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The map label for this gene is mutS [H]

Identifier: 153935795

GI number: 153935795

Start: 2050428

End: 2051993

Strand: Direct

Name: mutS [H]

Synonym: CLC_1932

Alternate gene names: 153935795

Gene position: 2050428-2051993 (Clockwise)

Preceding gene: 153934872

Following gene: 153936138

Centisome position: 54.52

GC content: 27.52

Gene sequence:

>1566_bases
TTGAATAAAAAGGTAGCTTTAAATTGGGCAAAAACACAGTATGAAGAAGGTGATGAAAAGGATAGAAAGTTTAAAAATAT
AAGAAAATTTTTTGATATGAAAGAAAAACAGGATTATACCATTGATGATGAAACCTGGTCAGATATGGATATGGATAGAG
TCTATGGAAAATTAGATAGAAATTCTAGTACTTTAGGAGAGTCTGTTTTATATCATATGCTTAGAAATCCCCTAAGGGAT
GAGGAAAAATTAAAGGATAGGAATAAGTTAATTCAATCATTTAAAGAGGATATGAAATTAAGAGAACAGCTTTTAATTAC
ATACTACCAATTAGGTAGAGATAGAAAAAATACCTTTTTAGAGATGATAGAAAGTGAACTAGTAGTAAATAAAATGAAAT
ATTATTTATACACAATATTAGGAAAAATATTTCCTTTAATAGCTATATTATTTACTATATTTGTAGATGAAAGTTATGCT
AAATATATAGCTATTTCTGCTGCTTTAAATATGTCTGTTAATTATATGGAAAGAAATACAATAAAATCTAGAGGAATTAT
ATATTTAAGAGGAATTATAAAAGCAGCTAAAAAAATAGCTAGTATAAAAAATAATGAACTTAGTTATTATGCAGATAATA
TAAATAATAATCTTAAAGAAGTAAAATCTATTGATAGAGGCACTTTTTTAATAGGTTTTGTAAATATGTGGCAAGGTTTA
TTTGAGGCTATATGTGTAATATTTTTAATTGAAGAGTGCGCTTATTATAAAGTATCTGAGGTTTTAAAATACAAAAAAGA
ACACATAATGAATATATTTTATATTCTAGGTGAACTAGAAGCGCTATTATCTATATCTGGGTATCAAAAGAACTTAAAGG
AGTACTATGTAAATCCAATTTTTACAAAGGAAGTCTCTTTAGATATTAAAGAGGGAATTCATCCCCTTTTAGATAAACCC
GTAGCAAATTCTATTTCTATTAAAGATAAGGGTATAGTACTTACAGGTACAAATATGTCTGGTAAATCAACCTTTTTAAG
AATGCTAGGCATAAACATACTATTATCACAAACCTTTTATTTTGCATTAGCTAAAGAATATAAGGCTTCTTTTTTCAATA
TAGTATCCTCTATTAGTCCTAATGATGACCTATCAAAGGGAAAAAGTTACTATATGGCTGAAGCAGAAGGAATACTTAGA
ATAGTTAAAGCGCTAGAAAAAGATTTACCTGTATTCTGCCCTATAGATGAGATATTTAGAGGAACAAATCCTATTGAGAG
AATAGCTATGTCAGCAGAAATACTTTCTTATCTTCAAAATGGAAGAACAGTCTCTATTGTAGCTACTCACGATAGAGAAT
TAGTAGATATTTTAAAGGATAGTTACGAGTTTTATTATTTCAGCGAATCCGTTGATAGTAAAAATGGATTAAACTTTGAT
TATAAGCTAAAGGTTGGAGTTTCTAATACAAGAAATGCCATAAGACTTTTAGAATATATTGGCTATCCAAAGGAAGTAAC
TAAAAAAGCCTATAAACGAGCTGAAACTATTAAAGGATTTATCTAA

Upstream 100 bases:

>100_bases
ATAAAATGTAAAAAACTAATATTAAGTCATAAAATACATGTTAAAATATTATTATATAGAATTTTTATATTTCATATTCA
AAATTGAAAGGAGAGCGAAA

Downstream 100 bases:

>100_bases
CTTATCATAGTATACTATATTTTAATACAGTATTAAAAATAGTATTTTCAGTATATAAGTTAAAAATTTAAAACTATGTA
ATGATTACTCTTAAATTAAT

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MNKKVALNWAKTQYEEGDEKDRKFKNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLRD
EEKLKDRNKLIQSFKEDMKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAILFTIFVDESYA
KYIAISAALNMSVNYMERNTIKSRGIIYLRGIIKAAKKIASIKNNELSYYADNINNNLKEVKSIDRGTFLIGFVNMWQGL
FEAICVIFLIEECAYYKVSEVLKYKKEHIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKP
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI

Sequences:

>Translated_521_residues
MNKKVALNWAKTQYEEGDEKDRKFKNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLRD
EEKLKDRNKLIQSFKEDMKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAILFTIFVDESYA
KYIAISAALNMSVNYMERNTIKSRGIIYLRGIIKAAKKIASIKNNELSYYADNINNNLKEVKSIDRGTFLIGFVNMWQGL
FEAICVIFLIEECAYYKVSEVLKYKKEHIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKP
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI
>Mature_521_residues
MNKKVALNWAKTQYEEGDEKDRKFKNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDRNSSTLGESVLYHMLRNPLRD
EEKLKDRNKLIQSFKEDMKLREQLLITYYQLGRDRKNTFLEMIESELVVNKMKYYLYTILGKIFPLIAILFTIFVDESYA
KYIAISAALNMSVNYMERNTIKSRGIIYLRGIIKAAKKIASIKNNELSYYADNINNNLKEVKSIDRGTFLIGFVNMWQGL
FEAICVIFLIEECAYYKVSEVLKYKKEHIMNIFYILGELEALLSISGYQKNLKEYYVNPIFTKEVSLDIKEGIHPLLDKP
VANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFYFALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILR
IVKALEKDLPVFCPIDEIFRGTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. Binds double-stranded DNA [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=275, Percent_Identity=30.5454545454545, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI284813531, Length=255, Percent_Identity=22.3529411764706, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557761, Length=271, Percent_Identity=24.3542435424354, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789089, Length=276, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=254, Percent_Identity=26.3779527559055, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=270, Percent_Identity=29.2592592592593, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319935, Length=259, Percent_Identity=25.4826254826255, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=221, Percent_Identity=23.9819004524887, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584320, Length=252, Percent_Identity=25, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 60503; Mature: 60503

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKVALNWAKTQYEEGDEKDRKFKNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDR
CCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
NSSTLGESVLYHMLRNPLRDEEKLKDRNKLIQSFKEDMKLREQLLITYYQLGRDRKNTFL
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EMIESELVVNKMKYYLYTILGKIFPLIAILFTIFVDESYAKYIAISAALNMSVNYMERNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHH
IKSRGIIYLRGIIKAAKKIASIKNNELSYYADNINNNLKEVKSIDRGTFLIGFVNMWQGL
HHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
FEAICVIFLIEECAYYKVSEVLKYKKEHIMNIFYILGELEALLSISGYQKNLKEYYVNPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FTKEVSLDIKEGIHPLLDKPVANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFY
EEHHCCCCHHHCCHHHHCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILRIVKALEKDLPVFCPIDEIFR
HHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEE
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI
EEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKKVALNWAKTQYEEGDEKDRKFKNIRKFFDMKEKQDYTIDDETWSDMDMDRVYGKLDR
CCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
NSSTLGESVLYHMLRNPLRDEEKLKDRNKLIQSFKEDMKLREQLLITYYQLGRDRKNTFL
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
EMIESELVVNKMKYYLYTILGKIFPLIAILFTIFVDESYAKYIAISAALNMSVNYMERNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHH
IKSRGIIYLRGIIKAAKKIASIKNNELSYYADNINNNLKEVKSIDRGTFLIGFVNMWQGL
HHHCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCHHHHHHHCCCCHHHHHHHHHHHHH
FEAICVIFLIEECAYYKVSEVLKYKKEHIMNIFYILGELEALLSISGYQKNLKEYYVNPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
FTKEVSLDIKEGIHPLLDKPVANSISIKDKGIVLTGTNMSGKSTFLRMLGINILLSQTFY
EEHHCCCCHHHCCHHHHCCCCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FALAKEYKASFFNIVSSISPNDDLSKGKSYYMAEAEGILRIVKALEKDLPVFCPIDEIFR
HHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHC
GTNPIERIAMSAEILSYLQNGRTVSIVATHDRELVDILKDSYEFYYFSESVDSKNGLNFD
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEE
YKLKVGVSNTRNAIRLLEYIGYPKEVTKKAYKRAETIKGFI
EEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8604304; 9722634 [H]