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The map label for this gene is neuC [H]

Identifier: 57238374

GI number: 57238374

Start: 1407868

End: 1409034

Strand: Direct

Name: neuC [H]

Synonym: CJE1517

Alternate gene names: 57238374

Gene position: 1407868-1409034 (Clockwise)

Preceding gene: 57238373

Following gene: 57238375

Centisome position: 79.19

GC content: 28.88

Gene sequence:

>1167_bases
ATGAGCTTATCCGTGAGTAAAAGAAAAATTTGTATAGTCAGTGCAACAAGGGCTGAATGGTATCTTTTAAGAAATTTATG
TCATGAAATTCAAAACGATAAAGATCTAAGCCTTCAAATCATTGCTACAGGAGCACATTTAAGCCCTGAGTTTGGACTCA
CTTATAAAGAAATAGAAAAAGAATTTAAAATCACTAAGAAAATTCCTATCCTACTTGCAAATGATGATAAAATAAGCCTT
TGCAAAAGCATGAGTTTAGCTTTTAGTGCTTTTAGCGATGCTTTTGAAGACTTAAAACCTGATATGGTGGTAATTTTAGG
CGATCGTTATGAAATGCTTAGCGTAGCAAGTGTATGTCTTTTGATGCACATACCTTTAGTGCATTTATGTGGCGGGGAGC
TTACTTTAGGGGCTATTGATGATAGTATAAGACACAGCATTTCAAAAATGTCACATTTACATTTTGTAAGTCATGAAATT
TATAAAAAAAGGCTTTTGCAACTTGGAGAAGAAGAAAAAAGGGTTTTTAATATAGGTTCTTTAGCTTCTACTATCATAAA
AAATATGAATTTTTTAAACAAAAAAGATTTAGAAAAAGCCTTAGAAATGAAACTAGATAAAGAACTTTACTTAATCACTT
ATCATCCTTTAACCTTAAATGTAAAAAATACTCAAAAAGAGATTAAAACCTTACTTAAAAAACTTGACACCCTTAAAAAC
GCAAGTTTGATTTTTACCAAAGCAAATGCCGATGAAAATGGACTTTTAATCAATGAAATTTTGCAAAATTACTGCCAAAA
AAACTCACACAAGGCTAAACTTTTTGATAATCTTGGCTCACAAAAATACCTAAGTCTTATGAAAATAGCCAAAACCATGA
TAGGCAATTCTTCAAGTGGTATTAGTGAAAGTCCTTTTTTTAAAACTCCTTGCATTAATATAGGCGATAGACAAAAAGGG
CGTTTAAGAACTCAAAATATCATTGATTGTGAAATTAATGATCTTGATCAAGCTTTTGAAAAATTAGAAAGCAAAGAATT
TAAACAAATTTTAAAAAATTTTAAAAACCCTTATGATAATGATAAAAATCCCAATAAATTCATAAAAACTTGCCTAAAAA
ATGTAAATTTAGATACAATTTTACATAAAAATTTCATCGATTTATAA

Upstream 100 bases:

>100_bases
AGCGAAGAAAATCTTACTACCAAACGCCCCGCAAATGGTATAAGTGCTATGAGATATGAAGAGTTTTTAGGTAAAATTGC
TACTAAAAACTACAAAGAAG

Downstream 100 bases:

>100_bases
GGCTTAGTGTGGATATAAACAAACTCAAACTCACCCCTGATTCTAGCATAAAAGAAGCTTTAAAAATAGTCGGGCAAGAG
CGCGTTAGATTAGGCATTAT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSLSVSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEKEFKITKKIPILLANDDKISL
CKSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCLLMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEI
YKKRLLQLGEEEKRVFNIGSLASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKN
ASLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKTMIGNSSSGISESPFFKTPCINIGDRQKG
RLRTQNIIDCEINDLDQAFEKLESKEFKQILKNFKNPYDNDKNPNKFIKTCLKNVNLDTILHKNFIDL

Sequences:

>Translated_388_residues
MSLSVSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEKEFKITKKIPILLANDDKISL
CKSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCLLMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEI
YKKRLLQLGEEEKRVFNIGSLASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKN
ASLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKTMIGNSSSGISESPFFKTPCINIGDRQKG
RLRTQNIIDCEINDLDQAFEKLESKEFKQILKNFKNPYDNDKNPNKFIKTCLKNVNLDTILHKNFIDL
>Mature_387_residues
SLSVSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEKEFKITKKIPILLANDDKISLC
KSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCLLMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEIY
KKRLLQLGEEEKRVFNIGSLASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKNA
SLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKTMIGNSSSGISESPFFKTPCINIGDRQKGR
LRTQNIIDCEINDLDQAFEKLESKEFKQILKNFKNPYDNDKNPNKFIKTCLKNVNLDTILHKNFIDL

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=385, Percent_Identity=26.7532467532467, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI190014632, Length=385, Percent_Identity=26.7532467532467, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI4885285, Length=385, Percent_Identity=26.7532467532467, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI298566325, Length=351, Percent_Identity=27.0655270655271, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI298566315, Length=121, Percent_Identity=32.2314049586777, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14

Molecular weight: Translated: 44290; Mature: 44159

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSVSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEK
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
EFKITKKIPILLANDDKISLCKSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCL
HHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
LMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEIYKKRLLQLGEEEKRVFNIGS
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKN
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHCC
ASLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKTMIGNSSSG
CEEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ISESPFFKTPCINIGDRQKGRLRTQNIIDCEINDLDQAFEKLESKEFKQILKNFKNPYDN
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKNPNKFIKTCLKNVNLDTILHKNFIDL
CCCHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SLSVSKRKICIVSATRAEWYLLRNLCHEIQNDKDLSLQIIATGAHLSPEFGLTYKEIEK
CCCCCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHH
EFKITKKIPILLANDDKISLCKSMSLAFSAFSDAFEDLKPDMVVILGDRYEMLSVASVCL
HHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
LMHIPLVHLCGGELTLGAIDDSIRHSISKMSHLHFVSHEIYKKRLLQLGEEEKRVFNIGS
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LASTIIKNMNFLNKKDLEKALEMKLDKELYLITYHPLTLNVKNTQKEIKTLLKKLDTLKN
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEECHHHHHHHHHHHHHHHHCC
ASLIFTKANADENGLLINEILQNYCQKNSHKAKLFDNLGSQKYLSLMKIAKTMIGNSSSG
CEEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ISESPFFKTPCINIGDRQKGRLRTQNIIDCEINDLDQAFEKLESKEFKQILKNFKNPYDN
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKNPNKFIKTCLKNVNLDTILHKNFIDL
CCCHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-glucosamine

Specific reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]