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The map label for this gene is map [H]

Identifier: 57238662

GI number: 57238662

Start: 1716639

End: 1717397

Strand: Reverse

Name: map [H]

Synonym: CJE1823

Alternate gene names: 57238662

Gene position: 1717397-1716639 (Counterclockwise)

Preceding gene: 57238663

Following gene: 57238648

Centisome position: 96.6

GC content: 35.97

Gene sequence:

>759_bases
ATGATAGAATTGAAAAAACCAGATGAAATAGAAAAATTAAGAATAGCAAATCAAATTGTAGCAAAAACTTTAAATTTTTT
AGAGAATGAAATTAAAATAGGAATGAGCTTAAAACAAATCGATAAAATGGCAGAAGATTATATTTTAAGCCTTGGTGCCA
AGCCATCATTTAAGGGACTTTATGGTTTTCCAGGTGCCATTTGCACATCTTTAAATCAAGTTTGTATCCATGGAATTCCA
GATGATAAAATTATCAAAGAGGGTGATATTTTAGGTCTTGATGTGGGAAGTTTGATTGATGGGTATTATGGGGATGCAGC
AAGAACTATTGCTATAGGAGAAGTTTCACCCGCTGATAAAGCTTTAATCTCTTGTGCTAAAGACGCGTTATATCATGCTA
TAGATATTATTCGTGATGGAATGCGTTTTAAGGAACTTTCAGCTGCTTTAGGCGAATTTATCCATGCAAGAGGTTTTGTC
CCGCTTCGTGGATATTGCGGGCATGGTATAGGACGAAAGCCCCATGGAGAGCCTGAAATTTTAAACTATTTAGAAAAAGG
TGCGAGTGCAAAAAGTGGCCCTAAAATTAAAAATGGAATGGTGTTTTGCATAGAGCCTATGATATGCCAAAAAGATGGAA
CACCAAAGCATTATAATGGAAAATGGGATGCTGGAAGTATTGATGGGCTTAATGCGGCTCATTATGAACATTGTGTTGCC
GTGATTAATGGGCGTGCTGAAATTCTTTCTATGATATGA

Upstream 100 bases:

>100_bases
TTTGAAAAATCATAAAGCAAAATTACATTTTTATGCTTCAAGCGATGTTGAATCTTTAAAAAATACTGCTAAAATTTGGC
TAAATTTATAAGGAAATAAA

Downstream 100 bases:

>100_bases
TATTAAATTATAAAAATAATATTTTTTTCTTAAAATTCTAAAAATTTAAAATTTTTTAAATAATATTGTAGTAATATTCT
TTAATAATTTAAGTTACTAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIELKKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGLYGFPGAICTSLNQVCIHGIP
DDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADKALISCAKDALYHAIDIIRDGMRFKELSAALGEFIHARGFV
PLRGYCGHGIGRKPHGEPEILNYLEKGASAKSGPKIKNGMVFCIEPMICQKDGTPKHYNGKWDAGSIDGLNAAHYEHCVA
VINGRAEILSMI

Sequences:

>Translated_252_residues
MIELKKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGLYGFPGAICTSLNQVCIHGIP
DDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADKALISCAKDALYHAIDIIRDGMRFKELSAALGEFIHARGFV
PLRGYCGHGIGRKPHGEPEILNYLEKGASAKSGPKIKNGMVFCIEPMICQKDGTPKHYNGKWDAGSIDGLNAAHYEHCVA
VINGRAEILSMI
>Mature_252_residues
MIELKKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGLYGFPGAICTSLNQVCIHGIP
DDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADKALISCAKDALYHAIDIIRDGMRFKELSAALGEFIHARGFV
PLRGYCGHGIGRKPHGEPEILNYLEKGASAKSGPKIKNGMVFCIEPMICQKDGTPKHYNGKWDAGSIDGLNAAHYEHCVA
VINGRAEILSMI

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=33.6, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI40385867, Length=251, Percent_Identity=33.4661354581673, Blast_Score=150, Evalue=7e-37,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=35.3174603174603, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1788728, Length=215, Percent_Identity=29.7674418604651, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=30.6772908366534, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=32, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355531, Length=243, Percent_Identity=30.8641975308642, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24583427, Length=248, Percent_Identity=31.8548387096774, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27384; Mature: 27384

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
YGFPGAICTSLNQVCIHGIPDDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADK
CCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEECHHHHHHHHCCCCEEEEEECCCCHHHH
ALISCAKDALYHAIDIIRDGMRFKELSAALGEFIHARGFVPLRGYCGHGIGRKPHGEPEI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LNYLEKGASAKSGPKIKNGMVFCIEPMICQKDGTPKHYNGKWDAGSIDGLNAAHYEHCVA
HHHHHHCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VINGRAEILSMI
HHCCHHHHHHCC
>Mature Secondary Structure
MIELKKPDEIEKLRIANQIVAKTLNFLENEIKIGMSLKQIDKMAEDYILSLGAKPSFKGL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
YGFPGAICTSLNQVCIHGIPDDKIIKEGDILGLDVGSLIDGYYGDAARTIAIGEVSPADK
CCCCHHHHHHHHHHHCCCCCCCCEECCCCEEEECHHHHHHHHCCCCEEEEEECCCCHHHH
ALISCAKDALYHAIDIIRDGMRFKELSAALGEFIHARGFVPLRGYCGHGIGRKPHGEPEI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LNYLEKGASAKSGPKIKNGMVFCIEPMICQKDGTPKHYNGKWDAGSIDGLNAAHYEHCVA
HHHHHHCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VINGRAEILSMI
HHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]