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The map label for this gene is nhaA-2 [H]

Identifier: 57238666

GI number: 57238666

Start: 1719785

End: 1720933

Strand: Reverse

Name: nhaA-2 [H]

Synonym: CJE1827

Alternate gene names: 57238666

Gene position: 1720933-1719785 (Counterclockwise)

Preceding gene: 57238667

Following gene: 57238665

Centisome position: 96.8

GC content: 28.81

Gene sequence:

>1149_bases
ATGCAAATGATAAAGAAGATGGTTTTAAGTGAAACTTTCCCTGGTATTTTGCTTATATTTTTTACATTTTTAGCTTTATT
ATGTAAAAATTCTTCTTTAAGTGTTATTTATACAGATTTTTTTCATGCTAATTTTACAGTAGGATTTGATCATTTTCAAA
TTTCAAAGTCGTTGGATTTATGGATAAATGATGGTTTGATAGCTATATTTTTTCTATGTATAGGGCTTGAGTTAAAATAT
GAAATTTTACGTGGGCAACTTAAAAATATAAGAGCTGTATCTTTACCTATATTTGGAGCTTTAGGGGGTATGATTACTCC
GGCTTTAATTTTTATTGCTATTAATTATGCTCATGATTTTGCTATGAAAGGTTGGGCAATACCTACAGCAACTGATATAG
CTTTTGCAGTGGGTATTTTAATGCTTTTGGGAAATAAAATTCCTACAAGTTTAAAACTTTTTTTACTCTCTTTAGCTATT
TTTGATGATTTGGGTGCTATTGTTATTATTGCTTTGTTTTATACAGATCAGCTTTCAGCTTTAGCAATTATTATTTGTTT
GTTTTGTATATTTGCTCTGCTTTTGTTAAATTATTATCACATCACCCATCTTTCTTTGTACGTGTTGGTAGGTGTTGTGT
TGTGGATAGCTATGCTTAAAAGTGGAGTGCATGCAACTTTGGCTGGTGTGATCATTTCTTTGTTTATACCTCTTGATACA
AAAAATAAAAAACCTTATTTACATGAAGTTCTTAAGGATTTAAATCCTTGGGTAGTTTATTTTATTTTACCTTTATTTGC
TTTTGCTAATGCTGGGATTGATATTAGAGATATGCATCTTGGTTCAGTATTTTCGCCTGTAAGTCTTGGGATTATTTTAG
GACTATTTTTAGGAAAACAATTAGGTGTTTTCACTTTTTGTTTTATTGCTATCAAACTTAAACTTGCAAAATTACCTGAA
AATATTAAATATGGAAAATTTTATGGTATATGTATTTTAACAGGCATCGGTTTTACGATGAGCTTGTTTATTGATGGTTT
GGCTTATAAAAATAGTGATATTTTTGAATATGCGGATAAACTTGCTATTTTAGTAGCTAGTTTTTTAAGTGCCATTGTTG
GTTTTATTTATCTTAAGATTGTTAAATGA

Upstream 100 bases:

>100_bases
TTGTTTTTTTAAATAATTATTTCTTTAGTATTTTTTCGTTATAATTTTACCATTTTATTTATCGTATTAAATTTTTACAA
ATATTTACTTAGGAGCAAGG

Downstream 100 bases:

>100_bases
ATAATATAGTACATAAATTAAAAACTTTAGTTTTAAATGAGGCTTTTGGCGGCGTTTTACTTATAGTTTGTACTTTGCTT
GCTTTGCTTGTGCAAAATGG

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 2 [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDLWINDGLIAIFFLCIGLELKY
EILRGQLKNIRAVSLPIFGALGGMITPALIFIAINYAHDFAMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAI
FDDLGAIVIIALFYTDQLSALAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDT
KNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQLGVFTFCFIAIKLKLAKLPE
NIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEYADKLAILVASFLSAIVGFIYLKIVK

Sequences:

>Translated_382_residues
MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDLWINDGLIAIFFLCIGLELKY
EILRGQLKNIRAVSLPIFGALGGMITPALIFIAINYAHDFAMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAI
FDDLGAIVIIALFYTDQLSALAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDT
KNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQLGVFTFCFIAIKLKLAKLPE
NIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEYADKLAILVASFLSAIVGFIYLKIVK
>Mature_382_residues
MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDLWINDGLIAIFFLCIGLELKY
EILRGQLKNIRAVSLPIFGALGGMITPALIFIAINYAHDFAMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAI
FDDLGAIVIIALFYTDQLSALAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDT
KNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQLGVFTFCFIAIKLKLAKLPE
NIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEYADKLAILVASFLSAIVGFIYLKIVK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=354, Percent_Identity=48.5875706214689, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42390; Mature: 42390

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECEEEEECCCEEECCCHHE
WINDGLIAIFFLCIGLELKYEILRGQLKNIRAVSLPIFGALGGMITPALIFIAINYAHDF
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAIFDDLGAIVIIALFYTDQLSA
HHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
KNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQ
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LGVFTFCFIAIKLKLAKLPENIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEYADK
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAILVASFLSAIVGFIYLKIVK
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQMIKKMVLSETFPGILLIFFTFLALLCKNSSLSVIYTDFFHANFTVGFDHFQISKSLDL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECEEEEECCCEEECCCHHE
WINDGLIAIFFLCIGLELKYEILRGQLKNIRAVSLPIFGALGGMITPALIFIAINYAHDF
EECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
AMKGWAIPTATDIAFAVGILMLLGNKIPTSLKLFLLSLAIFDDLGAIVIIALFYTDQLSA
HHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAIIICLFCIFALLLLNYYHITHLSLYVLVGVVLWIAMLKSGVHATLAGVIISLFIPLDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
KNKKPYLHEVLKDLNPWVVYFILPLFAFANAGIDIRDMHLGSVFSPVSLGIILGLFLGKQ
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHH
LGVFTFCFIAIKLKLAKLPENIKYGKFYGICILTGIGFTMSLFIDGLAYKNSDIFEYADK
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAILVASFLSAIVGFIYLKIVK
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA