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The map label for this gene is tetA [H]

Identifier: 89256899

GI number: 89256899

Start: 1551964

End: 1553190

Strand: Reverse

Name: tetA [H]

Synonym: FTL_1622

Alternate gene names: 89256899

Gene position: 1553190-1551964 (Counterclockwise)

Preceding gene: 89256900

Following gene: 89256898

Centisome position: 81.92

GC content: 34.15

Gene sequence:

>1227_bases
ATGAAATTGCGTACAAAAAATATTTTAATTCCGGTACTTATTACAACAATTATCATAGACATAATGGGTGCGGGACTTGT
TTTTCCTATTATGCCATCGTTATTTTTTGGACAATCATGTATTACTTTTGGTGATCCAGGTAGTAACTTTCAGAACTGGT
ATTATTCGATAGCCTTAGCATGTTGGCCATTAGGATTAATGATTGGCTGTCCTATTATTGGTGAATTATCGGATAAATAT
GGACGCAAAATTATACTAATCGTTGCTTTATCAACCACATGTGTATCATATATTTTATCAGCATATGCTATATACTCACA
TCACTATCTACTATTTGTAGCAAGTAGATTTGTTTGTGGGTTAGCTGGAGGAGCTTTTGAAATTGCTCAAGCTGCGGTGA
TTGATATATCTACAGAAGAAGATAAATCTAAAAATTTGGGCTATATTACGATGGCAGCATCTTTAGGCTTTGTGGTTGGT
CCAATAGTTACAAGTTTTGTTTCAGTAATGAATATTAGTCATACTTTACCGTTTATCTTTGCAGCAGTATTATCACTGCT
GAATATTATTTTTATAGTTATTATCATGACAAAAGATTTACCAAAGAATCCTGGTTTGGTTATTCAACTTGCGACAATCT
ACAAGACAATATCATTTTTATTATCTGATAAGCGTGTTAGATTAATTGGGGTGGTGTATTTGCTAGTACAATGCGCGTGG
GGCTTTTATGGTCAAGGTATAGCATTGTTTTTAAACCTAACTTATAGCTATACAGTTTCACAAACGGGCGCCTTTTATGC
TCTTATGGGATTATCTACAGCGCTTGCAAGTATTATTATTCAGCCGGTAATTTTTGCAAGATTATCTAATCAGGTTGCTT
TTGTAAGAGCTGCTGTTGTTTGTGGTATAGGTTTTATTTTTGTGGCTATTTTAACTAATCAAATCGCACAATGGTTGCTA
ACAATAGTTTTATCATCATCTCAACTTATCTGTTATACAGCTCTTTTAGCAATGATTTCAGGTGCAGTTACAGATAAAGA
ACAAGGTAAAGCAATGGGTGCTGCAGGTGCAGGTTTTGGTTTAGCTTGGTTTTTAAATGATATTATGATGGGACATCTTG
CATCAATATCTCCGAGTTCGCCAATTTCATTTGGTGGCAGGATGTATTTTATTGCAGCGATTATCTTTGTATTTTCTATT
AAAATCTTGCGTGAAAGGGTACAATAA

Upstream 100 bases:

>100_bases
AAGATTTCTAAACATTGATAAAAAAGCATCGTTACGGTAGTATATAACGTTGAATTTTTCTTAATACTTATTAGTATTTT
TATGATATACGAGGTCTACA

Downstream 100 bases:

>100_bases
TCAGCATTGATTAAATTTGATTATTTTTCTTAAATGCAACTAATATCTGTTAAAAATGTAAGCCTAAATTTTGGTACGCA
AATAGTCCTTGATAATGTTA

Product: multidrug transporter (tetracycline resistance protein)

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKLRTKNILIPVLITTIIIDIMGAGLVFPIMPSLFFGQSCITFGDPGSNFQNWYYSIALACWPLGLMIGCPIIGELSDKY
GRKIILIVALSTTCVSYILSAYAIYSHHYLLFVASRFVCGLAGGAFEIAQAAVIDISTEEDKSKNLGYITMAASLGFVVG
PIVTSFVSVMNISHTLPFIFAAVLSLLNIIFIVIIMTKDLPKNPGLVIQLATIYKTISFLLSDKRVRLIGVVYLLVQCAW
GFYGQGIALFLNLTYSYTVSQTGAFYALMGLSTALASIIIQPVIFARLSNQVAFVRAAVVCGIGFIFVAILTNQIAQWLL
TIVLSSSQLICYTALLAMISGAVTDKEQGKAMGAAGAGFGLAWFLNDIMMGHLASISPSSPISFGGRMYFIAAIIFVFSI
KILRERVQ

