LOCUS NC_009496 16344 bp DNA circular BCT 29-JUL-2008 DEFINITION Clostridium botulinum A str. ATCC 3502 plasmid pBOT3502, complete sequence. ACCESSION NC_009496 VERSION NC_009496.1 GI:148381586 DBLINK Project:193 KEYWORDS complete genome. SOURCE Clostridium botulinum A str. ATCC 3502 ORGANISM Clostridium botulinum A str. ATCC 3502 Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium. REFERENCE 1 (bases 1 to 16344) AUTHORS Sebaihia,M., Peck,M.W., Minton,N.P., Thomson,N.R., Holden,M.T., Mitchell,W.J., Carter,A.T., Bentley,S.D., Mason,D.R., Crossman,L., Paul,C.J., Ivens,A., Wells-Bennik,M.H., Davis,I.J., Cerdeno-Tarraga,A.M., Churcher,C., Quail,M.A., Chillingworth,T., Feltwell,T., Fraser,A., Goodhead,I., Hance,Z., Jagels,K., Larke,N., Maddison,M., Moule,S., Mungall,K., Norbertczak,H., Rabbinowitsch,E., Sanders,M., Simmonds,M., White,B., Whithead,S. and Parkhill,J. TITLE Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes JOURNAL Genome Res. 17 (7), 1082-1092 (2007) PUBMED 17519437 REFERENCE 2 (bases 1 to 16344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (29-MAY-2007) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 16344) AUTHORS Sebaihia,M. TITLE Direct Submission JOURNAL Submitted (21-NOV-2006) Sebaihia M., Sulston Laboratories, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UNITED KINGDOM COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AM412318. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..16344 /organism="Clostridium botulinum A str. ATCC 3502" /mol_type="genomic DNA" /strain="ATCC 3502" /db_xref="taxon:413999" /plasmid="pBOT3502" gene complement(1..3585) /gene="dnaE" /locus_tag="CBOP01" /db_xref="GeneID:5188018" CDS complement(1..3585) /gene="dnaE" /locus_tag="CBOP01" /EC_number="2.7.7.7" /note="catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria." /codon_start=1 /transl_table=11 /product="DNA polymerase III DnaE" /protein_id="YP_001256127.1" /db_xref="GI:148381587" /db_xref="GeneID:5188018" /translation="MSDKKFTHLHLHTGYSLLDGAGKINNIIASAKELGMDSIAITDH GAMYGCVDFYKAAKNAGLKAIIGCEVYIVPKSMSIKNSDPNNKIYHLVLLVKNEIGYK NLIKIVSKASIDGFYYKPRTDHQFLKDHSEGLIALSACLGGEIQSNLLNENKEKAKEI ALFYKSIFKDGFYLELQYHGNDAERKVNDMNIRLARELKIPLVATNDVHYIEQKDSKF HDILLCIQTGKTVNKENRLRYPSDQFYLKSADEMWEMFSHVPEALKNTEKIAEQCNFH YDFHTSKLPKFLLPEGTDPFEYMKKFCFKGLIKRCDLFRDLLTKSFNINEIIALGKEN EEAKIYIDRLQYELSVIDHMGYVDYFLIVSDFIKFANEKKIPTGPGRGSGAGSLVAYT LGITKIDPIKYGLIFERFLNPERISMPDIDSDFCYERRGEIIDYVVEKYGKENVSQII TFGTMAARVCIRDVGRAMNYSYVEVDKIAKMIPIVPGIIITIDKALALNPELKNEYEN NLRVKELIDVSMNLEGLPRHSSTHAAGIIISSSPIGDYVPLQKNEHNIVSQFDMTTLD ELGFLKMDFLGLKTLTVLKDAVDMIMQNHNVDIDLDKIDINDKEVYKMIGEGKTIGIF QLESTGMTSFMKELKPDSLEDIIAGISLYRPGPIDEIPKYIENKKNPDKITYLTPQLE PILKITYGCLVYQEQVMEIVRKLAGYSMGRSDLVRRAMSKKKHKVMEEERKNFIYGIV KEDGEIEVPGCIRNEVSEKIGNELFDSMMDFASYAFNKSHAVAYALVAYQTAYLMKYY PAEYIAAKLNSVMGDNGKVAYYINYAESLGIQVLPPDINESFSKFIVEDNTIRFGLDA IKNVGIGAAKIIVKSRKKNGNFKSLIDFASKIDLTTINKRAIESLIKAGAFDCFKVFR SRLLAVYEKVLDSISNQRKRNIDGQVSLFNADNTIVNIPIIKYPEIKEFDKKYLLAME KEMLGIYITGHPLDEYAQSLKIQTSIRIEKILCSHNKVLNDDSIIEISSDNNIIRGDI NDGERVVIGGIITKVSRKITRNNTIMAFLKLEDLSGIIEVIVFPKTLENVNPLINEDS LVVIRGRVSLAEDELPKLICEKIHPLEKLNLSKVYIRVKDNKKVRTANKFLKTILKSH KGDTPIYIFSEKEKQNFRLSKNLLISLDEDILSTLRSYFGDENIKVVD" misc_feature complement(235..726) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Superfamily:SSF50249" /note="superfamily hit to SSF50249, Nucleic acid-binding proteins, score 1.5e-10" misc_feature complement(244..480) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Pfam:PF01336" /note="HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 4.4e-14" misc_feature complement(1357..2856) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Pfam:PF07733" /note="HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 1.2e-269" misc_feature complement(2797..3573) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Superfamily:SSF89550" /note="superfamily hit to SSF89550, PHP domain, score 3.4e-59" misc_feature complement(2935..3327) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Pfam:PF02811" /note="HMMPfam hit to PF02811, PHP domain C-terminal region, score 3.2e-33" misc_feature complement(3370..3567) /gene="dnaE" /locus_tag="CBOP01" /inference="protein motif:Pfam:PF02231" /note="HMMPfam hit to PF02231, PHP domain N-terminal region, score 3.3e-32" gene complement(3754..3951) /locus_tag="CBOP02" /db_xref="GeneID:5188036" CDS complement(3754..3951) /locus_tag="CBOP02" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256128.1" /db_xref="GI:148381588" /db_xref="GeneID:5188036" /translation="MTYYFNDDSVQLENYFFEADELGNINVYNADTMQFLDLIHVSYR YDRYKFLDNCKEWICKKNEGI" gene complement(3951..4142) /locus_tag="CBOP03" /pseudo /db_xref="GeneID:5188020" misc_feature complement(3987..4133) /locus_tag="CBOP03" /inference="protein motif:ProDom:PD008230" /note="BlastProDom hit to PD008230, Q9ZAN0_STAAU_Q9ZAN0;,score 0.0009" /pseudo gene 4356..4556 /locus_tag="CBOP04" /db_xref="GeneID:5188021" CDS 4356..4556 /locus_tag="CBOP04" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256129.1" /db_xref="GI:148381589" /db_xref="GeneID:5188021" /translation="MYRLNKGFVKLSIDNHVEFVNRELGKDKKYGINKSTIISIFTTK GYKYNAELRCYIKDIKKLKECN" gene 4798..5343 /locus_tag="CBOP005" /db_xref="GeneID:5188022" CDS 4798..5343 /locus_tag="CBOP005" /codon_start=1 /transl_table=11 /product="site-specific recombinase" /protein_id="YP_001256130.1" /db_xref="GI:148381590" /db_xref="GeneID:5188022" /translation="MELVQPIRDKEVINKFKNELLKKGYRNYMLFVIGINTGLRISDI LKLKVEDVKDKTHIVIREQKTSKRTRVLINSMLREDIEKYIEGMDNTEYLFKSRNGKN KPITRVQAYRILSEVGKHLGMSEVGTHTLRKTFGYWHYKQYKDVAILQDIFNHSAPSI TLKYIGINDDIKDNTIENFYL" misc_feature 4810..5328 /locus_tag="CBOP005" /inference="protein motif:Superfamily:SSF56349" /note="superfamily hit to SSF56349, DNA breaking-rejoining enzymes, score 6.1e-34" misc_feature 4816..5319 /locus_tag="CBOP005" /inference="protein motif:Pfam:PF00589" /note="HMMPfam hit to PF00589, Phage integrase family,score 2e-15" gene 5464..6117 /locus_tag="CBOP06" /db_xref="GeneID:5188019" CDS 5464..6117 /locus_tag="CBOP06" /codon_start=1 /transl_table=11 /product="putative DNA-binding protein" /protein_id="YP_001256131.1" /db_xref="GI:148381591" /db_xref="GeneID:5188019" /translation="MYDNIKVLLKYYRGDDMDRTDFDKLEVQDQVIYINKQLGEGSTL RDIASNLNIARSTLRDRFKKIGYIYNKKLNTYSKTNNEYNKNNTNVLYKEPVKKQNTL EIESYKSNTIVSNKELQSIKEVNNLKKEVFELINNKDIILEMIKDYKSNTKIIDIPQL DINNLPVEMQKDITTKSIKVYKPIYNLFNKLCEEYSSIKKQDLISLALYEFYIRYKK" misc_feature 5569..5685 /locus_tag="CBOP06" /inference="protein motif:Superfamily:SSF47954" /note="superfamily hit to SSF47954, Cyclin-like, score 0.0053" misc_feature 5587..5652 /locus_tag="CBOP06" /note="Predicted helix-turn-helix motif with score 1388.000, SD 3.91 at aa 42-63, sequence STLRDIASNLNIARSTLRDRFK" gene 6306..6569 /locus_tag="CBOP07" /db_xref="GeneID:5188023" CDS 6306..6569 /locus_tag="CBOP07" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256132.1" /db_xref="GI:148381592" /db_xref="GeneID:5188023" /translation="MLNVGRKRGKIKTSFFKNKIKKSFNSYISYGNTLYKPIQLCTGI HKRTLERPYNLLFNYRIDYTKLLREFQAFFSMNVLRSAFLMFK" gene 6619..6810 /locus_tag="CBOP08" /db_xref="GeneID:5188024" CDS 6619..6810 /locus_tag="CBOP08" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256133.1" /db_xref="GI:148381593" /db_xref="GeneID:5188024" /translation="MKRVKSCRKCEFYNEDEEFNCTNFKMVILDFNNARKCIYYQERM GRRKRCKTCMYLSTTYKQV" gene 6921..7064 /locus_tag="CBOP09" /db_xref="GeneID:5188025" CDS 6921..7064 /locus_tag="CBOP09" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256134.1" /db_xref="GI:148381594" /db_xref="GeneID:5188025" /translation="MLRSISRKNKRPTNQSVLLPLEGRKTSQKNICKILTSVCDCPSW GRR" gene 7133..7282 /locus_tag="CBOP10" /db_xref="GeneID:5188026" CDS 7133..7282 /locus_tag="CBOP10" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256135.1" /db_xref="GI:148381595" /db_xref="GeneID:5188026" /translation="MDIRIPLIPIRIKRSKKYIPLCSNIIYIRAQGGESRFPYQAYQI KIKIV" gene 7704..8258 /locus_tag="CBOP11" /db_xref="GeneID:5188027" CDS 7704..8258 /locus_tag="CBOP11" /note="Weakly Similar to Pediococcus pentosaceus plasmid orf1 TR:Q9X3B9 (EMBL:AF069302) (111 aa) fasta scores: E(): 0.0014, 33.000 38d in 100 aa, and to Pediococcus pentosaceus mobc-like protein TR:Q9RHE2 (EMBL:AF033858) (73 aa) fasta scores: E(): 0.6, 36.111 38d in 72 aa, and to Pasteurella multocida, mbecy or mobC TR:Q51926 (EMBL:U57647) (101 aa) fasta scores: E(): 0.77, 29.808 38d in 104 aa" /codon_start=1 /transl_table=11 /product="mobilisation protein" /protein_id="YP_001256136.1" /db_xref="GI:148381596" /db_xref="GeneID:5188027" /translation="MNKEKAEEIIESVQGNIKHSDMILTDDERALLEEYILGNITREE YIEKSLEDVQKDNIRYGIKGEKILDSTINLSENCKVNRKRNKQIVIRATRKEFNTIKN KVKKSKLSQNEYLLKCALDKRIVVVDGLKDLNVELKRIGNNLNQLIKSVHEGKANCSK ELLEINEEMKEVWQLLRQLTPKAL" misc_feature 8100..8225 /locus_tag="CBOP11" /inference="protein motif:Pfam:PF05713" /note="HMMPfam hit to PF05713, Bacterial mobilisation protein (MobC), score 0.00019" gene 8219..8989 /locus_tag="CBOP12" /db_xref="GeneID:5188028" CDS 8219..8989 /locus_tag="CBOP12" /note="Similar to Staphylococcus aureus Plasmid pS194 rlx protein SW:RLX1_STAAU (P12054) (320 aa) fasta scores: E(): 6.8e-15, 33.333 38d in 252 aa, and to Fusobacterium nucleatum DNA relaxation protein homolog rlxA TR:Q9L9V7 (EMBL:AF159249) (348 aa) fasta scores: E(): 8.4e-15,36.458 38d in 288 aa, and to Staphylococcus epidermidis mobilization protein moba2 TR:Q9R968 (EMBL:AF045472) (337 aa) fasta scores: E(): 4.4e-13, 25.681 38d in 257 aa" /codon_start=1 /transl_table=11 /product="mobilisation protein" /protein_id="YP_001256137.1" /db_xref="GI:148381597" /db_xref="GeneID:5188028" /translation="MAVIKAVNSKSSLDGIIKYVTREEKTEERLITGKDCSPSNVLEE MKVTKEIFNKTTGRQYKHFIQSFDPNDNLDYMKANKIGLEWAEKIFKGFEVLISTHKD KGHIHNHFVVNSVSFEDGRKLRYSNKELQNFKNVNDRICEREGLNIVREVSKEITSFN HNKYKVIEKAFKGMGESYLLNTGLEVSNSLKVSKTKEEFIKSMEEKGYKVNWKDTRKY ITFTTPEGRKIRNSNLQNTLKNDKFTKEGMENELRYNR" misc_feature 8243..8968 /locus_tag="CBOP12" /inference="protein motif:Pfam:PF03432" /note="HMMPfam hit to PF03432, Relaxase/Mobilisation nuclease domain, score 8.3e-39" gene 9252..9509 /locus_tag="CBOP13" /db_xref="GeneID:5188029" CDS 9252..9509 /locus_tag="CBOP13" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256138.1" /db_xref="GI:148381598" /db_xref="GeneID:5188029" /translation="MVDKLNEILKGLSIKLDKVYKVYIERMGTETEKKIQALNELQKE AENRCESYYNRKTIIAYLIYINLAITPILFFIIIYIQFFKK" misc_feature 9423..9491 /locus_tag="CBOP13" /inference="protein motif:TMHMM:2.0" /note="1 probable transmembrane helix predicted for CBOP13 by TMHMM2.0 at aa 58-80" gene 9738..9929 /locus_tag="CBOP14" /db_xref="GeneID:5188030" CDS 9738..9929 /locus_tag="CBOP14" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_001256139.1" /db_xref="GI:148381599" /db_xref="GeneID:5188030" /translation="MLFLSYFSEKVFFMQHHVKKNGNTLPYYGVYVNSEKRNNCPNYS LYCNKYKYILFSWIYINNV" gene 10033..11325 /locus_tag="CBOP15" /db_xref="GeneID:5188031" CDS 10033..11325 /locus_tag="CBOP15" /codon_start=1 /transl_table=11 /product="putative bacteriocin biosynthesis protein" /protein_id="YP_001256140.1" /db_xref="GI:148381600" /db_xref="GeneID:5188031" /translation="MYPQLTDNSFVKQTPDKEAHVFSFFINEMRSYVSINESASSILG LCNGMHSIEDIISILSNKYEEDPNVVKKNVQTFLDPFIKNSIVRDNKVEFSNRNIVNG SLEVYYPHALCWEITDYCPLNCRHCYLPEKNNSILSRDNIDNVLEIIDSAGIQQVQVT GGEALTHPELEYIIDSLINRGIITSISTSGFNFTNDMFKYLVKLKEVKGSKLRVSLDG DKNIHNYIRKNEYAYNNAIEFIKTAVKNGIICQVETSVINQSKQDLEDLVVLVKELGV SSIEIARISDQGNARKNNLELVWSPKEFDDFLYQLNSKYANETFKIRLPKEEKNKNCG AGYKIIRIKPNFDVTPCPMLEFRLGNLHKDTMFQIMSKCGNIFHEFEAPQNKFCSECE NKDTCDHCIASGFNSKDKVKDCRWFRNIEYCLKPFLDR" misc_feature 10153..10188 /locus_tag="CBOP15" /inference="protein motif:ProSite:PS00442" /note="PS00442 Glutamine amidotransferases class-I active site.; ScanRegExp hit to PS00442, GATASE_TYPE_I, score NA" misc_feature 10372..10845 /locus_tag="CBOP15" /inference="protein motif:Pfam:PF04055" /note="HMMPfam hit to PF04055, Radical SAM superfamily,score 1.4e-23" gene 11531..11692 /gene="btcB" /locus_tag="CBOP16" /db_xref="GeneID:5188032" CDS 11531..11692 /gene="btcB" /locus_tag="CBOP16" /codon_start=1 /transl_table=11 /product="bacteriocin" /protein_id="YP_001256141.1" /db_xref="GI:148381601" /db_xref="GeneID:5188032" /translation="MEKPKITNANMVACSGNPYAAIAMLGLACGADFAYCQMPSVSDL WGSGTAKAL" misc_feature 11567..11635 /gene="btcB" /locus_tag="CBOP16" /inference="protein motif:TMHMM:2.0" /note="1 probable transmembrane helix predicted for btcB by TMHMM2.0 at aa 13-35" misc_feature 11585..11617 /gene="btcB" /locus_tag="CBOP16" /inference="protein motif:ProSite:PS00013" /note="PS00013 Prokaryotic membrane lipoprotein lipid attachment site." gene 11905..13080 /locus_tag="CBOP17" /db_xref="GeneID:5188035" CDS 11905..13080 /locus_tag="CBOP17" /note="May be involved in bacteriocin maturation/secretion. Similar to Sulfolobus solfataricus zn-dependent protease, TldD protein homolog, putative tldD TR:AAK40965 (EMBL:AE006693) (443 aa) fasta scores: E(): 5.2e-13, 30.736 38d in 231 aa, and to Escherichia coli tldd protein tldd or b3244 SW:TLDD_ECOLI (P46473) (481 aa) fasta scores: E(): 1.6e-11, 27.306 38d in 271 aa" /codon_start=1 /transl_table=11 /product="TldD family protein" /protein_id="YP_001256142.1" /db_xref="GI:148381602" /db_xref="GeneID:5188035" /translation="MNYKQSVYTIQLKYIKDDFEYIVDSFSGEREETIRNIKLNTCKN LFDDVQLNISTPYLINLKKSLRYIKKDLEKQDINLSIFMNLHNERVLIDNEEEDNRSY GFLRLICKDNDNNMHIDDIPILSCNPIDLEDKINYYAKKYISMKNLHDIREQVSFESI PHILSPKAAGYFIHEIVGHTLESDFYSYYKDKYENMKISKKLTVTDSINGYNRLIGLQ GYDDVGTKIESLTLINKGKIQNMLAIKKEDSFDHKLYGVARRASYKFEVLPRMRSTYI HPFDDMDQQDILDKYENAIFVNEIFLGGVDHKSGKYNLNGNGFIVKNGELQNFIGDLR ISGDILKDISSIDYIGKDFDMFGNYCEKFGQFVRVGSGGPTISISSLNARGVLYGRR" gene 13067..14290 /locus_tag="CBOP18" /db_xref="GeneID:5188033" CDS 13067..14290 /locus_tag="CBOP18" /note="May be involved in bacteriocin maturation/secretion. Similar to Buchnera aphidicola (subspAcyrthosiphon pisum) (Acyrthosiphon pisum pmba protein homolog pmba or bu089 SW:PMBA_BUCAI (P57191) (446 aa) fasta scores: E(): 0.19, 23.797 38d in 395 aa, and to Escherichia coli pmba protein pmba or tlde or b4235 SW:PMBA_ECOLI (P24231) (450 aa) fasta scores: E(): 0.98,20.716 38d in 391 aa" /codon_start=1 /transl_table=11 /product="PmbA family protein" /protein_id="YP_001256143.1" /db_xref="GI:148381603" /db_xref="GeneID:5188033" /translation="MEEDKRIEKRLLSKGIMEYKIIRTILRGMKYKEYFGSVSIEDLS DDKILVLFKTEEGIAKFTVSSFQSDNIIDRIIETSMKNQMKMSLQWHDDNFSDVKIEQ NENYNRFYKFNSNDYIMWIKKEIDNISKKIKFTFNTIYTINVNKYCLRTNKDYIEQYN TSSEFLCIENKTFKRRSKLSNRFLKDDIALSIIKQLNNDDIPRNNINLNSKQRILLKA KGLSDFLNVYISLYYANYIYSNQSFIKTNYIGKQISKSNFDLIAIPYNGIKFDSEGSR IFKKLIVGSGKLINLLSNNSFSEYFNINSFGNASLDTHNTVSHQRLIFTCKNSERIVS KSVDLIIHQFENAYIDFEDNEVFRGNAICSDKSGYFRTTISFNLKYIFNNIYPIGNKS TWINNVYCQDVIILR" misc_feature 13199..13501 /locus_tag="CBOP18" /inference="protein motif:Superfamily:SSF75001" /note="superfamily hit to SSF75001, Dipeptidyl peptidase I (cathepsin C), exclusion domain, score 0.015" gene 14411..16054 /locus_tag="CBOP19" /db_xref="GeneID:5188034" CDS 14411..16054 /locus_tag="CBOP19" /note="May be involved in bacteriocin secretion. Contains IM domain at N-terminus and ATP-binding domain at C-terminus. Similar to Campylobacter jejuni lipid export ABC transport protein msba or cj0803 TR:Q9PPB7 (EMBL:AL139076) (580 aa) fasta scores: E(): 4.6e-36,28.755 38d in 546 aa, and to Synechocystis sp hlyb family hlyb or sll1180 TR:P74176 (EMBL:D90913) (1011 aa) fasta scores: E(): 1e-32, 26.488 38d in 521 aa, and to Leuconostoc mesenteroides mesentericin y105 transport ATP-binding protein MesD mesD SW:MESD_LEUME (Q10418) (722 aa) fasta scores: E(): 3.1e-31, 27.370 38d in 559 aa" /codon_start=1 /transl_table=11 /product="ABC transporter" /protein_id="YP_001256144.1" /db_xref="GI:148381604" /db_xref="GeneID:5188034" /translation="MGKLRSLLKLKPFLQKYKLLLFFALIGIILGSIVAIPVPYIIGK IMDDVLIGSKSFNEFYFYIGIITILYVLKYFISITSNYLSSKFNNFMSNDLRFILIDK VMDLPMDYLANVEKGYLQGRISECDSITAIFSGTIISILLSTVNAVLSVSTMFVINYK LAIAVLILVPFFFILAKFSNHALTKNTKKMLEDSAILNAECFEIINGVEDIKILNGKA YSLGKFKKKLDQFIKITLKQNKTMLLLSQNVVGVNDVGTLLILLIAGNLIIKGEFTVG LYTTFSLYSSKIFSSTQLLANIGPSLKQACLSIERLYELIDMDDENKGKNKHLNKKIE SIKLENVTFKYKNSIKNVLDSLNFEINKGEKVLISGENGTGKSTLIKLLVGLYEPTEG RILYNNLDLATINNESLRSRIGIVSQNMFLFKGTVLDNILYGQNQKKRKDVEKLIIKL NLENYISRLPEGLDSKIIQNNNGISGGQTQVIAFIRAVLSNKDIIILDEPISNVDAET RNIILNILKESKFDGILIIISHFTKGMEFINKTIKVGKK" sig_peptide 14411..14515 /locus_tag="CBOP19" /product="hypothetical protein" /inference="protein motif:SignalP:2.0" /note="probability 1.000, with cleavage site probability 0.548 between residues 35 and 36" misc_feature 14438..15346 /locus_tag="CBOP19" /inference="protein motif:Superfamily:SSF90123" /note="superfamily hit to SSF90123, Multidrug resistance ABC transporter MsbA, N-terminal domain, score 3.6e-61" misc_feature order(14468..14536,14594..14662,14795..14863,14891..14959, 15137..15205) /locus_tag="CBOP19" /inference="protein motif:TMHMM:2.0" /note="5 probable transmembrane helices predicted for CBOP19 by TMHMM2.0 at aa 20-42, 62-84, 129-151, 161-183 and 243-265" misc_feature 14474..15286 /locus_tag="CBOP19" /inference="protein motif:Pfam:PF00664" /note="HMMPfam hit to PF00664, ABC transporter transmembrane region, score 2.5e-17" misc_feature 15416..16048 /locus_tag="CBOP19" /inference="protein motif:Superfamily:SSF52540" /note="superfamily hit to SSF52540, P-loop containing nucleoside triphosphate hydrolases, score 1e-49" misc_feature 15497..16045 /locus_tag="CBOP19" /inference="protein motif:Pfam:PF00005" /note="HMMPfam hit to PF00005, ABC transporter, score 3.7e-45" misc_feature 15518..15541 /locus_tag="CBOP19" /inference="protein motif:ProSite:PS00017" /note="PS00017 ATP/GTP-binding site motif A (P-loop)." misc_feature 15833..15958 /locus_tag="CBOP19" /inference="protein motif:ProDom:PD000006" /note="BlastProDom hit to PD000006, Q97IT2_CLOAB_Q97IT2;,score 7e-11" ORIGIN 1 ttaatccacg acttttatat tttcatctcc aaaatagctc cttaatgtag acagtatatc 61 ttcatctaag gatatcaata aatttttact aagtctaaaa ttttgtttct ccttttcaga 121 gaatatatat ataggggtat ctcccttatg agattttagt atagttttta aaaacttatt 181 tgctgttctt acttttttat tatccttaac tctaatatat accttagata aattgagttt 241 ttcaagtgga tgtatttttt cacatattag tttaggtaat tcatcttctg ctagggatac 301 tctacctctt ataactacca atgaatcttc atttatcagt ggattaacat tttctaaggt 361 tttggggaaa actattactt caataattcc actaagatct tcaagcttta aaaaagccat 421 aatagtatta tttctagtta tttttcttga tactttagtt attattcctc caataacaac 481 tctttcacca tcatttatat ctcctcttat aatgttatta tcgcttgata tttctataat 541 tgaatcatca tttagcactt tgttatgaga acataagatt ttttcaattc taatagaagt 601 ttgaattttt aaactctgtg catattcatc taaaggatgt cctgttatat aaattcctag 661 catttctttt tccattgcaa gtagatattt tttatcaaat tcttttattt caggatattt 721 tattataggt atgttaacta ttgtattatc agcattaaaa agacttacct gaccatctat 781 attccttttt ctttgattac tgatactgtc taaaactttt tcatatactg caagaagtct 841 agatctaaat actttgaagc aatcaaaagc acctgctttt ataagacttt ctattgctct 901 tttatttatg gttgttaaat ctattttact agcaaagtca ataagtgact taaagtttcc 961 attctttttt cttgatttaa caataatttt cgctgcacct atacctacat tttttattgc 1021 atcaagacca aatcttattg tgttatcctc aactataaat ttagaaaaac tttcatttat 1081 atctggggga agtacctgta ttcccaaact ttcagcataa tttatataat atgctacttt 1141 cccattgtcc cccatcaccg aatttagttt tgcggcaata tattcagctg gataatactt 1201 cattaagtat gcagtttgat aagctaccag agcataagcg acagcatgac ttttattaaa 1261 tgcataggag gcaaaatcca tcatagaatc aaatagttca ttccctattt tttctgatac 1321 ttcatttcta atgcatccag ggacttctat ttctccatct tccttaacaa ttccataaat 1381 aaagttcttt ctttcctctt ccataacttt atgttttttc ttagacatag cccttcttac 1441 aaggtcgcta cgtcccattg aatagcccgc tagttttcta acaatttcca taacttgttc 1501 ttgataaact aaacaaccat atgtaatctt caatattggt tctaattgtg gtgtcaaata 1561 cgttatttta tcaggatttt ttttattttc tatatatttt ggaatttcat ctattggccc 1621 tggtctatat agtgatattc ctgctataat atcctctaat gaatctggtt taagttcctt 1681 cataaaagaa gtcatacctg ttgattctaa ctgaaaaatt ccaatagttt tgccttctcc 1741 aatcatctta tatacttctt tatcattaat atctatttta tctaagtcta tatctacatt 1801 gtggttttgc attatcatat caacagcatc tttcaataca gttaaagtct ttagccctaa 1861 aaaatccatc tttaaaaacc caagttcgtc aagtgtagtc atatcaaatt gggatacaat 1921 attatgctca tttttttgaa gtggaacata gtccccgata gggcttgatg atataataat 1981 tcccgcagca tgtgttgaag aatgtcttgg cagtccctct aaattcatac taacatcaat 2041 taattcttta acccttaaat tattttcata ctcattcttt aattctggat ttagagctaa 2101 tgccttatct atagtaatta ttattccagg cacaataggt atcatttttg cgattttatc 2161 cacttctaca taagagtagt tcatggctct tcctacatct ctaatacaaa ctcttgcagc 2221 cattgttcca aatgttatta tttgtgatac gttttccttt ccgtattttt ctactacata 2281 atctataatc tctcctcttc tttcatagca aaaatcgcta tctatatctg gcatgcttat 2341 tctttcagga ttaaggaatc tttcaaagat aagaccatat tttattggat caatcttagt 2401 tattcctaaa gtatatgcaa ctaaagatcc tgctccagag cctcttcctg ggcctgtggg 2461 tatttttttc tcatttgcaa actttataaa atcgctaact attaaaaagt aatctacata 2521 tcccatatga tctattacag aaagttcata ttggagtcta tctatataaa tcttagcttc 2581 ttcattttct ttacccaatg ctattatttc atttatatta aatgatttag ttaagagatc 2641 tctaaacaaa tcacatcgct taattagacc tttaaaacaa aattttttca tatattcaaa 2701 aggatctgtt ccttctggta gtaaaaattt gggaagcttt gaagtatgaa aatcataatg 2761 aaaattgcat tgttctgcta ttttctcagt attttttaaa gcttctggaa catgtgaaaa 2821 catctcccac atttcgtctg cagacttcaa atagaactga tctgaaggat atcttagtct 2881 attctcttta tttacagttt tccctgtttg tatacataat agaatatcat gaaacttaga 2941 atctttttgt tctatatagt ggacatcatt tgtagctaca agtggtattt taagttctct 3001 agctagcctt atattcatat cattaacttt tctctcagcg tcattaccat gatactgaag 3061 ttcaagataa aaaccatctt tgaatattga tttataaaat aatgcaattt cttttgcttt 3121 ttccttattt tcatttaaca aatttgattg tatttctcca cctaagcaag cacttaaagc 3181 tattagccct tcactatggt cttttaaaaa ttggtgatca gttctaggtt tataataaaa 3241 accatcaata gatgcctttg aaactatctt aattaaattt ttataaccta tttcattttt 3301 cacaagaagc actaggtgat aaatcttgtt attaggatca ctattcttta tactcattga 3361 tttggggaca atataaactt cacatcctat aatagccttc aatcctgcat ttttagcggc 3421 tttataaaaa tcaacacatc catacatagc tccatgatct gttatagcta tactatccat 3481 acccagttct ttagcactgg ctattatatt atttatcttt ccagccccat ccaataagct 3541 atatccagta tgaagatgaa gatgtgtaaa ctttttatca ctcaaaaact ggtcctcctt 3601 ttttattatt tttgttaatt aatcatattc aagataattc taatatgatt tttcccaata 3661 taaaaagaag ctcatgagat atttattata ttgttaaatc aagtatctca gttcctaaat 3721 atatgaatac accttaaaaa gatgtgaatc gccttaaatc ccctcatttt ttttgcatat 3781 ccattcttta caattgtcta aaaacttata acgatcatat ctatagctta catgaattaa 3841 gtctaagaat tgcatagtat cagcgttgta aacatttata ttgcccaatt cgtcagcttc 3901 aaagaagtaa ttctctagct gcacgctatc atcattaaaa taataagtca ttattcttcc 3961 acctctgttt caatacaatt aactttatct tttcctaaag aataaaattg ggtcattaaa 4021 tatcgagcgc tactttcatc acctttatga attaatttat tactaagaat aattttatca 4081 gttctacggt ttattaaatt agcatcttca attaatttaa atatttctaa gacaacaatc 4141 ttttaatctc atgataactc acaaagttct catctaaccg tggtttatac ttataataat 4201 attacataac taaataaaag taaaaaatac tttaatatag aatttatata ataataactt 4261 atagatattt atagttaata tatacctata ggatatatat attaaactgt tataaaaata 4321 taaattatat ataaattatt aaattgtatg aggtgatgta taggttgaat aaaggatttg 4381 taaaattaag tatagataat catgtggaat ttgttaatag agaattgggg aaagataaaa 4441 aatatgggat aaataaaagt acaattataa gtatatttac aacaaaaggg tataaatata 4501 atgcagaatt aagatgttat ataaaagata ttaaaaagtt aaaagaatgc aactagaaat 4561 caatggggca tcacatacat acttacaaca atattaaaaa aatattttaa tatcactttt 4621 gcaatgtaac gtaatgatga ttttgttaca ttgaagccga ataggctata agtattgcaa 4681 tgtaaatact tatagcctat tttttattat tctactggga aagcatttat gtaaatgtaa 4741 catattgtat ttataagtat catttaatgt attataatgt atgtaagagg tgataaaatg 4801 gaattagttc aacctataag ggataaagaa gttataaata aatttaagaa tgaattactt 4861 aaaaagggtt ataggaacta tatgctcttt gtgataggaa taaatacagg tttaagaata 4921 tcagatatat taaagcttaa ggttgaagat gtaaaggata aaacacatat agtgatccga 4981 gagcaaaaga caagtaaaag gacacgagtt ttaataaatt caatgttaag agaggatatt 5041 gaaaagtata tagagggtat ggataataca gaatacctat ttaaaagccg taatgggaaa 5101 aataagccta taacgagggt acaagcctat agaatattat cagaggtagg aaagcatcta 5161 ggaatgtctg aggtgggtac acacactctc agaaagactt ttggctattg gcactataaa 5221 caatataaag atgttgcgat attgcaagat atattcaatc attcagcacc aagtataaca 5281 ttgaagtata ttggaataaa tgatgatata aaagataata ccatagaaaa cttttattta 5341 taaagtagct aaaatgctgc tttttattta tttaaaatta atcataaagg attttgtaaa 5401 aataatactt tagcaatact attgtaatat attaccaatt agtatattat taaagtatta 5461 tttatgtatg ataatataaa agtattacta aagtattata ggggtgatga tatggataga 5521 acggactttg ataagttaga agtacaggat caagtaattt atataaataa acaattaggt 5581 gaaggatcta cacttagaga tattgcaagt aatttaaata tagcacgtag cacattaaga 5641 gatagattta aaaagatagg atatatttat aataaaaaat taaatacata ttcaaagact 5701 aataatgagt ataacaaaaa taatactaat gtattatata aagaacctgt aaagaaacaa 5761 aatacacttg aaattgaatc atacaaaagt aatactattg taagtaataa ggaattacag 5821 agcataaaag aagttaataa tttaaaaaaa gaagtattcg aattgataaa taataaagat 5881 ataatacttg aaatgattaa ggattacaaa agtaatacta aaataataga tatacctcag 5941 ttagatataa ataatttacc agtagaaatg caaaaggata taacaactaa aagtataaaa 6001 gtatataagc ctatatataa tttatttaat aaattgtgtg aagaatattc tagtataaaa 6061 aaacaagatc taattagttt agcattatat gaattttata taagatataa aaaataattt 6121 aattttatat aaaatgttga ttttactagc ttaattagaa tattaaatta tatttatata 6181 ttaaaattaa atataatcat gtattttttc atgaaaaaat aatacaatat agtacattgt 6241 attactttat attattttgt attacattgt attatttaaa aataatttat tttttataaa 6301 taaaattgtt gaatgttgga aggaaaagag gtaaaataaa gacaagtttt tttaaaaata 6361 aaataaaaaa gtccttcaac tcttatatat cgtacgggaa tacgttatat aagccaattc 6421 aattatgtac gggaatacat aaaagaacgt tagaaagacc ttataattta ctattcaatt 6481 atagaataga ttatacaaaa ttattaagag aatttcaagc attttttagt atgaacgtac 6541 taagaagtgc ttttttaatg tttaaataaa aatagacaag ccttattaat caatatataa 6601 gtgattagag gtggttatat gaaaagagtg aaaagctgta gaaagtgtga attttataat 6661 gaagatgaag agtttaattg tacaaacttt aaaatggtaa ttcttgattt taataatgca 6721 cgtaaatgta tttattatca agagcgtatg ggaaggagaa agcgttgtaa gacctgtatg 6781 tatttaagta ccacatataa acaagtataa gtatgtatgt gtaaagacag gaaaaatacg 6841 atcatatacg cagctagtgc actgtaacag atataaaaaa ataaatagta gttagtttat 6901 tagggagaca aagttaaatc gtgttgagga gtatatcacg taaaaacaag cgaccgacta 6961 atcaatcggt gctgttgccg ttagagggta ggaaaacttc tcagaagaac atatgtaaaa 7021 ttttaacatc ggtttgtgac tgtcctagtt gggggcgtag gtgaaggatt gtgataatcc 7081 tagttggtaa tactagacct gagcgacttt gaacctatga cgttgtaatg acgtggatat 7141 acggatacct ttgattccta tacggattaa aagaagtaaa aagtatattc ccttgtgctc 7201 gaatataatc tatattcgag cacaaggggg ggaaagccgt tttccttatc aagcctacca 7261 gattaaaatt aagatcgttt aaagtcaata tataaattaa aaatttttaa tttaacaggc 7321 ttgaaggggt aagagtatag gtagtttata ttaaatataa agtttaaaat tatatttagc 7381 atttaaatac taaaggtgtt aaaaatataa gaagagataa caaagttgat gatagatctt 7441 acggaagtag aataagaata actattattt tgccataata gttattctta tttaatttgg 7501 ttgaaattaa ataattgata aagtaaaata gtactagtta agtgtgagtg cgcacagcac 7561 agcagcggca agctccccga atggatagcc attaggctcc cattttattc agagcttgtg 7621 aggggatacc ccttcaaacc cctatttttt aacattggtt tttaaaccaa tgtatttata 7681 atttagttat taaggaggtc aaaatgaata aagaaaaagc tgaagagata atagaaagtg 7741 tacaaggaaa tataaagcat tctgatatga tactaacaga cgatgaaaga gctcttttgg 7801 aggaatatat attagggaat attacaagag aagaatatat tgaaaaatca ctagaagatg 7861 tacagaagga taatattaga tatggcatta aaggggaaaa gatattagat agtactatta 7921 atttaagtga aaattgtaaa gttaatagaa aaaggaataa acaaatagtt ataagagcta 7981 caaggaaaga gtttaacact ataaaaaata aagttaaaaa atctaagtta agtcaaaatg 8041 aatatctttt aaaatgtgca ttagataaaa ggatagtagt agtagatgga ttgaaagatt 8101 tgaatgtaga gctaaaaagg ataggtaata atcttaatca gctaattaaa tcggtacatg 8161 aaggtaaggc taattgttca aaggaactat tagaaataaa tgaggagatg aaagaggtat 8221 ggcagttatt aaggcagtta actccaaaag ctctttagat ggaattatta agtatgttac 8281 tagggaagag aagacagaag aaagattaat tactgggaag gattgtagtc cttcaaatgt 8341 gcttgaagaa atgaaagtaa ctaaagaaat atttaataaa actacaggaa ggcagtataa 8401 acattttatt caaagttttg atccaaatga taatttagat tatatgaaag ctaataaaat 8461 aggcttagaa tgggcagaaa aaatttttaa aggtttcgaa gttttaataa gtactcataa 8521 ggataaaggg catatacata atcattttgt tgttaattct gtaagttttg aagatggtag 8581 aaaacttaga tatagcaata aagaattaca aaattttaaa aatgtaaatg accgtatatg 8641 tgaaagagaa ggattaaata tagtaagaga agtaagcaaa gagataacaa gctttaatca 8701 taataaatat aaagtaatag aaaaggcatt taagggcatg ggtgaaagct atcttttaaa 8761 tacaggtctt gaagtaagta attcattaaa ggtatcaaaa acaaaagaag aatttataaa 8821 atctatggag gaaaagggtt ataaagttaa ctggaaggat acaagaaagt atataacttt 8881 tacaactcct gaaggtagaa aaataagaaa ttcaaattta caaaatacac ttaaaaatga 8941 taaatttacc aaggagggca tggaaaatga acttcgatac aatagataaa aagaaagaga 9001 atgtaatttt agagaatcag gcatttcaaa aactccagga gataaattta atgcaaaaaa 9061 tgggactgga gaacagtttg ctgaaagagt ccttggctca atcacacgag aaattgcagg 9121 aattgaagta agagcaaaag gagagcctag tgaaaataaa agagatacaa gatcaaacaa 9181 cagagaagat aaaagaattg aagacaagca acgaactatt aaaagagagc atagaggaaa 9241 aactagagat cttggtagat aaattaaacg aaatacttaa aggattgtcc ataaaattag 9301 ataaggttta taaggtttat atagaacgta tgggaacaga aacagaaaaa aagatacaag 9361 ccctcaatga gttgcagaaa gaggctgaaa atcgatgtga gagctattat aatagaaaaa 9421 caataatagc ttatttaatc tatataaatt tagcaataac tcctatatta ttttttataa 9481 taatatatat tcagtttttt aagaaataaa cggacggtga ggcattggta tatcctggtt 9541 atagcagagt taaaatagag ttaatttata gtaaaaatgg agtcaaatag aactcatatg 9601 gagttaaaat agagtaaaaa cagagttaaa aaaagtctta aaatgatatc acttttttaa 9661 gattttttta gatagaaata tagttagcac agttaactta ccacttacta tttagtaagt 9721 ggtatcatat ttcccttatg ctctttttaa gttacttttc tgagaaagta ttttttatgc 9781 aacatcatgt aaaaaaaaat gggaacactt taccatatta tggagtatat gtcaattcag 9841 aaaaaaggaa taattgtcca aattatagct tatattgtaa taaatataaa tatattttat 9901 tcagttggat ttatattaat aatgtataat ttgataaatt ataccaaatg atataatatt 9961 ttactaaaat caatcaaaaa ttatatttaa ataacaagta tagactaaag aatttctaaa 10021 aggagtaaag atatgtatcc acaattaaca gacaactctt ttgtaaagca aacaccagat 10081 aaagaagcgc atgttttttc gttcttcatt aatgagatgc gtagttatgt gagtataaat 10141 gaaagtgcga gtagtatttt aggcttatgt aatggaatgc attcaataga agatatcata 10201 tctatcctaa gtaataaata tgaagaagat cccaatgtgg taaaaaaaaa tgtacaaaca 10261 tttttagacc ctttcattaa gaatagtatt gtaagggata ataaggttga attttcaaat 10321 agaaatattg ttaatggaag tttggaagtt tattatcccc atgcactttg ttgggagatt 10381 accgattatt gtccgttgaa ttgtaggcat tgttatttgc ctgaaaaaaa taatagcata 10441 ctttctagag ataatatcga taatgttcta gaaataatag attctgcagg tatacagcag 10501 gttcaagtga caggaggaga agcgttaacg catcctgaat tggaatatat aatagatagt 10561 cttattaata gaggtataat tacatctata tccacaagtg gatttaattt tactaatgat 10621 atgtttaaat atttagtgaa attaaaagaa gtgaaaggaa gtaagttgcg tgtaagtctt 10681 gatggcgata aaaatataca caattatatt cgcaaaaatg aatatgcata taacaatgca 10741 atagaattca taaaaaccgc agttaaaaat ggtatcattt gtcaagtgga gactagtgta 10801 ataaaccaaa gcaaacaaga tcttgaagac ttagttgttc tggtaaaaga attaggtgtt 10861 agttccattg aaattgcaag gataagcgat cagggaaatg ctcgtaaaaa taacctggag 10921 ttagtgtgga gtccaaaaga atttgatgat tttttatatc aattaaattc caagtatgct 10981 aatgaaacat ttaaaataag gttacctaaa gaagaaaaaa acaaaaattg tggtgcagga 11041 tataaaataa ttagaataaa accaaatttt gatgttacac catgcccaat gctagaattc 11101 agattaggaa atctgcataa agatactatg tttcaaataa tgtcgaaatg cggcaatata 11161 tttcatgaat ttgaagctcc ccaaaataaa ttttgtagtg aatgtgaaaa caaggatact 11221 tgtgatcatt gcattgcatc aggttttaac tctaaagata aagttaaaga ctgtcgttgg 11281 tttagaaata ttgaatattg tctaaagcct tttttagaca ggtaaaaaac ataatatata 11341 gtatatttta aaagaaataa tttttatcta tcttgcataa caatttatta aaaaaaatat 11401 atatacgtaa atgctctgaa cactttctgg ttaccagaaa ggatgaaata gataaatttt 11461 ttacattcag agaaagaata ttttgtttta tagaaacatt ctttaaattt tttaatgggg 11521 aggtgagaaa atggaaaagc ctaaaattac aaatgctaat atggtagctt gtagtggaaa 11581 cccttacgct gcaattgcta tgttgggttt agcatgtgga gcagactttg catattgcca 11641 gatgccgtca gtatcggatc tatggggttc aggaacagca aaagcacttt aattataata 11701 gcatggatga taaataaaca tccatgctat tatattatta aagatagaat gatcctttaa 11761 aataaagaaa ttctttataa caggggaaag agtacagtta gatataaaga tgttaatatt 11821 actacaagta actcactaac attgagtgat agtatttttt aattatggtt tttgcctaat 11881 ttttattaga aggtggaata tgtaatgaat tataagcaga gtgtgtatac aatacagtta 11941 aaatatatta aagatgattt tgaatatata gttgattcat ttagtggcga aagggaagaa 12001 actataagaa atatcaaact aaatacctgt aaaaatttat ttgatgatgt tcaattaaat 12061 ataagtacac cttatttaat aaatttgaaa aaatctttac gatatattaa gaaagattta 12121 gaaaaacaag atattaatct ttctattttt atgaatttac ataatgaaag agtgctgatt 12181 gacaatgagg aagaagataa tcgttcatat ggattccttc gattgatttg taaagataat 12241 gataataata tgcatataga tgatatccca attttatcat gtaatcctat tgatctagaa 12301 gataagatta attactatgc aaaaaaatat ataagtatga aaaatcttca tgatataaga 12361 gaacaggtaa gttttgaatc tatacctcat attttatcac ctaaagctgc tggttatttt 12421 atacatgaaa tagtaggaca tactttagaa agtgattttt attcatacta caaggataaa 12481 tatgaaaata tgaaaatttc taaaaaacta acagttactg attctataaa tggttataat 12541 cgattaatag gccttcaagg ttatgatgat gttggaacta aaatagaatc attaacatta 12601 attaataaag gaaaaattca aaatatgcta gcaattaaga aagaagatag cttcgatcat 12661 aagctatatg gtgtagcaag aagagcatct tacaaattcg aggtacttcc tagaatgagg 12721 agcacataca ttcacccttt tgatgatatg gatcaacaag atatattaga taaatatgaa 12781 aatgcaatat ttgtgaatga aattttttta ggtggagttg atcataaatc aggtaaatat 12841 aatttaaatg gaaatggatt tattgtaaaa aatggagagc tacaaaattt tattggagat 12901 ttaagaataa gtggggatat attaaaggat atttcttcga ttgactatat aggcaaagat 12961 tttgatatgt ttggtaacta ttgtgaaaaa tttggtcaat ttgtacgtgt tggaagtggc 13021 ggccccacta ttagtatatc atctttaaat gcaagggggg tattatatgg aagaagataa 13081 gcgtatagaa aaaagattat tatcaaaagg aatcatggag tataagatta ttcgtaccat 13141 attaagaggt atgaaatata aagagtattt tgggagtgta tctattgaag atttgtcaga 13201 tgataaaata ttggttctgt ttaaaaccga agaaggaatt gcgaaattta cggtttcatc 13261 ttttcaatca gacaatataa tagataggat tattgaaaca agcatgaaaa accaaatgaa 13321 gatgtcatta caatggcatg atgataattt tagtgatgta aaaatagaac aaaatgaaaa 13381 ttataatcgt ttttataaat ttaatagcaa cgactacata atgtggataa aaaaagaaat 13441 agataatatt tcgaaaaaaa taaaattcac atttaataca atatatacaa taaatgtgaa 13501 taaatattgt ttacgtacaa ataaagatta tattgaacaa tataatacta gctcagagtt 13561 tctatgcata gaaaataaaa catttaaaag gagatctaag ttaagtaata gatttttaaa 13621 agacgatata gcactctcaa ttattaaaca attaaataat gatgatattc caagaaataa 13681 tataaatttg aactctaaac aacgtatact tttaaaggca aaagggttat cagatttttt 13741 aaatgtctat atttctttat attatgccaa ttatatatat tccaatcaat catttataaa 13801 aacaaattat attggaaaac aaatttcaaa aagtaacttt gatctaattg ctattccata 13861 taacggaatt aaatttgata gtgaagggtc tagaatcttt aaaaagctga ttgtcggttc 13921 tggaaagtta attaatttgt taagtaataa cagtttttct gaatacttta atattaatag 13981 ttttggtaat gcaagtttag atactcataa tactgtttca catcaacgat taatttttac 14041 atgtaaaaat tcagaaagaa ttgtttctaa atcagtagat ttaataattc atcaatttga 14101 aaatgcatat atagattttg aagataatga agtatttagg ggaaatgcta tttgcagtga 14161 taaatcgggt tacttccgta ctacaattag ttttaatcta aaatatattt ttaataatat 14221 atatcctatt ggtaataaaa gtacttggat taataatgta tattgccaag acgttataat 14281 attaagataa agataaaatt taatggattt cttaagtatt aaataaaaat ttaaattaga 14341 tagatttatg tagtatataa tggttttatt gtattataaa tatacataat tcaggaagga 14401 gattctaggt gtgggtaagt taaggagttt attaaaatta aagccatttt tacaaaagta 14461 taaactactt ttgttttttg ctttaatagg aataatatta ggttcaattg ttgctattcc 14521 agttccatat ataataggaa aaataatgga tgatgtactt ataggtagta aaagttttaa 14581 tgaattttat ttctatattg gtataataac aatattatat gttttgaaat attttatttc 14641 tattacatca aattatttat cttctaaatt taacaatttc atgtccaatg atttgagatt 14701 tatactaata gataaagtta tggatttgcc tatggattat ttggcaaatg ttgaaaaggg 14761 atatctacaa ggtagaatat ctgaatgtga ctcaattaca gctatttttt ctggaactat 14821 cataagtata ttattgagta cggttaatgc tgtattatca gtatcaacta tgtttgtaat 14881 aaattacaag ttggctatag ctgttcttat tttggtacca ttttttttca tcttagctaa 14941 attttcaaac catgcactta caaaaaatac aaaaaaaatg ttagaggata gtgcgatttt 15001 aaatgcagaa tgttttgaaa taattaatgg agttgaagat ataaaaatac ttaatggtaa 15061 ggcatatagt ttggggaaat tcaaaaaaaa gttagatcaa tttataaaaa ttacattaaa 15121 acaaaataaa actatgttat tattatcgca aaatgttgta ggagttaacg atgttggaac 15181 acttttaata ttacttattg caggaaattt aattattaaa ggggaattta ctgtaggttt 15241 gtatacaaca ttttcattat attcgagtaa aattttttcg agtactcaat tacttgcaaa 15301 cataggacca tccttaaagc aggcatgttt aagtatagaa agattatatg aacttataga 15361 tatggatgat gaaaataaag gtaaaaataa acatttaaac aaaaaaatag aatccataaa 15421 gttagaaaac gtaactttta aatataaaaa tagtattaaa aatgtcttag attccttaaa 15481 ttttgaaatt aataaaggtg aaaaagtact tattagtggt gaaaatggga caggaaaatc 15541 aacattaata aagttactag ttggtctata tgaacctaca gaaggaagaa tattatataa 15601 taatttagat ttagctacaa ttaacaatga aagtttaaga tcgcggatag gtattgtttc 15661 acaaaatatg tttcttttta aaggaactgt attagataat atattatatg ggcaaaatca 15721 aaaaaagcgt aaagatgttg aaaaacttat aattaaattg aatctagaaa attacataag 15781 taggctacct gaaggcttag attctaaaat aattcaaaat aataatggaa tttcaggcgg 15841 ccaaactcaa gttatagctt ttataagagc agtactttca aataaagata taataatttt 15901 ggatgagcct atatcaaatg tagatgctga aactagaaat ataattttaa atattctaaa 15961 agaaagcaaa tttgatggaa tattaattat tatttctcat tttacaaaag gaatggagtt 16021 cataaataaa acgattaaag ttggtaaaaa ataattacaa tgtaaaagta ttggcaaagt 16081 ctttatccga gattatatat aaaaatcaga taaagagtat ataatttatt ttaaaagaaa 16141 tcctagtaac tctaataaaa actacctaaa attaaaaaat ttgtacttga ggaagttctt 16201 tattagggtt acttttgata actcatgtat aagtatgatt tatattaatt tataaaattt 16261 aaatttcaaa gcaacatatg agtaaccatt ttgaggatat tgacctcaat accttagttc 16321 aggctagtct gttaaaatca aaat //