LOCUS       NC_008503              14041 bp    DNA     circular BCT 23-JUL-2008
DEFINITION  Lactococcus lactis subsp. cremoris SK11 plasmid 1, complete
            sequence.
ACCESSION   NC_008503
VERSION     NC_008503.1  GI:116326529
DBLINK      Project:401
KEYWORDS    .
SOURCE      Lactococcus lactis subsp. cremoris SK11
  ORGANISM  Lactococcus lactis subsp. cremoris SK11
            Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
            Lactococcus.
REFERENCE   1  (bases 1 to 14041)
  AUTHORS   Makarova,K., Slesarev,A., Wolf,Y., Sorokin,A., Mirkin,B.,
            Koonin,E., Pavlov,A., Pavlova,N., Karamychev,V., Polouchine,N.,
            Shakhova,V., Grigoriev,I., Lou,Y., Rohksar,D., Lucas,S., Huang,K.,
            Goodstein,D.M., Hawkins,T., Plengvidhya,V., Welker,D., Hughes,J.,
            Goh,Y., Benson,A., Baldwin,K., Lee,J.H., Diaz-Muniz,I., Dosti,B.,
            Smeianov,V., Wechter,W., Barabote,R., Lorca,G., Altermann,E.,
            Barrangou,R., Ganesan,B., Xie,Y., Rawsthorne,H., Tamir,D.,
            Parker,C., Breidt,F., Broadbent,J., Hutkins,R., O'Sullivan,D.,
            Steele,J., Unlu,G., Saier,M., Klaenhammer,T., Richardson,P.,
            Kozyavkin,S., Weimer,B. and Mills,D.
  TITLE     Comparative genomics of the lactic acid bacteria
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (42), 15611-15616 (2006)
   PUBMED   17030793
REFERENCE   2  (bases 1 to 14041)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2006) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 14041)
  AUTHORS   Lucas,S., Copeland,A., Detter,J.C., Glavina del Rio,T., Pitluck,S.,
            Grigoriev,I., Rokhsar,D., Slesarev,A., Pavlov,A., Pavlova,N.,
            Karamychev,V., Polouchine,N., Shakhova,V., Kozyavkin,S.,
            Makarova,K., Koonin,E., Mills,D.A. and Richardson,P.
  CONSRTM   US DOE Joint Genome Institute (JGI), The Lactic Acid Bacteria
            Genome Consortium and Fidelity Systems Inc.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2006) US DOE Joint Genome Institute, 2800
            Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CP000426.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 2662180
            Source DNA and bacteria available from Bart Weimer
            (milkbugs@cc.usu.edu)
            Contacts: Bart Weimer (milkbugs@cc.usu.edu)
                      Larry McKay (lmckay@umn.edu)
                      Paul Richardson (microbes@cuba.jgi-psf.org)
            Annotation done by Kira Makarova and Eugene Koonin
            Finishing done by Fidelity Systems Inc. (Gaithersburg) URL --
            http://www.fidelitysystems.com
            Project Information available at:
            http://genome.jgi-psf.org/mic_home.html
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..14041
                     /organism="Lactococcus lactis subsp. cremoris SK11"
                     /mol_type="genomic DNA"
                     /strain="SK11"
                     /sub_species="cremoris"
                     /db_xref="taxon:272622"
                     /plasmid="1"
     gene            complement(406..1776)
                     /locus_tag="LACR_A01"
                     /note="LactoCOG number LaCOG00047"
                     /db_xref="GeneID:4405781"
     CDS             complement(406..1776)
                     /locus_tag="LACR_A01"
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin A ABC transporter permease protein"
                     /protein_id="YP_796453.1"
                     /db_xref="GI:116326530"
                     /db_xref="GeneID:4405781"
                     /translation="MNHHNWQNSSQVYTQSHKHFYRWMTYPTLFLFLFILSFLFLGKK
                     EMIIKSQGQLTSTIVSKIQIPIEGKVLENKLSENLAVKKGETLVKLDLESFKKNKEAL
                     EQEIPLIENQIKSAETFIESLNKGTSQFTSDDEFGYKNQLESLLAENSANDASLNQSI
                     ETHKNEQATYENTKKSIALSIYKKKEERRNWQDIRSAWTSQSNITNFPTEITAQYTTF
                     QNQLKTSSKEEKEQVKSTVASTINEKIEQIQKEIDQLEMDQSRLTPPVPYSNEISNQG
                     YKKKQSIEQAIAETKQKVIGLKESLKKNNIELSELKNQIKNEVIASPISGFVHVNDNF
                     KEQKLIPKGEVIAEIYPEINDKEIQFTSQIQASDLTQVKTGMKVHFKLDSKGNDPIMM
                     DGKIDEIAVNATNSERGTFYLIKGTLKQSNHVHFNSRYGLSGRLSLIVGKKTYFNVLK
                     DIILKK"
     gene            complement(1792..3942)
                     /locus_tag="LACR_A02"
                     /note="LactoCOG number LaCOG00046"
                     /db_xref="GeneID:4405782"
     CDS             complement(1792..3942)
                     /locus_tag="LACR_A02"
                     /codon_start=1
                     /transl_table=11
                     /product="bacteriocin-processing peptidase"
                     /protein_id="YP_796454.1"
                     /db_xref="GI:116326531"
                     /db_xref="GeneID:4405782"
                     /translation="MKKMKIIYQQDEKDCGVTCIAMVLSNYKTKIPIYKLREISGTDL
                     HGVSALGIKETLELFGLICQIGQANNEVWQETDLPLPLIAHVISEQKYPHYVVVYKVK
                     GNQLFIADPAKGKVKKSIEEFAKEWTGVLLLASPKESYQPSIEKVDGLSSFLPILLEQ
                     KALIFHIVLASFFITLFGIISSYYFQGLLDNVIPNQAKSTLNMISIGLLFVYLFRVVF
                     EYSRSYILMVLGQRMSMSIMLNYFKHVLSLPLNFFATRTSGEIISRFLDANKIIDALA
                     SATLSIFLDIGMVILVGTTLAIQSTPLFLLTLAFLPFYILVVYIFIKSYDKANTEEMS
                     AGASVNSSIIESLNGIETIKSYNGEAVVYQRVDSEFVTLMKKSFKSGILDNIQQALKL
                     AIQLISSALILWLGSIYVIEGKISLGQLITYNALLVFFTEPLQNIINLQVKMQKARIA
                     NKRLNEIMSISSEKGDKEKTLNISETYFNKEIKLEKVTFSYNMKLPILKEISFKIAPY
                     SKVALVGVSGSGKSTLAKLLVKFYSPSEGSINYGDINSLDIENKELRNHVTYVPQESF
                     FFSGTILENLTFGLETNPNFEKILEVCQATCLIDFINEQPLRFETILEEGGNNLSGGQ
                     KQRLAIARALLKDSEILILDEATSGLDTLLEKEILDVLLQMRNKTIIFIAHHLSIAKA
                     CDKIIVLDKGILVEQGTHQELSNQDGIYQKLLEA"
     gene            4674..5354
                     /locus_tag="LACR_A03"
                     /note="LactoCOG number LaCOG03056"
                     /db_xref="GeneID:4405783"
     CDS             4674..5354
                     /locus_tag="LACR_A03"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="YP_796455.1"
                     /db_xref="GI:116326532"
                     /db_xref="GeneID:4405783"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSH
                     TTIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDI
                     WLRKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIK
                     YLNNLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEI
                     KVLLGIPA"
     gene            complement(5388..5969)
                     /locus_tag="LACR_A04"
                     /pseudo
                     /db_xref="GeneID:4405784"
     gene            complement(5960..6496)
                     /locus_tag="LACR_A05"
                     /note="LactoCOG number LaCOG01517"
                     /db_xref="GeneID:4405785"
     CDS             complement(5960..6496)
                     /locus_tag="LACR_A05"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796456.1"
                     /db_xref="GI:116326533"
                     /db_xref="GeneID:4405785"
                     /translation="MSEELKTIKELADEIGVSKQAVWQKIKKESSIDLRQFTSKKGNT
                     VYVDVDGQKVIKNAFFNKTSTKKRQQKLFVDDNVNDSVDGNLEGNEEILFLRNLVSEL
                     QSEKKELHKLLDQQQRLALQDKKLLEEYKEEIKELKSLMVPVRKDNKDPMVQKSKDID
                     NTKEELHTKNKKWWKLWK"
     gene            complement(6489..7649)
                     /locus_tag="LACR_A06"
                     /db_xref="GeneID:4405786"
     CDS             complement(6489..7649)
                     /locus_tag="LACR_A06"
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein"
                     /protein_id="YP_796457.1"
                     /db_xref="GI:116326534"
                     /db_xref="GeneID:4405786"
                     /translation="MSSIPEKQENQKQVLTLNELSKRKVVEHNSLITSIAKMDKTPLK
                     MFELAVSCINTEEPPKDNIIYLSKRDLFAFFKVSDNDKHSRFKEAIEKMQKQAFFQIK
                     EEAGKGFKFKSIVPIPYVEWTDYHDEVKIEFHREILPYLINLKKNFTQHALSDIAELN
                     SKYSIILYRWLSMNYNQYEHYSTKGGRRAEQVESYRNPSISIKELRIMTDTVNDYERF
                     QSLETWILKKPLEEINDHTSFTVTYDKVKKGRSIDSIVFHIEKKRQADDNSYKMEDQA
                     YQTDKKIKEETEEKLVYQAMKSKYTQILLENMLLSPYEMTDTALMAGLQKNVYPLYDE
                     LKELRGLKGVKDHLSYVASKREDYSKKNICKYLKKAIEQYLPTVKRQDLNHE"
     gene            8401..9081
                     /locus_tag="LACR_A07"
                     /note="LactoCOG number LaCOG03056"
                     /db_xref="GeneID:4405787"
     CDS             8401..9081
                     /locus_tag="LACR_A07"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="YP_796458.1"
                     /db_xref="GI:116326535"
                     /db_xref="GeneID:4405787"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSH
                     TTIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDI
                     WLRKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIK
                     YLNNLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEI
                     KVLLGIPA"
     gene            9729..10040
                     /locus_tag="LACR_A08"
                     /note="LactoCOG number LaCOG00345"
                     /db_xref="GeneID:4405777"
     CDS             9729..10040
                     /locus_tag="LACR_A08"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleoid DNA-binding protein"
                     /protein_id="YP_796459.1"
                     /db_xref="GI:116326536"
                     /db_xref="GeneID:4405777"
                     /translation="MVNKKELAKAISEKSGNIMKKHPLTIYESKKVVDAITASITELL
                     VQDGKIQMIDFGTFEKKTRASRGGFNPQVGERIQIPEKTVPTFKAGKGLKEAVKLKKK
                     K"
     gene            complement(10270..10512)
                     /locus_tag="LACR_A09"
                     /note="LactoCOG number LaCOG02691"
                     /db_xref="GeneID:4405778"
     CDS             complement(10270..10512)
                     /locus_tag="LACR_A09"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_796460.1"
                     /db_xref="GI:116326537"
                     /db_xref="GeneID:4405778"
                     /translation="MRKGEIIKLSDGQEATLVVGDESTIFKNCYIIYLVDKGPGVVDR
                     KRLTLTKPYPDSTGRRTYSKKTVNTKKASQGCPFYE"
     gene            complement(10600..11490)
                     /locus_tag="LACR_A10"
                     /db_xref="GeneID:4405779"
     CDS             complement(10600..11490)
                     /locus_tag="LACR_A10"
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein"
                     /protein_id="YP_796461.1"
                     /db_xref="GI:116326538"
                     /db_xref="GeneID:4405779"
                     /translation="MAHEIVQYHNDFNTVPLRGFNEREKRIVMALLHEVKGKDTQIVQ
                     LDFHTLRGLTGWDETNHKGANSNAEFVKYLEILSDKIMTLRGTLRSDDGLQIVKFSLF
                     PTFIIDGKKTNTLKVSINPEFKYLTNLFDMFTAFELEDYNKMHTSYGQELYRLIKQFR
                     TTGFYRVKTEDLRHLLSVPKSYTNAEMDRKVFSKTTVSDLTNAFSNFKIKQERGTGRG
                     RPIIGYTFTFDKEKTNQYEIDRKKEEQIAQFWKSDEPEPMPNAVAQTEYQNPELRKQK
                     EETDRHSAGFGDLLKGWFKK"
     gene            complement(12694..13662)
                     /locus_tag="LACR_A11"
                     /db_xref="GeneID:4405780"
     CDS             complement(12694..13662)
                     /locus_tag="LACR_A11"
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="YP_796462.1"
                     /db_xref="GI:116326539"
                     /db_xref="GeneID:4405780"
                     /translation="MATTHIKRSSGASRLVNYAEKRAVQKDGHNIDIDYAKSELKQVR
                     EIYGNKGSTQAYASRVAFSPKEFAPQNTQDQIKALEIAKEIYSTAYPNQQVALYVHND
                     TDSLHVHAVIGAIDLQTGKKMHGNWQQYRERLVKITDKVVERHGLEVTIPKHKPEKRS
                     MAEIKMKERGQVPWKDKIRQAIDTTMRESHISDFKSFKEKLGEFAINVIERGRDLTYG
                     LTGTNYKARGAKLGDDYKKETIFNELDRRNERKLTTTRKPSLGDFDFGEYKSQIKAGR
                     SQINNERSELNHKRTKKQTDELSRARRNARNLESKRAKTQPKGPTL"
ORIGIN      
        1 cgtccccaat tgtattttag catttttcgt gtcgacgctc aagctcgacc ctcaaaaagc
       61 aaaatacaat aaaggcttgg caagcaaccc acaagctagc cacttcgtgg cagttgtggt
      121 acttgtaagg gggagcaaag ctccaccctt aaccccctcc gttcgcagaa taaaaataaa
      181 agtggctaag caatatgcta gccaatcttt tatttttaac tgctcattta tttctcaaaa
      241 tcggagaaat aaagtctttc agaccgaggc tgtctgccga gaaattttgc atttcaagca
      301 tgatttcatc aagaccattt catggagagg ctctgccgta cctttcggca aaaacaagcg
      361 taacacgctt aaccgcctta atctcgcttc ttgcaaaagt tatttttact ttttaaggat
      421 gatgtctttt aagacattga aataagtttt cttccctaca ataagcgaaa gccgaccgct
      481 gagaccatag cgactattaa aatgaacgtg attgctttgc tttaatgttc ctttgattag
      541 ataaaaagtt ccgcgttctg agttagtggc attgacagca atctcatcta ttttaccgtc
      601 catcataatt gggtcatttc ctttagaatc taatttgaag tgaactttca ttccagtttt
      661 cacttgtgtt aaatctgagg cttggatttg cgatgtgaat tgaatttctt tatcatttat
      721 ttcaggataa atctcagcaa ttacctctcc cttaggaatc aatttttgct ctttgaaatt
      781 gtcattgacg tgaacaaaac cactaattgg agaagcaatg acttcatttt ttatttgatt
      841 ttttagttct gacaattcaa tattattctt ttttaagctt tctttgagtc ctatcacttt
      901 ttgctttgtt tctgcgatgg cctgttcgat actttgtttt ttcttatatc cttgattact
      961 aatttcatta gagtaaggga ctggaggagt tagtcttgat tgatccatct ctaattggtc
     1021 aatctctttt tgaatctgtt ctattttttc attaattgta gaagcgacag tagattttac
     1081 ttgttctttt tcttctttgg agcttgtttt gagttggttt tgaaaggtag tatactgggc
     1141 ggtaatttca gtagggaaat tagtaatatt gctttgagaa gtccaagcgg agcgaatgtc
     1201 ttgccagtta cggcgctctt ctttcttttt ataaatgctt aaagcaattg atttttttgt
     1261 attttcgtaa gtggcttgtt cgtttttgtg ggtctcgata ctttggttca ggctggcatc
     1321 attagcgctg ttttctgcta gcagactctc caattggttt ttataaccaa attcatcatc
     1381 tgaggtaaac tgacttgtgc ctttatttaa actctcaata aaggtttctg ccgacttaat
     1441 ttgattttca attaaaggaa tttcttgttc taatgcttcc ttattctttt taaaggactc
     1501 tagatctagc tttactaatg tttccccttt ttttacagct aaattttctg aaagtttgtt
     1561 ttctagtact ttaccctcaa tcggaatttg tatttttgaa acaatcgttg aagttaattg
     1621 tccttgtgat ttgataatca tttctttttt acctaggaaa agaaagctaa ggataaacaa
     1681 aaacaaaaag agtgttggat aagtcatcca acgatagaag tgcttatgac tctgagtata
     1741 gacttgagaa ctattttgcc aattgtgatg attcattttt cagctcctta cttaggcttc
     1801 taatagtttt tgatagattc catcttgatt agacaactct tgatgtgtcc cttgttctac
     1861 taaaattcct ttatcaagaa cgataatctt atcgcaggct ttagcaattg aaagatggtg
     1921 cgcaataaaa attatcgttt tattgcgcat ttgaagtaaa acatctagaa tttctttttc
     1981 taacaaggtg tcaagtccgc ttgttgcttc gtctaaaata agtatttccg aatctttcaa
     2041 tagtgctcga gcaattgcta aacgctgttt ttggccacct gatagattgt ttccgccctc
     2101 ctctaggatt gtctcaaacc ttaggggttg ttcgttgata aaatcaatta agcaagtggc
     2161 ttgacaaact tctaagattt tttcaaaatt agggtttgtt tctagtccaa aggtcaagtt
     2221 ttctaaaatt gtcccactaa agaagaaaga ctcctgaggg acataggtca catgatttct
     2281 tagctctttg ttttcgatat caagactatt aatgtccccg taattgatgc ttccttcaga
     2341 aggagaataa aacttaacta atagtttagc tagtgttgat ttccctgatc cactaactcc
     2401 gacgagggcg actttactgt aaggagcgat tttaaaagag atctctttta aaattggtaa
     2461 tttcatatta taagaaaaag ttactttctc aagcttaatc tctttattaa aatacgtttc
     2521 acttatattt aatgttttct ctttgtctcc tttttcggaa gagatcgaca taatctcatt
     2581 taaacgtttg tttgcgatac gtgctttctg catttttact tgaaggttga tgatgttttg
     2641 gaggggttct gtgaaaaaaa caaggagggc attgtaagtg atgagctgac ccaggctaat
     2701 cttaccctca atcacataaa ttgaccctag ccaaaggata agggcactgc ttatgagttg
     2761 aatggctaat ttcaaagctt gttggatatt atccaaaatt cctgatttaa aagacttttt
     2821 cattaaggta acaaattcag aatccacacg ctgataaact accgcctctc cattataaga
     2881 tttaatggtt tctatcccgt ttaaactttc gataatgcta gagttaacgg aagctccagc
     2941 gctcatctct tctgtatttg ccttgtcgta acttttgata aagatataga caactagaat
     3001 gtagaaaggg aggaaggcaa gggtaagtaa gaagaggggt gtgctttgaa ttgcaagggt
     3061 tgtccctact agaataacca tcccaatatc taagaatatt gataaggttg cgctcgcaag
     3121 ggcatcaata attttattgg catctaaaaa gcgagaaata atttctccag aggttcttgt
     3181 tgcaaaaaag ttaagcggaa gtgaaagtac atgtttaaaa tagttaagca tgatactcat
     3241 gctcattctt tgtcctaata ccattagaat gtagcttcga ctatattcaa aaactacgcg
     3301 aaaaagataa acaaaaagaa gcccaatgga tatcatattt agagttgatt tggcttgatt
     3361 tggaataaca ttgtctaaaa gtccttgaaa ataatacgag ctgataatcc caaaaagtgt
     3421 gatgaaaaag gacgccaaca caatgtgaaa aatcaatgct ttctgttcta acaaaatcgg
     3481 aagaaacgaa gataaaccgt ctactttttc aatagacggt tgatatgatt cctttggact
     3541 tgcgaggagc aacacccctg tccattcttt ggcaaattcc tctatacttt tctttacttt
     3601 ccctttagca gggtcagcaa tgaagagttg attgcctttc actttataaa cgacaacata
     3661 gtgcggatac ttttgttcac ttatcacgtg ggcaattaaa ggaagaggta agtctgtttc
     3721 ttgccaaacc tcattattcg cttgacctat ttgacatatt aacccaaata attctaaagt
     3781 ttctttaatt cctaaagcag aaactccatg taaatcagtt ccagaaattt cccgtaattt
     3841 ataaatgggt attttggttt tataattact taaaaccata gcgatacatg tgacaccgca
     3901 atctttttcg tcttgctggt atattatctt catttttttc aataaaatcc tatacgtata
     3961 atcatttaat aattaaggcc atttattaat gaggccaata aataaaaaaa ttaaaaaatt
     4021 gttgctcatg cagaaagaat actttttatt tttagataaa gtaattgtat tgcagcagag
     4081 attatgaata ttaagataaa aagaaataga ataatgaaca agttattgat tgaaaaaaca
     4141 tcaattagtc tttctataac gatagaaaca caaatgatga ctattatgtt agttaatcta
     4201 ttctcttttt gtttccacaa tttatcatac gaataaagaa gttgtttaaa atgtgtttta
     4261 agcataaaac cttatacctc cacgttaatt taaggttaga ctgcaaaaaa tagcagtaat
     4321 gcagtaatat aatgaaaaaa gcttcaaaaa ggtaagttat tttaaatatg agtactacaa
     4381 ccagtttgac gtctaaaaaa ttaatggtta cggtgaaatc cttttttcca gcctttaatt
     4441 atctgatcag aatgatttat gccactaact atgacaggga tgagatattg cgcccatcca
     4501 cccgtaatat gttgaagttt atcagagtcg acttccttaa agcttgatga actgaaattt
     4561 ttaatcatat tctctttatc ctttttatat tcttttaagg gttctgttgc aaagttttaa
     4621 atctactatc aaataaggta gaataataga aaaagatagc aggaggaatg acgatgaatc
     4681 attttaaagg aaagcaattt cagcaggatg tgattattgt agccgtgggc tactatcttc
     4741 gttataacct tagctatcgt gaagttcaag aaatcttata tgatcgtggc attaacgttt
     4801 ctcatacgac gatttatcgt tgggtgcaag aatatggcaa actactctat caaatttgga
     4861 aaaagaaaaa taaaaaatcc ttttattcat ggaaaatgga tgaaacgtac atcaaaatta
     4921 aaggaaaatg gcattatttg tatcgagcca tcgatgcaga tggtttaacc ttggatattt
     4981 ggttacgtaa aaaacgggac acacaagcag cctatgcttt tcttaagcgg ttagtgaagc
     5041 agtttgatga accgaaggtt gtagtcacag ataaagcccc ctctattaca agtgccttta
     5101 agaaactaaa agaatacggc ttttatcaag ggacagaaca tcgtaccatt aaatacctga
     5161 ataatttgat tgaacaagac catcgtccag taaagagacg caataaattc tatcgaagtt
     5221 tacgcactgc ctctaccacg attaaaggca tggaagccat tcgaggatta tataagaaaa
     5281 cccgaaaaga aggcactctc ttcgggtttt cggtctgtac tgaaatcaag gtattattgg
     5341 gaatcccagc ttaaatcata gatactgtaa gggattttat tctttattta aaactttgca
     5401 acagaacctt ctttattatc aatagaaaca aaaataactc catttgggga taataatttt
     5461 ttagcaatga ttaatcttcg ttccataaaa cttaaccact tagaatgttt aaattcgtca
     5521 tcttttccga caaaatcatc attataaaca aaatctttat ttccggtatt atagggagga
     5581 tcaatataaa taatgtctat cttccctaga tgtgtttttt ctaaaagatg taggctatgc
     5641 agattatcac cttctaaaag aaaattgaat ttatttgaat ccttatcgta atgcattttt
     5701 ttacttttat tttctacaaa gactgggata ttaaatttca tatctgcttc aaattgttca
     5761 gcatgctgtt cccaaactaa cccatatttt ttttgagata gtaatttttg aatatcttcg
     5821 agttccttaa tatcttcagc tctgttttct ttactattta ttgcctcctc taataactta
     5881 gaaacatata ctaatgcacg ggtcttctca ttttcatgtg gacgttctat aaatgtcatt
     5941 ttcttctgca ctcctttttt tatttccata atttccacca ttttttattt tttgtatgaa
     6001 gttcttcttt tgtattatct atgtctttag atttttgtac cataggatct ttattatctt
     6061 ttcgtactgg taccatcaaa gattttaatt ccttgatttc ttctttatat tcttcaagta
     6121 attttttatc ttgtaaggct aaacgttgtt gctggtctaa tagcttatga agctcttttt
     6181 tttctgattg gagttcggac actagattcc ttaaaaataa aatctcttca ttcccctcta
     6241 gattaccatc aactgaatca ttcacgttgt cgtcaacaaa aagtttttgt tgacgttttt
     6301 tagttgacgt tttgttaaaa aaagcattct taataacttt ttgaccatca acgtcaacgt
     6361 aaacggtatt tccttttttt gacgtaaatt gacgtaaatc tattgacgat tcttttttta
     6421 ttttttgcca tacagcttgc tttgaaacac ctatttcatc cgcaagttct tttatggttt
     6481 ttaattcttc actcatggtt taagtcctgt cttttaaccg ttggtagata ttgttcaatg
     6541 gcttttttaa ggtacttaca aatatttttc tttgagtagt cctcacgttt gctggcaacg
     6601 taagacaagt ggtctttcac gccttttaat cctcttaatt ctttcagttc gtcataaagc
     6661 ggataaacgt ttttctgtaa gcctgccata agtgccgtat cggtcatttc atagggactt
     6721 aacaacatgt tttctaataa aatttgagtg tatttacttt tcatggcttg ataaacaagt
     6781 ttttcttcgg tttcttcttt gatttttttg tcggtttgat aagcttggtc ttccattttg
     6841 tagctgttat cgtccgcttg gcgtttcttc tcgatatgaa aaacgataga atcaatcgag
     6901 cgcccctttt tgactttgtc atacgtcacg gtaaaagaag tatgatcatt gatttcttcc
     6961 aacggttttt ttaatatcca tgtttctaaa ctctgaaacc gttcataatc atttacggta
     7021 tcagtcatga tacgcaattc tttaattgaa atagacggat ttcggtagct ttctacttgt
     7081 tctgctcgcc gtccgccttt agtgctgtaa tgctcgtatt ggttgtaatt catggataac
     7141 caacgataca agataatgct gtacttgcta ttgagttcgg ctatatctga caaagcgtgt
     7201 tgtgtaaaat tctttttaag attgattaag taaggcagaa tttcacgatg aaattcaatt
     7261 tttacttcat catgataatc tgtccattcc acgtaaggta taggaacaat gcttttaaat
     7321 ttaaacccct tgcctgcttc ttctttgatt tgaaaaaagg cttgtttttg cattttctca
     7381 atcgcttctt taaagcgact atgcttgtca ttatcggata ctttaaagaa agcgaaaagg
     7441 tctctctttg agagataaat aatattgtct tttggtggct cttcggtatt gatacaagac
     7501 accgctaatt caaacatttt cagtggggtt ttatccattt tagcaataga cgtaatcaag
     7561 ctgttatgct ctaccacttt tctttttgac agttcattca aggtcagcac ctgcttttga
     7621 ttttcttgtt tttctggtat actagacata gaaagttact cctttgtgag tgattttaag
     7681 gtggcataga gaaagtcatt tcgcgctgaa ttttctctat gcttttatta taacacaata
     7741 tagcaagatt atataatttt ttcttgctat atacacagtt ttttcttgct atatacacag
     7801 ttttttcttg ctatatacac agttttttct tgctataaaa agtcagcata gacttactat
     7861 tgctgacttt tttttcacgc aaaagaacaa aagattaaaa tatatatgat aaattaatat
     7921 aggcttcgcc tttttttgtt tttttcaaaa atttaaaacc aaaggtcaaa gtcaaaaggt
     7981 taaaaccata aaatctcaaa agctcttaat ttgctttcta agcaaattta cttgtcattg
     8041 agtacaaaac atcaaacaaa cacctatctt tctaaatagc ctaactgaaa ggcttcgttg
     8101 gtctgcttga cgacagaagc agttcgcttg aaaagcgaaa attcttttct aaagggctaa
     8161 agcattctac gatagagcta gaagctcata ttttagctta taagcgattt taaattattt
     8221 ctagtgtaat tcttccacta acaggtaatc gttgcttata aggctttata ttgtcttatt
     8281 tataaacgtg gggaatgttg acttttattt ttggtgtgtt cttgctggtt ctgttgcaaa
     8341 gttttaaatc tactatcaaa taaggtagaa taatagaaaa agatagcagg aggaatgacg
     8401 atgaatcatt ttaaaggaaa gcaatttcag caggatgtga ttattgtagc cgtgggctac
     8461 tatcttcgtt ataaccttag ctatcgtgaa gttcaagaaa tcttatatga tcgtggcatt
     8521 aacgtttctc atacgacgat ttatcgttgg gtgcaagaat atggcaaact actctatcaa
     8581 atttggaaaa agaaaaataa aaaatccttt tattcatgga aaatggatga aacgtacatc
     8641 aaaattaaag gaaaatggca ttatttgtat cgagccatcg atgcagatgg tttaaccttg
     8701 gatatttggt tacgtaaaaa acgggacaca caagcagcct atgcttttct taagcggtta
     8761 gtgaagcagt ttgatgaacc gaaggttgta gtcacagata aagccccctc tattacaagt
     8821 gcctttaaga aactaaaaga atacggcttt tatcaaggga cagaacatcg taccattaaa
     8881 tacctgaata atttgattga acaagaccat cgtccagtaa agagacgcaa taaattctat
     8941 cgaagtttac gcactgcctc taccacgatt aaaggcatgg aagccattcg aggattatat
     9001 aagaaaaccc gaaaagaagg cactctcttc gggttttcgg tctgtactga aatcaaggta
     9061 ttattgggaa tcccagctta aatcatagat actgtaaggg attttattct ttatttaaaa
     9121 ctttgcaaca gaaccctttt aagttaccct tagtagtact catatttaaa acaactcaca
     9181 actttgagag cttctaatta tttaaattag gcgatgctat caaataattt gatatttatt
     9241 atattatcct aaaaaatatc aaaagtaaaa taaaagcgtt atctatacca ctagaaacct
     9301 agtaaagtag gtattaaatt taggtgttaa agttcctatt ttaattgctt attgatgtct
     9361 accctataaa agtaaatagt agaatcgtat taaaaataaa agaaccgata agagataaaa
     9421 agtttaattt ggggtcacga gtgcgaacga gcattttgta tcaataaagg aataattttt
     9481 gaaaaaacga agttttttag tacaataagt ccaaatttgg ttattttctt tttcatttta
     9541 tctcctctcc tctttaaaaa tagactgtaa gtattaatcg attttaacac ttatagttag
     9601 ttaataaaaa aactaaaagt gaatcgttag cataattact attactaaat tttcgcggtc
     9661 tatcaaaaaa ggcgacggct atgctatact agagctattc aaatataaaa aaagattgag
     9721 gagaaccagt ggtaaataaa aaagaacttg ctaaagctat ttcagaaaag tcagggaaca
     9781 tcatgaaaaa acaccctctc acgatttatg aatcaaaaaa agtagtagat gcaatcactg
     9841 cctctatcac agaactttta gtacaagatg gtaaaatcca aatgattgat tttgggacat
     9901 ttgaaaagaa aactcgagca agtcgaggag gcttcaatcc acaagttggg gaacgtatcc
     9961 aaattccaga aaaaacggtc cctactttta aagcggggaa aggtttgaaa gaagctgtta
    10021 aactcaaaaa gaaaaaatga aatccaaaaa gaagtatttt tttaattgac aattcataga
    10081 aagattgtta tacttatctc acagttcagg gtacggtctt cgacatatcc gaaacacaaa
    10141 taaaaagagg tagtcccttc catgaggcta ccttttttcg tgggaataat gtataattaa
    10201 ttcgtgtact ataaagtcat tagaaacttt ttgggcagat aaaaaaggag ttttgtttgg
    10261 ttttactatt tattcataga aagggcatcc ttgtgatgcc ttttttgtat ttactgtttt
    10321 ttttgagtag gttcttcgcc ctgttgaatc tggatagggt tttgtcagcg tcaatctttt
    10381 tctgtctacc acgcctggtc ctttatctac aagataaata atatagcagt ttttgaagat
    10441 tgttgactca tcacctacaa caagtgttgc ttcttgtcca tcagatagtt taatgatttc
    10501 accttttctc atagattacc tcgcttatat tgattttttg gtatatttag tcctttatta
    10561 taattgccta ttcatgattt aagaccataa gagcttattt tattttttaa accaaccttt
    10621 taataaatcg ccaaatccag cgctatgcct gtctgtttct tctttttgtt tgcgtaattc
    10681 aggattttga tattcggttt gagccacggc atttggcatg ggttcaggtt catcagattt
    10741 ccaaaattga gcgatttgtt cttctttttt acggtcaatc tcgtattgat tggtcttttc
    10801 cttatcgaaa gtaaaggtat atccaataat tggtcgacct cgacctgtac ctctttcttg
    10861 cttaattttg aagttagaga aagcatttgt gagatcagat acggttgttt ttgaaaaaac
    10921 ttttctatcc atttcagcat tagtatagct tttaggaact gataaaagat gtcttaagtc
    10981 ttcagttttt acacgataaa aaccagtggt tcgaaattgt ttgattaatc gatagagctc
    11041 ttgtccatag ctagtatgca ttttattata atcttctaat tcaaaagcgg taaacatatc
    11101 gaaaagattt gtaagatact taaattcagg gtttatagaa actttaaggg tgtttgtttt
    11161 ttttccgtct atgataaaag tcggaaataa actaaattta acaatttgta gtccatcatc
    11221 acttctcaaa gttcctctta aagtcataat tttatctgat agaatttcta aatatttaac
    11281 aaattccgca ttagaattag ctcctttatg atttgtttca tcccaaccag ttaaaccacg
    11341 caatgtatgg aaatctaatt gaacaatttg agtatctttt cctttgactt catggagtag
    11401 agccatcaca attcgttttt cacgttcatt aaatccacga agtggaacag tattaaaatc
    11461 attatgatat tgtacaattt cgtgagccat atatcctcct atttatgccc tgaggcataa
    11521 ataaagtata gcaaatcatt taaaataaaa ctaccccatt taaggcatgt aaaattaccc
    11581 catttaaggc atgtaaacag aaaagaccgt attaaagggc tttaaagcac accccattta
    11641 gggcatataa agaaatatca caccccattt agggcatata aagaaatatc acaccccatt
    11701 tagggcatat aaaaattttc gccccattta ggtacatgta gtgccccatt taggtacatg
    11761 tagtgcccca tttaggtaca tgtagtgccc catttaggta catgtaaagg tagttatacg
    11821 tcagtcatac caacgtttac caagccccta aaagatgttt aaaagaatta taaaagaatt
    11881 ataaaagagc ccccagaaaa aaatcgattt ttaaaagaga tgtttctttt tccaaaaaag
    11941 agaaaaaaag ccgacttctt tcgacttaaa aaagtgcctt actaaaaatt aatacgttca
    12001 gctaaaagaa ctggcgcagg caaagccttt gcggatacat tgtcttgtga tacaataagt
    12061 tttggcgcta acgcctatcc taagggaaag gaggtagctt tatgactata ttattctctt
    12121 ttgtttctgc tctggcatta aattgcttga ctgaactttt caagtattgg ctaggtactc
    12181 gaaagcaaag caagaaacac aaaaagcgcc actagtcgct taaggtcaga tgttggagca
    12241 tctggctttt tgatacaaaa aaagcagaca ttggagtgtc tgctttttgg tagcctatgg
    12301 ctatatttct ctttaactag aatttatcac aagttatatt ttttgtcaac ctaatcaatt
    12361 ccatatcttt ttctaaactt gatttctaat tcttcctgaa gtttagcgtc atgcattttg
    12421 agctgaaaac cagtgattcc accgtctaat agttttttat ttttggcaaa aaggctctta
    12481 cacatttctt gtgttctttt agattcatct ctcgcttgaa taacaatgtc taaaactttt
    12541 ctcaaatcgt catattttag gtttttaacg cctccagtta atgatttaga ggcattattg
    12601 ataatatcaa aagcagggct tgtcatttga tgaaaatcag ttttaagctc tacaactatg
    12661 tcaggctctg cggtaaattt ctttttgagt tcctcataaa gttggtcctt ttggttgagt
    12721 ttttgctctt ttactttcaa ggtttcttgc atttcttcta gctctactaa gctcatctgt
    12781 ttgtttttta gtgcgtttat gattgagctc tgatcgctca ttattgattt ggcttcttcc
    12841 agctttaatt tgagatttgt attctccaaa gtcaaagtct ccaaggcttg gttttcttgt
    12901 tgttgtaagt ttccgttcgt ttcgtctgtc cagctcatta aaaatcgtct cctttttgta
    12961 gtcgtctccg agtttcgccc cacgagcttt ataatttgtt cctgtgagcc catatgtgag
    13021 gtctctgcca cgttcaatta cgtttatggc gaattccccc agtttttctt taaaactctt
    13081 aaaatcgcta atatggcttt ctcgcatggt tgtatcaatt gcttgtctaa ttttatcttt
    13141 ccaaggcact tgtcctcgct ctttcatttt gatttccgcc atagaccgct tttcaggctt
    13201 atgcttagga atcgtaacct ctaaaccgtg tctttctacg actttatcgg ttattttgac
    13261 gagcctttca cggtattgtt gccaatttcc gtgcattttc ttgccagtct gtaggtcaat
    13321 cgctccaatg acagcgtgaa cgtggagcga atcggtgtca ttatggacgt ataaagcgac
    13381 ttgttggttg ggataagcgg tagaatagat ttctttagca atttcaagtg ccttgatttg
    13441 gtcttgcgtg ttttgagggg caaattcttt tggagagaaa gccactcttg aagcgtaggc
    13501 ttgtgttgac cctttatttc catagatttc tctgacttgt ttcaattctg atttggcgta
    13561 atcaatgtca atattgtgtc cgtctttttg aacggctctc ttttcagcgt aattaacaag
    13621 cctagaagcg ccagaggagc gttttatgtg agttgtcgcc atatttcccc cagaccgttc
    13681 aaagcacggc ttaaatcgcc tgctatgagc tcctgtgtct ttttatccgc aaattcgatt
    13741 tgattgaccc ttttagcgag ttggttcacg ttattaccaa gtgctgccaa ctgccgagcc
    13801 atctcttttg aatcgtctgg attaatttta ggtgccacca cacgggcgcc ttgtgccttc
    13861 tttttgacaa aagcaggcac cgaaatattt aaaactttcg ctgaccgctc aagatttaaa
    13921 tattccgatt cgctcactct gaaacttatt tgtttgggtt gctttcgatt tggttgtttc
    13981 tttttgttgc tagccatctc taagtgttcg ctcatgaaac cccgcctttc tggggacgtt
    14041 c
//
