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The map label for this gene is moaA [H]

Identifier: 222102888

GI number: 222102888

Start: 565611

End: 566639

Strand: Reverse

Name: moaA [H]

Synonym: Avi_7629

Alternate gene names: 222102888

Gene position: 566639-565611 (Counterclockwise)

Preceding gene: 222102889

Following gene: 222102874

Centisome position: 89.69

GC content: 57.34

Gene sequence:

>1029_bases
ATGCTAACCCCGGGGACTGCCTTGCCTTCTTCGTGTGGTCTGATCGACCGGTTCGGTCGCCGCGTGACTTATCTACGTCT
TTCAGTGACCGATCGTTGCGATCTACGCTGCATGTATTGCATGCCGGAAAACATGACATTCATGCCGAAGCGTGATGTGC
TGTCGATTGATGAGCTGGAACGTCTTGCGGTTGCCTTCATCCGATCCGGCGTCACGCGGATCCGCCTCACGGGTGGTGAA
CCTCTCGTTCGCAAGGGTATCATCGACTTAATCCGCTCGCTAGGACGCAATTTGCAAGGCGGTCCGCTACAAGAGCTGAC
ATTGACAACCAACGGCACTCAGCTTGCCCGTTATGCTGAAGACTTGGCGCAGGCGGGTATTCGACGCCTCAATGTTTCGC
TTGATACACTCGCGCCAGAGCGGTTTCGCACTTTGACGCGGGGTGGCTCGCTTACCACGGTGCTTGAGGGCATCGACGCG
GCCCGTGCAGCGGGGCTTGCGGTCAAGATCAATTCGGTAGCACTCCGGGACAGCACCGAACAGGAAATTCATGATCTTAT
CGCGTTTGCTCATGGCCCCGGCATGATGCTTTCTCTGATCGAGACCATGCCGCTTGGAGATATCGGTGTCGATCGCATCG
ATCAGTATCTTCCACTCAACGAATTGCGCAAGACGATTGAAACCCGCTGGTCACTGACAGATATTCCCCTGCGGACGGGA
GGCCCGGCGCGCTATGCCCGCATTGCCGAAACCGGCGGAACAATCGGCTTCATCACGCCGCTGACACATAATTTCTGCGA
AGGCTGCAACCGTGTTCGCGTAACTGCTGCCGGTGTGCTTCACACTTGCCTGGGGCAGGAAGACGCCGTTGATCTCAAAG
CGGTGATGCGCCGGTCGCCACATGATCAGGATCTGTTTGCCGCGATCAACCAGGCAATCCTGGACAAATCGCGTGGGCAC
GACTTTGCGATCGACCGAACCAACGCCCCGACAACGATCAGCCGGCATATGTCAGCCACCGGTGGCTGA

Upstream 100 bases:

>100_bases
ATGCTGCGGAATTGGAGCAAGGCCGCCTTGCTGGAAAGCCCCGAGAAAAATTTTTGTCTGTCGACCAGATGATTTCTGTC
GTCACAAAGAGACGCACAGC

Downstream 100 bases:

>100_bases
TGCATGTCTGCTGTATCAAATGCCTCTCCTGAAGGGAAAGAGGATACGCCTGGCCCTAAGAAAGCTGGTGCTGTTGATTT
TCACTCTGAAATGAGCCGTA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MLTPGTALPSSCGLIDRFGRRVTYLRLSVTDRCDLRCMYCMPENMTFMPKRDVLSIDELERLAVAFIRSGVTRIRLTGGE
PLVRKGIIDLIRSLGRNLQGGPLQELTLTTNGTQLARYAEDLAQAGIRRLNVSLDTLAPERFRTLTRGGSLTTVLEGIDA
ARAAGLAVKINSVALRDSTEQEIHDLIAFAHGPGMMLSLIETMPLGDIGVDRIDQYLPLNELRKTIETRWSLTDIPLRTG
GPARYARIAETGGTIGFITPLTHNFCEGCNRVRVTAAGVLHTCLGQEDAVDLKAVMRRSPHDQDLFAAINQAILDKSRGH
DFAIDRTNAPTTISRHMSATGG

Sequences:

>Translated_342_residues
MLTPGTALPSSCGLIDRFGRRVTYLRLSVTDRCDLRCMYCMPENMTFMPKRDVLSIDELERLAVAFIRSGVTRIRLTGGE
PLVRKGIIDLIRSLGRNLQGGPLQELTLTTNGTQLARYAEDLAQAGIRRLNVSLDTLAPERFRTLTRGGSLTTVLEGIDA
ARAAGLAVKINSVALRDSTEQEIHDLIAFAHGPGMMLSLIETMPLGDIGVDRIDQYLPLNELRKTIETRWSLTDIPLRTG
GPARYARIAETGGTIGFITPLTHNFCEGCNRVRVTAAGVLHTCLGQEDAVDLKAVMRRSPHDQDLFAAINQAILDKSRGH
DFAIDRTNAPTTISRHMSATGG
>Mature_342_residues
MLTPGTALPSSCGLIDRFGRRVTYLRLSVTDRCDLRCMYCMPENMTFMPKRDVLSIDELERLAVAFIRSGVTRIRLTGGE
PLVRKGIIDLIRSLGRNLQGGPLQELTLTTNGTQLARYAEDLAQAGIRRLNVSLDTLAPERFRTLTRGGSLTTVLEGIDA
ARAAGLAVKINSVALRDSTEQEIHDLIAFAHGPGMMLSLIETMPLGDIGVDRIDQYLPLNELRKTIETRWSLTDIPLRTG
GPARYARIAETGGTIGFITPLTHNFCEGCNRVRVTAAGVLHTCLGQEDAVDLKAVMRRSPHDQDLFAAINQAILDKSRGH
DFAIDRTNAPTTISRHMSATGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=317, Percent_Identity=37.8548895899054, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI22027536, Length=317, Percent_Identity=37.8548895899054, Blast_Score=211, Evalue=6e-55,
Organism=Escherichia coli, GI1786999, Length=332, Percent_Identity=33.1325301204819, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17561210, Length=313, Percent_Identity=33.8658146964856, Blast_Score=184, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI32566331, Length=314, Percent_Identity=34.0764331210191, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=33.8658146964856, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574490, Length=321, Percent_Identity=37.3831775700935, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=36.9565217391304, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37437; Mature: 37437

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTPGTALPSSCGLIDRFGRRVTYLRLSVTDRCDLRCMYCMPENMTFMPKRDVLSIDELE
CCCCCCCCCCCCCHHHHHCCEEEEEEEEECCCCCCEEEEECCCCCEECCCCCCCCHHHHH
RLAVAFIRSGVTRIRLTGGEPLVRKGIIDLIRSLGRNLQGGPLQELTLTTNGTQLARYAE
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
DLAQAGIRRLNVSLDTLAPERFRTLTRGGSLTTVLEGIDAARAAGLAVKINSVALRDSTE
HHHHHHHHHHCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCH
QEIHDLIAFAHGPGMMLSLIETMPLGDIGVDRIDQYLPLNELRKTIETRWSLTDIPLRTG
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
GPARYARIAETGGTIGFITPLTHNFCEGCNRVRVTAAGVLHTCLGQEDAVDLKAVMRRSP
CCHHHHHHHHCCCCEEEECHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHCCC
HDQDLFAAINQAILDKSRGHDFAIDRTNAPTTISRHMSATGG
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MLTPGTALPSSCGLIDRFGRRVTYLRLSVTDRCDLRCMYCMPENMTFMPKRDVLSIDELE
CCCCCCCCCCCCCHHHHHCCEEEEEEEEECCCCCCEEEEECCCCCEECCCCCCCCHHHHH
RLAVAFIRSGVTRIRLTGGEPLVRKGIIDLIRSLGRNLQGGPLQELTLTTNGTQLARYAE
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHH
DLAQAGIRRLNVSLDTLAPERFRTLTRGGSLTTVLEGIDAARAAGLAVKINSVALRDSTE
HHHHHHHHHHCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEEEEEECCCCH
QEIHDLIAFAHGPGMMLSLIETMPLGDIGVDRIDQYLPLNELRKTIETRWSLTDIPLRTG
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
GPARYARIAETGGTIGFITPLTHNFCEGCNRVRVTAAGVLHTCLGQEDAVDLKAVMRRSP
CCHHHHHHHHCCCCEEEECHHHHHHHHCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHCCC
HDQDLFAAINQAILDKSRGHDFAIDRTNAPTTISRHMSATGG
CCHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA