatc gttattattt actagggaaa 1201 catgttcatt aaactcctta atcatgctac ttacgttatt atctaattct tcaatagaaa 1261 aattgtaaac ccaagtatca cggtttgttt taagaccagc cgaaaaagtc ttgaatatct 1321 tttcttcttt tttttgtctc ttgactccaa ttactggaaa tagctcgaat ttttcatctc 1381 tcttactaat ccagtcatgg ttctcatttg gtattatttg ctcccattta actccgttaa 1441 tattactaaa tttatttaat cttgaaagtt tatcttcttt acttagataa tcaccaatat 1501 catggtaata aatttctgct gatccagctt ttgaattatc ctttattaaa acaattaaag 1561 ctactccagc tcgacttcct tgaccaaata ttttatcccc ttctttgcgc caagcttcac 1621 cagatagacg tgcatttccc cttaaattaa caatataaat ttttgaaaac tcttcactta 1681 aacatttcct taaaccatca gcagtattac catcaagaaa accactatta gttacaaaag 1741 caataattcc tttgcccttt aattctgtct gtcgccatcc ttattgcacg tatataagaa 1801 tcaaaaagtg aaattttaag acgagctgat gaattagctg cataagattc ttctattctc 1861 tcatctaata attcataatc tgttgattga atccctcgat tttcatcgtc ttgccaagca 1921 aaccaaggtg ggtttgaaat aatcacatta attttagcct ctttttgctt ttccatttgt 1981 tcagcatatt gttcaggaaa caactctact tgtggtttat ctctatcctc cattagctga 2041 aaagaatcta ctaacaataa attgtcaaaa tgtttatact cccctgtaat ttcataataa 2101 gtactttcta tatttgcaag agctatatag taaggtaata gtaaaatttc atttccccaa 2161 atttcaccat cattatattt tctctgtaat ccctcaggac tgatatggtg cattaattga 2221 gcaagaaatg tacctgtacc tgaaaaaggt tcaaggataa caacatcttc atcttccaaa 2281 ctctgtccaa attcatcttg taaggcagca tctgcgcttt taactaggaa gttcactgct 2341 tctacaggtg tataaactat gcccaaaagc tctgctgttt taggaaaagc tatcttaaag 2401 aaagtatcat aaagtttacg taaaaactcc tggcgttctg attccttatc taaccctttt 2461 gctcttactt caactaatct ataaaagcta tctaaagctc tagtttcttt acggacaaaa 2521 acttcaaaaa cgtctgctac gctttcaaaa ctaagggaaa caggattctg ttgtaaaaat 2581 tcatattctc caaatacagc atcaaaaata ggtttagtta taatgtgctg aactaacatg 2641 ctacgggcat cttcttctgt cacagtgggg tttattacat tacgtagtgc agaaaggaac 2701 tcatagaaag cattttgtgc tttttgtccg tactcagttt cactttctag tgcttcgttt 2761 atatgacgtt ctatacgagt tgaagctgct gctacgtcct tagcccaagt ttccaaataa 2821 ccacgatcac ctacacgctc tacaagcttc cctaaaatag catcaaaaag ccttccagtg 2881 aaatcttcca tggttagctg cgtttgctta tcgctttgta cttcaagttt actgtcatct 2941 tcatcagatc cttgagactc tcctgtctct cctgtttgcc cacgtttaat tgaaagttct 3001 ctgacttctg catcaaaacg atcatctatg gatcttagag cccctaatat ctgccatact 3061 ttcttaaatt cttcattatt atctaattgc tcagctgcat cctcttctgg atcaactaac 3121 actggaatta ctacataacc atattcttta cctggagctt ttcgcatagc ccgtcctaca 3181 gcttgaacta tatctactgt acttctcttt ggtcttaaaa aaactatagc atcaagagat 3241 ggtacatcaa ttccttcttt tagaacttgc gcattagaaa gcactttaga ttctccagga 3301 tcaggttctt ctcttaacca atctaaaagc aatttcctgt tagttgctgt agtagaacca 3361 tcaacatgtc taatatcaaa attgcatgaa tcatcttcta catcttcatc aatattttct 3421 tgataagctt caatagtgtt tacaaactta gacgcaaact ttttagagtc agctatccta 3481 tttgtaaaag aaactgcacg tttaagtgga gcattaatat tctcatcctt tatacggcca 3541 ctaagagcat tccaaacacc aataatcttt gaggcttctt caacctcagg ggaatcttct 3601 tgattaagaa aactaaacag tttacgttga acatcagctt catctactgt aaaaacaatc 3661 accttgtagt cacttaaaaa accttcgtca acagcctggc caaaaccata ccggaaaaat 3721 tcctctccat atgtatcttc atcatccata gtaaaatact catacccctg ttcttcaact 3781 ttttctcgca acctaggcac aaaaaccctt ggtgttgccg tcatatatag tctttttgaa 3841 ccttttataa aatcttcgtc atggactttg tgatagtaag aagcgtcttg gttatccgat 3901 attcccgtag tacggtgagc ttcatctgca aaaataacat caaactctgg tagacctaaa 3961 tcctgtgctt gtgacacaac atcaatcgag tgatatgtag aaacaacaac cgccatttca 4021 tcctcactta cattctgaac accatttgca agttcttctg cgtttgtggt tggagggatc 4081 gtaagtacat ttgtgcgatc aatgtattca tcttcctggc ctacggtatg atcagaggtt 4141 actgcaaaca cttttatagg tgtttctgta tctgaaagcc atgccctaag agtttgttcc 4201 actaaagcaa tagaaggagc caagaaaaat acaaatccac ctggtcctgc gatttcctgt 4261 ttttctgcta tttttaaaga aacaaaggtt ttaccagaac caggaggcat gattaattta 4321 cctctattag tacgtttaaa acccttaatt gttgaatcga ctgcttcctt ctgaaacgga 4381 taaagatcct tccgttcttt taatgttata ttttcgggat ctgaccatgt aaattgctcc 4441 caatcaatag agctatttaa aaggtcagaa agagttaata caactaccgg tttatcttga 4501 ttattaaggg cactttcagc atttgaactt aaggatgaag tagtaataag catacgttta 4561 gaaaatctct cttgaccaga aagtgccaaa aaagtagaaa tatcgtttag acttaattga 4621 ccttcatgaa attttgcttg tattgcccat agttttccag tttctttttc ttcagctact 4681 atatctatac ctgtatcagt ttcatttcct cgtcctggcc agtcactcca tctccatata 4741 tttgaaaaaa gttgtccata gtattcatca tgtttaaggt aggcaacagc aaaacgttca 4801 aaaagatctc cttgctctct tgtgtttctc gctatttcat ttaagcgatt aagtaattgt 4861 tgagcagttg tcatgccaat caacccctct cctttaaaag attttcgtat acgattacgg 4921 atacaggaat acagttttct ttaaatacat atttacagaa tttagtcttt catatattct 4981 tttaaagctt cttctacaac gtccaccatt tttttgtttt ggcgagcagc atagattttt 5041 aattgagtat gtaggtcact atcaagttca aaagtggctt tcttttttgt tttattatta 5101 tttacacctt cctcttcttc gctgtattcc tgtatttttg tattactatc gctatcttct 5161 aaaagttggt taattgcctt tcttttggac acgagaaatc aactcctttg taaagttttt 5221 atagtatttt aaggcttcac gatcaacttt ggttctttcc tctataccaa ataaagaaaa 5281 ctctttgatt cgattacgtc ttcttataat agtttcaaat actacatcct cataatcttt 5341 tctagcttta ttgattattt cagaatctat agctgctcgt gaatctaaca tagtagaaag 5401 tatacctatt aatttcatgt ttgagttagc ttttttctgc actcccataa gtacttcgag 5461 ataacgatct aacgcatcta gtgcaaaggg ttctgactgc aataggacaa cagcgtagtc 5521 tgaagcagat aaaccgttaa tagtttgatc tcctaaatgc ggtggtaaat ctatagttat 5581 ataattatat tgttctctga caacgtctaa tgtttctttt aataatagag ctttgtttcc 5641 ctgatattct tggtacaaaa agcgcgaaaa ggtagctaaa aaatcttcag caggtaaaat 5701 atgtaaatta tctgatattt tataaatata cggtctagga tcctttgctt taacagcctc 5761 taaaacagtt ttctcagtaa aattataaat gttttgttgc gttaaaaatc tagttaaatt 5821 tccctgacta tcaaaatcaa cagcaagggt tttatgttct ttggataata tataactagt 5881 tatagccgta gtggttgtct taccaactcc tcctttttga atcccaaaac ttattgtagt 5941 acccattata aaacctcctg attcttttct aaatgttttt atttctatat attctgctgt 6001 aaatccattt ttccttcttc ctgtatttat gtattttgat tactctcaaa tttttttaat 6061 aatttaggat cttaactcaa cccttaattg caggaaaata ttacctgata aagaatttta 6121 tgattataca cagatatttt aaaaggagtg ggtgtatgaa gataattaaa gaaaaagccg 6181 agctctacaa gcaaagccgc gaagaagtta acagaaaaat tgaagtatgg gaaaacgaaa 6241 tatttgatct tgttgagaat aaattacaag aaatagtaag tgaaattggt tcaattgagg 6301 gattgaaagt tacagtaggt gaatcgccta tggcaagatc tgttaggtta acgtttggag 6361 taggaccata cggaaaagtg gatgatgagg ctttcataaa acgtggtggt agtctattat 6421 tcatccctaa gttaaatggg gggattttag tatcaacttc atccccttct attgaatctg 6481 atgaaagaat cctagttgag gaggagaaaa aacctttaga aaattacaat gatcccaata 6541 aaattacaga agataaagtt gaaaagcatg tagaagaatt ttttgatgat ttgataaatt 6601 ggtgggacac tctttaataa tctttaaaat accacctttg caaggggtat caaaattaaa 6661 atcccgatcc cgattaaggt aaaaaatttg gtcaaaaaaa ttaaaccgct tttgataatt 6721 tggccaaaag aatttaacca aattaccaaa tatagacaat tttctcgggc caaatttgtt 6781 attcttagtg aaagttagtg aaagtggagt gatatataat gagatatcca aattgcgtca 6841 gcttacatcg tcaaaaaaaa ggaattacgc aggagcagtt ggctagagaa gtcgatgtct 6901 ccctgaacac cattaaaaac gtagaacatg gaaaaactaa tcctcgggtc accacagcta 6961 ttcgaattag tcaagtgata ggaattagcg tggaagagtt gtttgcacct aaagatcagt 7021 tcataagcct aaaaagtgag cgctgaagca atgatgtgga tttctaccac ccctgttagt 7081 cttaaggcag acaatagcgg gtggatcagg aaaaaggttg gcaggctatc gcctgccatt 7141 tatctttcgt acacgtttac gtctgctcat tctctttacc cacttaaaaa agttatacat 7201 aataaacgat gctaaatacc tgcacctttc tgctattctt agggtaaaca attagcaggt 7261 agatcagaaa aaaggtagcc aggcttatgc ctggctttta tttttaaaaa ccttcatgta 7321 gattccacat atattaatgg accaaaattt aagtttttta tctctcaccc cccccatgat 7381 taaggtataa acaagctttt cacataaggt cggtaacaat aagacctatt ctcttcaaac 7441 aatagaaact tatcgttacc gaccttatcc taatgtgtta tcaacccatt catttcagta 7501 cttcatagca tatgaatttt taaattttgg tccatttttg gtccagaaaa caaaagagta 7561 ggttttatcc tactctttga ttaacttcag gcgttactat tatccacggg tatccgtcta 7621 actggtacat ttgctttaaa gttttgtttg cttttcgttt aacacagcct aactcattga 7681 ttagtatagg ctcaattctt ttaaattcaa ttttaacctg ttctctgggt actcttttac 7741 ctttcacttt cagccttata aagttttgcc aacatgtata tcccttatga ccaagttgct 7801 ccttagcctt tttcaaaagt ttatctctga tcatagcact ctttttaaaa ttcggagtaa 7861 attcagcagc gtagatttcc tctgttggat actgatggtt agctacatat gcttcgctca 7921 tagccgaaat agaatatctg tatttctttc ttaattgttc agccttttct tccagctcct 7981 gcttaatctc gtacaagtta ggcatcgaat aatagctgat cacattatat gaaaattctt 8041 ttttataacc tatttcttta gctttttctt tccctgattc ctctgctctt ttaactgaat 8101 cttgatatat ttttgaatta ctactgggtt gttctagtct aaacacgcct aaccaaataa 8161 gcaaattcac gtattgattc actctttcga gccacttttt agtacgttta gctatatatc 8221 gattgcttat gaagaacata cttaagccat ctttactaca taatgacgga gtaacttttg 8281 taattcccat agtcaacatc tcgtttataa ttggaatcgc atgtctaaac aattgataag 8341 tatgatacat attttctcta gtcatttctt ctttgatgaa gttcatgtta gcaatatatt 8401 tttctttctc tttttgacac cattcatttg atataagttt catgttaaaa gtttcgctta 8461 tagtcctgat tatctgacta aaatcagtaa ttccatttaa ttgcattaaa tctattatgg 8521 ttaaaccgta cgggttattt gctccacacc catcagcaaa acaacgatat ctataatgac 8581 ctttttccga tattcccatt ctagccgacg gtttttgatc gtcatgataa atacacgaaa 8641 agttttcatt taaggggaca tttaacccta tatattctct caaatctttc tgcttagcaa 8701 cttcaaaaaa atcatgatag ttataataga cttcttctgc tacttggcta gtttttggtt 8761 tgtctatcgt atttggagta gcacttggaa tatcattagt aattttttga tttgattcct 8821 tctctttctt ctttttaggt ttaggttcag cgtaatagtg tcttagcagc tcttcctggg 8881 tatatctacg atctgatgtt tctataattt tacctttaaa gcttggtagt cgcataccct 8941 gacaaagtag attaactcca gtacaagaat tgaaatacgc ggctaaagcg tcttggacgt 9001 atttaaactg gttaatttcc tgaactattt gttttggcgt cttatcttct tgtttctgca 9061 ttaaccaata cgcatggact cctcttggag atacaactat tatactaggt ggcaaaggta 9121 agttttttag catctctatc ttttcatttt ttttcttttc taattcttct ggatcatctt 9181 catggtgaaa atcaatatct acacaatgag ctgtaatatt ataaatatct ttatctaaat 9241 aaccgccact attcaactta aaataaacct tataaccttg tttatggtaa ttacatagcc 9301 tgtcccatac attctccaat tgatctacag ttacttttgg ttctttcaat tttcctgtat 9361 taaaatcttt tttgggaatc tgagggttgt gatcgtcccc aaccatttga aaataaactt 9421 caccatcctg gccatgaaac tttgctagaa actcttttaa ttgcttaatc ttttcctctc 9481 cctgctgcaa agcaaaaaac acctcctaat cggtttttag aatcccgaca gaaggtgtta 9541 tatttcgcca ttatataccg ttgaaacggc atataaagtt tggtacaata taatcagcat 9601 ttaaaaaggc gaatataata cctgtcggga agagagtcca gtagatttcc ccaaatctac 9661 atcaagggac tctctttctc gtttctacta tcttccattt tatcatactc cttttataag 9721 tttctaccta cctacactaa aacacatttt tttcaaaccg tacgatcatg gtccagccat 9781 ggccttgact ccacgtaacg cctatgagtt ccttcacacc ttgcatctct tcaatctgca 9841 tttgagcgaa tctttcagcg tcttgcggtt tttgattttc gctaattcca agcatataaa 9901 ctcctatagc atatccatct ttaaattcaa gacgcatcat tccatcatgc cattttccct 9961 gatcttcttc tttttctcca gacagctctt tggctttttc acgccacttt tcatatgctt 10021 ttttgtaacc gatacaatca ttttcagtct tttgaagccg atctctcagc tctttcagtt 10081 caacattttt ctgacgttca atttcttttt gattttgtaa ttgcttattt aatctacttt 10141 cttgctcact aagctcaact tctaattgac gatttttttg taacaactgc tcgttctctt 10201 gatttaattc atccaatttc ttttggctaa ctaaaattct atatacacct cctttttgaa 10261 attaataggg gttatacctt tcttgagtca ctaaaaaaca aaatacaggc aattctgtgg 10321 cttatatgag gtattattaa tcttttctaa agattttttt ccaccacggt ttctttaact 10381 ctttcatttc atttctgagc tcttctattg ttttgtttaa ttttttaatt tcctctatgt 10441 tggcaatttc ttcttcaagc ttttttcgtg ttttttgatg atccagttga ttagaattgt 10501 aaatttgacg ttgttcttct tgaatttgat taaggatccg ttcttctgat tgtttaactt 10561 tttgatctaa ttttttatca tgttcgttaa gtactgcctg aaaaaactct ttcagttttt 10621 tgccatccat ggccgaactc tcggtcacgc gatccacttc aaccaacatg ctatccccgt 10681 cgttatcgag tttttggtca acttgcgcta cggtcatacc ctggtcatat aattcacgaa 10741 ttttagtgat cattggtaag gcatactcag ctatcatata tttccggtct tgtttttcga 10801 aaggtatata ttgtccatgt ttttgaatat aacgccttat ggttcttgcc ggtaccccag 10861 ttttttgttc tgcctcactt aaagttatat gatcctccaa tttcacctca cccctctata 10921 ttcggtcatg gttcggtcat gaccagttca aaaatactga tataaaagcg tttttcagac 10981 agtcatgacg gacatgatca gttatgaata atgtttcaat attagttttc cttctatctt 11041 ttttagagtt ttttcttcct ttgctctagt tttttctcct aaattcttct ctaaatttct 11101 taggactgtt tctcgttgtt ctagcagcct gtctatttca aaatcacttt ggccagaaga 11161 ccatcttttt tgaaaatctg gaagtaaacc acttaattct gcaaccccat aggctattcg 11221 aagatattcg tcttgctgat atttattata agcgtctgct aatgatcgta aaacctgttc 11281 tgcctctatt tgacctttct gttgaacttt atttttcttt tggagaaagt cctgcaagtc 11341 tttctctttt acttgataac catgataccg gctaggaaga ctcgcaggaa gcctgccact 11401 tctgatccag cgacgcacag actctacatg aactcctgct tgttctgcta cttcttctac 11461 tgtcagcatt ttctcattca tacaaaacac catcctttgt tgttgacttg tgttgtattg 11521 ttagtttgat tatatcaatc atctcaacac aagtcaatat ttataagctt tcgccagcaa 11581 gataagtgcg tagtacatcg gtacgattgt gccccatctc aagacttaaa tcttctgcag 11641 ctttctgtct atctccaaga tgttcattaa gcaattcatc ttttctttct tgagcgtagc 11701 aatatctgag cccatgaaaa ttaagattag tgctgccatc tcctgttgat cctcttaatt 11761 ctatcccttc tacagtcgca aatttatcct gattgttgat gagaaaatcc tgtatcgatc 11821 tagttgcttg atgtgctttc tggtcatatt ctgtaaaaag cctaccccca cgttcagttt 11881 cagatagtct tttttctaaa acctcacgaa cctctctttc tcgttcagaa ttagtattta 11941 taggcacaac acgttctctt ccaccttttg ttcctctatc gaccggcatt actcctgttt 12001 tgagagcctg ttctgcttga cgacgttcca tacaagttac ttctgatatt cggagtccag 12061 tatttttggc cagtgtaatt gcatctttca catcttctct acccatctct gtagccactt 12121 caactgcttt gtctacttct ttttcgtgcc aggctcggtt tacttcttcc ttaatctctg 12181 gggttttatt aaacttaaaa tcgtatttct cttggagtgt tttgttatca cttatttgat 12241 gacgtggatt tgatacttga tcatgaaaaa atctaattga tgacagttta tttttaattg 12301 ttgcgtcaga attgcctttg tcttgctggt atttaacaaa gctggcaacg tgctggtctt 12361 tgatattttt aaaattttgg accttatatt catcatggat ataccttgca aactcctttg 12421 ctctctttac actgtcgatc ctataccctt tgctaccttg ccgacagtgg cggtataact 12481 tttcaagttg ttgttctaat ggatttgaca tactttttca cctcctttct tttgggtatg 12541 taatgccaaa ttcagaacca ctggcacgca gtgattttgc gtctattcta tttaggaatc 12601 actatattgc atttataata ttggagacat taaattaagg aggtatattt atgttgttag 12661 ctctactttt tagtttagat ataccattta tccctgtcat tatagtcttt aaaaggacat 12721 aggtgtcaca ttggcacgaa accccttcac ccctacttta ctctatagaa aacttcaact 12781 ttgcagttat attagagggt ttcatgctta atggccgtct gtcactctcg ccctcatcgc 12841 tctaaaaaaa tttttatcta aatttttttg agagctttta ttgtttgttt ttctcgctac 12901 gctcgaaaaa tcgggcgaga gtgacagact taattcatat tcaaaatgtc tggttagcta 12961 ccgctaaccg aagggttgga cagtacccta aggatcttcc tcgccaatac gagtgttcag 13021 tgaaagctga actgatccca cgaccattta ctactcctag agtagctcgg agacgctgta 13081 caccatctcc gaaggtcgtt gccttttaca acataaggtt ggctagacct tatgccgcac 13141 catcaaccgt tttacgtcac tccatcagaa ctgccggtga aacagtctga tagctgggag 13201 ttagttacta gagaatctta atgttctcta aaaagagaac tctttgtctc tagctcccat 13261 ctgtaccttg aaaatttgaa ttgtagtgat gacgttgttt cattgcttaa ttgaaagtta 13321 agttaatatc atgttgtggt acaggtgacg gatcccaaaa cctgtcaatt aaggtttaaa 13381 gagatcataa tctattttaa atttgttaca tacttgttgg aaaacaaata aaaaaggctg 13441 cgcgaaatac acacgtcttt acgcgtagca tttcacacag ccttttttac acccattaat 13501 tacgttgcta gaaaatttag ttatctctaa ttctagttta aattctgaaa ttaaaaattt 13561 caagtgattt tggtagcaga attttttctt tattctttta ttacttgttg tatttttaaa 13621 gaccttttaa tttttatcta ctatcgtgaa ctacatctcc atctatattt aaatatctta 13681 atcgccactt atctttatct tccaaaaatt ccacttgtga ttgcattcta aagtgcttat 13741 tatcgtgcac tcgtgatatt ttaccattta cttggtagta atcttcatgt atctcattta 13801 caactaaatc atcatgatca tatgacatgt cgtaccctat agcctcttca gcaaaatcaa 13861 ctgcttgtag tattgctaca ccttctccat tacctattat attaaataaa aatattgcta 13921 cacctattac tattaatgct attattacta aacagcctac tacagcgcct tttgaaacct 13981 gtttttctcc gcagtatgga catgcagaag catcttgctt aatttcttcc ttacatgaat 14041 cacatgcttt tgtttttttc tcctgctctc ccataaaaaa tcctccataa gctaattatt 14101 tatatttcaa accagcgtat attatctcgg gtatcttgta tcactccatg taaaaaagga 14161 tcagcatcat atccaatata aatatcacca ctgtaatgtt cccatattcc tcctaaactt 14221 tcgctatctg gaccttctat atcaccttca ccatgaatcg atgcattact agcaaaggat 14281 cttataaaat cttctcctag ctgtttagca tctgcttcac ggtggattac taaatataaa 14341 gttatatcat ttgcttcttt ttctatggta gtatctacta cttcgttata atcttctata 14401 attttagttg tttctgtttt cacctcttct gtaatagaga cctgcacttc ttctttttgt 14461 tctttatcat tatcagtttt ttcttgttta tcatttaatt cttcataaat cgcatgtact 14521 gtcataccta atatcaaaat aatacctact aaaataagtt gggttttctt cgtcataata 14581 tcgcaccttt cagcttttaa tataaaattt aattttctac tgaaattatg aattcacccc 14641 atgtatcacc agaataacca taatattgga ctacttcctc ttgcccgata aattcatatt 14701 ctgaaacgaa atatccttcg taatccgtaa ttcctaattc agtgaaacag ctcttttgct 14761 tttcatatgt atcccctttt atatacattt ctttcactag tcaatatttt ccttttaact 14821 tatcaaaaag aaaggaggat atacatgtac aacagtaata tacttaaaac cattatctaa 14881 ttgaataatt gtaaacccgg gggatttcga ttttgtcccc ccctttaatc gaaatcgatt 14941 tcgatttcga ttaattatga ttttcatagt gccgaatata tctatatatc gtcggtttag 15001 agacccccat aattctagca aattcaaccg cagtcatatc tccgtttttc cattcaggat 15061 accatttaga aaagtttttt ggtaatttcc tttttggtct gcctattggc tttccctctt 15121 tctgcgcctg tcttacaccc tctctgactc tttcagtaat tctttcatgc tctttttcag 15181 caaaataaga gagtaattca accattaaat tatttaataa cttacctaat ttttgatctt 15241 taacgtcagt aaaagtaggc aaatcgagta ttactacttg aacatttata tttctgaatt 15301 cggttaattc ttgctttatt tgatcataag ttctgcctaa cctatctaac tcttttataa 15361 cgataacatc accaggcgct acaacctttt tcaatgcttg atattgttct ctttcagaaa 15421 agcatttccc agtcaattta tccatgaata tagtcaattt cacttcatga tctttttcaa 15481 attgcttcaa agcctgtaat tgtctagatt cgttctgttc gtcagtactt actctgatat 15541 agccataata attattcaaa tatatcacct ccaatttgta tcaaaaaacc tttctatttt 15601 ttgatacttt ttttatatct aaaaacctcc tataaaactg tatttttatg aaattttata 15661 ctgtaacaaa aaagtgtagg tttttgatac atgatctaga ttattaagct ttctttaaaa 15721 ttttacattt aagaccacat gaatgccatt caggtgacct ccaacatttg gtcatttatt 15781 taaacaaagg ctctgttata ttctgttgtt gctagctgaa ctcttcaatt gaacgtattt 15841 tgtgtacaag ggttgatatt acgtcttaac gagcaaacag tcgaatttaa accaaataac 15901 aggatgttat ttgctgatct tgcttatgga tgagcagttg atcaggaagg ttaaatttca 15961 ctggtaggga gttttagatg taccacccca aaacattaga tgtgaaattg aagagttctg 16021 ctaaccatag tgatcaatta atattaccag gatacaattt ttcttcagaa cgtctgttgc 16081 gaatatactc atttggtttt tttaaagaat caaacaaatc gggttcataa ataatttctc 16141 caccgacatt tccgtcatac gctggattca cttcaatttt atcaaccacc agttcatgaa 16201 ctttggcaat agctcgtaga tcttccaatt catcattttc aaattggaaa aattcttcgt 16261 cagtgcgcgc tgcggcttta actttgtaat aagctaagag accatgggca tttcttattt 16321 cccctgtcaa tgtttctaaa ttatcccggg aaattcctga taataaaaag gtaggatcat 16381 tattcatact tcctgctacc ctttggatat tacggctatg gtttactaca tcactccaca 16441 actctctgtg agtttcataa tctgtattat cttgttcacg tccactctga tcattttcaa 16501 cctcatcaat caaatcagtt aacgcacctt caaaaaaact catctcgctt tgcagatatt 16561 caaaaccgat taatggtctc ccaaagaagt atgtataaat ataaggatat gcgagataaa 16621 ggttcatacc aattgataag acaagtagta ataccaagat tataattggt ttatttctct 16681 ttttcttaga agatttagct ttagcaacag cttcttttaa atcagacatt ttaattccct 16741 tctttaaaaa atttttaacg actttttaaa agcataaaag ttcagttcaa accatttatt 16801 agctttgtta ttacatattt taacattttg aagttaatca caaaagggag agggaattac 16861 ggtctatgaa ggttagacaa aatgagatta tataaattgc tgaactcttc aatttcacat 16921 tcgatatttc agattggttc agctatcaac agtcgacttt aacacagcct aaacaaaaat 16981 ttatattagt gtttatataa atattgttat acataaatac agttttacat aataagctaa 17041 ataagccgtt atttcaattt ataccgaacg ataatgtatt tatagtttta tttattataa 17101 atacattatt acataaatac agtaatacag ttttattaac cctccagatc cgaaaaaaaa 17161 ggacacttta cgtgtccttt ttaggtgcaa ttatataatt cttcttc //