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The map label for this gene is 158334857

Identifier: 158334857

GI number: 158334857

Start: 1673750

End: 1674988

Strand: Direct

Name: 158334857

Synonym: AM1_1694

Alternate gene names: NA

Gene position: 1673750-1674988 (Clockwise)

Preceding gene: 158334853

Following gene: 158334858

Centisome position: 25.74

GC content: 51.41

Gene sequence:

>1239_bases
GTGGTCGGCGTCAAGCCGACTGATCAGCAATATCCCCAAGGACTCGTTGGGTTTATTCTGTGTGCCTATCCTGCTCCTAG
GACTTTACCCCACCGCCGACAGTTACGGGAATATGAGTTTGTCTGTGCCACGGAGCAGATGCGCTCCCAGTGGATGAACG
CCATTCGCCAAGCGTTACAGGGCCACCCCATCCAACCCCAGCAGGCCGTCAGGCCCCGCCATCTCCAAGTCTTAGTCAAT
CCCAAGGGAGGACGGCGACAAGCCAAACAAGTCTTTCAATCCATTCAGCCCATTTTAGAAGATGCCCATTGCCAGGTGAG
CATTTTGGAAACCCAGGGGGGCGAAGGAACGATCCAGGCCGTGCGAGATTTCGACTTATCAGCGATAGATGGATTTGTCG
TTGTCGGTGGCGATGGAACGGTTTATGAGCTGATTAACGGGCTGATGACCCATGGGGATGCGGAGGTTGCGATCGCAAAA
CCCATCGGCATCATCCCAGCCGGTACCGGCAACGGTCTGGGAAAAACCATTCTCGACCTATCCCAAGAAACCTACGATCC
GAGTAATGCCGCGTTTATCATCGCCAAAGGCCAGTACCAGCCTATTAATTTAGGCGTCGTCAAACAGGATGGCAAAGAAT
ATTACAGCATTCTCTCCTTAGCTTGGGCTTTGATTAGCGATATCGATATTAAGTCCAACAAGCTTCGTTTTCTCAAGTTC
CTAGGCTCCTTACGTAGTGATCTCTATGCTTTTCTCAGCATCTTGGCCCTCCGCAGTTATCGAGGTCGGATTTCCTTTCT
ACCTGCCCCAGACTGGCCACCTAGCCCCGATACCCCTCAGCCAGACCTCCTAGCCGAACCGCAGCCAGCAGACATCGAGA
CCTCTACAGCTTCAGCTTGGCAAGTGCTTGAGGGTGAGTTTATTGCCCTTTGGGTGATGAACGTCGCTTGGGCCACCCAT
AGCGTTTTGGCAGCCCCACACGCTCGATTAGCCGATGGCTACATGGATGTCTTAATCATTCGTAAAGGAATTACCCGCTG
GCGTTTATTAACCGCATTTCTGAAAATTGCCACAGGCGAACATCTCCTGATTCCAGAGATGGAATACTACAAGGTGCGCT
GTCTCCACTTAGAACCTCTAAGTTCTGAAGGCTTACTGGCTGTTGACGGAGAACAAATCAAATACCGCTCCGTTGAAATG
AATGTTTTGGCAAACCATGCCCAAGTTTTTTGCCGTTAA

Upstream 100 bases:

>100_bases
CGAGCCCATCGCTGTCGATATGCGGGCTAGAGGTTGGTTGACGACCTCCAGTTTGTCCTGGTTCCACGCAGGTCTAAGGC
ACACATTAGCCTTTGATGAC

Downstream 100 bases:

>100_bases
TCTGCAGGCTAACCAGCCGATGTATACTCTTCCCCAACTGCCCGAGCTGAGCTAGGGCTGAGAACATCCCTGTACGACGT
ATTAGGGATTCAGTGGAGTC

Product: sphingosine kinase 2

Products: ADP; sphinganine 1-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MVGVKPTDQQYPQGLVGFILCAYPAPRTLPHRRQLREYEFVCATEQMRSQWMNAIRQALQGHPIQPQQAVRPRHLQVLVN
PKGGRRQAKQVFQSIQPILEDAHCQVSILETQGGEGTIQAVRDFDLSAIDGFVVVGGDGTVYELINGLMTHGDAEVAIAK
PIGIIPAGTGNGLGKTILDLSQETYDPSNAAFIIAKGQYQPINLGVVKQDGKEYYSILSLAWALISDIDIKSNKLRFLKF
LGSLRSDLYAFLSILALRSYRGRISFLPAPDWPPSPDTPQPDLLAEPQPADIETSTASAWQVLEGEFIALWVMNVAWATH
SVLAAPHARLADGYMDVLIIRKGITRWRLLTAFLKIATGEHLLIPEMEYYKVRCLHLEPLSSEGLLAVDGEQIKYRSVEM
NVLANHAQVFCR

Sequences:

>Translated_412_residues
MVGVKPTDQQYPQGLVGFILCAYPAPRTLPHRRQLREYEFVCATEQMRSQWMNAIRQALQGHPIQPQQAVRPRHLQVLVN
PKGGRRQAKQVFQSIQPILEDAHCQVSILETQGGEGTIQAVRDFDLSAIDGFVVVGGDGTVYELINGLMTHGDAEVAIAK
PIGIIPAGTGNGLGKTILDLSQETYDPSNAAFIIAKGQYQPINLGVVKQDGKEYYSILSLAWALISDIDIKSNKLRFLKF
LGSLRSDLYAFLSILALRSYRGRISFLPAPDWPPSPDTPQPDLLAEPQPADIETSTASAWQVLEGEFIALWVMNVAWATH
SVLAAPHARLADGYMDVLIIRKGITRWRLLTAFLKIATGEHLLIPEMEYYKVRCLHLEPLSSEGLLAVDGEQIKYRSVEM
NVLANHAQVFCR
>Mature_412_residues
MVGVKPTDQQYPQGLVGFILCAYPAPRTLPHRRQLREYEFVCATEQMRSQWMNAIRQALQGHPIQPQQAVRPRHLQVLVN
PKGGRRQAKQVFQSIQPILEDAHCQVSILETQGGEGTIQAVRDFDLSAIDGFVVVGGDGTVYELINGLMTHGDAEVAIAK
PIGIIPAGTGNGLGKTILDLSQETYDPSNAAFIIAKGQYQPINLGVVKQDGKEYYSILSLAWALISDIDIKSNKLRFLKF
LGSLRSDLYAFLSILALRSYRGRISFLPAPDWPPSPDTPQPDLLAEPQPADIETSTASAWQVLEGEFIALWVMNVAWATH
SVLAAPHARLADGYMDVLIIRKGITRWRLLTAFLKIATGEHLLIPEMEYYKVRCLHLEPLSSEGLLAVDGEQIKYRSVEM
NVLANHAQVFCR

Specific function: Unknown

COG id: COG1597

COG function: function code IR; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI217272885, Length=351, Percent_Identity=33.6182336182336, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI217272883, Length=351, Percent_Identity=33.6182336182336, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI21361088, Length=351, Percent_Identity=33.6182336182336, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI217272880, Length=351, Percent_Identity=33.6182336182336, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI20336726, Length=370, Percent_Identity=26.7567567567568, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI21361699, Length=242, Percent_Identity=34.297520661157, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI41680688, Length=351, Percent_Identity=23.0769230769231, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI8922701, Length=356, Percent_Identity=23.0337078651685, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71983700, Length=396, Percent_Identity=26.2626262626263, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983703, Length=396, Percent_Identity=26.2626262626263, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324745, Length=407, Percent_Identity=24.0786240786241, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323289, Length=200, Percent_Identity=27, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641298, Length=262, Percent_Identity=33.587786259542, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24641300, Length=262, Percent_Identity=33.587786259542, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45550531, Length=244, Percent_Identity=33.1967213114754, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24644207, Length=270, Percent_Identity=27.037037037037, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24644205, Length=270, Percent_Identity=27.037037037037, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.1.91

Molecular weight: Translated: 45732; Mature: 45732

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGVKPTDQQYPQGLVGFILCAYPAPRTLPHRRQLREYEFVCATEQMRSQWMNAIRQALQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHPIQPQQAVRPRHLQVLVNPKGGRRQAKQVFQSIQPILEDAHCQVSILETQGGEGTIQA
CCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHH
VRDFDLSAIDGFVVVGGDGTVYELINGLMTHGDAEVAIAKPIGIIPAGTGNGLGKTILDL
HHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
SQETYDPSNAAFIIAKGQYQPINLGVVKQDGKEYYSILSLAWALISDIDIKSNKLRFLKF
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGSLRSDLYAFLSILALRSYRGRISFLPAPDWPPSPDTPQPDLLAEPQPADIETSTASAW
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
QVLEGEFIALWVMNVAWATHSVLAAPHARLADGYMDVLIIRKGITRWRLLTAFLKIATGE
HHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
HLLIPEMEYYKVRCLHLEPLSSEGLLAVDGEQIKYRSVEMNVLANHAQVFCR
EEECCCCHHEEEEEEEECCCCCCCEEEECCCCEEEEEEEHHHHHCCHHHCCC
>Mature Secondary Structure
MVGVKPTDQQYPQGLVGFILCAYPAPRTLPHRRQLREYEFVCATEQMRSQWMNAIRQALQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHPIQPQQAVRPRHLQVLVNPKGGRRQAKQVFQSIQPILEDAHCQVSILETQGGEGTIQA
CCCCCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHH
VRDFDLSAIDGFVVVGGDGTVYELINGLMTHGDAEVAIAKPIGIIPAGTGNGLGKTILDL
HHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
SQETYDPSNAAFIIAKGQYQPINLGVVKQDGKEYYSILSLAWALISDIDIKSNKLRFLKF
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LGSLRSDLYAFLSILALRSYRGRISFLPAPDWPPSPDTPQPDLLAEPQPADIETSTASAW
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
QVLEGEFIALWVMNVAWATHSVLAAPHARLADGYMDVLIIRKGITRWRLLTAFLKIATGE
HHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
HLLIPEMEYYKVRCLHLEPLSSEGLLAVDGEQIKYRSVEMNVLANHAQVFCR
EEECCCCHHEEEEEEEECCCCCCCEEEECCCCEEEEEEEHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; sphinganine

Specific reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA