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The map label for this gene is msrA

Identifier: 153937534

GI number: 153937534

Start: 1976186

End: 1976659

Strand: Reverse

Name: msrA

Synonym: CLC_1868

Alternate gene names: 153937534

Gene position: 1976659-1976186 (Counterclockwise)

Preceding gene: 153934767

Following gene: 153934752

Centisome position: 52.56

GC content: 31.01

Gene sequence:

>474_bases
ATGAAAGAAATAGTTTTAGCTGGAGGTTGTTTTTGGGGAGTAGAAGAATATATGTCAAGAATTGAAGGAATAGTGGAAAC
AAAAGTTGGTTATGCCAATGGAATAAAAGAAAATCCTAGTTATGAAGAGGTATGCAGTGGAGTCACAGGTCATGCAGAAG
CTTGTTACATAAAATATGATGAAAGTATTATATCCTTAGAAGAACTGTTAAATAAATTTTGGAGCATAATAGATCCAACA
GTACTAAATAAACAGGGTAACGATAGAGGAACTCAGTATAGAACAGGTATATTTTACTTAGATGAAAAAGATTTAAATGT
AATTATAAAGAGTAAATATCAGGAGCAGAAAAATTATAGAAAGCCTATAGTTACTGAAGTAGAGCCCCTAAAGTGTTTTT
ATGAGGCTGAGGAGTATCATCAAAAATATTTAAAGAAAAATCCAGGAGGCTATTGTCATATACATTTAGATTAA

Upstream 100 bases:

>100_bases
AAAGTGTTTCTAAACTTAATTATGAAGTAATATATAAAGTTTAAGTAATTGCTAGTTGAAGTTATTAAGATTTCTTAAAG
AAATTATGGAGGTGTTAATT

Downstream 100 bases:

>100_bases
TTTTTATTATATGTTTTATAGGGTATGTAGGTAGATTTGTGTAAAAACAAATTTACCTACATACTCTATAAAGAGAATGT
AAATAATTTTATATATTTGT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD

Sequences:

>Translated_157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
>Mature_157_residues
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPT
VLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=44.8051948051948, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=44.3037974683544, Blast_Score=138, Evalue=2e-33,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=44.6428571428571, Blast_Score=97, Evalue=8e-21,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=44.4444444444444, Blast_Score=130, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=47.239263803681, Blast_Score=137, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=37.3239436619718, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=37.956204379562, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=36.6197183098592, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_CLOB1 (A7FUX9)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384182.1
- ProteinModelPortal:   A7FUX9
- SMR:   A7FUX9
- STRING:   A7FUX9
- GeneID:   5397044
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1861
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   TRHITTE
- ProtClustDB:   PRK14054
- BioCyc:   CBOT441770:CLB_1861-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 18178; Mature: 18178

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYD
CCCEEEECCHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEC
ESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYR
CHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHCC
KPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYD
CCCEEEECCHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEC
ESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYR
CHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHCC
KPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA