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The map label for this gene is rnc [H]

Identifier: 57238646

GI number: 57238646

Start: 1702110

End: 1702784

Strand: Reverse

Name: rnc [H]

Synonym: CJE1807

Alternate gene names: 57238646

Gene position: 1702784-1702110 (Counterclockwise)

Preceding gene: 57238647

Following gene: 57238645

Centisome position: 95.78

GC content: 32.74

Gene sequence:

>675_bases
ATGAAAAACATTGAAAAACTAGAGCGGAGTTTAACTTATGAATTTAAAGATAAAAATCTTCTCATACATGCTTTAACCCA
TAAAAGTTTTAAAAAATCTTACAACAACGAACGCTTGGAATTTTTAGGTGATGCTGTGCTTGATTTAGTTGTGGGTGAAT
ACCTTTTTCATAAATTCGCTAAAGATGCCGAAGGAGATTTATCTAAGCTTAGAGCGGCTTTAGTGAATGAAAAGTCTTTT
GCAAAAATTGCAAATAGTTTAAATTTGGGCGATTTTATTTTTATGAGTGTTGCTGAGGAAAACAATGGAGGAAGAGAAAA
GCCTTCTATACTTTCAGATGCGTTAGAAGCCATTATAGGTGCTATACATTTAGAAGCTGGATTTGAGTTTACAAAAACTA
TTGCTTTAAGACTTATAGAAAAAAATTTCCCTCAAATTGATGCAAAAATTCTTATAAAAGATTATAAAACAAAATTACAA
GAGATTACACAGGGAAAAATAGGACAAACTCCGCAGTATGAAACAGTGCGTGCTTTTGGTCCTGATCATTTAAAGCAATT
TGAAATCGCTTTAATGCTTGATGGTAAAGAACTTGCAAGAGCTATTGCGGGAAGCAAAAAAGAAGCACAGCAAATGGCAG
CAAAAATTGCACTTGAGAAATTAGGAGCTTTATAG

Upstream 100 bases:

>100_bases
ATTAAGGCTTTTTGGGTAAAAGCACATAATGGACATTTGGAAAATGAAAGGTGTGATACATTGGCGCGTGAAGCTGCTTT
GAAAATTGCAAGGGAAAATG

Downstream 100 bases:

>100_bases
TGAATACCTTTGGTACGAGATTGAAATTTACAAGTTTTGGTGAGTCTCATGGTGTGGCTGTTGGATGTATTATTGATGGA
ATGCCTGCTGGAGTTAAATT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKNIEKLERSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFAKDAEGDLSKLRAALVNEKSF
AKIANSLNLGDFIFMSVAEENNGGREKPSILSDALEAIIGAIHLEAGFEFTKTIALRLIEKNFPQIDAKILIKDYKTKLQ
EITQGKIGQTPQYETVRAFGPDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL

Sequences:

>Translated_224_residues
MKNIEKLERSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFAKDAEGDLSKLRAALVNEKSF
AKIANSLNLGDFIFMSVAEENNGGREKPSILSDALEAIIGAIHLEAGFEFTKTIALRLIEKNFPQIDAKILIKDYKTKLQ
EITQGKIGQTPQYETVRAFGPDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL
>Mature_224_residues
MKNIEKLERSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFAKDAEGDLSKLRAALVNEKSF
AKIANSLNLGDFIFMSVAEENNGGREKPSILSDALEAIIGAIHLEAGFEFTKTIALRLIEKNFPQIDAKILIKDYKTKLQ
EITQGKIGQTPQYETVRAFGPDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=237, Percent_Identity=29.1139240506329, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI155030236, Length=237, Percent_Identity=29.1139240506329, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI29294649, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI29294651, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788920, Length=202, Percent_Identity=36.1386138613861, Blast_Score=133, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI193202651, Length=236, Percent_Identity=26.271186440678, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=236, Percent_Identity=26.271186440678, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17552834, Length=167, Percent_Identity=29.940119760479, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137682, Length=232, Percent_Identity=30.6034482758621, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17738129, Length=160, Percent_Identity=32.5, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI22026807, Length=96, Percent_Identity=39.5833333333333, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25084; Mature: 25084

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIEKLERSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFA
CCCHHHHHHHHCCEECCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KDAEGDLSKLRAALVNEKSFAKIANSLNLGDFIFMSVAEENNGGREKPSILSDALEAIIG
CCCCCHHHHHHHHHHCHHHHHHHHHCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHH
AIHLEAGFEFTKTIALRLIEKNFPQIDAKILIKDYKTKLQEITQGKIGQTPQYETVRAFG
HHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
PDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL
HHHHHHHHHEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNIEKLERSLTYEFKDKNLLIHALTHKSFKKSYNNERLEFLGDAVLDLVVGEYLFHKFA
CCCHHHHHHHHCCEECCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KDAEGDLSKLRAALVNEKSFAKIANSLNLGDFIFMSVAEENNGGREKPSILSDALEAIIG
CCCCCHHHHHHHHHHCHHHHHHHHHCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHH
AIHLEAGFEFTKTIALRLIEKNFPQIDAKILIKDYKTKLQEITQGKIGQTPQYETVRAFG
HHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
PDHLKQFEIALMLDGKELARAIAGSKKEAQQMAAKIALEKLGAL
HHHHHHHHHEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA