BacMap

Definition	Clostridium botulinum A str. Hall, complete genome.
Accession	NC_009698
Length	3,760,560

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The map label for this gene is yusZ [H]

Identifier: 153937450

GI number: 153937450

Start: 2297069

End: 2297866

Strand: Direct

Name: yusZ [H]

Synonym: CLC_2159

Alternate gene names: 153937450

Gene position: 2297069-2297866 (Clockwise)

Preceding gene: 153936666

Following gene: 153937857

Centisome position: 61.08

GC content: 27.82

Gene sequence:

>798_bases
ATGAGTAAAATATTAATTACAGGTGCAGGTTCTGGTCTTGGGAAGGCTTCTTCTATTGCTTTAGCTAGAAGAGGACATAA
AGTTTATGCAACTACCCATAGAAAATCTCAAGCAGAAAATCTAAAAGACATAGCCTTAAAAGAAAATATAAGTAAAAATA
TTGAAAGCTTTAAGTTAGATATAACTTTAAAAGAAGATAGAGATATTGTAAAAAATTTAGATATAGATGCATTGATTAAT
AATGCTGCTATAGGAGATTCTGGTTCTGCATCAGAAGTTTCAATTGACAAATATAAAACTGTATTTGAAACCAATGTATT
TTCTGCTTTAGAACTTACTCAAGCTGTATTTGATAACATGATAAAAAAAAATGAGGGAAGAATTATCTTTTTATCTTCCT
TATCTGGTAGAATTGCAATACCTTTCTTATCACCTTATACATCTAGCAAATTTGCCTTAGAAGCAATAGTATCTTCTCTA
AAAGAAGAAATAAAAGAGCTTTCTGACTGTAACATTAATATAATTTTGATTGAACCTGGAGCTTATAAAACTGGCTTTAA
CCAAAAAAATATTGATAAGCAGTTTGTATGGATGAAAGAAAAATCCTATTTTAAAGATAAATTAGTAAAATTAAAAAAAA
AGCAATACAGCTATTTTGAATTAATGGAACATAAATCCTTTAATTCTATAGTAAATCAGTATATACATGCTATAGAAGAT
GAATCTCCTAAATTCAGATACAAAGCTCCTTTAGTTCAAAGTGCTTTTACCCAAGGACAAAGAATATTAGGTAAATAA

Upstream 100 bases:

>100_bases
TAATAATTTATTGAAATATGTTAAATGTTTCGCCTAACTAGGATAATCTAGCCTCAATTGTACAATATAAATAATATAAA
AGTTTTATGGAAGTGATATT

Downstream 100 bases:

>100_bases
TATATAAACTAGATTAAACATCTTCTAGTTTTATATTTATATCATATCATTGTAATATTATTCGATATCTTCCTTAAAGC
TATTGTAAATCCAGTAAAAT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: ORFA [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSKILITGAGSGLGKASSIALARRGHKVYATTHRKSQAENLKDIALKENISKNIESFKLDITLKEDRDIVKNLDIDALIN
NAAIGDSGSASEVSIDKYKTVFETNVFSALELTQAVFDNMIKKNEGRIIFLSSLSGRIAIPFLSPYTSSKFALEAIVSSL
KEEIKELSDCNINIILIEPGAYKTGFNQKNIDKQFVWMKEKSYFKDKLVKLKKKQYSYFELMEHKSFNSIVNQYIHAIED
ESPKFRYKAPLVQSAFTQGQRILGK

Sequences:

>Translated_265_residues
MSKILITGAGSGLGKASSIALARRGHKVYATTHRKSQAENLKDIALKENISKNIESFKLDITLKEDRDIVKNLDIDALIN
NAAIGDSGSASEVSIDKYKTVFETNVFSALELTQAVFDNMIKKNEGRIIFLSSLSGRIAIPFLSPYTSSKFALEAIVSSL
KEEIKELSDCNINIILIEPGAYKTGFNQKNIDKQFVWMKEKSYFKDKLVKLKKKQYSYFELMEHKSFNSIVNQYIHAIED
ESPKFRYKAPLVQSAFTQGQRILGK
>Mature_264_residues
SKILITGAGSGLGKASSIALARRGHKVYATTHRKSQAENLKDIALKENISKNIESFKLDITLKEDRDIVKNLDIDALINN
AAIGDSGSASEVSIDKYKTVFETNVFSALELTQAVFDNMIKKNEGRIIFLSSLSGRIAIPFLSPYTSSKFALEAIVSSLK
EEIKELSDCNINIILIEPGAYKTGFNQKNIDKQFVWMKEKSYFKDKLVKLKKKQYSYFELMEHKSFNSIVNQYIHAIEDE
SPKFRYKAPLVQSAFTQGQRILGK

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7657478, Length=270, Percent_Identity=28.5185185185185, Blast_Score=98, Evalue=7e-21,
Organism=Homo sapiens, GI22507405, Length=265, Percent_Identity=27.5471698113208, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI150247226, Length=262, Percent_Identity=27.0992366412214, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=30.1507537688442, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI223718074, Length=194, Percent_Identity=28.8659793814433, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI40548397, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI214010158, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI214010156, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22758144, Length=267, Percent_Identity=29.2134831460674, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI50726952, Length=261, Percent_Identity=27.2030651340996, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI157739938, Length=174, Percent_Identity=28.1609195402299, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI44680136, Length=271, Percent_Identity=25.4612546125461, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI44680133, Length=271, Percent_Identity=25.4612546125461, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI17738292, Length=271, Percent_Identity=25.4612546125461, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19743808, Length=264, Percent_Identity=25.7575757575758, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI142976729, Length=190, Percent_Identity=27.3684210526316, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI210032110, Length=193, Percent_Identity=25.9067357512953, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI119392083, Length=267, Percent_Identity=25.4681647940075, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI7706318, Length=169, Percent_Identity=27.2189349112426, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI109715829, Length=201, Percent_Identity=26.865671641791, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI32455239, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI5031765, Length=193, Percent_Identity=29.0155440414508, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4503817, Length=204, Percent_Identity=22.5490196078431, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786701, Length=260, Percent_Identity=29.2307692307692, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787526, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787820, Length=187, Percent_Identity=26.2032085561497, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787335, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788459, Length=192, Percent_Identity=29.1666666666667, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=207, Percent_Identity=25.6038647342995, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193210355, Length=259, Percent_Identity=29.7297297297297, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71997402, Length=194, Percent_Identity=32.4742268041237, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17570069, Length=194, Percent_Identity=30.4123711340206, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17557780, Length=264, Percent_Identity=24.6212121212121, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32563809, Length=268, Percent_Identity=24.2537313432836, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17507613, Length=268, Percent_Identity=24.2537313432836, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534660, Length=266, Percent_Identity=24.812030075188, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=211, Percent_Identity=31.7535545023697, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=195, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=169, Percent_Identity=30.1775147928994, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=196, Percent_Identity=26.530612244898, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=195, Percent_Identity=37.4358974358974, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322067, Length=179, Percent_Identity=29.608938547486, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358495, Length=189, Percent_Identity=30.6878306878307, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24580925, Length=198, Percent_Identity=30.8080808080808, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=28.735632183908, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640492, Length=193, Percent_Identity=26.9430051813472, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=29.4797687861272, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281364494, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571526, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29819; Mature: 29687

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILITGAGSGLGKASSIALARRGHKVYATTHRKSQAENLKDIALKENISKNIESFKLD
CCEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHEEEE
ITLKEDRDIVKNLDIDALINNAAIGDSGSASEVSIDKYKTVFETNVFSALELTQAVFDNM
EEECCCHHHHHCCCHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKNEGRIIFLSSLSGRIAIPFLSPYTSSKFALEAIVSSLKEEIKELSDCNINIILIEPG
HHCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
AYKTGFNQKNIDKQFVWMKEKSYFKDKLVKLKKKQYSYFELMEHKSFNSIVNQYIHAIED
CCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ESPKFRYKAPLVQSAFTQGQRILGK
CCCCEEEECHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
SKILITGAGSGLGKASSIALARRGHKVYATTHRKSQAENLKDIALKENISKNIESFKLD
CEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHEEEE
ITLKEDRDIVKNLDIDALINNAAIGDSGSASEVSIDKYKTVFETNVFSALELTQAVFDNM
EEECCCHHHHHCCCHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
IKKNEGRIIFLSSLSGRIAIPFLSPYTSSKFALEAIVSSLKEEIKELSDCNINIILIEPG
HHCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
AYKTGFNQKNIDKQFVWMKEKSYFKDKLVKLKKKQYSYFELMEHKSFNSIVNQYIHAIED
CCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ESPKFRYKAPLVQSAFTQGQRILGK
CCCCEEEECHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377; 8396117 [H]