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The map label for this gene is tdh [H]

Identifier: 89256808

GI number: 89256808

Start: 1453404

End: 1454459

Strand: Direct

Name: tdh [H]

Synonym: FTL_1523

Alternate gene names: 89256808

Gene position: 1453404-1454459 (Clockwise)

Preceding gene: 89256807

Following gene: 89256809

Centisome position: 76.66

GC content: 37.88

Gene sequence:

>1056_bases
ATGAAAGCATTAGCTAAATTAAAAAAACAACCAGGTATATGGATGATTAATGATGCGCCAATACCAGAATATGGCTACAA
TGATGTTTTGATTAAAATTAAAAAAACGGCTATTTGTGGTACTGATTTACATATTTATAATTGGGATAAATGGTCGCAAA
ACACCATTCCAGTTCCAATGATTACCGGACATGAGTTTGCTGGTGAAGTTGTAGCTAAAGGAGATGGTGTTACAAGCGTA
GATATCGGCGATAGAGTGTCAGGTGAGGGTCATCTTGTATGTGGGCAATGCCGTAATTGCAGAGCAGGTAAACGTCACCT
TTGTAGAAAAACTATAGGTATAGGAGTAAATGTACAGGGTGCATTTGCAGAATATCTAGTTATGCCTGCGGTTAATGTTT
TTAAGATCCCTGATTCTATCAGTGATGATATCGCTAGTACTTTTGATCCTATGGGCAATGCTATTCACACCGCACTTTCT
TTTAACTTAACAGGTGAGGATGTCCTTATAACTGGTGCTGGACCTATTGGCTTAATGGCTGTCAAAATAGCAAGATTCTG
TGGTGCACGCAGAATAGTAATCACAGATATTAATGAGTATCGCCTACAAATGGCTAGGGATTTTGGTGCAACTGTTGCTT
TGAATGTTGCTCCATTTAAGAATCAAGATGAGTTAGTAAAACAAATGCGCAAAGTTATGTCAGATATCGGCATGACAGAA
GGATTTGATGTTGGTCTAGAAATGTCTGGAATTAACTCTGCAATCTCAATGATGCTTGATGTTATGAATCATGGTGGTAA
GCTATCACTTCTAGGCATATCTGCTGGTGATATTTCTGTTGATTGGGGAGCTATATTGTTTAAGGGTCTGACTCTCAAGG
GTATATATGGTAGAGAAATGTTTGAAACATGGTACTTAATGACTAGTATGCTCCAAGCTGGTATGGATATGAACCCTATC
ATCACACATCGACTTCATATTGATGAGTTTCAAAAAGGATTTGAAATAATGAAAAGTGGTCAATGTGGTAAAGTAATACT
GGATTGGAGCAGCTAG

Upstream 100 bases:

>100_bases
ACTCATACTTTTGAGCAAATTGATAAAGCTGTAGATGGCTTTACAAAAGCAGCCAAAGAATTAGGTATTATTCAATAATA
TTCATCACAGGAATCTAATA

Downstream 100 bases:

>100_bases
AATGAAAAAACCAGATTACTCAAATACTACAAAAGTCGATATCCAGTGGGTATTTACGTTATTTGGTACTGCAATAGGTG
CAGGGTTACTTTATCTACCT

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKALAKLKKQPGIWMINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSV
DIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALS
FNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTE
GFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPI
ITHRLHIDEFQKGFEIMKSGQCGKVILDWSS

Sequences:

>Translated_351_residues
MKALAKLKKQPGIWMINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSV
DIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALS
FNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTE
GFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPI
ITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
>Mature_351_residues
MKALAKLKKQPGIWMINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSV
DIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALS
FNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTE
GFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPI
ITHRLHIDEFQKGFEIMKSGQCGKVILDWSS

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=27.6470588235294, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=26.6846361185984, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI4501929, Length=383, Percent_Identity=25.8485639686684, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI34577061, Length=382, Percent_Identity=25.9162303664921, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=26.3013698630137, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=28.1167108753316, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=28.1167108753316, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=383, Percent_Identity=25.065274151436, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=25.9562841530055, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI71565154, Length=347, Percent_Identity=28.2420749279539, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790045, Length=349, Percent_Identity=64.4699140401146, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1788075, Length=376, Percent_Identity=29.7872340425532, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788073, Length=341, Percent_Identity=29.0322580645161, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788407, Length=358, Percent_Identity=28.4916201117318, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787863, Length=357, Percent_Identity=28.0112044817927, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082125, Length=360, Percent_Identity=29.1666666666667, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786825, Length=375, Percent_Identity=29.6, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI226510992, Length=330, Percent_Identity=26.6666666666667, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786552, Length=386, Percent_Identity=28.7564766839378, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790718, Length=280, Percent_Identity=26.7857142857143, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081918, Length=275, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=27.4626865671642, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=343, Percent_Identity=27.6967930029155, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=227, Percent_Identity=33.4801762114537, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=354, Percent_Identity=25.9887005649718, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=26.3852242744063, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=353, Percent_Identity=24.0793201133144, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=25.2173913043478, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=149, Percent_Identity=29.5302013422819, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=347, Percent_Identity=28.2420749279539, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=347, Percent_Identity=28.2420749279539, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323099, Length=330, Percent_Identity=27.8787878787879, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=302, Percent_Identity=29.8013245033113, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=28.6885245901639, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=294, Percent_Identity=28.9115646258503, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=26.099706744868, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=27.2463768115942, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=27.1137026239067, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=263, Percent_Identity=27.7566539923954, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737897, Length=332, Percent_Identity=27.710843373494, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=28.0120481927711, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737895, Length=380, Percent_Identity=25, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45551930, Length=187, Percent_Identity=31.0160427807487, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550770, Length=187, Percent_Identity=31.0160427807487, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221457811, Length=187, Percent_Identity=31.0160427807487, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38400; Mature: 38400

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLKKQPGIWMINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPM
CCCHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEE
ITGHEFAGEVVAKGDGVTSVDIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQG
EECCHHCCCEEECCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEECH
AFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMA
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHEEHEEEEEECCCCEEEECCCCHHHHH
VKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTE
HHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
GFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREM
CCCCCEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCEECHHHHHHCCCEEECCCCHHH
FETWYLMTSMLQAGMDMNPIITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKALAKLKKQPGIWMINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPM
CCCHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEE
ITGHEFAGEVVAKGDGVTSVDIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQG
EECCHHCCCEEECCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEECH
AFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMA
HHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCHHEEHEEEEEECCCCEEEECCCCHHHHH
VKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTE
HHHHHHHCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCC
GFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREM
CCCCCEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCEECHHHHHHCCCEEECCCCHHH
FETWYLMTSMLQAGMDMNPIITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA