Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 153935337

GI number: 153935337

Start: 2424591

End: 2425940

Strand: Reverse

Name: ffh [H]

Synonym: CLC_2297

Alternate gene names: 153935337

Gene position: 2425940-2424591 (Counterclockwise)

Preceding gene: 153935263

Following gene: 153934843

Centisome position: 64.51

GC content: 32.59

Gene sequence:

>1350_bases
ATGGCCTTTGATGGATTAGCTTCTAAACTTCAGGATGCTTTAAAGAAGCTTAGAGGTAAAGGTAAGCTTTCAGAAAAAGA
TATAAAAGAAGCCATGAGAGAAGTAAAACTTGCATTATTAGAAGCAGATGTTAACTATAAAGTTGTTAAGAACTTTATAA
AAAGTGTTACTGAAAAATGCATGGGTAACGAAGTACTTGAAAGTTTAACACCAGGTCAACAGGTTATAAAGATAGTAAAC
GAAGAGTTAACAGAGCTTATGGGAAGTACAGAAAGTACTTTGAATTCTTCCACTTCAGGACTAACAGTTATAATGCTGGT
AGGTCTTCAAGGGGCAGGAAAAACTACTATGGCAGGAAAACTTGCTCTTCACCTTAGAAAGAGAAATAAAAGACCTTTAC
TTGTAGCCTGTGACGTATATAGACCAGCAGCTATAAAACAACTTCAAGTAGTTGGTAAACAAATTGATATTCCAGTTTTT
ACTATGGGGGATAAATTAAATCCTGTGGATATATCTAAAGCTGCTATAGAGCATGCTAAAAATAACAAGAATAATGTAGT
TATAATAGATACAGCAGGAAGGCTTCATATAGATGAAGAACTTATGGATGAGCTTCATAATATAAAGGAAGAAGTAAATC
CAAGTGAAATACTATTAGTAGTAGATGCTATGACTGGGCAAGATGCTGTAAATGTAGCTAATAATTTTAATGATAAACTA
GATATAAGTGGTGTAATACTTACAAAATTAGATGGGGACACAAGAGGTGGAGCTGCCCTTTCTATTAAATCTATGACAGG
TAAGCCTATAAAATTTGTAGGTTTAGGGGAAAAGATGAATGATTTAGAAGTATTTTACCCAGATAGAATGGCTTCAAGAA
TACTTGGCATGGGAGATGTACTTTCTTTAATTGAAAAAGCACAACAATCTATAGATGAGGAGAAAGCTAAAGAAATTGGA
GAGAGGATGTTAAATCAAGAATTTAACTTTGAAGATTTCTTAGAGTCCATGCAACAGATGAAGAAATTAGGTCCGATTAA
CAAGTTATTAGAAATGATTCCAGGAATGAATTCCAAAGAATTAAAAAACATAGATCTAAGTTCTAGTGAAAAAGAAATGA
AAAAAACAGAAGCTATAATTAGTTCAATGACTATAAAAGAGAGAAGAAACCCTTCATTAATATCTTCCTCACCTTCTAGA
AAAAGAAGGATAGCAAAGGGGTCAGGGACAAATGTTCAGCATGTAAATAAGCTTCTTAAGGATTTTCAAGCTTCTAAAAA
AATGATGAAGCAAATGAAAGGCATGGAAAAAGGATTTAAAAAAGGTTTATTTGGTAAATTACCATTTTAA

Upstream 100 bases:

>100_bases
AAAACTATTAAATATGTTAAATAAAGTGACAAAAGAAAATATAAAAGAAATTGATCATATAAAAAAATATATAATTGATA
ATATTTAGGAGTGGATTATA

Downstream 100 bases:

>100_bases
ATAAATAGATTTTTAAAGGAGGTGAAAAACATGGCAGTAAAGATGAGATTAAAAAGAATGGGTGCTAAAAAAGCTCCATT
TTACAGAGTAGTTGTTGCTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAFDGLASKLQDALKKLRGKGKLSEKDIKEAMREVKLALLEADVNYKVVKNFIKSVTEKCMGNEVLESLTPGQQVIKIVN
EELTELMGSTESTLNSSTSGLTVIMLVGLQGAGKTTMAGKLALHLRKRNKRPLLVACDVYRPAAIKQLQVVGKQIDIPVF
TMGDKLNPVDISKAAIEHAKNNKNNVVIIDTAGRLHIDEELMDELHNIKEEVNPSEILLVVDAMTGQDAVNVANNFNDKL
DISGVILTKLDGDTRGGAALSIKSMTGKPIKFVGLGEKMNDLEVFYPDRMASRILGMGDVLSLIEKAQQSIDEEKAKEIG
ERMLNQEFNFEDFLESMQQMKKLGPINKLLEMIPGMNSKELKNIDLSSSEKEMKKTEAIISSMTIKERRNPSLISSSPSR
KRRIAKGSGTNVQHVNKLLKDFQASKKMMKQMKGMEKGFKKGLFGKLPF

Sequences:

