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The map label for this gene is kbl [C]

Identifier: 89256807

GI number: 89256807

Start: 1452185

End: 1453381

Strand: Direct

Name: kbl [C]

Synonym: FTL_1522

Alternate gene names: 89256807

Gene position: 1452185-1453381 (Clockwise)

Preceding gene: 89256803

Following gene: 89256808

Centisome position: 76.59

GC content: 34.34

Gene sequence:

>1197_bases
ATGAATAAAGATTTCTATACAAATATTAATAGTAAAATACTAGAAATTAAACAATCTGGTACTTATAAGAGTGAGAGAGT
TATAGCAACACCCCAAGAACCTATAATTAATTTAGAAAATGGTGAAACATTAATTAATTTCTGTGCCAATAATTATCTTG
GTTTTGCCAATAACCCAGAAATAGTTGCCTACGCTAAAGAGCATATTGAAGAATGTGGCTATGGCATGGCTTCAGTAAGG
TTTATTTGTGGCACAAATAGTGTCCACAAACAACTAGAAAAAGAGCTGAGCAATTTTTTTGAGTTTGAAGACACAATTTT
ATACCCTTCATGTTTTGATGCAAATACTGGTCTTTTTGAGACACTTCTTACAAAAGACGATGCTATTATCAGCGACTCTC
TTAACCATGCTAGTATTATCGATGGTGTCAGACTTTGTAAAGCAATGCGCTTTAGATATAACAATAATGATATGCAAGAC
CTTGAAGCAAAACTTATAGAAGCAGATCAAGCTGGAGCGAGATTTAAAATGATTGCGACAGATGGCGTATTCTCTATGGA
TGGTATTATTGCTGATCTTAAATCTATTTGTGACTTAGCAGATAAGTATAATGCCATTGTTATGGTTGATGATTCTCATG
CAGCTGGGTTTGTTGGCAAGCATGGCAAAGGATCTATCGAGCACTGTGATGTTATGGGTAGAGTAGATATATTAACAGGA
ACTTTAGGTAAAGGATTAGGCGGTGCTTCAGGTGGTTATATATGTGCTAAAAAAGAAGTAGTAGATTTACTTAAAAACCT
TTCTAGACCATATCTTTTCTCAAATTCACTTGCACCAATAATTGCTAAGACTTCTATAAAAGCATTAGAAATTACTAAAG
GCTCGAATGAACTAAGAGAACAATTACAAGCTAACCAACAAAGATTCAGATCAAAAATGACTGCTGCTGGATTTGATTTA
ATTCCAGGTGAGCACCCTATCATTCCTGTAATGATCTATGATGAGAAAAAAGCTGCTGAGTTTGCTGAAAAACTTCTAGA
TTATGGAATCTATGTAATCGCCTTCTCATATCCAGTAGTCCCTAAAGGCAAAGCAAGAATTAGAACACAAATGTCTGCTA
CTCATACTTTTGAGCAAATTGATAAAGCTGTAGATGGCTTTACAAAAGCAGCCAAAGAATTAGGTATTATTCAATAA

Upstream 100 bases:

>100_bases
TTTTGTGATATCAACTAGTTTCAAAAAACAATTATATTAGTTAATATCTATATTTAGTCAAATCGATAATTTAAAAAATT
AAATGCTTAAAGGAGCTCAC

Downstream 100 bases:

>100_bases
TATTCATCACAGGAATCTAATAATGAAAGCATTAGCTAAATTAAAAAAACAACCAGGTATATGGATGATTAATGATGCGC
CAATACCAGAATATGGCTAC

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNKDFYTNINSKILEIKQSGTYKSERVIATPQEPIINLENGETLINFCANNYLGFANNPEIVAYAKEHIEECGYGMASVR
FICGTNSVHKQLEKELSNFFEFEDTILYPSCFDANTGLFETLLTKDDAIISDSLNHASIIDGVRLCKAMRFRYNNNDMQD
LEAKLIEADQAGARFKMIATDGVFSMDGIIADLKSICDLADKYNAIVMVDDSHAAGFVGKHGKGSIEHCDVMGRVDILTG
TLGKGLGGASGGYICAKKEVVDLLKNLSRPYLFSNSLAPIIAKTSIKALEITKGSNELREQLQANQQRFRSKMTAAGFDL
IPGEHPIIPVMIYDEKKAAEFAEKLLDYGIYVIAFSYPVVPKGKARIRTQMSATHTFEQIDKAVDGFTKAAKELGIIQ

Sequences:

>Translated_398_residues
MNKDFYTNINSKILEIKQSGTYKSERVIATPQEPIINLENGETLINFCANNYLGFANNPEIVAYAKEHIEECGYGMASVR
FICGTNSVHKQLEKELSNFFEFEDTILYPSCFDANTGLFETLLTKDDAIISDSLNHASIIDGVRLCKAMRFRYNNNDMQD
LEAKLIEADQAGARFKMIATDGVFSMDGIIADLKSICDLADKYNAIVMVDDSHAAGFVGKHGKGSIEHCDVMGRVDILTG
TLGKGLGGASGGYICAKKEVVDLLKNLSRPYLFSNSLAPIIAKTSIKALEITKGSNELREQLQANQQRFRSKMTAAGFDL
IPGEHPIIPVMIYDEKKAAEFAEKLLDYGIYVIAFSYPVVPKGKARIRTQMSATHTFEQIDKAVDGFTKAAKELGIIQ
>Mature_398_residues
MNKDFYTNINSKILEIKQSGTYKSERVIATPQEPIINLENGETLINFCANNYLGFANNPEIVAYAKEHIEECGYGMASVR
FICGTNSVHKQLEKELSNFFEFEDTILYPSCFDANTGLFETLLTKDDAIISDSLNHASIIDGVRLCKAMRFRYNNNDMQD
LEAKLIEADQAGARFKMIATDGVFSMDGIIADLKSICDLADKYNAIVMVDDSHAAGFVGKHGKGSIEHCDVMGRVDILTG
TLGKGLGGASGGYICAKKEVVDLLKNLSRPYLFSNSLAPIIAKTSIKALEITKGSNELREQLQANQQRFRSKMTAAGFDL
IPGEHPIIPVMIYDEKKAAEFAEKLLDYGIYVIAFSYPVVPKGKARIRTQMSATHTFEQIDKAVDGFTKAAKELGIIQ

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=53.0026109660574, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI284448556, Length=409, Percent_Identity=49.6332518337408, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI83977440, Length=397, Percent_Identity=31.2342569269521, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI83977444, Length=397, Percent_Identity=31.2342569269521, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI83977442, Length=397, Percent_Identity=31.2342569269521, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=31.830985915493, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=31.830985915493, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=33.0532212885154, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI119220554, Length=360, Percent_Identity=32.5, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI5454084, Length=249, Percent_Identity=28.9156626506024, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=62.2166246851385, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1786993, Length=343, Percent_Identity=32.3615160349854, Blast_Score=191, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71994529, Length=396, Percent_Identity=49.7474747474747, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=30.8943089430894, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=32.5905292479109, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=32.5905292479109, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=28.2229965156794, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=28.2229965156794, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=31.3672922252011, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=30.7486631016043, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=303, Percent_Identity=26.4026402640264, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24662918, Length=391, Percent_Identity=52.9411764705882, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=31.3218390804598, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI17136286, Length=369, Percent_Identity=31.9783197831978, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24653280, Length=372, Percent_Identity=26.3440860215054, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653276, Length=372, Percent_Identity=26.3440860215054, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653278, Length=372, Percent_Identity=26.3440860215054, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43953; Mature: 43953

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDFYTNINSKILEIKQSGTYKSERVIATPQEPIINLENGETLINFCANNYLGFANNPE
CCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCC
IVAYAKEHIEECGYGMASVRFICGTNSVHKQLEKELSNFFEFEDTILYPSCFDANTGLFE
EEHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHH
TLLTKDDAIISDSLNHASIIDGVRLCKAMRFRYNNNDMQDLEAKLIEADQAGARFKMIAT
HHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEE
DGVFSMDGIIADLKSICDLADKYNAIVMVDDSHAAGFVGKHGKGSIEHCDVMGRVDILTG
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCHHEEEC
TLGKGLGGASGGYICAKKEVVDLLKNLSRPYLFSNSLAPIIAKTSIKALEITKGSNELRE
HHCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEECCCCCCHHHHCCCEEEEEECCHHHHHH
QLQANQQRFRSKMTAAGFDLIPGEHPIIPVMIYDEKKAAEFAEKLLDYGIYVIAFSYPVV
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCC
PKGKARIRTQMSATHTFEQIDKAVDGFTKAAKELGIIQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKDFYTNINSKILEIKQSGTYKSERVIATPQEPIINLENGETLINFCANNYLGFANNPE
CCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCCCCCCC
IVAYAKEHIEECGYGMASVRFICGTNSVHKQLEKELSNFFEFEDTILYPSCFDANTGLFE
EEHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHH
TLLTKDDAIISDSLNHASIIDGVRLCKAMRFRYNNNDMQDLEAKLIEADQAGARFKMIAT
HHHCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEE
DGVFSMDGIIADLKSICDLADKYNAIVMVDDSHAAGFVGKHGKGSIEHCDVMGRVDILTG
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCHHEEEC
TLGKGLGGASGGYICAKKEVVDLLKNLSRPYLFSNSLAPIIAKTSIKALEITKGSNELRE
HHCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEECCCCCCHHHHCCCEEEEEECCHHHHHH
QLQANQQRFRSKMTAAGFDLIPGEHPIIPVMIYDEKKAAEFAEKLLDYGIYVIAFSYPVV
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCC
PKGKARIRTQMSATHTFEQIDKAVDGFTKAAKELGIIQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]