Definition Methanocaldococcus jannaschii DSM 2661 chromosome, complete genome.
Accession NC_000909
Length 1,664,970

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The map label for this gene is psmA

Identifier: 15668771

GI number: 15668771

Start: 524717

End: 525502

Strand: Direct

Name: psmA

Synonym: MJ0591

Alternate gene names: 15668771

Gene position: 524717-525502 (Clockwise)

Preceding gene: 15668770

Following gene: 15668772

Centisome position: 31.52

GC content: 34.22

Gene sequence:

>786_bases
ATGCAAATGGTACCTCCAAGTGCTTATGATAGGGCTATTACAGTGTTTAGCCCAGAAGGTAGATTATATCAAGTAGAGTA
TGCAAGAGAGGCAGTGAGAAGAGGGACAACAGCGATAGGTATTGCCTGTAAAGATGGTGTAGTTTTAGCGGTAGATAGAA
GAATAACAAGCAAACTCGTAAAAATCAGGTCAATAGAAAAGATATTCCAAATTGACGACCACGTTGCTGCTGCTACCTCT
GGATTGGTAGCTGATGCGAGAGTTTTAATAGATAGAGCGAGATTAGAAGCCCAAATTTACAGATTAACTTATGGAGAGGA
AATATCAATTGAAATGCTGGCTAAAAAGATTTGTGATATTAAACAAGCTTATACTCAACATGGTGGAGTTAGACCGTTTG
GAGTTTCATTATTAATTGCTGGAATAGACAAAAATGAAGCAAGATTATTTGAAACAGACCCAAGTGGGGCTTTAATTGAA
TATAAAGCAACAGCAATAGGTAGTGGAAGACCCGTAGTTATGGAATTATTGGAGAAAGAGTATAGAGATGATATAACATT
AGATGAAGGTTTGGAATTAGCTATAACTGCTTTAACAAAAGCAAACGAAGACATAAAACCTGAAAATGTTGATGTTTGTA
TCATAACGGTTAAAGACGCACAATTTAAAAAAATTCCTGTGGAAGAGATAAAAAAACTTATAGAAAAAGTTAAAAAGAAA
TTAAATGAAGAAAATAAGAAAGAGGAAGAGAATAGAGAAGAAACTAAAGAAAAACAAGAAGAATAA

Upstream 100 bases:

>100_bases
AAAAGAATAAAAATAATAAGATATTATAATGAGATGAATTAGTTAAAAACATTAAGCTAATTATTTAACTACTTTAAAAT
ACTTATAATGGTGATATTTT

Downstream 100 bases:

>100_bases
ATTATAGTAAAATTTTTAAATCCAACTATTTTAAATTATTTTTAGAGTATTAATATTATTTGGGAGTATCCTACTCACTC
TCACTAAAGTAATTTTTATA

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MQMVPPSAYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIACKDGVVLAVDRRITSKLVKIRSIEKIFQIDDHVAAATS
GLVADARVLIDRARLEAQIYRLTYGEEISIEMLAKKICDIKQAYTQHGGVRPFGVSLLIAGIDKNEARLFETDPSGALIE
YKATAIGSGRPVVMELLEKEYRDDITLDEGLELAITALTKANEDIKPENVDVCIITVKDAQFKKIPVEEIKKLIEKVKKK
LNEENKKEEENREETKEKQEE

Sequences:

>Translated_261_residues
MQMVPPSAYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIACKDGVVLAVDRRITSKLVKIRSIEKIFQIDDHVAAATS
GLVADARVLIDRARLEAQIYRLTYGEEISIEMLAKKICDIKQAYTQHGGVRPFGVSLLIAGIDKNEARLFETDPSGALIE
YKATAIGSGRPVVMELLEKEYRDDITLDEGLELAITALTKANEDIKPENVDVCIITVKDAQFKKIPVEEIKKLIEKVKKK
LNEENKKEEENREETKEKQEE
>Mature_261_residues
MQMVPPSAYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIACKDGVVLAVDRRITSKLVKIRSIEKIFQIDDHVAAATS
GLVADARVLIDRARLEAQIYRLTYGEEISIEMLAKKICDIKQAYTQHGGVRPFGVSLLIAGIDKNEARLFETDPSGALIE
YKATAIGSGRPVVMELLEKEYRDDITLDEGLELAITALTKANEDIKPENVDVCIITVKDAQFKKIPVEEIKKLIEKVKKK
LNEENKKEEENREETKEKQEE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, disp

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family

Homologues:

Organism=Homo sapiens, GI4506189, Length=230, Percent_Identity=44.7826086956522, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI68303563, Length=212, Percent_Identity=48.1132075471698, Blast_Score=188, Evalue=4e-48,
Organism=Homo sapiens, GI23110942, Length=237, Percent_Identity=40.5063291139241, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI68303561, Length=218, Percent_Identity=46.7889908256881, Blast_Score=181, Evalue=4e-46,
Organism=Homo sapiens, GI156713442, Length=233, Percent_Identity=42.0600858369099, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI4506185, Length=233, Percent_Identity=42.0600858369099, Blast_Score=178, Evalue=4e-45,
Organism=Homo sapiens, GI4506181, Length=231, Percent_Identity=39.3939393939394, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI23110944, Length=229, Percent_Identity=36.6812227074236, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4506183, Length=174, Percent_Identity=43.1034482758621, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI68303565, Length=212, Percent_Identity=41.5094339622642, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI23110939, Length=173, Percent_Identity=42.7745664739884, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI4506179, Length=258, Percent_Identity=30.6201550387597, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI23110935, Length=258, Percent_Identity=30.6201550387597, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=39.1566265060241, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4506191, Length=215, Percent_Identity=27.4418604651163, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI221316716, Length=109, Percent_Identity=35.7798165137615, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI73747875, Length=209, Percent_Identity=22.488038277512, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758970, Length=209, Percent_Identity=22.488038277512, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4506203, Length=200, Percent_Identity=25.5, Blast_Score=64, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17508491, Length=236, Percent_Identity=44.4915254237288, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17508493, Length=241, Percent_Identity=40.2489626556017, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25143215, Length=231, Percent_Identity=40.6926406926407, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17562790, Length=209, Percent_Identity=41.6267942583732, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17562788, Length=239, Percent_Identity=30.9623430962343, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17562792, Length=221, Percent_Identity=33.4841628959276, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71998965, Length=243, Percent_Identity=30.4526748971193, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508499, Length=223, Percent_Identity=25.1121076233184, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17541700, Length=165, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508495, Length=202, Percent_Identity=25.2475247524752, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321574, Length=197, Percent_Identity=46.7005076142132, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6321692, Length=250, Percent_Identity=42.4, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324535, Length=237, Percent_Identity=40.9282700421941, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324938, Length=243, Percent_Identity=37.037037037037, Blast_Score=161, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6323547, Length=246, Percent_Identity=36.5853658536585, Blast_Score=158, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6323974, Length=232, Percent_Identity=33.6206896551724, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321427, Length=202, Percent_Identity=34.6534653465347, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324731, Length=201, Percent_Identity=26.865671641791, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24654391, Length=239, Percent_Identity=42.2594142259414, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24654389, Length=239, Percent_Identity=42.2594142259414, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17933602, Length=212, Percent_Identity=44.811320754717, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21356137, Length=196, Percent_Identity=46.9387755102041, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17136420, Length=242, Percent_Identity=42.5619834710744, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19922898, Length=180, Percent_Identity=43.3333333333333, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=37.3913043478261, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24651571, Length=237, Percent_Identity=36.7088607594937, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281360341, Length=238, Percent_Identity=32.7731092436975, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586406, Length=238, Percent_Identity=32.7731092436975, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586400, Length=238, Percent_Identity=32.7731092436975, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586402, Length=238, Percent_Identity=32.7731092436975, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24652204, Length=250, Percent_Identity=34, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19921232, Length=234, Percent_Identity=35.042735042735, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737405, Length=172, Percent_Identity=39.5348837209302, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24584895, Length=257, Percent_Identity=26.8482490272374, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24639979, Length=196, Percent_Identity=27.0408163265306, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI20130281, Length=170, Percent_Identity=28.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573221, Length=184, Percent_Identity=26.6304347826087, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664391, Length=180, Percent_Identity=23.8888888888889, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSA_METJA (Q60177)

Other databases:

- EMBL:   L77117
- PIR:   G64373
- RefSeq:   NP_247571.1
- PDB:   3H4P
- PDBsum:   3H4P
- ProteinModelPortal:   Q60177
- SMR:   Q60177
- GeneID:   1451456
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0591
- NMPDR:   fig|243232.1.peg.608
- TIGR:   MJ0591
- HOGENOM:   HBG499923
- OMA:   IFQIDDH
- ProtClustDB:   PRK03996
- BioCyc:   MJAN243232:MJ_0591-MONOMER
- BRENDA:   3.4.25.1
- GO:   GO:0005737
- HAMAP:   MF_00289_A
- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353
- SMART:   SM00948
- TIGRFAMs:   TIGR03633

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N

EC number: =3.4.25.1

Molecular weight: Translated: 29321; Mature: 29321

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00388 PROTEASOME_A_1; PS51475 PROTEASOME_A_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMVPPSAYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIACKDGVVLAVDRRITSKLV
CCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHH
KIRSIEKIFQIDDHVAAATSGLVADARVLIDRARLEAQIYRLTYGEEISIEMLAKKICDI
HHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHH
KQAYTQHGGVRPFGVSLLIAGIDKNEARLFETDPSGALIEYKATAIGSGRPVVMELLEKE
HHHHHHCCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHH
YRDDITLDEGLELAITALTKANEDIKPENVDVCIITVKDAQFKKIPVEEIKKLIEKVKKK
HCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LNEENKKEEENREETKEKQEE
HCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQMVPPSAYDRAITVFSPEGRLYQVEYAREAVRRGTTAIGIACKDGVVLAVDRRITSKLV
CCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHHHH
KIRSIEKIFQIDDHVAAATSGLVADARVLIDRARLEAQIYRLTYGEEISIEMLAKKICDI
HHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHH
KQAYTQHGGVRPFGVSLLIAGIDKNEARLFETDPSGALIEYKATAIGSGRPVVMELLEKE
HHHHHHCCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHH
YRDDITLDEGLELAITALTKANEDIKPENVDVCIITVKDAQFKKIPVEEIKKLIEKVKKK
HCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHH
LNEENKKEEENREETKEKQEE
HCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10692374