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The map label for this gene is vanR [H]

Identifier: 153935275

GI number: 153935275

Start: 1973411

End: 1974112

Strand: Direct

Name: vanR [H]

Synonym: CLC_1866

Alternate gene names: 153935275

Gene position: 1973411-1974112 (Clockwise)

Preceding gene: 153936951

Following gene: 153935269

Centisome position: 52.48

GC content: 27.35

Gene sequence:

>702_bases
TTGCGTACTTACAATGTACTTGTAGTAGATGATGAGAAAGAAATTAGAGATGCTATTGAAATATATTTAAGAAGTATAGA
AAGCATAAATATAATAAAAGCAGCAGATGGATTAGATGCATTAGATATATTAGAAAATAATGAAATTCATGTAATAATAT
TAGATATTATGATGCCTAAATTAGATGGTATAAGAACCTGTATGAAAATAAGAGAAAGAAATAATATTCCTATAATTATG
CTATCTGCTAAAAATGAAGATATAGATAAAATTTTAGGCTTAAACATAGGAGCAGATGATTATATAGCAAAACCTTTTAA
TCCTTTAGAATTAGTAGCAAGAGTCAATTCTCAACTTAGAAGATATACAAATTTAGGCAACTTTCCTAAAACAGCAGATG
ATGATGAAATTTGTATAGATCAATTAGTTATAAATAAAACTAGTCATGTAGTTACTGTAGATGGCAAAAAAGTAAAATTA
ACACCTATAGAATATGATATTCTGCTACTTCTAGCCAATAATCCCGGTAGAGTGTTCCCTTCTTCACAAATATATGAATA
TGTTTGGAATGAACCTTCTTTTAAAACTGAGAACACAGTAGCAGTGCATATAAGAAGACTAAGAAAAAAAATAGAAATAG
ATCCTAAAGAACCTAAGTATATAAAAGTAATCTGGGGAGTTGGTTATAAAATTGATAAATAG

Upstream 100 bases:

>100_bases
ATAACAAAAATTGATACTATAAAAGGTAGTACAAAAGAACCTTTTAATTTTTTTATGTATAAGAAAAAAGGCTTTATATC
AAAAATGGGGGGGAATTAGT

Downstream 100 bases:

>100_bases
CATTAAAGATCAAGATAGATTAAAAAAACTATTAGGCAAAAATATAATTGTAATATTCTTAATTATTTTATCACTATTGT
TTGGTATATTTTTTCTTTTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRTYNVLVVDDEKEIRDAIEIYLRSIESINIIKAADGLDALDILENNEIHVIILDIMMPKLDGIRTCMKIRERNNIPIIM
LSAKNEDIDKILGLNIGADDYIAKPFNPLELVARVNSQLRRYTNLGNFPKTADDDEICIDQLVINKTSHVVTVDGKKVKL
TPIEYDILLLLANNPGRVFPSSQIYEYVWNEPSFKTENTVAVHIRRLRKKIEIDPKEPKYIKVIWGVGYKIDK

Sequences:

>Translated_233_residues
MRTYNVLVVDDEKEIRDAIEIYLRSIESINIIKAADGLDALDILENNEIHVIILDIMMPKLDGIRTCMKIRERNNIPIIM
LSAKNEDIDKILGLNIGADDYIAKPFNPLELVARVNSQLRRYTNLGNFPKTADDDEICIDQLVINKTSHVVTVDGKKVKL
TPIEYDILLLLANNPGRVFPSSQIYEYVWNEPSFKTENTVAVHIRRLRKKIEIDPKEPKYIKVIWGVGYKIDK
>Mature_233_residues
MRTYNVLVVDDEKEIRDAIEIYLRSIESINIIKAADGLDALDILENNEIHVIILDIMMPKLDGIRTCMKIRERNNIPIIM
LSAKNEDIDKILGLNIGADDYIAKPFNPLELVARVNSQLRRYTNLGNFPKTADDDEICIDQLVINKTSHVVTVDGKKVKL
TPIEYDILLLLANNPGRVFPSSQIYEYVWNEPSFKTENTVAVHIRRLRKKIEIDPKEPKYIKVIWGVGYKIDK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.4978165938865, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=35.0877192982456, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=32.5991189427313, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=32.4675324675325, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=34.3612334801762, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=34.5132743362832, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=31.0344827586207, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=32.7510917030568, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=215, Percent_Identity=30.2325581395349, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=28.0172413793103, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1790552, Length=192, Percent_Identity=34.375, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=27.4336283185841, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=25.974025974026, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=31.3725490196078, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26774; Mature: 26774

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTYNVLVVDDEKEIRDAIEIYLRSIESINIIKAADGLDALDILENNEIHVIILDIMMPK
CCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEEEEEECCC
LDGIRTCMKIRERNNIPIIMLSAKNEDIDKILGLNIGADDYIAKPFNPLELVARVNSQLR
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RYTNLGNFPKTADDDEICIDQLVINKTSHVVTVDGKKVKLTPIEYDILLLLANNPGRVFP
HHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEECEEEEEEEECCCCCCCC
SSQIYEYVWNEPSFKTENTVAVHIRRLRKKIEIDPKEPKYIKVIWGVGYKIDK
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEECC
>Mature Secondary Structure
MRTYNVLVVDDEKEIRDAIEIYLRSIESINIIKAADGLDALDILENNEIHVIILDIMMPK
CCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCCCEEEEEEEEECCC
LDGIRTCMKIRERNNIPIIMLSAKNEDIDKILGLNIGADDYIAKPFNPLELVARVNSQLR
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RYTNLGNFPKTADDDEICIDQLVINKTSHVVTVDGKKVKLTPIEYDILLLLANNPGRVFP
HHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCEEEEEEECEEEEEEEECCCCCCCC
SSQIYEYVWNEPSFKTENTVAVHIRRLRKKIEIDPKEPKYIKVIWGVGYKIDK
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]