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The map label for this gene is nuoD [H]

Identifier: 57238589

GI number: 57238589

Start: 1648069

End: 1649295

Strand: Reverse

Name: nuoD [H]

Synonym: CJE1747

Alternate gene names: 57238589

Gene position: 1649295-1648069 (Counterclockwise)

Preceding gene: 57238590

Following gene: 57238588

Centisome position: 92.77

GC content: 35.94

Gene sequence:

>1227_bases
ATGCAAATTCCTAGCAAGTTAAAACCTTATTATGAAAATATAGCTTTTGAGCAAGAAGACTCAAAAATGATTATCAACTT
AGGCCCTCAACATCCTTCAGCGCATGGAAATTTGCGTCTTATTTTAGAACTCGATGGAGAGCAAGTTGTAAAAGCGCGTC
CTTGTATAGGTTATATGCATCGCGGTATGGAAAAAATGGCTGAAAATATGATTTATCAAGAATTTATTCCTACTACTGAT
AGAATGGACTATATCGCTGCTTCAGCGAATAATTATGCTTATTGTGCAGCGGTTGAAAAGCTTTGTGGTTTAGAGATTCC
ACGCCGTGCCGCAGTGATACGCATGATACTTTTAGAATTAAACCGTATCACATCGCATTTGCTTTGGCTTGCTACTCATG
CGCTTGATATTGGTGCGATGAGTGTGTTTTTATACTGCTTTAGAGAACGAGAATATGTTTTGGATTTGATAGAAAAGTAT
TGTGGTGCAAGGCTTACACATTCTTCTATGAGAATAGGCGGGGTTATGCTTGATTTACCTGAGAATTATTTAGAAGAAAT
GCTTGCATTTTGCGATAAATTTCCAAATGATTTAAAAGATTATGAAGATCTTTTAGATGATAATAGAATTTGGCGTTTAA
GAACTGAAAATGTAGGTGTGGTTACTAAAGAACAAGCCTTAAATTGGGGTTGTACGGGTGTGATGTTAAGAGGAAGTGGC
ATAAAATACGATATACGCAAAGAAGAGCCTTATTTGCTTTATAATGAAGTTGAATTTGGTGTGCCTTATGCAACGCAAGG
AGATTCTTATGCTAGATATAAAGTTTATATGCAAGAATTTCGTGAAAGTTTGAAAATCCTTAGACAATGTGCCATGCTTT
ATAAAGATACTTCGCCTGAAATTTTAGCTACGCATCCTGAGTATGTAAGTGCTTCAAAGGAACAAATTTTAACGCAGAAT
TATTCTTTAATGCAGCATTTTGTTTTAATCACTCAAGGTTTAAAACCCCCTAAAGGCGAAGTTTATGTGCCTACTGAAAG
TCCAAAAGGTGAGCTTGGCTTTTTTATCCATAGTGATGGTACAGGAAGACCTTATCGTTTAAAGGCTAGAACGCCTAGTT
ATTGGCATTGTGCGTTTTTTGAAGAAATGCTTGTAGGTACTTATTTAGCTGATGTTGTAGCCATTATGGGTAATGTAAAT
ATAGTTTTAGGTGAGATAGATCGATGA

Upstream 100 bases:

>100_bases
GAAATTTCCTTTAAACAAGAATATCAAGAAGATGAAGGTGTGGCTTTTGTAAAAAAAGTAAAACGTGATGAAGCAAAAAT
TTTAGAGAAAAGGCGTTAAA

Downstream 100 bases:

>100_bases
GAAGGGTAGATTTAAGAAAAAGCAAAGAGCTTTTTGAAGATTTAGCACAAATCATAAAAGAAGCAAAACAAGGTGAGGTT
TTAGTGGTGCTTTTTGAAAT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMHRGMEKMAENMIYQEFIPTTD
RMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLELNRITSHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKY
CGARLTHSSMRIGGVMLDLPENYLEEMLAFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSG
IKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCAMLYKDTSPEILATHPEYVSASKEQILTQN
YSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDGTGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVN
IVLGEIDR

Sequences:

>Translated_408_residues
MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMHRGMEKMAENMIYQEFIPTTD
RMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLELNRITSHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKY
CGARLTHSSMRIGGVMLDLPENYLEEMLAFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSG
IKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCAMLYKDTSPEILATHPEYVSASKEQILTQN
YSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDGTGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVN
IVLGEIDR
>Mature_408_residues
MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMHRGMEKMAENMIYQEFIPTTD
RMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLELNRITSHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKY
CGARLTHSSMRIGGVMLDLPENYLEEMLAFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSG
IKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCAMLYKDTSPEILATHPEYVSASKEQILTQN
YSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDGTGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVN
IVLGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=386, Percent_Identity=45.3367875647668, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI260898743, Length=380, Percent_Identity=45, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI145693162, Length=395, Percent_Identity=38.4810126582278, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1789076, Length=409, Percent_Identity=27.3838630806846, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=395, Percent_Identity=27.8481012658228, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17555284, Length=402, Percent_Identity=43.5323383084577, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17568379, Length=398, Percent_Identity=43.9698492462312, Blast_Score=366, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=45.4081632653061, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221459469, Length=387, Percent_Identity=45.2196382428941, Blast_Score=351, Evalue=4e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46938; Mature: 46938

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMH
CCCCHHCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHH
RGMEKMAENMIYQEFIPTTDRMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLEL
HHHHHHHHHHHHHHHCCCCCCHHHEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHH
NRITSHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKYCGARLTHSSMRIGGVMLDLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEECCEEEECC
ENYLEEMLAFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSG
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEHHHHCCCCCCEEEEECCC
IKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCAMLYKDTSPE
CEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILATHPEYVSASKEQILTQNYSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDG
EEECCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEECCC
TGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVNIVLGEIDR
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure
MQIPSKLKPYYENIAFEQEDSKMIINLGPQHPSAHGNLRLILELDGEQVVKARPCIGYMH
CCCCHHCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHH
RGMEKMAENMIYQEFIPTTDRMDYIAASANNYAYCAAVEKLCGLEIPRRAAVIRMILLEL
HHHHHHHHHHHHHHHCCCCCCHHHEEECCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHH
NRITSHLLWLATHALDIGAMSVFLYCFREREYVLDLIEKYCGARLTHSSMRIGGVMLDLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEECCEEEECC
ENYLEEMLAFCDKFPNDLKDYEDLLDDNRIWRLRTENVGVVTKEQALNWGCTGVMLRGSG
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEHHHHCCCCCCEEEEECCC
IKYDIRKEEPYLLYNEVEFGVPYATQGDSYARYKVYMQEFRESLKILRQCAMLYKDTSPE
CEEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ILATHPEYVSASKEQILTQNYSLMQHFVLITQGLKPPKGEVYVPTESPKGELGFFIHSDG
EEECCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEECCC
TGRPYRLKARTPSYWHCAFFEEMLVGTYLADVVAIMGNVNIVLGEIDR
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA