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The map label for this gene is nuoM [H]

Identifier: 57238580

GI number: 57238580

Start: 1638966

End: 1640453

Strand: Reverse

Name: nuoM [H]

Synonym: CJE1738

Alternate gene names: 57238580

Gene position: 1640453-1638966 (Counterclockwise)

Preceding gene: 57238581

Following gene: 57238579

Centisome position: 92.27

GC content: 29.3

Gene sequence:

>1488_bases
ATGCTAAATTATTTGATATTTTTTCCTTTAATTTCTGCTTTTGTGGTTTTGCTATTAAATCGCGGAGGCGTTAAGGTTTT
TAGCGTTGTTGTAAGTTTTATGATTTTGGCTTTAAATTTGGATACTTTTGCGGATTTTTTACAAGGGGTAAGCTTTGATT
ATAATCTCTCTTTTAAAATTTTGAAATTTTTTAGCTTTCATGTAGGAGTAGACAGTATTGCACTTGTATTGATGCTTTTA
AGTTCTTTGATGATATTTTTAAGCTTTTTATTTTTGAAACTAGAACAGAAAGCGCTTATATCTTGTATATTCTTTTTAGA
ATTTGCTATTATGGGACTTTTTAGCGCAAAAGATGGTTTGTTGTTTTATATTTTTTGGGAATTTTCTCTTTTGCCTTTGC
TTTATATTATGGGAGTTTATGGTAAAGATTTTAGAGCAGGGGTGAAATTTTTTATCTATGCTTTTGCGGGTTCAATTTTA
ATGCTTGTAGCATTGATTTATCAAGCTTATTTAAATTATCAGCTTTTAAATATCTTCACTTTTGACTTGGAAATTTGGAA
AAATAATGCCTCAGCAGCAAATTTTACAGAGCAACTTTTACTTTTTGGAGCATTTTTTATCGCTTTTGCTATCAAAGCTC
CTTTATTTCCACTTCATACTTGGGCACCTAAGGTTTATGCAAATTCGCCTATACTTGTTTCTGTAATGCTTGTAGTTTTT
AAAATGGCTCCTTTTGGATTTTTACTTTTTTGTTTACCACTTTTTCCAGATGCGAGTGTGTATTTTATGCCTTTAATTGT
AGCTTTATGTATAGTAAGTATCGTTTATAATGCTTTAATTGCTTATAGAGCAGAAAATATTAAAGAATTGATTGCTTATA
GTTCTATTTCACATCTTGGTGTGATGATTTTGGGAATTTTTTCTTTAAATGCTTTGGGTATTAGTGGTGCAGTTTTTTAT
ATGTTTGCACACGGTATTGTAACAGGAACTTTATTTTTAATGGTTGAACTTTTATACCAAAGATATCATACTTATGATAT
TTCTTTTTACCATTCTTTGGCCAAAAAAGCACCTTTATTTTCAATTTTCTTTATGTTAATTTTACTCGCAAGCGTTTCTT
TGCCTTTAACTGTTTCTTTTGTGGGAGAGTTTTTAATTCTTTTAGGTATAGCAAAGATTAATTTATTTTACGCTTTGTTG
GCAGGTTTGGTGATTATTTTAGGAGCGATTTATATGTTCGCAGTATTTAGAAAAATATTTTTCATGCAAAAACAAAGCTT
TATAGAGGGTTTTTCTTTACGTTTTAGAGAAATAGTAGCGCTTGTGTGCATTGTAGTAATGATTTTTGGACTAGGGCTTA
TGCCAAATATACTTTTAAAGCCGATACAAAAAGATGTGGATAATCTTATAAAAACAATGAATATTAGAGCTGTTGAGCAA
AATACTTTAGATTTTTTATCTAAAATAGGAGAGGCAAATGTTAAATAA

Upstream 100 bases:

>100_bases
ATTTCACAAAAAATGATTATGCCAAACAGCTTAAACTTAATGCTTAGGTTTTTGGTGGCAGCTTTTGTGATTTTGTTGAT
TTTAGTATGGATGGTGTAAA

Downstream 100 bases:

>100_bases
TTTTTTAAATTTAGAACTTTTAAATATAAGCTTATCTTATCCATTTTTATTTTTAATTACAACTGCAATAGTTCTTTTGC
TTTGCTCTGGTTTTTGGAAA

Product: NADH-quinone oxidoreductase, M subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLNYLIFFPLISAFVVLLLNRGGVKVFSVVVSFMILALNLDTFADFLQGVSFDYNLSFKILKFFSFHVGVDSIALVLMLL
SSLMIFLSFLFLKLEQKALISCIFFLEFAIMGLFSAKDGLLFYIFWEFSLLPLLYIMGVYGKDFRAGVKFFIYAFAGSIL
MLVALIYQAYLNYQLLNIFTFDLEIWKNNASAANFTEQLLLFGAFFIAFAIKAPLFPLHTWAPKVYANSPILVSVMLVVF
KMAPFGFLLFCLPLFPDASVYFMPLIVALCIVSIVYNALIAYRAENIKELIAYSSISHLGVMILGIFSLNALGISGAVFY
MFAHGIVTGTLFLMVELLYQRYHTYDISFYHSLAKKAPLFSIFFMLILLASVSLPLTVSFVGEFLILLGIAKINLFYALL
AGLVIILGAIYMFAVFRKIFFMQKQSFIEGFSLRFREIVALVCIVVMIFGLGLMPNILLKPIQKDVDNLIKTMNIRAVEQ
NTLDFLSKIGEANVK

Sequences:

>Translated_495_residues
MLNYLIFFPLISAFVVLLLNRGGVKVFSVVVSFMILALNLDTFADFLQGVSFDYNLSFKILKFFSFHVGVDSIALVLMLL
SSLMIFLSFLFLKLEQKALISCIFFLEFAIMGLFSAKDGLLFYIFWEFSLLPLLYIMGVYGKDFRAGVKFFIYAFAGSIL
MLVALIYQAYLNYQLLNIFTFDLEIWKNNASAANFTEQLLLFGAFFIAFAIKAPLFPLHTWAPKVYANSPILVSVMLVVF
KMAPFGFLLFCLPLFPDASVYFMPLIVALCIVSIVYNALIAYRAENIKELIAYSSISHLGVMILGIFSLNALGISGAVFY
MFAHGIVTGTLFLMVELLYQRYHTYDISFYHSLAKKAPLFSIFFMLILLASVSLPLTVSFVGEFLILLGIAKINLFYALL
AGLVIILGAIYMFAVFRKIFFMQKQSFIEGFSLRFREIVALVCIVVMIFGLGLMPNILLKPIQKDVDNLIKTMNIRAVEQ
NTLDFLSKIGEANVK
>Mature_495_residues
MLNYLIFFPLISAFVVLLLNRGGVKVFSVVVSFMILALNLDTFADFLQGVSFDYNLSFKILKFFSFHVGVDSIALVLMLL
SSLMIFLSFLFLKLEQKALISCIFFLEFAIMGLFSAKDGLLFYIFWEFSLLPLLYIMGVYGKDFRAGVKFFIYAFAGSIL
MLVALIYQAYLNYQLLNIFTFDLEIWKNNASAANFTEQLLLFGAFFIAFAIKAPLFPLHTWAPKVYANSPILVSVMLVVF
KMAPFGFLLFCLPLFPDASVYFMPLIVALCIVSIVYNALIAYRAENIKELIAYSSISHLGVMILGIFSLNALGISGAVFY
MFAHGIVTGTLFLMVELLYQRYHTYDISFYHSLAKKAPLFSIFFMLILLASVSLPLTVSFVGEFLILLGIAKINLFYALL
AGLVIILGAIYMFAVFRKIFFMQKQSFIEGFSLRFREIVALVCIVVMIFGLGLMPNILLKPIQKDVDNLIKTMNIRAVEQ
NTLDFLSKIGEANVK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=375, Percent_Identity=29.8666666666667, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1788613, Length=506, Percent_Identity=30.4347826086957, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1788827, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI145693160, Length=287, Percent_Identity=26.4808362369338, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI2367154, Length=260, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55898; Mature: 55898

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA