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The map label for this gene is hmgL [H]

Identifier: 222102936

GI number: 222102936

Start: 624612

End: 625535

Strand: Direct

Name: hmgL [H]

Synonym: Avi_7692

Alternate gene names: 222102936

Gene position: 624612-625535 (Clockwise)

Preceding gene: 222102935

Following gene: 222102938

Centisome position: 98.87

GC content: 58.77

Gene sequence:

>924_bases
ATGCACCAAACCAGCGGCGACAACATCGTCATTGTCGAGGTCGGCCCAAGAGACGGCTTGCAAAACGAAGCCGCTATTGT
TTCCACCGATGTAAAGATCGAATTGGTGAAACGGCTGGCCAGAGCTGGCCTTGATCACATCGAAGCAACCGCTTTTGTGT
CGCCAAAATGGGTTCCGCAAATGGCCGATAGTACCGATGTTATGACGGCTTGCGCCTCGGCAGCGGAGCTTTCGCATGTC
ACCCTCTCGGCCCTCACGCCCAATCTCAAAGGTTTCGAGGCCGCCATTACTGCCGGAAGCCGCGAGGTGGCGGTGTTTGC
CTCTGCCTCCGAGACCTTCTCCCGGCGCAACATCAATTGCTCGATTGACGACTCCTTCACACGCTTCGAGCCGATTTTCG
AGGCGGCGCGGGCTGTGGGCATTCCAGTGCGCGGCTATGTTTCCTGCGTCATCGCCTGCCCTTATGAGGGCGCGATTGAT
CCGCATGCTGTCGCGCGCGTTAGCCGTCTGCTGCTGGAAAAGGGAGCGCGTGAAGTCTCCCTTGGCGACACAATCGGGGT
TGGAACACCTGCGAAGGTCAAGCGCATGATTGAAGCGGTGGCGGCAGAGGCACCCTTATCGGTGCTGGCAGGACATTTCC
ACGACACCTATGGCATGGGGATCGCCAATATTCAGGCCGCACTCGATGCGGGCATCCGTGTGTTCGACAGCTCTGTCGGT
GGCCTCGGCGGCTGCCCTTATGCCGCTGGCGCGGCTGGCAATGTTGCGACAGAGGAAGTGGTCTATCTGCTGCAAGACCT
CGGCCTGTGCCGCGATATAGACCTGCCCAGACTGGCTGAAACTGCCGCATGGATCAGCCACATCACCGGACTAACGGATG
TCTCGCGTGTTACGAAAGCTCTGATGGGCAGTTCAAAGAGCTGA

Upstream 100 bases:

>100_bases
TCCGATGGCACGCTTGCCAGCTTCCATTTTGCGGTTGGCGATCAGGTGGTGGCCGGCGCGGAGCTGGTTGATTTCCAGCC
CGCCGCATAAGGACAAGATC

Downstream 100 bases:

>100_bases
CATGGCCTCAGCCAGAGAACGATGCGCGGACCTTTGTTGTGTCCGGGCAGACCCACGCATCCATAAATTTCAGAAAAAGC
GGACGTGGCGAGCCTTGTTG

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MHQTSGDNIVIVEVGPRDGLQNEAAIVSTDVKIELVKRLARAGLDHIEATAFVSPKWVPQMADSTDVMTACASAAELSHV
TLSALTPNLKGFEAAITAGSREVAVFASASETFSRRNINCSIDDSFTRFEPIFEAARAVGIPVRGYVSCVIACPYEGAID
PHAVARVSRLLLEKGAREVSLGDTIGVGTPAKVKRMIEAVAAEAPLSVLAGHFHDTYGMGIANIQAALDAGIRVFDSSVG
GLGGCPYAAGAAGNVATEEVVYLLQDLGLCRDIDLPRLAETAAWISHITGLTDVSRVTKALMGSSKS

Sequences:

>Translated_307_residues
MHQTSGDNIVIVEVGPRDGLQNEAAIVSTDVKIELVKRLARAGLDHIEATAFVSPKWVPQMADSTDVMTACASAAELSHV
TLSALTPNLKGFEAAITAGSREVAVFASASETFSRRNINCSIDDSFTRFEPIFEAARAVGIPVRGYVSCVIACPYEGAID
PHAVARVSRLLLEKGAREVSLGDTIGVGTPAKVKRMIEAVAAEAPLSVLAGHFHDTYGMGIANIQAALDAGIRVFDSSVG
GLGGCPYAAGAAGNVATEEVVYLLQDLGLCRDIDLPRLAETAAWISHITGLTDVSRVTKALMGSSKS
>Mature_307_residues
MHQTSGDNIVIVEVGPRDGLQNEAAIVSTDVKIELVKRLARAGLDHIEATAFVSPKWVPQMADSTDVMTACASAAELSHV
TLSALTPNLKGFEAAITAGSREVAVFASASETFSRRNINCSIDDSFTRFEPIFEAARAVGIPVRGYVSCVIACPYEGAID
PHAVARVSRLLLEKGAREVSLGDTIGVGTPAKVKRMIEAVAAEAPLSVLAGHFHDTYGMGIANIQAALDAGIRVFDSSVG
GLGGCPYAAGAAGNVATEEVVYLLQDLGLCRDIDLPRLAETAAWISHITGLTDVSRVTKALMGSSKS

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=292, Percent_Identity=53.7671232876712, Blast_Score=326, Evalue=1e-89,
Organism=Homo sapiens, GI109150422, Length=300, Percent_Identity=53, Blast_Score=325, Evalue=3e-89,
Organism=Homo sapiens, GI109150427, Length=300, Percent_Identity=53, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=49.2647058823529, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17510563, Length=308, Percent_Identity=45.1298701298701, Blast_Score=278, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24582381, Length=300, Percent_Identity=50.6666666666667, Blast_Score=311, Evalue=4e-85,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32136; Mature: 32136

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQTSGDNIVIVEVGPRDGLQNEAAIVSTDVKIELVKRLARAGLDHIEATAFVSPKWVPQ
CCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHEECCCCCCCC
MADSTDVMTACASAAELSHVTLSALTPNLKGFEAAITAGSREVAVFASASETFSRRNINC
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCEEEEEECCHHHHHHCCCCE
SIDDSFTRFEPIFEAARAVGIPVRGYVSCVIACPYEGAIDPHAVARVSRLLLEKGAREVS
EECCCHHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEE
LGDTIGVGTPAKVKRMIEAVAAEAPLSVLAGHFHDTYGMGIANIQAALDAGIRVFDSSVG
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCC
GLGGCPYAAGAAGNVATEEVVYLLQDLGLCRDIDLPRLAETAAWISHITGLTDVSRVTKA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
LMGSSKS
HHCCCCC
>Mature Secondary Structure
MHQTSGDNIVIVEVGPRDGLQNEAAIVSTDVKIELVKRLARAGLDHIEATAFVSPKWVPQ
CCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHCCCHHHHHHEECCCCCCCC
MADSTDVMTACASAAELSHVTLSALTPNLKGFEAAITAGSREVAVFASASETFSRRNINC
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCEEEEEECCHHHHHHCCCCE
SIDDSFTRFEPIFEAARAVGIPVRGYVSCVIACPYEGAIDPHAVARVSRLLLEKGAREVS
EECCCHHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEE
LGDTIGVGTPAKVKRMIEAVAAEAPLSVLAGHFHDTYGMGIANIQAALDAGIRVFDSSVG
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCC
GLGGCPYAAGAAGNVATEEVVYLLQDLGLCRDIDLPRLAETAAWISHITGLTDVSRVTKA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHH
LMGSSKS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]