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The map label for this gene is sdaC [H]

Identifier: 57238637

GI number: 57238637

Start: 1694309

End: 1695559

Strand: Reverse

Name: sdaC [H]

Synonym: CJE1797

Alternate gene names: 57238637

Gene position: 1695559-1694309 (Counterclockwise)

Preceding gene: 57238638

Following gene: 57238636

Centisome position: 95.37

GC content: 31.41

Gene sequence:

>1251_bases
ATGAATACTCCTAAATGGACTAGTCACGATACAAGGTGGGTTTTATCTCTTTTTGGAACAGCTATTGGAGCCGGCGTACT
TTTGTTACCTATTAGTGCTGGGCTTGGTGGATTGATACCTTTATTAGTTATACTTGTTTTAGCTTTTCCTATGACTTACT
TAGCTCATAGAAATTTATGTCGCTTTGTGCTTTCAAGTTCTAATCCAAAAGATGATATTACTTTTGTTGCAGAAAGTTAT
TTTGGCAAGGGCGGTGGATTTTTAATTACACTTTTGTATTTTTTTGCTATTTTGCCTATTTTATTGGTTTATAGTGCTAA
TCTTACAACAACTTTGCTTGAGTTCTTAATCAATCAGTTCAATTTCAATGCAGATCTTACTCATGCTGCTCGTTGGTGGG
TGAGTTTTTTGATTGTTGGAGTTTTGGTTTTGATTTCTATTCTTGGTGAAAATGTTGTAACAAAAGCAATGAGTTTTCTT
GTTTTTCCTTTTATTATATTTTTATTTATTTTTTCATTGCTTTTAATTCCACAATGGAATTCATCATTATTTGCAAATGT
TGATTTTTCCGTAATTTCAACAAGTAATTTTTGGGTTACTTTATGGCTTGTTATTCCTGTGATGGTATTTAGTTTTAATC
ACTCTCCTATCATTTCTTCACTTGCTTGTTATTGTAAAAAAGAATATGGTGATTATGCTGAACCTCGCGCTAGAAAAATT
ATTTCTTTGGCAATTATTCTTATGGTTTTTGTTGTAATGTTTTTTGTTTTTTCTTGTGCTTTAACCTTTACACCAGAAGA
TTTTGCATCAGCAAAAGATCAAAATATCAATATTCTTACTTTTATAGCAAATAAATTTCCTGAAGTTTCTTTACTAGCTT
ATGTTGGACCTATTGTTGCACTTGTGGCTATTAGCAAAAGTTTCTTAGGACATTATCTTGGTTCTCAAGAAGGCTTAAAT
GGCATTTTATATAAAGCAAGTAATGGTAGAATTCAAGGTAAATTCGCTCAAACTTTAACAGCGATCATTACCTTTGCTAT
TGCTTGGCTTGTTGCGTATAAAAATCCAAGTGTTATAGGAATTATCGAGGCTATTGGTGGCCCTGTTTTGGCTATTTTGC
TTTTCTTAATGCCACTTTATTGTATTTATCGTTTTGATATTTTGGCAAGATTTCGTAATAAATTTTTAGATCTTTTTATT
TTGGTAATGGGGATAGTTGCAATTTCTGCTGCAATTCATGATCTTTTATAA

Upstream 100 bases:

>100_bases
AAAATGTTACATAAGATTTAAAATATTTTTTTTAAAAATAATTATTTATAAATATTTTGCTAAAATAAAAGAGATGTAAT
CTTAAATTTAAGGAAGAATA

Downstream 100 bases:

>100_bases
ATTAAGGATAAAAAATGAGTAATTTAAGCATTTTTAAAATAGGTGTTGGTCCTTCTTCTTCTCATACTTTAGGGCCTATG
CTTGCTGGAAATTTATTTTG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNTPKWTSHDTRWVLSLFGTAIGAGVLLLPISAGLGGLIPLLVILVLAFPMTYLAHRNLCRFVLSSSNPKDDITFVAESY
FGKGGGFLITLLYFFAILPILLVYSANLTTTLLEFLINQFNFNADLTHAARWWVSFLIVGVLVLISILGENVVTKAMSFL
VFPFIIFLFIFSLLLIPQWNSSLFANVDFSVISTSNFWVTLWLVIPVMVFSFNHSPIISSLACYCKKEYGDYAEPRARKI
ISLAIILMVFVVMFFVFSCALTFTPEDFASAKDQNINILTFIANKFPEVSLLAYVGPIVALVAISKSFLGHYLGSQEGLN
GILYKASNGRIQGKFAQTLTAIITFAIAWLVAYKNPSVIGIIEAIGGPVLAILLFLMPLYCIYRFDILARFRNKFLDLFI
LVMGIVAISAAIHDLL

Sequences:

>Translated_416_residues
MNTPKWTSHDTRWVLSLFGTAIGAGVLLLPISAGLGGLIPLLVILVLAFPMTYLAHRNLCRFVLSSSNPKDDITFVAESY
FGKGGGFLITLLYFFAILPILLVYSANLTTTLLEFLINQFNFNADLTHAARWWVSFLIVGVLVLISILGENVVTKAMSFL
VFPFIIFLFIFSLLLIPQWNSSLFANVDFSVISTSNFWVTLWLVIPVMVFSFNHSPIISSLACYCKKEYGDYAEPRARKI
ISLAIILMVFVVMFFVFSCALTFTPEDFASAKDQNINILTFIANKFPEVSLLAYVGPIVALVAISKSFLGHYLGSQEGLN
GILYKASNGRIQGKFAQTLTAIITFAIAWLVAYKNPSVIGIIEAIGGPVLAILLFLMPLYCIYRFDILARFRNKFLDLFI
LVMGIVAISAAIHDLL
>Mature_416_residues
MNTPKWTSHDTRWVLSLFGTAIGAGVLLLPISAGLGGLIPLLVILVLAFPMTYLAHRNLCRFVLSSSNPKDDITFVAESY
FGKGGGFLITLLYFFAILPILLVYSANLTTTLLEFLINQFNFNADLTHAARWWVSFLIVGVLVLISILGENVVTKAMSFL
VFPFIIFLFIFSLLLIPQWNSSLFANVDFSVISTSNFWVTLWLVIPVMVFSFNHSPIISSLACYCKKEYGDYAEPRARKI
ISLAIILMVFVVMFFVFSCALTFTPEDFASAKDQNINILTFIANKFPEVSLLAYVGPIVALVAISKSFLGHYLGSQEGLN
GILYKASNGRIQGKFAQTLTAIITFAIAWLVAYKNPSVIGIIEAIGGPVLAILLFLMPLYCIYRFDILARFRNKFLDLFI
LVMGIVAISAAIHDLL

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=416, Percent_Identity=50.2403846153846, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1789504, Length=431, Percent_Identity=43.1554524361949, Blast_Score=333, Evalue=9e-93,
Organism=Escherichia coli, GI1789211, Length=410, Percent_Identity=35.609756097561, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789961, Length=416, Percent_Identity=27.4038461538462, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI145693183, Length=406, Percent_Identity=25.615763546798, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46159; Mature: 46159

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPKWTSHDTRWVLSLFGTAIGAGVLLLPISAGLGGLIPLLVILVLAFPMTYLAHRNLC
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFVLSSSNPKDDITFVAESYFGKGGGFLITLLYFFAILPILLVYSANLTTTLLEFLINQF
HHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NFNADLTHAARWWVSFLIVGVLVLISILGENVVTKAMSFLVFPFIIFLFIFSLLLIPQWN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SSLFANVDFSVISTSNFWVTLWLVIPVMVFSFNHSPIISSLACYCKKEYGDYAEPRARKI
CCEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
ISLAIILMVFVVMFFVFSCALTFTPEDFASAKDQNINILTFIANKFPEVSLLAYVGPIVA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LVAISKSFLGHYLGSQEGLNGILYKASNGRIQGKFAQTLTAIITFAIAWLVAYKNPSVIG
HHHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IIEAIGGPVLAILLFLMPLYCIYRFDILARFRNKFLDLFILVMGIVAISAAIHDLL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTPKWTSHDTRWVLSLFGTAIGAGVLLLPISAGLGGLIPLLVILVLAFPMTYLAHRNLC
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RFVLSSSNPKDDITFVAESYFGKGGGFLITLLYFFAILPILLVYSANLTTTLLEFLINQF
HHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NFNADLTHAARWWVSFLIVGVLVLISILGENVVTKAMSFLVFPFIIFLFIFSLLLIPQWN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SSLFANVDFSVISTSNFWVTLWLVIPVMVFSFNHSPIISSLACYCKKEYGDYAEPRARKI
CCEEEECCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
ISLAIILMVFVVMFFVFSCALTFTPEDFASAKDQNINILTFIANKFPEVSLLAYVGPIVA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LVAISKSFLGHYLGSQEGLNGILYKASNGRIQGKFAQTLTAIITFAIAWLVAYKNPSVIG
HHHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IIEAIGGPVLAILLFLMPLYCIYRFDILARFRNKFLDLFILVMGIVAISAAIHDLL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]