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The map label for this gene is lysP [H]

Identifier: 89256972

GI number: 89256972

Start: 1633666

End: 1635120

Strand: Reverse

Name: lysP [H]

Synonym: FTL_1703

Alternate gene names: 89256972

Gene position: 1635120-1633666 (Counterclockwise)

Preceding gene: 89256973

Following gene: 89256971

Centisome position: 86.24

GC content: 35.19

Gene sequence:

>1455_bases
ATGTCGCAGAAACTTAAACGTGGCTTACATACTCGTCATATGTCAATGATAGCTCTAGGTGGCTGTATTGGTACTGGTTT
ATTTGTAGCACTTGGTGGAGCAATCGCTGATGCGGGTCCTGGAGGAACTGTCTTGGCGTATGTTATTATAGCTATAATGG
TTTATTTCTTGATGGCGAGTCTTGGCGAAATGGCTGCGCATAGCCCTGTTAGTGGCACATTTTGTGAATATGCTACGCGC
TATGTTGATTCAGCGTTAGGCTTTAGTACCGGTTGGAGTTATTGGTTTAATTGGGCAATTACAGTTGCTACAGAGGTTAT
TGCCGCAGCGTTAATTATGCAGTATTGGTTTCCAGGTAGTTCAATTCTGTTGTGGAGTGGATTTTTCTTTGTACTAGTTT
TTGCTTTGAATATCTTCTCAGTAAAAATATATGGTGAAGTTGAATATTGGTTATCTTTTATAAAAGTTTCTACAGTTATT
ATATTTATAATTGTTGGTTTCTTATCAATACTTGGTTTAGTAGGTAATCACCAAAGTGTTGGTTTTCAGAACTGGCATAT
CGGAGATGCTCCTTTTCATAATGGTTGGTGGGGCTTTATATCAGTATTCATGATTGCTGGATTTTCTTTCCAAGGTAGTG
AGCTTATAGGTGTAACAGCTGGGGAAGCGAAAGATCCAAATACATCTATACCAAAAGCAATCAAACAAACATTTTGGCGT
TTATTTATATTTTATATACTTGCTGTAGTGATTATTAGCTTCTTGATTCCATACAATAATCCATCTTTGATAAAAGTTGG
AGCAAGTAATGATGTTTCAGTTAGTCCATTTACAATAGTTTTTGAAAACGTTGGTTTGAATTCAGCGGCAACTATTATGA
ATGTAATTATATTAACTGCGATAATATCTGCATGTAATGCAAGTATGTATAGTGCGACAAGGGTACTATGGCATTTAGGT
AACATTAAGCAAGCCCCGCAGTTTTTTGCAACTACTAATTCAAAAGGTACGCCAATGATTGCTCTTTTGGTTACAGCAGT
TATAGGCTCGTCATTCTTCTTTGTATCTTTTGTTGGTAGTGGATATATATTTACATGGTTAGTCAACGTTTCAAGTTTAG
CGGGATTTATTGCATGGTTTACAATTGCACTTAGTCACTATCGTTTTAGAAGAGCATATATAAAGCAGGGTAAAAGCTTA
GAAGATTTACCATATGTAGCAAAGTTTTTCCCATGGGCGCCTATTATTGCTTTAACTATGGTAAGTATAGTAATCGTTGG
TCAAGGTGTTACAATGTTGACAATGGATGGTAGAACTTGGTTTAGTGTAATAATAGAGTTTTTATCAACTTATATAGGTT
TCTTTGCATTTGTGATACTATATTTTGTATATAAGTTTATTAAAAAGACAAAATTGATAAGACTAGAAGATTGTGATCTT
ACTAGAGAATCTTAG

Upstream 100 bases:

>100_bases
TTTCTCAATTTCTCTAAATCTTATCTTAATCGTAAAGGGTTAAATCTATTAAACTCTTTAATTTTTTTAATTAATACCTT
TTTGGAGGGAAATAAAATAG

Downstream 100 bases:

>100_bases
TTGTAGTTATGGATACTTTTTTTATTCAAGGTCAAGCTGGTCGTATCGAGACAGCTTATGATAAAGTCAAAGGTGCCAAC
AAAGACATCGTTGCTGTAAT

Product: amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATR
YVDSALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVI
IFIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
LFIFYILAVVIISFLIPYNNPSLIKVGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLG
NIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSL
EDLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMDGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
TRES

Sequences:

>Translated_484_residues
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATR
YVDSALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVI
IFIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
LFIFYILAVVIISFLIPYNNPSLIKVGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLG
NIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSL
EDLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMDGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
TRES
>Mature_483_residues
SQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMASLGEMAAHSPVSGTFCEYATRY
VDSALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGSSILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVII
FIIVGFLSILGLVGNHQSVGFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWRL
FIFYILAVVIISFLIPYNNPSLIKVGASNDVSVSPFTIVFENVGLNSAATIMNVIILTAIISACNASMYSATRVLWHLGN
IKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGSGYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLE
DLPYVAKFFPWAPIIALTMVSIVIVGQGVTMLTMDGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDLT
RES

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI71999149, Length=340, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788480, Length=480, Percent_Identity=48.9583333333333, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI87081708, Length=429, Percent_Identity=38.2284382284382, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI48994972, Length=480, Percent_Identity=35, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1786789, Length=432, Percent_Identity=34.9537037037037, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1786302, Length=395, Percent_Identity=34.9367088607595, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI1786602, Length=391, Percent_Identity=35.8056265984655, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=30.7511737089202, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1790653, Length=417, Percent_Identity=32.6139088729017, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87081915, Length=418, Percent_Identity=31.8181818181818, Blast_Score=209, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6320772, Length=493, Percent_Identity=36.7139959432049, Blast_Score=328, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=493, Percent_Identity=35.0912778904665, Blast_Score=316, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324059, Length=491, Percent_Identity=35.6415478615071, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6324990, Length=495, Percent_Identity=35.1515151515151, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=34.9473684210526, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=488, Percent_Identity=32.3770491803279, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=33.1262939958592, Blast_Score=263, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6324553, Length=491, Percent_Identity=31.9755600814664, Blast_Score=259, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6322967, Length=432, Percent_Identity=32.6388888888889, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321053, Length=417, Percent_Identity=34.2925659472422, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324981, Length=473, Percent_Identity=33.4038054968288, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6320717, Length=476, Percent_Identity=30.2521008403361, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=489, Percent_Identity=30.6748466257669, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6319543, Length=428, Percent_Identity=32.0093457943925, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319542, Length=490, Percent_Identity=30.2040816326531, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319608, Length=498, Percent_Identity=29.1164658634538, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320251, Length=488, Percent_Identity=29.3032786885246, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320364, Length=559, Percent_Identity=26.1180679785331, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53452; Mature: 53321

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGEMAAHSPVSGTFCEYATRYVDSALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVIIFIIVGFLSILGLVGNHQSV
HHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
LFIFYILAVVIISFLIPYNNPSLIKVGASNDVSVSPFTIVFENVGLNSAATIMNVIILTA
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
IISACNASMYSATRVLWHLGNIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGS
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHCC
GYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLEDLPYVAKFFPWAPIIALTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
VSIVIVGQGVTMLTMDGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
HHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
TRES
CCCC
>Mature Secondary Structure 
SQKLKRGLHTRHMSMIALGGCIGTGLFVALGGAIADAGPGGTVLAYVIIAIMVYFLMAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGEMAAHSPVSGTFCEYATRYVDSALGFSTGWSYWFNWAITVATEVIAAALIMQYWFPGS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SILLWSGFFFVLVFALNIFSVKIYGEVEYWLSFIKVSTVIIFIIVGFLSILGLVGNHQSV
HHHHHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GFQNWHIGDAPFHNGWWGFISVFMIAGFSFQGSELIGVTAGEAKDPNTSIPKAIKQTFWR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
LFIFYILAVVIISFLIPYNNPSLIKVGASNDVSVSPFTIVFENVGLNSAATIMNVIILTA
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHH
IISACNASMYSATRVLWHLGNIKQAPQFFATTNSKGTPMIALLVTAVIGSSFFFVSFVGS
HHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHCC
GYIFTWLVNVSSLAGFIAWFTIALSHYRFRRAYIKQGKSLEDLPYVAKFFPWAPIIALTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHH
VSIVIVGQGVTMLTMDGRTWFSVIIEFLSTYIGFFAFVILYFVYKFIKKTKLIRLEDCDL
HHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
TRES
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]