Click here to switch to the map view.

The map label for this gene is moeB [H]

Identifier: 153937555

GI number: 153937555

Start: 1988890

End: 1989573

Strand: Reverse

Name: moeB [H]

Synonym: CLC_1879

Alternate gene names: 153937555

Gene position: 1989573-1988890 (Counterclockwise)

Preceding gene: 153936804

Following gene: 153936008

Centisome position: 52.91

GC content: 28.07

Gene sequence:

>684_bases
ATGTCTAGATATGATAGAAATATAAAAACTCTTTCTTTAGAAGAAAATGAAAAACTTAAAGATTTTAAAGTCTGCGTAAT
TGGTTGTGGAGGATTAGGTGGATATATAATTGAAATGTTAGGAAGAATTGGAGTAGGCCATATAACAGCAGTAGATGGCG
ATACTTTTAGTGAATCTAATTTGAATAGACAAATTATTAGTAGCGATTTAAATTTAGGAAAAAATAAGGCTATAGAAGCT
AAAAAAAGAATGAAAGTAGTTAATGATTTAATATATGTAAATCCTATTACAACATTTATAAATAAGGATAATGTATTAAA
TATTTTAAAAGAACATGATGTAGTTATTGATGCGATTGATAATATAGAAACTAGATTTTTATTACAAGAAAGTTGTGAGA
AGCTTAAAATACCTTTTATTCATGGTGCCATTGCAGGATGGTATGGGCAAGTAACAACTATATTTCCAGGTGATAGAACA
CTGGATATTATTTATAAGAATAAAAGTAAAAAGGGCATAGAGGATGTCCTTGGGAATCCCTCTTTTACACCAGCTTTAGT
GGCTTCTATACAGGTAAGTGAAGCGTTAAAAGTGTTAATTAATAGAGGAGAAATTCTAAGAAATAAAATATTCATGATAG
ATCTACTGTATCAAGATTTCTATATATTGAATTTAAAAGAGTAG

Upstream 100 bases:

>100_bases
GTGGCTATATTACTTATTAATGGGAGAGATGGAAAGGTAGATACTTTATTGAAGGATGGGGATGTATTGTCTTTATTCCC
ACCAGTAGGAGGAGGATAGA

Downstream 100 bases:

>100_bases
TTTAAAGCTGTATATAGGTGTTTTTATCCAACTTCATAAGTTATTTCTAGACTAAGAAAATATATTTCATAAGTGAATTC
AACCTGAAATTAAAAATTAT

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGVGHITAVDGDTFSESNLNRQIISSDLNLGKNKAIEA
KKRMKVVNDLIYVNPITTFINKDNVLNILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRT
LDIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE

Sequences:

>Translated_227_residues
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGVGHITAVDGDTFSESNLNRQIISSDLNLGKNKAIEA
KKRMKVVNDLIYVNPITTFINKDNVLNILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRT
LDIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
>Mature_226_residues
SRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGVGHITAVDGDTFSESNLNRQIISSDLNLGKNKAIEAK
KRMKVVNDLIYVNPITTFINKDNVLNILKEHDVVIDAIDNIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTL
DIIYKNKSKKGIEDVLGNPSFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=152, Percent_Identity=30.9210526315789, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4885649, Length=153, Percent_Identity=32.0261437908497, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1787048, Length=232, Percent_Identity=31.0344827586207, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1789177, Length=134, Percent_Identity=35.0746268656716, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082356, Length=156, Percent_Identity=30.1282051282051, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540406, Length=157, Percent_Identity=31.8471337579618, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193203301, Length=146, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=156, Percent_Identity=31.4102564102564, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322639, Length=169, Percent_Identity=29.585798816568, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325323, Length=178, Percent_Identity=30.3370786516854, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320598, Length=147, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582879, Length=227, Percent_Identity=28.6343612334802, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28573937, Length=163, Percent_Identity=27.6073619631902, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24660640, Length=145, Percent_Identity=33.1034482758621, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 25549; Mature: 25418

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGVGHITAVDGDTFSESN
CCCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
LNRQIISSDLNLGKNKAIEAKKRMKVVNDLIYVNPITTFINKDNVLNILKEHDVVIDAID
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHHHHCCEEEEECC
NIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTLDIIYKNKSKKGIEDVLGNP
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCHHHHHCCC
SFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCEEEEEECC
>Mature Secondary Structure 
SRYDRNIKTLSLEENEKLKDFKVCVIGCGGLGGYIIEMLGRIGVGHITAVDGDTFSESN
CCCCCCCEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
LNRQIISSDLNLGKNKAIEAKKRMKVVNDLIYVNPITTFINKDNVLNILKEHDVVIDAID
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEECHHHHHHCCCHHHHHHHHCCEEEEECC
NIETRFLLQESCEKLKIPFIHGAIAGWYGQVTTIFPGDRTLDIIYKNKSKKGIEDVLGNP
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCHHHHHCCC
SFTPALVASIQVSEALKVLINRGEILRNKIFMIDLLYQDFYILNLKE
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]