Click here to switch to the map view.

The map label for this gene is gltT [H]

Identifier: 38234556

GI number: 38234556

Start: 2042051

End: 2043478

Strand: Direct

Name: gltT [H]

Synonym: DIP1992

Alternate gene names: 38234556

Gene position: 2042051-2043478 (Clockwise)

Preceding gene: 38234555

Following gene: 38234570

Centisome position: 82.06

GC content: 55.81

Gene sequence:

>1428_bases
GTGAACAATTACGTCGCGCCGGACGCCTCCCCAAGAACGTTGGCGAGATCTCAAAGCCTGGTCGACCTGCAAAAAAGCAC
CAATAGACCAATCGGTCTTTTAAAAACAGACCACCAAGTACTACTGTGTCTATTTATGAAATGGAATAGCTTCGGAGCTC
AGGTCATCTACGGCCTCATCGCAGGCGTAGTCTTAGGGCTCATCGCCAACAAAATGCCGGAAGGTAATTGGCTCACAGCC
ACACTGACCACCATTGGCAGTCATTACGTCACCCTCCTCAAAGTGTTGATCCCGCCACTGGTGGTCACCGCTGTTATTAC
GTCCATCGCCAACCTGCGGCAAGTCACCAACGCCGCCCGATTAGCAGTAAAAACCCTGATCTGGTTCGCCATCACCGCGT
TCTTCTCTGTACTAGCAGGCATCGCGGTCGGCCTTATCTTCAAACCAGGTCAAACTACTGGCCTGCAAGACACCGCCAAG
GCGCCGTCGTCAGTCGGCTCGTGGTGGGCATTTATCGAAGGCATCGTGCCCTCCAACATTTTAGGTTTACAGTCCACCAC
CAAAATCGTTGATGGCGCCGCCACCACCTCGCTGAGCTTCAACGTGCTGCAAATCCTCGTGATCGCCATCGCACTCGGCA
TCGCTGCAGTCAAGGTGGGCGAAAAGGCCGAACCGTTTATCAACTTCAACCGCTCCTTTTTGGAGATCATCCAGAAGGTG
TTGTGGTGGATCATTAGGCTCGCCCCCATCGGCACCGCAGCCTTGATCGGCAAAGCAGTAGCCACCTATGGTTTCGAAGC
CATGGGCGCACTGGGCAAATTCGTCCTCACGATTTATGTGGGCCTTGCCATCGTGGTTGTTGTGATCTATCCGCTGGTAC
TGAAGTTCCACGGACTGAGCGTGATCCAGTTTTACAAGCGCGTCTGGCCAGTATTCTCCTTGGGTTTTGTCACCCGCTCC
TCAATGGGCGTTATGCCCGTAACCGAGCAGACTAGCGAAGCGATCGGCGTGCCTAAGCACTATGCATCCTTTGCGGTGCC
ACTGGGCGCTACCACCAAGATGGACGGTTGTGCAGCGGTCTACCCTGCTGTGGCGGCCATCTTCGTGTCACAGTTCTACG
CCATGCCACTGACGTTTACCGATTACATCCTCATCGTTATCGTCTCTGTCTTGGGCTCTGCGGCAACGGCTGGCACCACG
GGCGCTACCGTGATGCTCACCTTGACGCTGTCTACTTTGGGTCTGCCACTTGAGGGCGTTGGCCTTCTGCTTGCTATCGA
GCCGATCATCGACATGGGCCGTACCGCGGTCAACGTGACCGGCCAAGCATTGGTCCCAGCGATCGTGGCCCGCCAGGAAA
AGATCTTGGATCGCACGCTTTTCGACGCCTCCCGCGAGGACGCCGAAGCCCGTATCACCGCCTCCTAG

Upstream 100 bases:

>100_bases
AATATTCCGCTTCGCATCGATCCCGCTGTGGCCGATGCGATTTCGCGGTGGGCGCAGGACGAAACACGTAGCGTGAATTC
CCAAATCGAAATGATGTTAC

Downstream 100 bases:

>100_bases
TCCTCCTAGTGTCCTCCTAGTCGAGGTTTTTAAATCCCACTCCCACCGGCACACCGGCGTTATCTGTTAGCTGCACATCC
CCAAAGGTTGCGGCTACAAA

Product: sodium/dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MNNYVAPDASPRTLARSQSLVDLQKSTNRPIGLLKTDHQVLLCLFMKWNSFGAQVIYGLIAGVVLGLIANKMPEGNWLTA
TLTTIGSHYVTLLKVLIPPLVVTAVITSIANLRQVTNAARLAVKTLIWFAITAFFSVLAGIAVGLIFKPGQTTGLQDTAK
APSSVGSWWAFIEGIVPSNILGLQSTTKIVDGAATTSLSFNVLQILVIAIALGIAAVKVGEKAEPFINFNRSFLEIIQKV
LWWIIRLAPIGTAALIGKAVATYGFEAMGALGKFVLTIYVGLAIVVVVIYPLVLKFHGLSVIQFYKRVWPVFSLGFVTRS
SMGVMPVTEQTSEAIGVPKHYASFAVPLGATTKMDGCAAVYPAVAAIFVSQFYAMPLTFTDYILIVIVSVLGSAATAGTT
GATVMLTLTLSTLGLPLEGVGLLLAIEPIIDMGRTAVNVTGQALVPAIVARQEKILDRTLFDASREDAEARITAS

Sequences:

>Translated_475_residues
MNNYVAPDASPRTLARSQSLVDLQKSTNRPIGLLKTDHQVLLCLFMKWNSFGAQVIYGLIAGVVLGLIANKMPEGNWLTA
TLTTIGSHYVTLLKVLIPPLVVTAVITSIANLRQVTNAARLAVKTLIWFAITAFFSVLAGIAVGLIFKPGQTTGLQDTAK
APSSVGSWWAFIEGIVPSNILGLQSTTKIVDGAATTSLSFNVLQILVIAIALGIAAVKVGEKAEPFINFNRSFLEIIQKV
LWWIIRLAPIGTAALIGKAVATYGFEAMGALGKFVLTIYVGLAIVVVVIYPLVLKFHGLSVIQFYKRVWPVFSLGFVTRS
SMGVMPVTEQTSEAIGVPKHYASFAVPLGATTKMDGCAAVYPAVAAIFVSQFYAMPLTFTDYILIVIVSVLGSAATAGTT
GATVMLTLTLSTLGLPLEGVGLLLAIEPIIDMGRTAVNVTGQALVPAIVARQEKILDRTLFDASREDAEARITAS
>Mature_475_residues
MNNYVAPDASPRTLARSQSLVDLQKSTNRPIGLLKTDHQVLLCLFMKWNSFGAQVIYGLIAGVVLGLIANKMPEGNWLTA
TLTTIGSHYVTLLKVLIPPLVVTAVITSIANLRQVTNAARLAVKTLIWFAITAFFSVLAGIAVGLIFKPGQTTGLQDTAK
APSSVGSWWAFIEGIVPSNILGLQSTTKIVDGAATTSLSFNVLQILVIAIALGIAAVKVGEKAEPFINFNRSFLEIIQKV
LWWIIRLAPIGTAALIGKAVATYGFEAMGALGKFVLTIYVGLAIVVVVIYPLVLKFHGLSVIQFYKRVWPVFSLGFVTRS
SMGVMPVTEQTSEAIGVPKHYASFAVPLGATTKMDGCAAVYPAVAAIFVSQFYAMPLTFTDYILIVIVSVLGSAATAGTT
GATVMLTLTLSTLGLPLEGVGLLLAIEPIIDMGRTAVNVTGQALVPAIVARQEKILDRTLFDASREDAEARITAS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=505, Percent_Identity=28.3168316831683, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=26.4775413711584, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI223468564, Length=266, Percent_Identity=32.3308270676692, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI223468566, Length=266, Percent_Identity=32.3308270676692, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI5032093, Length=270, Percent_Identity=32.2222222222222, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI194239697, Length=428, Percent_Identity=27.1028037383178, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=26.7002518891688, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI4827012, Length=457, Percent_Identity=24.945295404814, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI169790839, Length=490, Percent_Identity=25.1020408163265, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI262359914, Length=417, Percent_Identity=24.220623501199, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI301601644, Length=144, Percent_Identity=31.9444444444444, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=29.0094339622642, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1788024, Length=401, Percent_Identity=29.6758104738155, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789947, Length=426, Percent_Identity=25.3521126760563, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1789473, Length=393, Percent_Identity=25.4452926208651, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71996953, Length=443, Percent_Identity=28.4424379232506, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17537407, Length=386, Percent_Identity=29.5336787564767, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71983099, Length=439, Percent_Identity=27.5626423690205, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983106, Length=439, Percent_Identity=27.5626423690205, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=477, Percent_Identity=24.5283018867925, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=25.8064516129032, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=398, Percent_Identity=25.1256281407035, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583025, Length=466, Percent_Identity=25.9656652360515, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17137668, Length=466, Percent_Identity=25.9656652360515, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583023, Length=466, Percent_Identity=25.9656652360515, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281360483, Length=476, Percent_Identity=24.3697478991597, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17137666, Length=476, Percent_Identity=24.3697478991597, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281360481, Length=476, Percent_Identity=24.3697478991597, Blast_Score=95, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 50510; Mature: 50510

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNYVAPDASPRTLARSQSLVDLQKSTNRPIGLLKTDHQVLLCLFMKWNSFGAQVIYGLI
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHH
AGVVLGLIANKMPEGNWLTATLTTIGSHYVTLLKVLIPPLVVTAVITSIANLRQVTNAAR
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVKTLIWFAITAFFSVLAGIAVGLIFKPGQTTGLQDTAKAPSSVGSWWAFIEGIVPSNI
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCC
LGLQSTTKIVDGAATTSLSFNVLQILVIAIALGIAAVKVGEKAEPFINFNRSFLEIIQKV
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHH
LWWIIRLAPIGTAALIGKAVATYGFEAMGALGKFVLTIYVGLAIVVVVIYPLVLKFHGLS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VIQFYKRVWPVFSLGFVTRSSMGVMPVTEQTSEAIGVPKHYASFAVPLGATTKMDGCAAV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHEECCCCCCCCCCHHHH
YPAVAAIFVSQFYAMPLTFTDYILIVIVSVLGSAATAGTTGATVMLTLTLSTLGLPLEGV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCCCCC
GLLLAIEPIIDMGRTAVNVTGQALVPAIVARQEKILDRTLFDASREDAEARITAS
HHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC
>Mature Secondary Structure
MNNYVAPDASPRTLARSQSLVDLQKSTNRPIGLLKTDHQVLLCLFMKWNSFGAQVIYGLI
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHH
AGVVLGLIANKMPEGNWLTATLTTIGSHYVTLLKVLIPPLVVTAVITSIANLRQVTNAAR
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVKTLIWFAITAFFSVLAGIAVGLIFKPGQTTGLQDTAKAPSSVGSWWAFIEGIVPSNI
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCC
LGLQSTTKIVDGAATTSLSFNVLQILVIAIALGIAAVKVGEKAEPFINFNRSFLEIIQKV
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHH
LWWIIRLAPIGTAALIGKAVATYGFEAMGALGKFVLTIYVGLAIVVVVIYPLVLKFHGLS
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VIQFYKRVWPVFSLGFVTRSSMGVMPVTEQTSEAIGVPKHYASFAVPLGATTKMDGCAAV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHEECCCCCCCCCCHHHH
YPAVAAIFVSQFYAMPLTFTDYILIVIVSVLGSAATAGTTGATVMLTLTLSTLGLPLEGV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCCCCC
GLLLAIEPIIDMGRTAVNVTGQALVPAIVARQEKILDRTLFDASREDAEARITAS
HHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]