>Translated_449_residues
MAFDGLASKLQDALKKLRGKGKLSEKDIKEAMREVKLALLEADVNYKVVKNFIKSVTEKCMGNEVLESLTPGQQVIKIVN
EELTELMGSTESTLNSSTSGLTVIMLVGLQGAGKTTMAGKLALHLRKRNKRPLLVACDVYRPAAIKQLQVVGKQIDIPVF
TMGDKLNPVDISKAAIEHAKNNKNNVVIIDTAGRLHIDEELMDELHNIKEEVNPSEILLVVDAMTGQDAVNVANNFNDKL
DISGVILTKLDGDTRGGAALSIKSMTGKPIKFVGLGEKMNDLEVFYPDRMASRILGMGDVLSLIEKAQQSIDEEKAKEIG
ERMLNQEFNFEDFLESMQQMKKLGPINKLLEMIPGMNSKELKNIDLSSSEKEMKKTEAIISSMTIKERRNPSLISSSPSR
KRRIAKGSGTNVQHVNKLLKDFQASKKMMKQMKGMEKGFKKGLFGKLPF
>Mature_448_residues
AFDGLASKLQDALKKLRGKGKLSEKDIKEAMREVKLALLEADVNYKVVKNFIKSVTEKCMGNEVLESLTPGQQVIKIVNE
ELTELMGSTESTLNSSTSGLTVIMLVGLQGAGKTTMAGKLALHLRKRNKRPLLVACDVYRPAAIKQLQVVGKQIDIPVFT
MGDKLNPVDISKAAIEHAKNNKNNVVIIDTAGRLHIDEELMDELHNIKEEVNPSEILLVVDAMTGQDAVNVANNFNDKLD
ISGVILTKLDGDTRGGAALSIKSMTGKPIKFVGLGEKMNDLEVFYPDRMASRILGMGDVLSLIEKAQQSIDEEKAKEIGE
RMLNQEFNFEDFLESMQQMKKLGPINKLLEMIPGMNSKELKNIDLSSSEKEMKKTEAIISSMTIKERRNPSLISSSPSRK
RRIAKGSGTNVQHVNKLLKDFQASKKMMKQMKGMEKGFKKGLFGKLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=32.7354260089686, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI226371618, Length=383, Percent_Identity=32.6370757180157, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=38.6206896551724, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI23308697, Length=300, Percent_Identity=27, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI295424842, Length=300, Percent_Identity=27, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=50, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=34.8484848484849, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=447, Percent_Identity=29.7539149888143, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=29.5918367346939, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=405, Percent_Identity=34.0740740740741, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=27.4447949526814, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17647949, Length=445, Percent_Identity=32.3595505617978, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24641198, Length=300, Percent_Identity=27, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49692; Mature: 49561

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDGLASKLQDALKKLRGKGKLSEKDIKEAMREVKLALLEADVNYKVVKNFIKSVTEKC
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MGNEVLESLTPGQQVIKIVNEELTELMGSTESTLNSSTSGLTVIMLVGLQGAGKTTMAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEECCCCCCCHHHHH
LALHLRKRNKRPLLVACDVYRPAAIKQLQVVGKQIDIPVFTMGDKLNPVDISKAAIEHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHC
NNKNNVVIIDTAGRLHIDEELMDELHNIKEEVNPSEILLVVDAMTGQDAVNVANNFNDKL
CCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCE
DISGVILTKLDGDTRGGAALSIKSMTGKPIKFVGLGEKMNDLEVFYPDRMASRILGMGDV
ECCEEEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCCCEEECCHHHHHHHHCHHHH
LSLIEKAQQSIDEEKAKEIGERMLNQEFNFEDFLESMQQMKKLGPINKLLEMIPGMNSKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
LKNIDLSSSEKEMKKTEAIISSMTIKERRNPSLISSSPSRKRRIAKGSGTNVQHVNKLLK
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHH
DFQASKKMMKQMKGMEKGFKKGLFGKLPF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AFDGLASKLQDALKKLRGKGKLSEKDIKEAMREVKLALLEADVNYKVVKNFIKSVTEKC
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
MGNEVLESLTPGQQVIKIVNEELTELMGSTESTLNSSTSGLTVIMLVGLQGAGKTTMAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEECCCCCCCHHHHH
LALHLRKRNKRPLLVACDVYRPAAIKQLQVVGKQIDIPVFTMGDKLNPVDISKAAIEHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHC
NNKNNVVIIDTAGRLHIDEELMDELHNIKEEVNPSEILLVVDAMTGQDAVNVANNFNDKL
CCCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCE
DISGVILTKLDGDTRGGAALSIKSMTGKPIKFVGLGEKMNDLEVFYPDRMASRILGMGDV
ECCEEEEEEECCCCCCCCEEEEECCCCCCEEEEECCCCCCCCEEECCHHHHHHHHCHHHH
LSLIEKAQQSIDEEKAKEIGERMLNQEFNFEDFLESMQQMKKLGPINKLLEMIPGMNSKE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHH
LKNIDLSSSEKEMKKTEAIISSMTIKERRNPSLISSSPSRKRRIAKGSGTNVQHVNKLLK
HCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHH
DFQASKKMMKQMKGMEKGFKKGLFGKLPF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]