LOCUS NC_008119 10778 bp DNA circular BCT 28-JUL-2008 DEFINITION Yersinia pestis Nepal516 plasmid pPCP, complete sequence. ACCESSION NC_008119 VERSION NC_008119.1 GI:108793837 DBLINK Project:16646 KEYWORDS . SOURCE Yersinia pestis Nepal516 ORGANISM Yersinia pestis Nepal516 Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Yersinia. REFERENCE 1 (bases 1 to 10778) AUTHORS Chain,P.S., Hu,P., Malfatti,S.A., Radnedge,L., Larimer,F., Vergez,L.M., Worsham,P., Chu,M.C. and Andersen,G.L. TITLE Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen JOURNAL J. Bacteriol. 188 (12), 4453-4463 (2006) PUBMED 16740952 REFERENCE 2 (bases 1 to 10778) AUTHORS Barry,K., Lucas,S., Lapidus,A., Copeland,A., Detter,J.C., Glavina del Rio,T., Hammon,N., Dalin,E., Tice,H., Pitluck,S., Chain,P., Hu,P., Malfatti,S.A., Radnedge,L., Vergez,L.M., Larimer,F., Land,M., Hauser,L., Worsham,P., Chu,M.C., Andersen,G. and Richardson,P. CONSRTM US DOE Joint Genome Institute TITLE Complete sequence of Plasmid pPCP of Yersinia pestis Nepal516 JOURNAL Unpublished REFERENCE 3 (bases 1 to 10778) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (12-JUN-2006) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 4 (bases 1 to 10778) AUTHORS Barry,K., Lucas,S., Lapidus,A., Copeland,A., Detter,J.C., Glavina del Rio,T., Hammon,N., Dalin,E., Tice,H., Pitluck,S., Chain,P., Hu,P., Malfatti,S.A., Radnedge,L., Vergez,L.M., Larimer,F., Land,M., Hauser,L., Worsham,P., Chu,M.C., Andersen,G. and Richardson,P. CONSRTM US DOE Joint Genome Institute TITLE Direct Submission JOURNAL Submitted (06-APR-2006) US DOE Joint Genome Institute, 2800 Mitchell Drive B100, Walnut Creek, CA 94598-1698, USA COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CP000307. URL -- http://www.jgi.doe.gov JGI Project ID: 2773192 Source DNA and bacteria available from Gary Andersen (glandersen@lbl.gov) Contacts: Gary Andersen (glandersen@lbl.gov) Paul Richardson (microbes@cuba.jgi-psf.org) Annotation done by JGI-ORNL Finishing done by JGI-LLNL Finished microbial genomes have been curated to close all gaps with greater than 98% coverage of at least two independent clones. Each base pair has a minimum q (quality) value of 30 and the total error rate is less than one per 50000. The JGI and collaborators endorse the principles for the distribution and use of large scale sequencing data adopted by the larger genome sequencing community and urge users of this data to follow them. It is our intention to publish the work of this project in a timely fashion and we welcome collaborative interaction on the project and analysis. (http://www.genome.gov/page.cfm?pageID=10506376). COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..10778 /organism="Yersinia pestis Nepal516" /mol_type="genomic DNA" /strain="Nepal516" /db_xref="taxon:377628" /plasmid="pPCP" gene 81..1103 /locus_tag="YPN_PCP0001" /db_xref="GeneID:4122532" CDS 81..1103 /locus_tag="YPN_PCP0001" /codon_start=1 /transl_table=11 /product="transposase" /protein_id="YP_636674.1" /db_xref="GI:108793838" /db_xref="InterPro:IPR007101" /db_xref="GeneID:4122532" /translation="MVTFETVMEIKILHKQGMSSRAIARELGISRNTVKRYLQAKSEP PKYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIR SLSVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVLGYSRMLYIEFTDNMR YDTLETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFS PRLCRPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGITVDVETANRHGLRWLHDVA NQRKHETIQARPCDRWLEEQQSMLALPPEKKEYDVHLDENLVNFDKHPLHHPLSIYDS FCRGVA" gene 1103..1882 /locus_tag="YPN_PCP0002" /db_xref="GeneID:4122533" CDS 1103..1882 /locus_tag="YPN_PCP0002" /codon_start=1 /transl_table=11 /product="transposase/IS protein" /protein_id="YP_636675.1" /db_xref="GI:108793839" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="GeneID:4122533" /translation="MMELQHQRLMALAGQLQLESLISAAPALSQQAVDQEWSYMDFLE HLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIERN ENIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQR GVMAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDA ALTSAMLDRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE" gene 2919..3113 /locus_tag="YPN_PCP0008" /db_xref="GeneID:4122539" CDS 2919..3113 /locus_tag="YPN_PCP0008" /codon_start=1 /transl_table=11 /product="replication regulatory protein" /protein_id="YP_636676.1" /db_xref="GI:108793845" /db_xref="InterPro:IPR000769" /db_xref="GeneID:4122539" /translation="MNKQQQTALNMARFIRSQSLILLEKLDALDADEQAAMCERLHEL AEELQNSIQARFEAESETGT" gene 4086..4280 /locus_tag="YPN_PCP0009" /db_xref="GeneID:4122540" CDS 4086..4280 /locus_tag="YPN_PCP0009" /codon_start=1 /transl_table=11 /product="replication regulatory protein" /protein_id="YP_636677.1" /db_xref="GI:108793846" /db_xref="InterPro:IPR000769" /db_xref="GeneID:4122540" /translation="MNKQQQTALNMARFIRSQSLILLEKLDALDADEQAAMCERLHEL AEELQNSIQARFEAESETGT" gene complement(5976..7049) /locus_tag="YPN_PCP0003" /db_xref="GeneID:4122534" CDS complement(5976..7049) /locus_tag="YPN_PCP0003" /codon_start=1 /transl_table=11 /product="pesticin" /protein_id="YP_636678.1" /db_xref="GI:108793840" /db_xref="GeneID:4122534" /translation="MSDTMVVNGSGGVPAFLFSGSTLSSYRPNFEANSITIALPHYVD LPGRSNFKLMYIMGFPIDTEMEKDSEYSNKIRQESKISKTEGTVSYEQKITVETGQEK DGVKVYRVMVLEGTIAESIEHLDKKENEDILNNNRNRIVLADNTVINFDNISQLKEFL RRSVNIVDHDIFSSNGFEGFNPTSHFPSNPSSDYFNSTGVTFGSGVDLGQRSKQDLLN DGVPQYIADRLDGYYMLRGKEAYDKVRTAPLTLSDNEAHLLSNIYIDKFSHKIEGLFN DANIGLRFSDLPLRTRTALVSIGYQKGFKLSRTAPTVWNKVIAKDWNGLVNAFNNIVD GMSDRRKREGALVQKDIDSGLLK" gene 7279..7584 /locus_tag="YPN_PCP0004" /db_xref="GeneID:4122535" CDS 7279..7584 /locus_tag="YPN_PCP0004" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_636679.1" /db_xref="GI:108793841" /db_xref="GeneID:4122535" /translation="MSKTKSGRHRLSKTDKRLLAALVVAGYEERTARDLIQKHVYTLT QADLRHLVSEISNGVGQSQAYDAIYQARRIRLARKYLSGKKPEGVEPREGQEREDLP" gene 7827..8765 /locus_tag="YPN_PCP0005" /db_xref="GeneID:4122536" CDS 7827..8765 /locus_tag="YPN_PCP0005" /EC_number="3.4.23.48" /note="outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA" /codon_start=1 /transl_table=11 /product="outer membrane protease" /protein_id="YP_636680.1" /db_xref="GI:108793842" /db_xref="InterPro:IPR000036" /db_xref="InterPro:IPR010916" /db_xref="GeneID:4122536" /translation="MKKSSIVATIITILSGSANAASSQLIPNISPDSFTVAASTGMLS GKSHEMLYDAETGRKISQLDWKIKNVAILKGDISWDPYSFLTLNARGWTSLASGSGNM DDYDWMNENQSEWTDHSSHPATNVNHANEYDLNVKGWLLQDENYKAGITAGYQETRFS WTATGGSYSYNNGAYTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFELNALFKFSD WVRAHDNDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGKGG TQTIDKNSGDSVSIGGDAAGISNKNYTVTAGLQYRF" sig_peptide 7827..7889 /locus_tag="YPN_PCP0005" /product="outer membrane protease" /note="Signal predicted by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.997 at residue 21" gene complement(8952..9251) /locus_tag="YPN_PCP0006" /db_xref="GeneID:4122537" CDS complement(8952..9251) /locus_tag="YPN_PCP0006" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="YP_636681.1" /db_xref="GI:108793843" /db_xref="InterPro:IPR001387" /db_xref="GeneID:4122537" /translation="MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQK QVAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMGGKLSLDVELPTGRRVAFHV" gene complement(9251..9598) /locus_tag="YPN_PCP0007" /db_xref="GeneID:4122538" CDS complement(9251..9598) /locus_tag="YPN_PCP0007" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_636682.1" /db_xref="GI:108793844" /db_xref="GeneID:4122538" /translation="MWMVLFSQRFDDWLNEQEDALQEKVLADLKKLQVYGPELPRPYA DTVKGSRYKNMKELRVQFSGRPIRAFYAFDPIRRAIVLCAGDKSNDKRFYEKLVRIAE DEFTAHLNTLESK" ORIGIN 1 gaacggtgca atagtgatcc acacccaacg cctgaaatca gatccagggg gtaatctgct 61 ctcctgattc aggagagttt atggtcactt ttgagacagt tatggaaatt aaaatcctgc 121 acaagcaggg aatgagtagc cgggcgattg ccagagaact ggggatctcc cgcaataccg 181 ttaaacgtta tttgcaggca aaatctgagc cgccaaaata tacgccgcga cctgctgttg 241 cttcactcct ggatgaatac cgggattata ttcgtcaacg catcgccgat gctcatcctt 301 acaaaatccc ggcaacggta atcgctcgcg agatcagaga ccagggatat cgtggcggaa 361 tgaccattct cagggcattc attcgttctc tctcggttcc tcaggagcag gagcctgccg 421 ttcggttcga aactgaaccc ggacgacaga tgcaggttga ctggggcact atgcgtaatg 481 gtcgctcacc gcttcacgtg ttcgttgctg ttctcggata cagccgaatg ctgtacatcg 541 aattcactga caatatgcgt tatgacacgc tggagacctg ccatcgtaat gcgttccgct 601 tctttggtgg tgtgccgcgc gaagtgttgt atgacaatat gaaaactgtg gttctgcaac 661 gtgacgcata tcagaccggt cagcaccggt tccatccttc gctgtggcag ttcggcaagg 721 agatgggctt ctctccccga ctgtgtcgcc ccttcagggc acagactaaa ggtaaggtgg 781 aacggatggt gcagtacacc cgtaacagtt tttacatccc actaatgact cgcctgcgcc 841 cgatggggat cactgtcgat gttgaaacag ccaaccgcca cggtctgcgc tggctgcacg 901 atgtcgctaa ccaacgaaag catgaaacaa tccaggcccg tccctgcgat cgctggctcg 961 aagagcagca gtccatgctg gcactgcctc cggagaaaaa agagtatgac gtgcatcttg 1021 atgaaaatct ggtgaacttc gacaaacacc ccctgcatca tccactctcc atctacgact 1081 cattctgcag aggagtggcg tgatgatgga actgcaacat caacgactga tggcgctcgc 1141 cgggcagttg caactggaaa gccttataag cgcagcgcct gcgctgtcac aacaggcagt 1201 agaccaggaa tggagttata tggacttcct ggagcatctg cttcatgaag aaaaactggc 1261 acgtcatcaa cgtaaacagg cgatgtatac ccgaatggca gccttcccgg cggtgaaaac 1321 gttcgaagag tatgacttca cattcgccac cggagcaccg cagaagcaac tccagtcgtt 1381 acgctcactc agcttcatag aacgtaatga aaatatcgta ttactggggc catcaggtgt 1441 ggggaaaacc catctggcaa tagcgatggg ctatgaagca gtccgtgcag gtatcaaagt 1501 tcgcttcaca acagcagcag atctgttact tcagttatct acggcacaac gtcagggccg 1561 ttataaaacg acgcttcagc gtggagtaat ggccccccgc ctgctcatca ttgatgaaat 1621 aggctatctg ccgttcagtc aggaagaagc aaagctgttc ttccaggtca tcgctaaacg 1681 ttacgaaaag agcgcaatga tcctgacatc caatctgccg ttcgggcagt gggatcaaac 1741 gttcgccggt gatgcagcac tgacctcagc gatgctggac cgtatcttac accactcaca 1801 tgtcgttcaa atcaaaggag aaagctatcg actcagacag aaacgaaagg ccggggttat 1861 agcagaagct aatcctgagt aaaacggtgg atcaatattg ggccgttggt ggagatataa 1921 gtggatcact tttcatccgt cgttgacacc ctgatgaatt cacgtgttca cgcctgaata 1981 acaagaatgc cggagatacg cagtcatatt ttttacacaa ttctctaatc ccgacaaggt 2041 cgtaggtcgt tataggaaaa ttcttagcac cattccggaa caatcagaac agcaggccat 2101 gaacgactga caacattacg aatataaaaa acgcacccgg gccagacatt ccccctactg 2161 attaaaccag ccggacttgt ccacggaacg gtctttttaa accgacacac agtctgagta 2221 cagatacatg tcacgatgat gcaggattag cggaagagtg tgagcacgtt tccgggaact 2281 gtggtgaacc atagctcaat attcgagtga gggcataccg gaaacgcgct cagattcgtt 2341 gtaacgcgat tttccgtacc gggcaatttt ttcagttgtt ttttcgtttc atgtcgtcag 2401 aaacgttctg agcgcgtttc cggcatctga tgctacgcaa accatcccca tggtcagttg 2461 acagccggaa acacgcgggt gtcgttttag cgtatcgacg ggacggcgtc gagaagcaca 2521 aaaaacagat gttgtactca gtcagttgtt ttacagacag cactgcggca gattgaaaaa 2581 gtaccgtact ttcaggaatg tccagaaacc atgtgtcaga cttcgttctc ccccttccgg 2641 gtgaattttt ttgtcatccg ttcaggaatc tctttataac gattactcca tttcaggatt 2701 ttttatgtgg cgtttactac aggcaggata ttcaaaggca aaaaaatccc ccggaacagg 2761 cggaacccgg acagggggag aacgaatcgc taaataattt tcgtagttgt atttcccatc 2821 gttgctactg caacgggatg aatttgccgc agtttatcct gtaaaacaat cctgatttac 2881 tcacactcca catatcactg acggagcaca acggaatagt gaacaaacaa caacaaactg 2941 cgctgaatat ggcgcgattt atcagaagcc agagcctgat actgcttgaa aaactggatg 3001 ctctggatgc cgacgagcag gcggccatgt gtgaacgact gcacgaactc gcggaagaac 3061 tccagaacag catccaggct cgctttgaag ccgaaagtga aacaggaaca taacgacctg 3121 atgaattcac gtgttcacgc ctgaataaca agaatgccgg agatacgcag tcatattttt 3181 tacacaattc tctaatcccg acaaggtcgt aggtcgttat aggaaaattc ttagcaccat 3241 tccggaacaa tcagaacagc aggccatgaa cgactgacaa cattacgaat ataaaaaacg 3301 cacccgggcc agacattccc cctactgatt aaaccagccg gacttgtcca cggaacggtc 3361 tttttaaacc gacacacagt ctgagtacag atacatgtca cgatgatgca ggattagcgg 3421 aagagtgtga gcacgtttcc gggaactgtg gtgaaccata gctcaatatt cgagtgaggg 3481 cataccggaa acgcgctcag attcgttgta acgcgatttt ccgtaccggg caattttttc 3541 agttgttttt tcgtttcatg tcgtcagaaa cgttctgagc gcgtttccgg catctgatgc 3601 tacgcaaacc atccccatgg tcagttgaca gccggaaaca cgcgggtgtc gttttagcgt 3661 atcgacggga cggcgtcgag aagcacaaaa aacagatgtt gtactcagtc agttgtttta 3721 cagacagcac tgcggcagat tgaaaaagta ccgtactttc aggaatgtcc agaaaccatg 3781 tgtcagactt cgttctcccc cttccgggtg aatttttttg tcatccgttc aggaatctct 3841 ttataacgat tactccattt caggattttt tatgtggcgt ttactacagg caggatattc 3901 aaaggcaaaa aaatcccccg gaacaggcgg aacccggaca gggggagaac gaatcgctaa 3961 ataattttcg tagttgtatt tcccatcgtt gctactgcaa cgggatgaat ttgccgcagt 4021 ttatcctgta aaacaatcct gatttactca cactccacat atcactgacg gagcacaacg 4081 gaatagtgaa caaacaacaa caaactgcgc tgaatatggc gcgatttatc agaagccaga 4141 gcctgatact gcttgaaaaa ctggatgctc tggatgccga cgagcaggcg gccatgtgtg 4201 aacgactgca cgaactcgcg gaagaactcc agaacagcat ccaggctcgc tttgaagccg 4261 aaagtgaaac aggaacataa cgaagctccc ggagacggtc acagcttgtc tgtgaacgga 4321 tgccgggagc agacaagccc gtcagggcgc gtcagcgggt tttagcgggt gtcggggcgc 4381 agccatgacc cagtcacgta gcgatagcgg agtgtatact ggcttagtca tgcggcatca 4441 gtgcggattg tatgaaaagt gcaccatgta cggtgtgaaa tgccgcacag atgcgtaagg 4501 agaacatgca gatgccgatg ctcttccgct tcctcgctca ctgactcgct gcgctcggtc 4561 gttcggctgc ggcgagcggt gtctgctcac tcaaaagcgg tgatactgtt atccacacaa 4621 tcaggggata acgccggaaa gaacatgtga gcaaaaaacg aagaccccag aaaaggccgc 4681 gccggaggcg ctttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct 4741 caagtcagag gtggcgaaac ccgacaggac ttaaagatac caggcgtttc cccccggaag 4801 ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctct ccgcctttct 4861 cccttcggga agcgtggcgc tttctcatag ctcacgctgt tggtatctca gttcggtgta 4921 ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accactgcgc 4981 cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttta cgccactggc 5041 agcagccatt ggtaactgaa aagtggattt agatacgcag aactcttgaa gttgaagcct 5101 tatcgcggct acactgaaag gacagcattt ggtatctgtg ctccacttaa gccagctacc 5161 acaggttaga aagcctgaga aacttctaac cttcgaaaga acccacgcct gagaacgtgg 5221 gttttttcgt ttacaggcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt 5281 tgatcttttc tactgaattg cgctcccgat cagttcagca gaagattatg atggggttct 5341 atgggtattg ctgcggtaac acccatgtta cttgaggttg tatgtagtct gtgtagaatt 5401 atacacataa ggcttaaact gctctttttt ttcaatatgc aattggaagt tcattgacta 5461 cataaataga ttattccaaa taatttattt atgtaagaac aggatgggag ggggaatgat 5521 ctcaaagtta ttttgcttgg ctctcatatt tttatcatca agtggccttg cagaaaaaaa 5581 cacatataca gcaaaagaca tcttgcaaaa cctagaatta aatacctttg gcaattcatt 5641 gtctcatggc atctatggga aacagacaac cttcaagcaa accgagttta caaatattaa 5701 aagcaacacc aaaaaacaca ttgcacttat caataaagac aactcatgga tgatatcatt 5761 aaaaatacta ggaattaaga gagatgagta tactgtctgt tttgaagatt tctctctaat 5821 aagaccgcca acatatgtag ccatacatcc tctacttata aaaaaagtaa aatctggaaa 5881 ctttatagta gtgaaagaaa taaagaaatc tatccctggt tgcactgtat attatcatta 5941 atagcaagcc cctcattatt atgaggggct catggttatt ttaacaatcc actatcgata 6001 tctttttgca ccagagcgcc ctctcgttta cgtctgtcag acattccatc aacaatatta 6061 ttaaaagcat ttacaaggcc attccagtct tttgcgataa ctttattcca tactgtggga 6121 gcagttctgg ataacttaaa ccctttttga tatccaatag acaccagtgc tgtacgggtt 6181 ctcaacggta aatcgctgaa ccgaagaccg atattagcgt cattgaaaag accttcaatc 6241 ttatgtgaga atttatcaat ataaatatta gataagagat gagcttcatt atcagaaagc 6301 gtcagaggtg ctgttctcac tttatcataa gcctccttcc ctcgaagcat ataataccca 6361 tcaagtctat ctgcaatata ctgagggaca ccgtcattca ataaatcctg tttgcttcgc 6421 tgaccaaggt caaccccgga accgaatgta acaccggtac tgttaaaata atcgctacta 6481 ggattagacg gaaaatgact tgtcggatta aacccttcaa aaccattact ggagaaaata 6541 tcgtggtcaa caatatttac cgaacgacgt aaaaattcct tcagttgact aatattgtca 6601 aagttaatga cagtgttgtc cgctaggacg atgcgatttc ggttattatt cagaatgtct 6661 tcgttctctt tcttatcgag atgttcaata gattcggcaa tcgttccctc aagaaccatg 6721 acacggtaga ctttcacacc gtctttttcc tgacctgttt caacagttat tttctgttcg 6781 taagacacgg tcccttcagt ttttgaaatt ttactttcct ggcggatctt atttgaatat 6841 tcactgtctt tctccatctc cgtatcaatc ggaaacccca taatgtacat cagtttaaaa 6901 ttactccggc caggcagatc cacataatgt ggtaatgcaa ttgtaatcga attagcttca 6961 aaatttggtc tgtaactgct taatgtactt ccggaaaaga gaaaagccgg aacaccacct 7021 gaaccattca ctaccattgt atctgacata aaaattcctc tttaacacat aaaaaaaaca 7081 ataagttaaa aaaaaatact gtacataaaa ccactgtttt tatgtacagt aataaaatta 7141 cgccgcttta ttttctctgt caataatatg aaatttcatt tttgtgatct gaatcactct 7201 tataaaaatc aggaagggaa gattcgcagc agaaaaacag caccgggtaa catcagaaaa 7261 aaacagaaag gagataacgt gagcaaaaca aaatctggtc gccaccgact gagcaaaaca 7321 gacaaacgcc tgctggctgc acttgtcgtt gccggatacg aagaacggac agcccgtgac 7381 ctcatccaga aacacgttta cacactgaca caggccgacc tgcgccatct ggtcagtgaa 7441 atcagtaacg gtgtgggaca gtcacaggcc tacgatgcga tttaccaggc gagacgcatt 7501 cgtctcgccc gtaaatacct gagcggaaaa aaaccggaag gggtggaacc ccgggaaggg 7561 caggaacggg aagatttacc ataactcccg ttatcagtac catcggctca acgctcgttg 7621 tcggatctga aaaattcgct caaaagatca tatttccctg gatattttcc accgtttctt 7681 atgtgagcaa agtcacataa ttctgtcaga cgacgagaaa acggatatcg attattgttt 7741 aatattttta cattattaaa aatgaaatta gataatcaga tacaaataat atgttttcgt 7801 tcatgcagag agattaaggg tgtctaatga agaaaagttc tattgtggca accattataa 7861 ctattctgtc cgggagtgct aatgcagcat catctcagtt aataccaaat atatcccctg 7921 acagctttac agttgcagcc tccaccggga tgctgagtgg aaagtctcat gaaatgcttt 7981 atgacgcaga aacaggaaga aagatcagcc agttagactg gaagatcaaa aatgtcgcta 8041 tcctgaaagg tgatatatcc tgggatccat actcatttct gaccctgaat gccagggggt 8101 ggacgtctct ggcttccggg tcaggtaata tggatgacta cgactggatg aatgaaaatc 8161 aatctgagtg gacagatcac tcatctcatc ctgctacaaa tgttaatcat gccaatgaat 8221 atgacctcaa tgtgaaaggc tggttactcc aggatgagaa ttataaagca ggtataacag 8281 caggatatca ggaaacacgt ttcagttgga cagctacagg tggttcatat agttataata 8341 atggagctta taccggaaac ttcccgaaag gagtgcgggt aataggttat aaccagcgct 8401 tttctatgcc atatattgga cttgcaggcc agtatcgcat taatgatttt gagttaaatg 8461 cattatttaa attcagcgac tgggttcggg cacatgataa tgatgagcac tatatgagag 8521 atcttacttt ccgtgagaag acatccggct cacgttatta tggtaccgta attaacgctg 8581 gatattatgt cacacctaat gccaaagtct ttgcggaatt tacatacagt aaatatgatg 8641 agggcaaagg aggtactcag accattgata agaatagtgg agattctgtc tctattggcg 8701 gagatgctgc cggtatttcc aataaaaatt atactgtgac ggcgggtctg caatatcgct 8761 tctgaaaaat acagatcata tctctctttt catcctcccc tagcggggag gatgtctgtg 8821 gaaaggaggt tggtgtttga ccaaccttca gatgtgtgaa aaatcacctt tttcaccata 8881 atgacggggc gctcattctg ttgttttgcc ttgacattct ccacgtcttt cagggcatgg 8941 agaaggtcaa attagacatg gaacgctact ctccttcctg taggaagctc aacatccaag 9001 cttaatttgc ctcccattgc ttcaacgtaa cgctttaacg tcgccagctt taaatcattt 9061 ccgcgctgct ccagctttgt tactgctggc tggcttatac ccatcgcctc agcaacttgt 9121 ttttgtgata actggagttc ttcacgcatc atctgcaagc cgacctcaag aatcatctca 9181 tctgccattt ctttaattcg tgtctggctt tcaggtgaac gactggcaat cacctcatct 9241 aatgttctca ttacttgctc tccagtgtgt tcagatgtgc tgtaaattca tcctcagcta 9301 tacgcaccag tttttcataa aaccgcttat cattactttt atctcctgca caaagaacga 9361 tagcccgacg aatcggatcg aacgcataaa aggctcttat cggacggcca gaaaactgaa 9421 cgcgaagctc tttcatattt ttgtaccgag aacctttcac ggtatcggca tatggcctgg 9481 gtaactcagg tccgtaaacc tgtagctttt tcaaatcagc caaaaccttt tcctgaagag 9541 cgtcttcttg ctcatttagc cagtcgtcaa atcgctggct aaaaagtacc atccacatgc 9601 tcaaccctat aacctgtagc ttaccccact aacaatataa cctacgagtt atattttcaa 9661 gaaaagctgg ctatttaaca taacggcaat ttgtacgcac cactgaaatg cgttcagcgc 9721 gatcacggca acagacaggc aaaaatagca acaaacctcc cgaaaaaccg ccgcgatcgc 9781 gcctgataaa ttttaacctt atgcatatct atgcagccag gcgaatcacg aacgaattgc 9841 ctgcctgatg taactgaaac gggtgttttt tcctgatttg gtgggcgtgg aagacggaac 9901 atgaacggga aaacagaatt catgccagat gagcgcgatc tggcaattaa ggcaaaacac 9961 agcaacaaag acacgccaga atcgcgcccg gatatgtttt aacgcgattt tcagactcag 10021 acaaattcag cagaatgcta ctccattcac cgggctgatg gtgaatacat gcgtatccag 10081 gatgagtaca tttctggctc tgccacagct ctgtctgttg gcagctttcg cctgtccgga 10141 aacctgctta aaacgctccc gaaaggcctc tgaaccagaa agcaacaaaa cacaggccat 10201 taagtaaatc gcgttaaaac acgtctgatg gattgctgca aaaaaaagtc cctaatggag 10261 cagggactgt taaacccagt gaatagcgtc taaattaaag taagaatacg accaggtact 10321 cttcagaaaa gagattaatc caccgcacag aataatcaac agtaaaaaca aacaaccctg 10381 attttttatt tttctttttt tcgataaaaa caaaattaaa gaaataatta atcagaacat 10441 tccttaactt cagggcattg cctgtgttcc attttgtgat tagtctgaaa cttccgaagg 10501 tggataacac ccggtatttt tttgctcaca taaagcccct ccttcaggca gaggggcttt 10561 ttctttgcca ccacataaaa aaggccctca caggaggtgt tctgtgaggg cgtatgataa 10621 ggactgaatc gatggttaat atgtctagtc ctgacttttg catctccgaa tataaaaccc 10681 tgtttaacgg catgcaaaac caaaaaataa aaatgtgaca tcgcaatgcc agataatatt 10741 gacgcatgag ggaatgcgta ccccgacccc tgtgtaac //