Click here to switch to the map view.

The map label for this gene is nuoL [H]

Identifier: 57238581

GI number: 57238581

Start: 1640455

End: 1642245

Strand: Reverse

Name: nuoL [H]

Synonym: CJE1739

Alternate gene names: 57238581

Gene position: 1642245-1640455 (Counterclockwise)

Preceding gene: 57238582

Following gene: 57238580

Centisome position: 92.37

GC content: 32.16

Gene sequence:

>1791_bases
ATGCAAAATTTGGCTTTGATTTCTCTTTTTAGTCCTTTTGTAGCTTTTTTGTTTGCAAGTTGTTTTGCTTTGAGTGAGAA
AAAACAATTCGTAGGGATATTTTGTTCACTTCTAGTAGCTTTGAGTACTTTTTGTTCTTTGTATTTGCTTTTTTGCAATG
AAGCTTTTAATGTGAGTTTGTTTGAATGGTTTGCTGGAGTAAATTTTGGTTTTGATATAGATGCTATTTCGCTTACTATG
ATGAGTATTGTAGGTATTGTAGCCACTTGTGTGCATTTTTATAGTATTTTTTATATGGCTCATGATGAAGGTTTTAATAA
ATTTTTTGCTTATTTGGGGCTTTTTGTCTTTTCTATGCTTTTTTTAGTCATGAGTGATAATTTTTTAGGACTTTTCGTAG
GTTGGGAAGGCGTTGGGCTTTGCTCTTGGTTGCTCATAGGTTTTTGGTATAAAAACGATACTTATTCTTTTGCGGCTAAT
GAAGCTTTTATTATGAATCGTATTGCGGATTTGGGTATGCTTTTAGGAATTTTTTGGCTTTATTTGCAAGCAGGAACTTT
AAAATATGATGAAGTTTTTTCCATGGCACAAAGCCTAGATCACAATGCTTTGATCTTAATCGCAACTTGTTTATTTATAG
GGGCTATGGGAAAATCTGCACAATTTCCTTTTCACACTTGGCTTGCTGATGCTATGGCAGGGCCAACTCCTGTTTCTGCA
TTAATCCATGCAGCAACCATGGTAACAGCGGGGGTTTATTTGGTAATTCGTGCGAGTACGCTTTATGATTTAGTTCCTGA
AGTTTCTTATATTATTGCCTTACTCGGAGCTTTTGTAGCGATTTTTGCAGCCTCTATGGCTTTGGTGGTTAGGGATTTAA
AACGTATTATTGCTTACTCTACCTTATCGCAACTTGGATATATGTTTGTGGCTGCAGGACTTGGGGCTTATGGTATAGCT
TTATTTCACTTAGCTACGCATGCTTTTTTTAAATCTTTACTTTTCTTAGGCGCTGGAAATGTAATGCATGCTATGAATGA
TAAATTAGACATTAAAAAAATGGGTGGACTTTTTAAACCTTTAAAAATTACAGCTATTTTAATGTGTATAGGATCTTTAG
CTTTAGCAGGAATTTATCCTTTTGCAGGATTTTTCTCTAAAGATTTGATTTTGGGATATTCTTTCATTTCTTTTCACCAT
GGTATTTTTTTAGTGCTTTTAATCGCAGCTTTTTTAACAGCATTTTATAGCTTTAGACTTTTAATGTTGGTATTTTTTAC
CCCTGCAAGACATGATGAACATCCGAATGAAGCAAGTAAAATAGCACTCTTGGCTATGAGTCCTTTGATGGTTTTAGCTA
TTATTGCAGGATTTTTTGAACATAGTTTTTTTGAATATTTAAGCACAAAATTAGTTTTTATTGATGCACAAAATCAAATT
GTAATGATTTGTGCGAGTGTAGCAGCTATTTTGGGTGTAATTTTGGCTATTTTTGCTTATAAAAATTCTTGGTTTAAGGA
AAGTATTGAAGAAAATAAAATTCACAAACTTTTAAGTAATGATTATTTTATTCCTAGATTTTATCATCAATTTATCGTTT
CAAAATATGAAAGTTTATGTGCGATTTTAAAGCATTGTGATCTTTATATTTTTGACAGAATAGTTGAAAAAATTGCTTTG
TATTCTCAAAATATTTCACAAAAAATGATTATGCCAAACAGCTTAAACTTAATGCTTAGGTTTTTGGTGGCAGCTTTTGT
GATTTTGTTGATTTTAGTATGGATGGTGTAA

Upstream 100 bases:

>100_bases
GCGGCTTGTGAAGTAGCTGTTGGTGTAGCTTTGTGCGTGCTTTGGTATAGAAGAAAAGGCACTTTGGAATTAAAAAGCTT
AAAAGAAGTGGAGGCTTAGT

Downstream 100 bases:

>100_bases
AATGCTAAATTATTTGATATTTTTTCCTTTAATTTCTGCTTTTGTGGTTTTGCTATTAAATCGCGGAGGCGTTAAGGTTT
TTAGCGTTGTTGTAAGTTTT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MQNLALISLFSPFVAFLFASCFALSEKKQFVGIFCSLLVALSTFCSLYLLFCNEAFNVSLFEWFAGVNFGFDIDAISLTM
MSIVGIVATCVHFYSIFYMAHDEGFNKFFAYLGLFVFSMLFLVMSDNFLGLFVGWEGVGLCSWLLIGFWYKNDTYSFAAN
EAFIMNRIADLGMLLGIFWLYLQAGTLKYDEVFSMAQSLDHNALILIATCLFIGAMGKSAQFPFHTWLADAMAGPTPVSA
LIHAATMVTAGVYLVIRASTLYDLVPEVSYIIALLGAFVAIFAASMALVVRDLKRIIAYSTLSQLGYMFVAAGLGAYGIA
LFHLATHAFFKSLLFLGAGNVMHAMNDKLDIKKMGGLFKPLKITAILMCIGSLALAGIYPFAGFFSKDLILGYSFISFHH
GIFLVLLIAAFLTAFYSFRLLMLVFFTPARHDEHPNEASKIALLAMSPLMVLAIIAGFFEHSFFEYLSTKLVFIDAQNQI
VMICASVAAILGVILAIFAYKNSWFKESIEENKIHKLLSNDYFIPRFYHQFIVSKYESLCAILKHCDLYIFDRIVEKIAL
YSQNISQKMIMPNSLNLMLRFLVAAFVILLILVWMV

Sequences:

>Translated_596_residues
MQNLALISLFSPFVAFLFASCFALSEKKQFVGIFCSLLVALSTFCSLYLLFCNEAFNVSLFEWFAGVNFGFDIDAISLTM
MSIVGIVATCVHFYSIFYMAHDEGFNKFFAYLGLFVFSMLFLVMSDNFLGLFVGWEGVGLCSWLLIGFWYKNDTYSFAAN
EAFIMNRIADLGMLLGIFWLYLQAGTLKYDEVFSMAQSLDHNALILIATCLFIGAMGKSAQFPFHTWLADAMAGPTPVSA
LIHAATMVTAGVYLVIRASTLYDLVPEVSYIIALLGAFVAIFAASMALVVRDLKRIIAYSTLSQLGYMFVAAGLGAYGIA
LFHLATHAFFKSLLFLGAGNVMHAMNDKLDIKKMGGLFKPLKITAILMCIGSLALAGIYPFAGFFSKDLILGYSFISFHH
GIFLVLLIAAFLTAFYSFRLLMLVFFTPARHDEHPNEASKIALLAMSPLMVLAIIAGFFEHSFFEYLSTKLVFIDAQNQI
VMICASVAAILGVILAIFAYKNSWFKESIEENKIHKLLSNDYFIPRFYHQFIVSKYESLCAILKHCDLYIFDRIVEKIAL
YSQNISQKMIMPNSLNLMLRFLVAAFVILLILVWMV
>Mature_596_residues
MQNLALISLFSPFVAFLFASCFALSEKKQFVGIFCSLLVALSTFCSLYLLFCNEAFNVSLFEWFAGVNFGFDIDAISLTM
MSIVGIVATCVHFYSIFYMAHDEGFNKFFAYLGLFVFSMLFLVMSDNFLGLFVGWEGVGLCSWLLIGFWYKNDTYSFAAN
EAFIMNRIADLGMLLGIFWLYLQAGTLKYDEVFSMAQSLDHNALILIATCLFIGAMGKSAQFPFHTWLADAMAGPTPVSA
LIHAATMVTAGVYLVIRASTLYDLVPEVSYIIALLGAFVAIFAASMALVVRDLKRIIAYSTLSQLGYMFVAAGLGAYGIA
LFHLATHAFFKSLLFLGAGNVMHAMNDKLDIKKMGGLFKPLKITAILMCIGSLALAGIYPFAGFFSKDLILGYSFISFHH
GIFLVLLIAAFLTAFYSFRLLMLVFFTPARHDEHPNEASKIALLAMSPLMVLAIIAGFFEHSFFEYLSTKLVFIDAQNQI
VMICASVAAILGVILAIFAYKNSWFKESIEENKIHKLLSNDYFIPRFYHQFIVSKYESLCAILKHCDLYIFDRIVEKIAL
YSQNISQKMIMPNSLNLMLRFLVAAFVILLILVWMV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=395, Percent_Identity=38.7341772151899, Blast_Score=268, Evalue=8e-72,
Organism=Escherichia coli, GI1788614, Length=592, Percent_Identity=37.1621621621622, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1788829, Length=462, Percent_Identity=32.4675324675325, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1788831, Length=343, Percent_Identity=31.4868804664723, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788827, Length=346, Percent_Identity=28.6127167630058, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI2367154, Length=221, Percent_Identity=28.0542986425339, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=407, Percent_Identity=24.0786240786241, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=350, Percent_Identity=25.4285714285714, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66640; Mature: 66640

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNLALISLFSPFVAFLFASCFALSEKKQFVGIFCSLLVALSTFCSLYLLFCNEAFNVSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FEWFAGVNFGFDIDAISLTMMSIVGIVATCVHFYSIFYMAHDEGFNKFFAYLGLFVFSML
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FLVMSDNFLGLFVGWEGVGLCSWLLIGFWYKNDTYSFAANEAFIMNRIADLGMLLGIFWL
HHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
YLQAGTLKYDEVFSMAQSLDHNALILIATCLFIGAMGKSAQFPFHTWLADAMAGPTPVSA
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHH
LIHAATMVTAGVYLVIRASTLYDLVPEVSYIIALLGAFVAIFAASMALVVRDLKRIIAYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSQLGYMFVAAGLGAYGIALFHLATHAFFKSLLFLGAGNVMHAMNDKLDIKKMGGLFKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCH
LKITAILMCIGSLALAGIYPFAGFFSKDLILGYSFISFHHGIFLVLLIAAFLTAFYSFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLVFFTPARHDEHPNEASKIALLAMSPLMVLAIIAGFFEHSFFEYLSTKLVFIDAQNQI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCH
VMICASVAAILGVILAIFAYKNSWFKESIEENKIHKLLSNDYFIPRFYHQFIVSKYESLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AILKHCDLYIFDRIVEKIALYSQNISQKMIMPNSLNLMLRFLVAAFVILLILVWMV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQNLALISLFSPFVAFLFASCFALSEKKQFVGIFCSLLVALSTFCSLYLLFCNEAFNVSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FEWFAGVNFGFDIDAISLTMMSIVGIVATCVHFYSIFYMAHDEGFNKFFAYLGLFVFSML
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FLVMSDNFLGLFVGWEGVGLCSWLLIGFWYKNDTYSFAANEAFIMNRIADLGMLLGIFWL
HHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
YLQAGTLKYDEVFSMAQSLDHNALILIATCLFIGAMGKSAQFPFHTWLADAMAGPTPVSA
HHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHH
LIHAATMVTAGVYLVIRASTLYDLVPEVSYIIALLGAFVAIFAASMALVVRDLKRIIAYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSQLGYMFVAAGLGAYGIALFHLATHAFFKSLLFLGAGNVMHAMNDKLDIKKMGGLFKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCH
LKITAILMCIGSLALAGIYPFAGFFSKDLILGYSFISFHHGIFLVLLIAAFLTAFYSFRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLVFFTPARHDEHPNEASKIALLAMSPLMVLAIIAGFFEHSFFEYLSTKLVFIDAQNQI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCH
VMICASVAAILGVILAIFAYKNSWFKESIEENKIHKLLSNDYFIPRFYHQFIVSKYESLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AILKHCDLYIFDRIVEKIALYSQNISQKMIMPNSLNLMLRFLVAAFVILLILVWMV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]