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The map label for this gene is vanRB [H]

Identifier: 153937795

GI number: 153937795

Start: 2030349

End: 2031014

Strand: Reverse

Name: vanRB [H]

Synonym: CLC_1914

Alternate gene names: 153937795

Gene position: 2031014-2030349 (Counterclockwise)

Preceding gene: 153934886

Following gene: 153936594

Centisome position: 54.01

GC content: 28.38

Gene sequence:

>666_bases
ATGCCAAAGAGAATTCTTGTAGTAGAGGACGATTTTGATATACATACTATTATAAGTGAGGTTCTAAAGGAAAGTGGATA
TTTAGTGGAGGTGGCTACAGATGGATTAATTGCGGTGGAGATGTTTAGAAGGGGGAATTTTGATTTAATAATTTTAGATG
TGATGCTTCCTAAAATAGATGGATTTGTAGTATGTGAAATTATAAGAAAAGAATCAAGTATGCCTATAATAATGCTTACT
GCTCTAGGAGAAGAGGAGGATGAGATGAAAGGTTTTGAATTAAAAGTAGATGATTATATAACAAAACCCTTTTCTATTAA
TTTATTAATAAAAAGAGTAGAAGCAGTACTTAGAAGAGCCAATGGATTAGAGGAAAATAATTCAACTTTAACCTTTGAAG
AAATAACAATATATCCTTCTAATTATAAAACTTTAGTTAATAATAAGGAAATAGAACTAACTTATAAAGAATTTCAGATA
TTAGAAATATTAATATCAAATGTAGGAAGGGTCTTTTCTAGAGAATCTTTATTAAATCAAATATGGGGATATGATTATTT
TGGAGATACCCGTGTTATAGATACTCATATCAAAAATTTAAGACAAAAACTAAACATAGATTATATAAAGACCATAAGGG
GAGTGGGGTATAAAATTGAGAAATAA

Upstream 100 bases:

>100_bases
GGATTTAAAGTATTTATTAGTATAAAATATAAAGGAATTTATTTTTATTTAAAAAATAATTATGTATATAATGATATATT
TAAACAGGAGATGGATTACA

Downstream 100 bases:

>100_bases
ATTAAAAAAAAGTATAGTATATAAGCTATTTTTAGTAACTACATTATTATTAGTAATAAGTTCTATATGCACTTACTCTA
TAATTTATATGCTGCTACCT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKIDGFVVCEIIRKESSMPIIMLT
ALGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRANGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQI
LEILISNVGRVFSRESLLNQIWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK

Sequences:

>Translated_221_residues
MPKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKIDGFVVCEIIRKESSMPIIMLT
ALGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRANGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQI
LEILISNVGRVFSRESLLNQIWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK
>Mature_220_residues
PKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKIDGFVVCEIIRKESSMPIIMLTA
LGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRANGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQIL
EILISNVGRVFSRESLLNQIWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.036036036036, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=34.2465753424658, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=36.9369369369369, Blast_Score=143, Evalue=7e-36,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=35.5555555555556, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=37.3333333333333, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=33.0316742081448, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=32.7188940092166, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=31.7972350230415, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.5315315315315, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=33.7662337662338, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=30.3571428571429, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.5315315315315, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=28.3842794759825, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=114, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=131, Percent_Identity=28.2442748091603, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788724, Length=140, Percent_Identity=29.2857142857143, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=28.3333333333333, Blast_Score=61, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=103, Percent_Identity=30.0970873786408, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25635; Mature: 25504

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKID
CCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCEEEEEHHHCCCCCEEEEEEECCCCC
GFVVCEIIRKESSMPIIMLTALGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRA
CCEEEEEHHCCCCCCEEEEEECCCCHHHCCCEEEEEHHHCCCCEEHHHHHHHHHHHHHHH
NGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQILEILISNVGRVFSRESLLNQ
CCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK
HCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCEEECC
>Mature Secondary Structure 
PKRILVVEDDFDIHTIISEVLKESGYLVEVATDGLIAVEMFRRGNFDLIILDVMLPKID
CCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCEEEEEHHHCCCCCEEEEEEECCCCC
GFVVCEIIRKESSMPIIMLTALGEEEDEMKGFELKVDDYITKPFSINLLIKRVEAVLRRA
CCEEEEEHHCCCCCCEEEEEECCCCHHHCCCEEEEEHHHCCCCEEHHHHHHHHHHHHHHH
NGLEENNSTLTFEEITIYPSNYKTLVNNKEIELTYKEFQILEILISNVGRVFSRESLLNQ
CCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IWGYDYFGDTRVIDTHIKNLRQKLNIDYIKTIRGVGYKIEK
HCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]