Sequences:

>Translated_408_residues
MKLRTKNILIPVLITTIIIDIMGAGLVFPIMPSLFFGQSCITFGDPGSNFQNWYYSIALACWPLGLMIGCPIIGELSDKY
GRKIILIVALSTTCVSYILSAYAIYSHHYLLFVASRFVCGLAGGAFEIAQAAVIDISTEEDKSKNLGYITMAASLGFVVG
PIVTSFVSVMNISHTLPFIFAAVLSLLNIIFIVIIMTKDLPKNPGLVIQLATIYKTISFLLSDKRVRLIGVVYLLVQCAW
GFYGQGIALFLNLTYSYTVSQTGAFYALMGLSTALASIIIQPVIFARLSNQVAFVRAAVVCGIGFIFVAILTNQIAQWLL
TIVLSSSQLICYTALLAMISGAVTDKEQGKAMGAAGAGFGLAWFLNDIMMGHLASISPSSPISFGGRMYFIAAIIFVFSI
KILRERVQ
>Mature_408_residues
MKLRTKNILIPVLITTIIIDIMGAGLVFPIMPSLFFGQSCITFGDPGSNFQNWYYSIALACWPLGLMIGCPIIGELSDKY
GRKIILIVALSTTCVSYILSAYAIYSHHYLLFVASRFVCGLAGGAFEIAQAAVIDISTEEDKSKNLGYITMAASLGFVVG
PIVTSFVSVMNISHTLPFIFAAVLSLLNIIFIVIIMTKDLPKNPGLVIQLATIYKTISFLLSDKRVRLIGVVYLLVQCAW
GFYGQGIALFLNLTYSYTVSQTGAFYALMGLSTALASIIIQPVIFARLSNQVAFVRAAVVCGIGFIFVAILTNQIAQWLL
TIVLSSSQLICYTALLAMISGAVTDKEQGKAMGAAGAGFGLAWFLNDIMMGHLASISPSSPISFGGRMYFIAAIIFVFSI
KILRERVQ

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17551570, Length=163, Percent_Identity=29.4478527607362, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17738085, Length=312, Percent_Identity=22.7564102564103, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44176; Mature: 44176

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRTKNILIPVLITTIIIDIMGAGLVFPIMPSLFFGQSCITFGDPGSNFQNWYYSIALA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
CWPLGLMIGCPIIGELSDKYGRKIILIVALSTTCVSYILSAYAIYSHHYLLFVASRFVCG
HHHHHHHHCCCCHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGGAFEIAQAAVIDISTEEDKSKNLGYITMAASLGFVVGPIVTSFVSVMNISHTLPFIF
HCCCHHHHHHHHEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVLSLLNIIFIVIIMTKDLPKNPGLVIQLATIYKTISFLLSDKRVRLIGVVYLLVQCAW
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GFYGQGIALFLNLTYSYTVSQTGAFYALMGLSTALASIIIQPVIFARLSNQVAFVRAAVV
CHHCCCEEEEEEEHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
CGIGFIFVAILTNQIAQWLLTIVLSSSQLICYTALLAMISGAVTDKEQGKAMGAAGAGFG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHH
LAWFLNDIMMGHLASISPSSPISFGGRMYFIAAIIFVFSIKILRERVQ
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLRTKNILIPVLITTIIIDIMGAGLVFPIMPSLFFGQSCITFGDPGSNFQNWYYSIALA
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
CWPLGLMIGCPIIGELSDKYGRKIILIVALSTTCVSYILSAYAIYSHHYLLFVASRFVCG
HHHHHHHHCCCCHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGGAFEIAQAAVIDISTEEDKSKNLGYITMAASLGFVVGPIVTSFVSVMNISHTLPFIF
HCCCHHHHHHHHEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVLSLLNIIFIVIIMTKDLPKNPGLVIQLATIYKTISFLLSDKRVRLIGVVYLLVQCAW
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GFYGQGIALFLNLTYSYTVSQTGAFYALMGLSTALASIIIQPVIFARLSNQVAFVRAAVV
CHHCCCEEEEEEEHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
CGIGFIFVAILTNQIAQWLLTIVLSSSQLICYTALLAMISGAVTDKEQGKAMGAAGAGFG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCHH
LAWFLNDIMMGHLASISPSSPISFGGRMYFIAAIIFVFSIKILRERVQ
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]