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The map label for this gene is codB [H]

Identifier: 153936526

GI number: 153936526

Start: 2138804

End: 2140075

Strand: Reverse

Name: codB [H]

Synonym: CLC_2016

Alternate gene names: 153936526

Gene position: 2140075-2138804 (Counterclockwise)

Preceding gene: 153937366

Following gene: 153935042

Centisome position: 56.91

GC content: 30.11

Gene sequence:

>1272_bases
ATGAGTAAAAAACAACATGTAGACAAAGATTATTCATTTGAATCAGTAAAGGAAAAGGATAAGAAAGGATTTATTTCAAT
GTTTGCAGTTATGCTAGGCTTTACATTTTTCTCAGCTAGTATGCTTACAGGTGGAAATTTAGGAGTAGCACTATCAATAA
AAGATTTTGCTTTAGCTGTATTTTTAGGAAATTTAATATTAGCAATTTATACAGGAGCACTGGCATATATAGGAGCAGAT
ACGGGACTTTCAATGCATTTATTAGCAAGATATTCTTTTGGAGAAAAGGGAGCATATTTACCATCTTTCTTAACAAGTTT
TACTCAAATAGGATGGTTTGGAGTTGGGGTTGCTATGTTTGCAATACCAGTAAGTAAAATAACAGGAATAAATATATATT
TATTAGTAGCAGTATCAGGATTATTAATGACTTCAACAGCATACTTTGGAATGAAATCTTTAACCATATTAAGTGTAATA
GCAGTGCCAGCCATAACATTGTTAGGATGTGCATCAATGTTTAGAGCTGTAAACGCAATAGGAGGTGCTTCACAATTATT
AAATATAGCACCGAAAGGAAAAATGGGATTAGTTACAGCAGTAACCTTATGTGTAGGATCTTTTATAAGTGGAGGAAGTA
CAACACCAGACTTTGTAAGATTTGCAAAAAATAAAAAGATTGCAGTAACAACAACAGTAGTAGCTTTTTTCATAGGTAAT
TCATTAATGTTTTTATTTGGAGCTATAGGAGCAATGGCTACAGGATATTCAGATATATCAGATGTTATGATATCACAAGG
ACTTATAATACCAGCAATATTAGCATTAGGATTAAACATATGGACAACTAATGACAATGCTATATATACATCAGGACTTG
GAATTTCAAATATAACAAAAATTCCTAAAAGTAAGGTGGTAATTTTTAATGGAATACTGGGTACTATAGGTGCTTTATGG
TTATATAATAATTTTGTAAGTTTTTTAAGTTTATTAGGAGCAATGATTCCAGCAGTTGGAGGAATAATAATAGCTGATTA
TTTCTTTGTAAGAAAAAGAAAATACGAAAGTCTTAAAGAAGCTAATTTTAAAGTGATAAATTATAAAGCTATAGGAGCTT
GTATATTAGGAATATTAGCTGGAAAATATTTAACTGTAGGAATTCCGTCAATAAATTCATTAATTATAACAGGAGTAATA
CATATTATATTAGAAAAAGCTATCAAAGAAAAAACACAAAAAAATGTACAGTGTGATGAGTACGCTGCTTAA

Upstream 100 bases:

>100_bases
TTACGACCTTTTATAGAAATATAAAAGGTCTTTTTTATTAATCAAAATCAACCTTGAATGAAAAATTGTACTAGTTCTCC
TTAAAAAAGGAGGAAGGTTT

Downstream 100 bases:

>100_bases
TATTAAGATGATTTTTTAGTGATATTAATAAGAGGGTGAATATATGTTAATAAAAAATGTTAAACTTACAGATAAAAATG
AATTAGTTAATATAAGAATT

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSKKQHVDKDYSFESVKEKDKKGFISMFAVMLGFTFFSASMLTGGNLGVALSIKDFALAVFLGNLILAIYTGALAYIGAD
TGLSMHLLARYSFGEKGAYLPSFLTSFTQIGWFGVGVAMFAIPVSKITGINIYLLVAVSGLLMTSTAYFGMKSLTILSVI
AVPAITLLGCASMFRAVNAIGGASQLLNIAPKGKMGLVTAVTLCVGSFISGGSTTPDFVRFAKNKKIAVTTTVVAFFIGN
SLMFLFGAIGAMATGYSDISDVMISQGLIIPAILALGLNIWTTNDNAIYTSGLGISNITKIPKSKVVIFNGILGTIGALW
LYNNFVSFLSLLGAMIPAVGGIIIADYFFVRKRKYESLKEANFKVINYKAIGACILGILAGKYLTVGIPSINSLIITGVI
HIILEKAIKEKTQKNVQCDEYAA

Sequences:

>Translated_423_residues
MSKKQHVDKDYSFESVKEKDKKGFISMFAVMLGFTFFSASMLTGGNLGVALSIKDFALAVFLGNLILAIYTGALAYIGAD
TGLSMHLLARYSFGEKGAYLPSFLTSFTQIGWFGVGVAMFAIPVSKITGINIYLLVAVSGLLMTSTAYFGMKSLTILSVI
AVPAITLLGCASMFRAVNAIGGASQLLNIAPKGKMGLVTAVTLCVGSFISGGSTTPDFVRFAKNKKIAVTTTVVAFFIGN
SLMFLFGAIGAMATGYSDISDVMISQGLIIPAILALGLNIWTTNDNAIYTSGLGISNITKIPKSKVVIFNGILGTIGALW
LYNNFVSFLSLLGAMIPAVGGIIIADYFFVRKRKYESLKEANFKVINYKAIGACILGILAGKYLTVGIPSINSLIITGVI
HIILEKAIKEKTQKNVQCDEYAA
>Mature_422_residues
SKKQHVDKDYSFESVKEKDKKGFISMFAVMLGFTFFSASMLTGGNLGVALSIKDFALAVFLGNLILAIYTGALAYIGADT
GLSMHLLARYSFGEKGAYLPSFLTSFTQIGWFGVGVAMFAIPVSKITGINIYLLVAVSGLLMTSTAYFGMKSLTILSVIA
VPAITLLGCASMFRAVNAIGGASQLLNIAPKGKMGLVTAVTLCVGSFISGGSTTPDFVRFAKNKKIAVTTTVVAFFIGNS
LMFLFGAIGAMATGYSDISDVMISQGLIIPAILALGLNIWTTNDNAIYTSGLGISNITKIPKSKVVIFNGILGTIGALWL
YNNFVSFLSLLGAMIPAVGGIIIADYFFVRKRKYESLKEANFKVINYKAIGACILGILAGKYLTVGIPSINSLIITGVIH
IILEKAIKEKTQKNVQCDEYAA

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=413, Percent_Identity=55.2058111380145, Blast_Score=420, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 44968; Mature: 44837

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
SKKQHVDKDYSFESVKEKDKKGFISMFAVMLGFTFFSASMLTGGNLGVALSIKDFALAV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHH
FLGNLILAIYTGALAYIGADTGLSMHLLARYSFGEKGAYLPSFLTSFTQIGWFGVGVAMF
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AIPVSKITGINIYLLVAVSGLLMTSTAYFGMKSLTILSVIAVPAITLLGCASMFRAVNAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGASQLLNIAPKGKMGLVTAVTLCVGSFISGGSTTPDFVRFAKNKKIAVTTTVVAFFIGN
CCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHH
SLMFLFGAIGAMATGYSDISDVMISQGLIIPAILALGLNIWTTNDNAIYTSGLGISNITK
HHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCEEEECCCCHHHHHH
IPKSKVVIFNGILGTIGALWLYNNFVSFLSLLGAMIPAVGGIIIADYFFVRKRKYESLKE
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANFKVINYKAIGACILGILAGKYLTVGIPSINSLIITGVIHIILEKAIKEKTQKNVQCDE
CCCEEEEHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
YAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]