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The map label for this gene is dxr

Identifier: 153936048

GI number: 153936048

Start: 2404558

End: 2405715

Strand: Reverse

Name: dxr

Synonym: CLC_2273

Alternate gene names: 153936048

Gene position: 2405715-2404558 (Counterclockwise)

Preceding gene: 153937361

Following gene: 153937005

Centisome position: 63.97

GC content: 30.48

Gene sequence:

>1158_bases
TTGAAGAACATTACCATATTAGGCGCAACAGGCTCTATTGGAACCCAAACTTTAGATGTAATAAGAAGAGAAAAGGAAGA
ATTAAAATTAGTAGCCATATCCGCGAATAAAAGCGATAAAAAAGTTATAGAAATTATAAAGGAATTTAAACCTAAATATG
CGGTTTTAATGGAAGAGAATGCTTTTAAAATAGTAGAAGATTTTTGTATAGATAATAAAATAGATACAAAAGTTTTAAAA
GGTATGGAAGGAATGATATATATAAGCACCTTAGAGGAGGTAAATACAGTAGTTACCTCTGTGGTAGGAATGATAGGATT
AGTTCCAACCATAAAAGCTATAGAAAGTGGAAAAGATATAGCTTTAGCTAACAAAGAAACCTTAGTAGTAGCTGGAGAAC
TAGTTATTAGTAAAGCTAAAGAGCATAATGTAAATATATTACCTGTAGATTCAGAACACGGAGCTATTTTTCAATGTTTA
AGAGGAAATAAAAAGGAAGAAGTTAAAAATATAATAGTAACAGCTTCAGGAGGACCTTTTAGAGGTAAAAAGAAGGAAGA
ACTCATAGATGTAAAGCCAGAGCATGCTCTTAAACATCCTAAATGGAATATGGGAAGAAAAATATCTATAGATTCTGCCA
CATTAATGAATAAAGGGTTAGAGGTTATAGAAGCTCACTTTTTATTTGGTGTGGATTATGAAAATATAAAGGTGGTGGTA
CATCCACAAAGTATAGTCCATTCTATGGTAGAATATAAAGATGGAAGTGTAATAGCACAAATGGCAACTCCAGATATGAA
ATTACCTATACAATATGCTTTGAATTATCCTAATAGGAAAGAAAGTCAAATAGAACCTTTAGATTTTTATAAAATATCTA
ATTTAACCTTTGAAAAACCGGATATGGATACATTCTTACCACTAAAGTTGGCTTATGAAGCAGGGAAAAAAGGTGGAGTA
ATGCCAGCCATATTAAATGGGGCCAATGAGGTTGCAGTAGATTTATTTTTAAAGGGCAAAATAGAATTTTTACAAATAGG
TGACCTATTACAAGAATGTATGAATAAATTTTATAAATCTATGGAAGCTACATTAGAGAATGTAATAAGTGTAGATAAGG
AAGTTAGAGAGTATTTAGGTAAAAAATATGATATATAA

Upstream 100 bases:

>100_bases
TTTTTTAGGGTTACTTCTAGGACCATTATATATAATAACCCTTAAAGAATTTGTAAAAACTTAAATGAAAGTTAAAAGTT
ATTAGAGGAGAGATGACATT

Downstream 100 bases:

>100_bases
TAATAAAATTAATTTATAGGCACAATTTTAAGGGAGGTTAGTTAATGTATATAGTAGCGGCTATTTTAGCCTTTGGCATA
TTAGTTTTAGTCCATGAATT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSDKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI

Sequences:

>Translated_385_residues
MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSDKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI
>Mature_385_residues
MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSDKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK
GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL
RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV
MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=43.8775510204082, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CLOB1 (A7FW01)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384601.1
- ProteinModelPortal:   A7FW01
- SMR:   A7FW01
- STRING:   A7FW01
- GeneID:   5397938
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_2290
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   CBOT441770:CLB_2290-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42991; Mature: 42991

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 176-176 BINDING 199-199 BINDING 221-221

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSDKKVIEIIKEFKPKYAVLMEEN
CCCEEEEECCCCCCHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC
RGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
CCCCHHHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCEECCC
DMDTFLPLKLAYEAGKKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS
CCCCCCHHHEEECCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
MEATLENVISVDKEVREYLGKKYDI
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSDKKVIEIIKEFKPKYAVLMEEN
CCCEEEEECCCCCCHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC
AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI
HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC
RGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV
CCCCHHHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE
HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP
CCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCEECCC
DMDTFLPLKLAYEAGKKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS
CCCCCCHHHEEECCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
MEATLENVISVDKEVREYLGKKYDI
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA