Click here to switch to the map view.

The map label for this gene is yvrG [H]

Identifier: 153935811

GI number: 153935811

Start: 1042274

End: 1043695

Strand: Direct

Name: yvrG [H]

Synonym: CLC_1025

Alternate gene names: 153935811

Gene position: 1042274-1043695 (Clockwise)

Preceding gene: 153936363

Following gene: 153934563

Centisome position: 27.72

GC content: 24.89

Gene sequence:

>1422_bases
ATGAAAAATAATATGAAGTGGAGAATTACAGGCAGATTTTTAGTAACAGTTATTTGCGTAGTTATAACTGTAGTCATAAT
AAATATTGTATCTTTAATTGGACTCGCAATTTATAGAAATGCTAATGAGATTAGTTCTAAAAAGTATAAAATTGAAGATT
CAGTTAGAAATTTTTCTTCGAATATTAAAGAAGCAGATAATAAAATATATATTGATGATAAAGGCAAAGCTATATTAGAT
AGTAACAATGGTTGGATACAGATTATAGATGCTAACAATAATGAAGTTTATAGCTATAAAAAACCTTCTTATATAAAAAA
TAAACCTACCGCTGCAGAAATAGTAAATTTACATAAATATAAAACTTCTGATAAGGGAAGTGAATTATCTACTAATTTTG
TAGCTGAAAAAAATATAGGAAATAAAAGATTAACTTATATTATGGGACTTCAGAATAATGATATAAATAAATACGTAGTC
ACTACTAAAAACTCAGAAGTAATCCAACTTATAAAATCTGCCACAATAATAATTATTATAGTAGACGGGATTATAGCTTT
AATTTTTGGATATCTTTTTATTAGAAAATTAACTAATCCTTTAGGAGAGATATTATTAGGCATAAAAAAATTAGAAAATG
AGGAATATGATTTATACTATGAAGCTAAAGGAATGTATAATGATTTATATTATAGCTTAAATAATTTATCAGATAGATTA
CAAGAAAATAAAAGGAATAGAAAAAAGCTAGATAATATGAGAGAAGAATGGATTTCAAACATTTCTCATGATATAAAAAC
TCCATTAGCTTCTATCCAAGGTTATGCAGAAATAATAAAAGATGAAGACTATGATTTTACAAAAGAGGAAATAGGAGAGT
ACGCTGAAATCATAGAAAATAAATCTAAATATATTAAGGAATTAGTAGAAGATTTAAATTTATCTACTAGATTAAAAAAT
AATACTTTAACTTTAAATAAGGAAAAGATTAATCTAGTTAATTTAATAAAGGACATTATAATAGATATATTAAATGATAC
CAGATATGAAAATAGGGAAATAGATTTTCACTGTGAGAATGACAATATTGAAATAAATGGAGACAGAATTCTTATAAGAA
GAGCTATAATTAATATTTTATTTAATGCCATTGTGCACAATAGTGAAGATGTAAAGATAAATGTTACACTAAAAAAACAG
GATAAGATAAGTATAATTATTGAAGACAATGGTAGGGGAATAAAAGGAGAAGAGTTAAATAGAATTTTTGATAGATATTA
TAGAGGAACTAATACAGGAGAGAGACATAAAGGTTCTGGATTAGGAATGGCTATATCAAAAGAAACAATTGTTGCCCATG
GAGGGGATATAACTATTGAAAGTGAACTAGGCAAAGGAACCAAAGTAAATATATTAATATAA

Upstream 100 bases:

>100_bases
GTCCACATTAGAAGACTTAGAGAAAAAATTGAAAAGGAACCATCAAGACCAGAGTATTTAATAAATGTTAAAGGTTTAGG
ATACAAATTGGTGATAAAAA

Downstream 100 bases:

>100_bases
TTAAGAAAATAAATATCTATAAAAATAAATAGAATACTTTATTTGTGGACTAATATTTAAACGTGAAGTAAACATAGTAT
TTACTTAGGACTGCTCCACA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKNNMKWRITGRFLVTVICVVITVVIINIVSLIGLAIYRNANEISSKKYKIEDSVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKGSELSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTKNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLVNLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI

Sequences:

>Translated_473_residues
MKNNMKWRITGRFLVTVICVVITVVIINIVSLIGLAIYRNANEISSKKYKIEDSVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKGSELSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTKNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLVNLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
>Mature_473_residues
MKNNMKWRITGRFLVTVICVVITVVIINIVSLIGLAIYRNANEISSKKYKIEDSVRNFSSNIKEADNKIYIDDKGKAILD
SNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKYKTSDKGSELSTNFVAEKNIGNKRLTYIMGLQNNDINKYVV
TTKNSEVIQLIKSATIIIIIVDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIENKSKYIKELVEDLNLSTRLKN
NTLTLNKEKINLVNLIKDIIIDILNDTRYENREIDFHCENDNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQ
DKISIIIEDNGRGIKGEELNRIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon. Probably activates yv

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.0701754385965, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=25.3246753246753, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=23.758865248227, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=27.5303643724696, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=23.1404958677686, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=24.8031496062992, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=25.5411255411255, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=25.8771929824561, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=336, Percent_Identity=20.2380952380952, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=24.6808510638298, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=22.6027397260274, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=25.7918552036199, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=301, Percent_Identity=22.5913621262458, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=214, Percent_Identity=28.5046728971963, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790346, Length=211, Percent_Identity=24.6445497630332, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=23.8907849829352, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=208, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54260; Mature: 54260

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNMKWRITGRFLVTVICVVITVVIINIVSLIGLAIYRNANEISSKKYKIEDSVRNFSS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEHHHHHHHHHH
NIKEADNKIYIDDKGKAILDSNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKY
HHHHCCCEEEEECCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHC
KTSDKGSELSTNFVAEKNIGNKRLTYIMGLQNNDINKYVVTTKNSEVIQLIKSATIIIII
CCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHCCEEEEEE
VDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
KSKYIKELVEDLNLSTRLKNNTLTLNKEKINLVNLIKDIIIDILNDTRYENREIDFHCEN
HHHHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
DNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQDKISIIIEDNGRGIKGEELN
CCEEECCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHH
RIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
HHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEECCCEEEECCCCCCCEEEEEC
>Mature Secondary Structure
MKNNMKWRITGRFLVTVICVVITVVIINIVSLIGLAIYRNANEISSKKYKIEDSVRNFSS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEHHHHHHHHHH
NIKEADNKIYIDDKGKAILDSNNGWIQIIDANNNEVYSYKKPSYIKNKPTAAEIVNLHKY
HHHHCCCEEEEECCCCEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHC
KTSDKGSELSTNFVAEKNIGNKRLTYIMGLQNNDINKYVVTTKNSEVIQLIKSATIIIII
CCCCCCCCCCCCEEEECCCCCCEEEEEEEECCCCCCEEEEEECCHHHHHHHHCCEEEEEE
VDGIIALIFGYLFIRKLTNPLGEILLGIKKLENEEYDLYYEAKGMYNDLYYSLNNLSDRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QENKRNRKKLDNMREEWISNISHDIKTPLASIQGYAEIIKDEDYDFTKEEIGEYAEIIEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
KSKYIKELVEDLNLSTRLKNNTLTLNKEKINLVNLIKDIIIDILNDTRYENREIDFHCEN
HHHHHHHHHHHCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECC
DNIEINGDRILIRRAIINILFNAIVHNSEDVKINVTLKKQDKISIIIEDNGRGIKGEELN
CCEEECCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHH
RIFDRYYRGTNTGERHKGSGLGMAISKETIVAHGGDITIESELGKGTKVNILI
HHHHHHHCCCCCCCCCCCCCCEEEEECCEEEEECCCEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]